Chemoenzymatic Synthesis of Ultra Low Molecular Weight Heparins

(page 2 of 2) One of the advantages of these new, short, synthetic heparins is that they can be synthesized in 10 to 12 steps (vs. Fondaparinux, over 50 steps!) in high yields. This is because they are made chemoenzymatically - made using special chemical cofactors and specialized enzymes. Because enzymes are very specific in how they link molecules together, many synthetic steps can be skipped or can be done at the same time. Here, heparin and heparan sulfate biosynthetic enzymes were used to transform a simple disaccharide isolated from a bacteria into two synthetic ultra-low molecular weight heparins. Making heparin synthetically will help ensure that this important drug is chemically pure.

RPI Press Release