Current Publications by Decade




680. "Combinatorial one-pot chemoenzymatic synthesis of heparin," U. Bhaskar, G. Li, L. Fu, A. Onishi, M. Suflita, J. S. Dordick, R. J. Linhardt, Carbohydrate Polymers, in press, 2014.


679. "Rapid and accurate determination of the lignin content of lignocellulosic biomass by solid-state NMR," L. Fu, S.A. McCallum, J. Miao, C. Hart, G. Tudryn, F. Zhang, R. J. Linhardt, Fuel, in press, 2014.


678. "Phenylethanoid glycosides," S. Zhao, Z. Wang, M. Koffas, R. J. Linhardt, Fuming Zhang, Recent Progress in Medicinal Plants, Studium Press, in press, 2014.


677. "Compositional analysis and structural elucidation of glycosaminoglycans in chicken eggs," Z. Liu, F. Zhang, L. Li, G. Li, W. He, R. J. Linhardt, Glycoconjugate Journal, in press, 2014.


676. "Stable-isotopic analysis of porcine, bovine, and ovine heparins," J. P. Jasper, F. Zhang, R. B. Poe, R. J. Linhardt, Journal of Pharmaceutical Sciences, in press, 2014.


675. "Chemoenzymatic synthesis of heparin," D. M. Dickinson, J. Liu, R. J. Linhardt, Glycoscience: Biology and Medicine, N. Taniguchi, T. Endo, G. Hart, P. Seeberger, C.-H. Wong (Eds.), Springer, in press, 2014.


674. "Chemoenzymatic synthesis of heparan sulfate and heparin," J. Liu, R.J. Linhardt, Natural Product Reports, in press, 2014.


673. "Polysaccharide-based nanocomposites and their applications," Y. Zheng, J. Monty, R. J. Linhardt, Carbohydrate Research, in press, 2014.


672. "Modulation of heparan sulfate biosynthesis by sodium butyrate in recombinant CHO cells," P. Datta, B. Yang, R. J. Linhardt, S.T. Sharfstein, Cytotechnology, in press, 2014.


671. "Isolation and structural characterization of glycosaminoglycans from heads of red salmon (Oncorhynchus nerka)," F. Zhang, J. Xie, R. J. Linhardt, Journal of Biotechnology and Bioengineering, 1, 1-5, 2014. LINK


670. "Nanoparticle coating during wet electrospinning of cellulose," Y. Zheng, J. Miao, R. J. Linhardt, T. J. Simmons, Journal of Materials Chemistry A, 2, 15029–15034, 2014. LINK


669. "Glycosaminoglycan-modulated divergent aggregation of Serum Amyloid A," J. J. Aguilera, J. Beaudet, F. Zhang, R. J. Linhardt, W. Colón, Biochemie, 104, 70-80, 2014 LINK


668. "Masquerading microbial pathogens: Capsular polysaccharides mimic host-tissue molecules." B. F. Cress, J. A. Englaender, W. He, D. Kasper, R. J. Linhardt, M. A. G. Koffas, FEMS Microbiology Reviews, 38, 660–697, 2014. LINK


667. "Capillary electrophoresis for total glycosaminoglycan analysis," E. Ucakturk, C. Cai, L. Li, G. Li, F. Zhang, R. J. Linhardt, Analytical and Bioanalytical Chemistry, 406, 4617–4626, 2014. LINK


666. "Bottom-up LMWH analysis using LC-FTMS for extensive characterization," G. Li, J. Steppich, Z. Wang, Y. Sun, C. Xue, R. J. Linhardt, L. Li, Analytical Chemistry, 86, 6626−6632, 2014. LINK


665. "Heparin stability by determining unsubstituted amino groups using HILIC-MS," L. Fu, L. Li, C. Cai, G. Li, F. Zhang, Robert J. Linhardt, Analytical Biochemistry, 461, 46–48, 2014. LINK


664. "The effects of metal ions on heparin/heparin sulfate-protein interactions," F. Zhang, X. Liang, J. M. Beaudet, Y. Lee, R. J. Linhardt, Journal of Biomedical Technology and Research, 1, 1-7, 2014 LINK


663. "Impact of GFP tagging on Robo1-heparin interaction," F. Zhang, B. Walcott, H. A. Moniz, K. W. Moremen, L. Wang, R. J. Linhardt, Glycoconjugate Journal, 31, 299–307, 2014. LINK


662. "Three Dimensional Cellular Microarray Platform for Human Neural Stem Cell Differentiation and Toxicology," L. Meli, H. S.C. Barbosa, A. M. Hickey, L. Gasimli, G. Nierode, M. M. Diogo, R. J. Linhardt, J.M.S. Cabral, Jonathan S. Dordick, Stem Cell Research, 12, 36–47, 2014. LINK


661. "Analysis of 3-O-sulfo group containing heparin tetrasaccharides in heparin by liquid chromatography-mass spectrometry," G. Li, B. Yang, L. Li, F. Zhang, C. Xue, R. J. Linhardt, Analytical Biochemistry,455, 3–9, 2014. LINK


660. "Fluorous-assisted chemoenzymatic synthesis of heparan sulfate oligosaccharides," C. Cai, D. M. Dickinson, L. Li, S. Masuko, M. Suflita, V. Schultz, U. Bhaskar, S. D. Nelson, J. Liu, R. J. Linhardt, Organic Letters, 16, 2240−2243, 2014. LINK


659. "Heparin activates a tumor-secreted protease via tethering and V-type allostery," Y. G. Fulcher, R.R.S. Gari, N.C. Frey, F. Zhang, R.J. Linhardt, G.M. King, S.R. Van Doren, ACS Chemical Biology, 9, 957−966, 2014. LINK


658. "Fibroblast growth factor-based signaling through synthetic heparan sulfate block copolymers studied using high-cell density 3D cell printing," E. Sterner, S. Masuko, G. Li, L. Li, D. E. Green, N. J. Otto, Y. Xu, P. L. DeAngelis, J. Liu, J. S. Dordick, R. J. Linhardt, Journal of Biological Chemistry, 289, 9754–9765, 2014. LINK


657. "Carbohydrate-containing molecules as potential biomarkers in colon cancer," E.-J. Joo, A. Weyers, G. Li, L. Gasimli, L. Li, W. J. Choi, K. B. Lee, R. J. Linhardt, Omics, 18, 231-241, 2014.. LINK


656. "Quantitative analysis of free and covalent anions in glycosaminoglycans and application in heparin stability studies," L. Liu, R.J. Linhardt, Z. Zhang, Carbohydrate Polymers, 106, 343–350, 2014. LINK


655. "Structure and activity of a new low molecular weight heparin produced by enzymatic ultrafiltration," L. Fu, F. Zhang, G. Li, A. Onishi, U. Bhaskar, P. Sun, R. J. Linhardt, Journal of Pharmaceutical Sciences, 103, 1375–1383, 2014. LINK


654. "Changes in glycosaminoglycan structure on differentiation of human embryonic stem cells towards mesoderm and endoderm lineages," L. Gasimli, A. M. Hickey, B. Yang, G. Li, M. dela Rosa, A. V. Nairn, M. J. Kulik, J. S. Dordick, K. W. Moremen, S. Dalton, R. J. Linhardt, Biochemica et Biophysica Acta, 1840, 1993–2003, 2014. LINK


653. "The Circulating Glycosaminoglycan Signature of Respiratory Failure in Critically Ill Adults," E. P. Schmidt, G. Li, L. Li, L. Fu, Y. Yang, K. H. Overdier, I. S. Douglas, R. J. Linhardt, Journal of Biological Chemistry, 289, 8194–8202, 2014. LINK


652. "Design of homogeneous and reversible low molecular weight heparins," Y. Xu, C. Cai, K. Chandarajoti, P.-H. Hsieh, L.Li, T. Q. Pham, E. M. Sparkenbaugh, J. Sheng, N. S. Key, R. Pawlinski, E. N. Harris, R.J. Linhardt, Jian Liu, Nature Chemical Biology, 10, 248-250, 2014. LINK


651. Proteomics of old world camelid (Camelus dromedarius): Better understanding the interplay between homeostasis and desert environment, M. Warda, A. Prince, H. Kyu Kim, N. Khafaga, T. Scholkamy, R. J. Linhardt, H. Jin, Journal of Advanced Research, 5, 219–242, 2014. LINK


650. "High Sensitivity Detection of Active Botulinum Neurotoxin (BoNT) by Glyco-qPCR," S. J. Kwon, E.J. Jeong, Y.C. Yoo, G.-H. Yang, J.C. Lee, J.S. Dordick, R.J. Linhardt, K.B. Lee, Analytical Chemistry, 86, 2279−2284, 2014. LINK


649. "Microarray platform affords improved product analysis in mammalian cell growth studies," P. Datta, L. Meli, L. Li, N. Migliore, E. Schaefer, S. T. Sharfstein, J. S. Dordick, R. J. Linhardt, Biotechnology Journal, 9, 386–395, 2014. LINK


648. "Bioengineering murine mastocytoma cells to produce anticoagulant heparin," L. Gasimli, C. A. Glass, P. Datta, B. Yang, G. Li, T. R. Gemmill, J. Y. Baik, S. T. Sharfstein, J. D. Esko, R. J. Linhardt, Glycobiology, 24, 272-280, 2014 LINK


647. "Mapping of glycosaminoglycan-derived, pre-column 2-aminoacridone-labeled disaccharides using liquid chromatography-fluorescence and -mass spectrometric detection," N. Volpi, F. Galeotti, B. Yang, R. J. Linhardt, Nature Protocols, 9, 541-558, 2014. LINK


646. "Characterization of human placental glycosaminoglycans and regional binding to VAR2CSA in malaria infected erythrocytes, " J. M. Beaudet, L. Mansur, E.-J. Joo, E. Kamhi, B. Yang, T. M Clausen, A. Salanti, F. Zhang, R. J. Linhardt, Glycoconjugate Journal, 31, 109–116, 2014. LINK


645. "Composite polysaccharide fibers prepared by electrospinning and coating," N. Maeda, J. Miao, T.J. Simmons, J.S. Dordick, R.J. Linhardt, Carbohydrate Polymers, 102, 950– 955, 2014. LINK


644. "New contaminant in heparin and determination by radical depolymerization and liquid chromatography-mass spectrometry," G. Li, C. Cai, L. Li, L. Fu, Y. Chang, F. Zhang, T. Toida, C. Xue, R. J. Linhardt, Analytical Chemistry, 86, 326−330, 2014. LINK


643. "High-field asymmetric-waveform ion mobility spectrometry and electron detachment dissociation of isobaric mixtures of glycosaminoglycans," M. J. Kailemia, M. Park, D.A. Kaplan, A. Venot, G.-J.Boons, L. Li, R. J. Linhardt, I. J. Amster, Journal of American Society for Mass Spectrometry, 25, 258-268, 2014. LINK


642. "Assays for determining heparan sulfate and heparin O-sulfotransferase activity and specificity," E. Sterner, L. Li, P. Paul, J. M. Beaudet, J. Liu, R. J. Linhardt, J. S. Dordick, Analytical and Bioanalytical Chemistry, 406, 525–536, 2014 LINK


641. "Congenital-diaphragmatic-hernia results from disruption of heparan sulfate-Slit3-Robo4 signaling-elicited developmental angiogenesis," B. Zhang, W. Xiao, H. Qiu, F. Zhang, H. Moniz, A. Jaworski, E. Condac, G. Gutierrez-Sanchez, C. Heiss, R. Clugston, P. Azadi, J. J. Greer, C. Bergmann, K. Moremen, D. Y. Li, R. J. Linhardt, J. D. Esko, L. Wang, Journal of Clinical Investigation, 124, 209-221, 2014. LINK


640. "Quantitation of heparosan with heparin lyase III and spectrophotometry," H. Huang, Y. Zhao, S. Lv, W. Zhong, F. Zhang,R. J. Linhardt, Analytical Biochemistry, 447, 46–48, 2014 LINK


639. "Biochemical strategies for enhancing the in vivo production of natural products with pharmaceutical potential," M. Mora-Pale, S.P. Sanchez-Rodriguez, R. J. Linhardt, J. S. Dordick, M. Koffas, Current Opinion in Biotechnology, 25, 86–94, 2014. LINK


638. "Bioengineered Chinese hamster ovary cells with Golgi-targeted 3-O-sulfotransferase-1 biosynthesize heparan sulfate with an antithrombin binding site," P. Datta, G. Li, B. Yang, X. Zhao, J.- Y. Baik, T. R. Gemmill, S. T. Sharfstein, R. J. Linhardt, Journal of Biological Chemistry, 288, 37308–37318, 2013. LINK


637. "FGF-FGFR signaling mediated through glycosaminoglycans in microtiter plate and cell-based microarray platforms," E. Sterner, L. Meli, J. S. Dordick, R. J. Linhardt, Biochemistry, 52, 9009−9019, 2013. LINK


636. "Characterization of the interaction between Robo1 and heparin/glycosaminoglycans," F. Zhang, H. A. Moniz, B. Walcott, K. W. Moremen, R. J. Linhardt, L. Wang, Biochemie, 95, 2345-2353, 2013. LINK


635. "Isoflavonoid Production by Genetically Engineered Microorganisms," B. F. Cress, R. J. Linhardt, M. A. G. Koffas, in Natural Products: Phytochemistry, Botany and Metabolism of Alkaloids, Phenolics and Terpenes, K.G. Ramawat, J.-M. Merillon (eds.), Springer Verlag, Chapter 54 pp 1647-1681, 2013. LINK


634. "Ultrasensitive detection and quantification of acidic disaccharides using capillary electrophoresis and quantum dot-based fluorescence resonance energy transfer," Y.Chang, C. Cai, L. Li, J. Miao, E. Ucakturk, G. Li, M. Ly, R.J. Linhardt, Analytical Chemistry, 85, 9356−9362, 2013 LINK


633. "Glycosaminoglycans in infectious disease," E. Kamhi, E. J. Joo, J. S. Dordick, R. J. Linhardt, Biological Reviews, 88, 928–943, 2013. LINK


632. "Expression of low endotoxin 3-O-sulfotransferase in Bacillus subtilis," W. Wang, P. Xu, J. Dordick, F. Zhang, Q. Yuan, M. Koffas, R.J. Linhardt, Applied Biochemistry and Biotechnology, 171, 954–962, 2013. LINK


631. "Characterization of Interactions between Heparin/Glycosaminoglycan and Adeno-associated Virus," F. Zhang, J.M. Beaudet, J. Aguilera, Q. Xie, T. F. Lerch, O. Davulcu, W. Colón, M. S. Chapman, R. J. Linhardt, Biochemistry, 52, 6275–6285, 2013. LINK


630. "Microanalysis of stomach cancer glycosaminoglycans," A. Weyers, B. Yang, J.-H. Park, Y.-S. Kim, S.-M. Kim, S.-E. Lee, F. Zhang, K. B. Lee, R. J. Linhardt, Glycoconjugate Journal, 30, 701–707, 2013. LINK


629. "Internal disulfide bond acts as a switch for intein activity," M.C. Nicastri, K. Xega, L. Li, J.Xie, C. Wang, R.J. Linhardt, J.N. Reitter, K. V. Mills, Biochemistry, 52, 5920–5927, 2013. LINK


628. "Structure of protein related to DAN and Cerberus (PRDC): Insights into the mechanism of BMP antagonism," K. Nolan, C. Kattamuri, D.M. Luedeke, A. Deng, A. Jagpal, F. Zhang, R. J. Linhardt, A. P. Kenny, A. M. Zorn, T. B. Thompson, Structure, 21, 1417–1429, 2013. LINK


627. "Immobilized enzymes to convert N-sulfo, N-acetyl heparosan to a critical intermediate in the production of bioengineered heparin," J. Xiong, U. Bhaskar, G. Li, L. Fu, L. Li, F. Zhang, J. S. Dordick, R. J. Linhardt, Journal of Biotechnology,167, 241– 247, 2013. LINK


626. "Effect of a variety of carbon nanotubes on the iodide-triiodide redox couple," T. J. Simmons, N. Maeda, M. Miyauchi, J. Miao, D. P. Hashim, P. M. Ajayan, J.S. Dordick, R. J. Linhardt, Carbon 62, 177–181, 2013. LINK


625. "Metabolic engineering and in vitro biosynthesis of natural and non-natural analogues of plant metabolites," M. Mora-Pale, S. P. Sanchez-Rodriguez, R. J. Linhatrdt, J. S. Dordick, M. A. G. Koffas, Plant Science, 210, 10–24, 2013. LINK


624. "N-sulfotestosteronan, a novel substrate for heparan sulfate 6-O-sulfotransferases and its analysis by oxidative degradation," G. Li, S. Masuko, D. E. Green, Y. Xu, L. Li, F. Zhang, C. Xue, J. Liu, P. L. DeAngelis, R. J. Linhardt, Biopolymers 99, 675-685, 2013 LINK


623. "Toward the chemoenzymatic synthesis of heparan sulfate oligosaccharides: Oxidative cleavage of p-nitrophenyl group with ceric ammonium salts," C. Cai, L. Li, C. Harvey, J. Liu, R.J. Linhardt, Tetrahedron Letters, 54, 4471–4474, 2013. LINK


622. "Chemoenzymatic synthesis of glycosaminoglycans: Re-creating, re-modeling, and re-designing nature’s longest or most complex carbohydrate chains," P. L. DeAngelis, J. Liu, R. J. Linhardt, Glycobiology, 23, 764–777, 2013. LINK


621. "Structural remodeling of proteoglycans on retinoic acid-induced differentiation of NCCIT cells," H. E. Stansfield, L. Gasimli, A. V. Nairn, H. Liu, J. L. Paluh, B. Yang, M. J. Saunders, J. S. Dordick, K. W. Moremen, R. J. Linhardt, Glycoconjugate Journal, 30, 497–510, 2013. LINK


620. "On-line separation and characterization of hyaluronan oligosaccharides derived from radical depolymerization," X. Zhao, B. Yang, L. Li, F. Zhang, R. J. Linhardt, Carbohydrate Polymers, 96, 503– 509, 2013. LINK


619. "Effect of eliminase gene (elmA) deletion on heparosan production and shedding in Escherichia coli K5," A. M. Hickey, U. Bhaskar, R. J. Linhardt, J. S. Dordick, Journal of Biotechnology, 165, 175–177, 2013. LINK


618. "Structurally informative tandem mass spectrometry of highly sulfated natural and chemo-enzymatically synthesized heparin and heparan sulfate glycosaminoglycans," M. J. Kailemia, L. Li, Y. Xu, J. Liu, R. J. Linhardt, I. J. Amster, Molecular and Cellular Proteomics, 12, 979-90, 2013. LINK


617. "Structural studies on the interaction of Crataeva tapia bark protein with heparin and other glycosaminoglycans," F. Zhang, B. Wacott, D. Zhou, A. Gustchina, Y. Lasanajak, D. F. Smith, R. S. Ferreira, M T. S. Correia, P. M.G. Paiva, N. V. Bovin, A. Wlodawer, M.L.V. Oliva, R. J. Linhardt, Biochemistry, 52, 2148−2156, 2013 LINK


616. "Sequence analysis and domain motifs in the decorin glycosaminoglycan chain," X. Zhao, B. Yang, K. Solakylidirim, E.-J. Joo, T. Toida, K. Higashi, R. J. Linhardt, L. Li, Journal of Biological Chemistry, 288, 9226-9237, 2013. LINK


615. "Self-assembly of carbon nanotube films from room temperature ionic liquids," T. J. Simmons, N. Maeda, J. S. Dordick, R. J. Linhardt, Carbon, 58, 226–231, 2013. LINK


614. "Structural characterization of pharmaceutical heparins prepared from different animal tissues," L. Fu, G. Li, B. Yang, A. Onishi, L. Li, P. Sun, F. Zhang, R.J. Linhardt, Journal of Pharmaceutical Science, 102, 1447-1457, 2013. LINK


613. "Neoproteoglycans in tissue engineering," A. Weyers, R. J. Linhardt, FEBS Journal, 280, 2511–2522, 2013. LINK


612. "Neutralizing the anticoagulant activity of ultra-low molecular weight heparins using N-acetylglucosamine 6-sulfatase," X. Zhou, L. Li, R. J. Linhardt, J. Liu, FEBS Journal, 280, 2523–2532, 2013. LINK


611. "Isolation of bovine corneal keratan sulfate and its growth factor and morphogen binding,"A. Weyers, B. Yang, K. Solakyildirim, V. Yee, L. Li, F. Zhang, R. J. Linhardt, FEBS Journal, 280, 2285–2293, 2013. LINK


610. "Impact of high salt diet on N-acetylgalactosamine-4-sulfatase activity, glycosaminoglycans, and kininogen in rat kidney," K. Kotlo, S. Bhattacharyya, B. Yang, S. Tejaskumar, R. J. Linhardt, R. Danziger, J. K. Tobacman, Glycoconjugate Journal, 30, 667–676, 2013. LINK


609. "High cell density cultivation of a recombinant E. coli strain expressing a key enzyme in bioengineered heparin production," O. F. Restaino, U. Bhaskar, P. Paul, L. Lin, M. De Rosa, J. S. Dordick, R. J. Linhardt, Applied Microbiology and Biotechnology, 97, 3893–3900, 2013. LINK


608. "Tunable thermo-responsive poly(N-vinylcaprolactam) cellulose nanofibers: Synthesis, characterization, and fabrication of potential affinity membranes" M. Webster, J. Miao, B. Lynch, D. Green, R. Linhardt, J. Mendenhall, Biomacromolecules, 298, 447–453, 2013. LINK


607. "An ‘omics approach towards CHO cell engineering," P. Datta, R. J. Linhardt, S. T. Sharfstein, Biotechnology and Bioengineering, 110, 1255–1271, 2013. LINK


606. "Capillary electrophoresis for the analysis of glycosaminoglycan-derived disaccharides," Y. Chang, B. Yang, A. Weyers, R. J. Linhardt, Chapter 7, In Capillary Electrophoresis of Biomolecules, Methods in Molecular Biology, 984:67-77, F. Maccari, N. Volpi eds., Humana Press, 2013. LINK


605. "Preparation and application of a “clickable” acceptor for enzymatic synthesis of heparin oligosaccharides," C. Cai, K. Edgar, J. Liu, R.J. Linhardt, Carbohydrate Research, 372, 30–34, 2013. LINK


604. "Draft Genome Sequence of Escherichia coli Strain ATCC #23506 (Serovar 1 O10:K5(L):H4)," B. F. Cress, Z.R. Greene, R. J. Linhardt, M.A.G. Koffas, Genome Announcements, 1, e00049-13, 2013. LINK


603. "Draft Genome Sequence of Escherichia coli Strain Nissle 1917 1 (Serovar O6:K5:H1)," B. F. Cress, R. J. Linhardt, M.A.G. Koffas, Genome Announcements, 1, e00047-13, 2013. LINK


602. "Draft Genome Sequence of Escherichia coli Strain ATCC #23502 (1 Serovar O5:K4(L):H4)," B. F. Cress, Z. R. Greene, R. J. Linhardt, M.A.G. Koffas, Genome Announcements, 1, e00046-13, 2013. LINK


601. "New type of sulfonated aramides nanoparticles and their copper complexes with anomalous electrical behavior: A simple method for the preparation of a microporous film-like layer," H. H. A. M. Hassan, A. F. Elhusseiny, A. M. Sweyllam, R. J. Linhardt, Journal of Applied Polymer Science, 128, 310–321, 2013. LINK


600. "Microscale separation of heparosan, heparan sulfate and heparin," X. Zhao, B. Yang, K. Linkens, P. Datta, A. Onishi, F. Zhang, R. J. Linhardt, Analytical Biochemistry, 434, 215–217, 2013. LINK


599. "Heparin oligosaccharides inhibit chemokine (C-X-C motif) ligand 12 (CXCL12) cardioprotection by binding orthogonal to the dimerization interface, promoting oligomerization, and competing with the chemokine (C-X-C motif) receptor 4 (CXCR4) amino-terminus," J. J. Ziarek, C. T. Veldkamp, F. Zhang, N.J. Murray, G. A. Kartz, X. Liang, J. Su, J. E. Baker, R. J. Linhardt, B.F. Volkman, Journal of Biological Chemistry, 288, 737–746, 2013. LINK


598. "Application of Carbon Nanotubes to Wound Healing Biotechnology," T. J. Simmons, C. J. Rivet, G. Singh, J. Beaudet, E. Sterner, D. Guzman, D. P. Hashim, S.-H. Lee, G. Qian, K. M. Lewis, R. Rosales, P. Karande, P. M. Ajayan, R. J. Gilbert, J. S. Dordick, R. J. Linhardt, Chapter 7, pp. 155-174, in Nanomaterials for Biomedicine (R. Nagarajan, ed.) ACS Symposium Series, 2012. LINK


597. "Addressing endotoxin issues in bioengineered heparin," J. Suwan, A. Torelli, A. Onishi, J. S. Dordick, R. J. Linhardt, Biotechnology and Applied Biochemistry, 59, 420-428, 2012. LINK


596. "Signal amplification by Glyco-qPCR for ultrasensitive detection of carbohydrates: Applications in glycobiology," S.-J. Kwon, K.-B. Lee, K. Solakyildirim, S. Masuko, M. Ly, F. Zhang, L. Li, J. S. Dordick, R. J. Linhardt, Angewandte Chemie, 51, 11800 –11804, 2012. LINK


595. "Top-down approach for the direct characterization of low molecular weight heparins using LC-FT-MS," L. Li, F. Zhang, J. Zaia, R. J. Linhardt, Analytical Chemistry, 84, 8822−8829, 2012. LINK


594. "Influence of a 3D microarray environment on human cell culture in drug screening systems," L. Meli, E. T. Jordan, D. Clark, R. J. Linhardt, J. S. Dordick, Biomaterials, 33, 9087-9096, 2012. LINK


593. "Molecular weight characterization for glycosaminoglycans with different degrees of sulfation by size exclusion chromatography," Z. Wang, F. Zhang, J. S. Dordick, R. J. Linhardt, Current Analytical Chemistry, , 8, 506-511, 2012. LINK


592. "Analysis of the Interaction between Heparin and Follistatin/Follistatin-ligand complexes Using Surface Plasmon Resonance" F. Zhang, J. Beaudet, D. Luedeke, R. Waker, T. Thompson, R. J. Linhardt, Biochemistry, 51, 6797−6803, 2012. LINK


591. "Functionalization of nitrogen-doped carbon nanotubes with gallium to form Ga-CN(x)-multi-wall carbon nanotube hybrid materials." T.J. Simmons, D.P. Hashim, X. Zhan, M. Bravo-Sanchez, M.G. Hahm, E. López-Luna, R.J. Linhardt, P.M. Ajayan, H. Navarro-Contreras, M.A. Vidal, Nanotechnology, 23, (325601) 1-9, 2012. LINK


590. "Hexuronic acid stereochemistry determination in chondroitin sulfate glycosaminoglycan oligosaccharides by electron detachment dissociation," F. E. Leach, M. Ly, T. N. Laremore, J. J. Wolff, J. Perlow, R. J. Linhardt, I. J. Amster, Journal of American Society of Mass Spectrometry, 23, 1488-1497, 2012. LINK


589. "Inhibitory effect of non-anticoagulant heparin (S-NACH) on pancreatic cancer cell adhesion and invasion in human umbilical cord vessel segment," T. Sudha, P. Phillips, C. Kanaan, R. J. Linhardt, L. Borsig, S.A. Mousa, Clinical & Experimental Metastasis, 29, 431-439, 2012. LINK


588. "Cell-based microscale isolation of glycoaminoglycans for glycomics study," X. Zhao, B. Yang, P. Dutta, L. Gasmili, F. Zhang, R. J. Linhardt, Journal of Carbohydrate Chemistry, 31, 420-435, 2012. LINK


587. "Towards a bioengineered heparin: challenges and strategies for metabolic engineering of mammalian cells," J.Y. Baik, C. L. Wang, B. Yang, R. J. Linhardt, S. T. Sharfstein, Bioengineered, 3, 225-229, 2012. LINK


586. "Complete mass spectral characterization of a synthetic ultralow molecular weight heparin using collision induced dissociation," M. J. Kailemia, L. Li, M. Ly, R. J. Linhardt, J. Amster, Analytical Chemistry, 84, 5475-5478, 2012. LINK


585. "Electrophoresis for the analysis of heparin purity and quality," N. Volpi, F. Maccari, R. J. Linhardt, Electrophoresis, 33, 1531-1537, 2012. LINK


584. "Analysis of glycosaminoglycan-derived disaccharides by capillary electrophoresis using laser-induced fluorescence detection," Y. Chang, B. Yang, X. Zhao, R. J. Linhardt, Analytical Biochemistry, 427, 91–98, 2012. LINK


583. "Synthetic heparin," R. J. Linhardt, J. Liu, Current Opinion in Pharmacology, 12, 217–219, 2012. LINK


582. "Effect of high aspect ratio filler on dielectric properties of polymer composites: A study on barium titanate fibers and graphene platelets," Z. Wang, J. K. Nelson, J. Miao, R.J. Linhardt, L. S. Schadler, H. Hillborg, S. Zhao, IEEE Transactions on Dielectrics and Electrical Insulation, 19, 960-967, 2012. LINK


581. "Recent advances in sulfotransferase enzyme activity assays," P. Paul, J. Liu, J. S. Dordick, R. J. Linhardt, Analytical and Bioanalytical Chemistry, 403, 1491–1500, 2012. LINK


580. "Preparation and characterization of electrospun core sheath nanofibers from multiwall carbon nanotubes and poly(vinyl pyrrolidone)," J. Miao, M. Miyauchi, J. S. Dordick, R. J. Linhardt, Journal of Nanoscience and Nanotechnology, 12, 2387-2393, 2012. LINK


579. "Exposure to common food additive carrageenan leads to reduced sulfatase activity and increase in sulfated glycosaminoglycans in human epithelial cells," B. Yang, S. Bhattacharyya, R. J. Linhardt, Tobacman, Biochemie, 94, 1309-1316, 2012. LINK


578. "Proteoglycans in stem cells," L. Gasimli, R. J. Linhardt, J. S. Dordick, Biotechnology and Applied Biochemistry, 59, 65–76, LINK


577. "Proteoglycan Sequence," L. Li, M. Ly, R. J. Linhardt, Molecular BioSystems, 8, 1613–1625, 2012. LINK


576. "Dissecting the substrate recognition of 3-O-sulfotransferase for the biosynthesis of anticoagulant heparin," A. F. Moon, Y. Xu, S. M. Woody, J. M. Krahn, R. J. Linhardt, J. Liu, L. C. Pedersen, Proceedings of the National Academy of Sciences USA, 109, 5265–5270, 2012. LINK


575. "Structure/function analysis of the Pasteurella multocida heparosan synthases: towards defining enzyme specificity and engineering novel catalysts," N. J. Otto, S. Masuko, A. Mayer, M. E. Tanner, Robert J. Linhardt, P. L. DeAngelis, Journal of Biological Chemistry, 287, 7203–7212, 2012. LINK


574. "A structural analysis of glycosaminoglycans from lethal and non-lethal breast cancer tissues: Towards a novel class of theragnostics for personalized medicine in oncology," A. Weyers, B. Yang, D. S. Yoon, J.-H. Park, F. Zhang, K. B. Lee, R. J. Linhardt, Omics, 16, 79-89, 2012. LINK


573. "Chemoenzymatic synthesis of the next generation of ultralow molecular weight heparin therapeutics, " S. Masuko, R. J. Linhardt, Future Medicinal Chemistry, 4, 289–296, 2012.. LINK


572. "Adsorption of doxorubicin on poly(methyl methacrylate)−chitosan−heparin-coated activated carbon beads," J. Miao, F. Zhang, M. Takieddin, S. Mousa, R. J. Linhardt, Langmuir, 28, 4396-403, 2012. LINK


571. "Metabolic engineering of Chinese hamster ovary cells: Towards a bioengineered heparin," J. Y. Baik, L. Gasimli, B. Yang, P. Datta, F. Zhang, C. A Glass, J. D. Esko, R.J. Linhardt, S. Sharfstein, Metabolic Engineering, 14, 81–90, 2012. LINK


570. "Intramolecular Disulfide Bond between Catalytic Cysteines in an Intein Precursor," W. Chen, L. Li, Z. Du, J. Liu, J. Reitter, K. Mills, R. J. Linhardt, C. Wang, Journal of the American Chemical Society, 134, 2500-2503, 2012. LINK


569. "Trimer hydroxylated quinone (IIIHyQ) derived from apocynin targets cysteine residues of p47phox preventing the activation of human vascular NADPH oxidase," M.Mora-Pale, S.J. Kwon, R. J. Linhardt, J. S. Dordick, Free Radical Biology and Medicine, 52, 962-969, 2012. LINK


568. "Chemoenzymatic synthesis of UDP-GlcNAc and UDP-GalNAc analogs for the preparation of unnatural glycosaminoglycans," S. Masuko, S. Bera, D. E. Green, M. Weïwer, P. L. DeAngelis, R. J. Linhardt, Journal of Organic Chemistry, 77, 1449-1456, 2012. LINK


567. "Disaccharide analysis of glycosaminoglycan mixtures by ultra-performance liquid chromatography-mass spectrometry," B. Yang, Y. Chang, A. M. Weyers, E. Sterner, R. J. Linhardt, Journal of Chromatography A,1225, 91– 98, 2012. LINK


566. "Engineering of routes to heparin and related polysaccharides," U. Bhaskar, E. Sterner, A. M. Hickey, A. Onishi, F. Zhang, J. S. Dordick, R.J. Linhardt, Applied Microbiology and Biotechnology, 93, 1–16, 2012. LINK


565. "Biophysical characterization of glycosaminoglycan-IL-7 interactions using SPR," F. Zhang, X. Liang, D. Pu, K. I. George, P. J. Holland, S. T. Walsh, R. J Linhardt, Biochemie, 94, 242-249, 2012. LINK


564. "Photochemical preparation of a novel low molecular weight heparin," K. Higashi, S. Hosoyama, A. Ohno, S. Masuko, B. Yang, E. Sterner, Z. Wang, R. J. Linhardt, T. Toida, Carbohydrate Polymers, 87, 1737-1743, 2012. LINK


563. "Semi-synthesis of chondroitin sulfate-E from chondroitin sulfate-A," C. Cai, K. Solakyildirim, B. Yang, J. M. Beaudet, A. Weyers, R. J. Linhardt, F. Zhang, Carbohydrate Polymers, 87, 822-829, 2012. LINK


562. "Binding affinities of vascular endothelial growth factor (VEGF) for heparin-derived oligosaccharides," W. Zhao, S. McCallum, Z. Xiao, F. Zhang, R. J. Linhardt, Bioscience Reports, 32, 71-81, 2012. LINK


561. "Stereoselective synthesis of a-C-sialyl compounds," J.-H. Kim, F. Huang, S. Masuko, D. Sail, R. J. Linhardt, Carbohydrate Chemistry, Proven Methods, CRC Press, Volume 1, CRC Press, Chapter 26, pp. 239-243, 2012. LINK


560. "Inhibition of human tumor xenograft growth in nude mice by a novel monoclonal anti-HSPG isolated from human liver," P. Vongchan, S. Kothan, Y. Wutti-In, N. Janejad, R.J. Linhardt, Anticancer Research, 31, 4067-4074, 2011. LINK


559. "Flexible electrospun cellulose fibers as an affinity packing material for the separation of bovine serum albumin," M. Miyauchi, J. Miao, T. J. Simmons, J. S. Dordick, R.J. Linhardt, Journal of Chromatography and Separation Techniques, 2,1-4, 2011. LINK


558. "Facile pretreatment of lignocellulosic biomass at high loadings in room temperature ionic liquids," H. Wu, J. Miao, M. Mora-Pale, T. V. Doherty, R. J. Linhardt, J. S. Dordick, Biotechnology and Bioengineering, 108, 2865-2875, 2011. LINK


557. "Electron detachment dissociation and infrared multiphoton dissociation of heparin tetrasaccharides," F. E. Leach, Z. Xiao, T. N. Laremore, R. J. Linhardt, I. J. Amster, International Journal of Mass Spectrometry, 308, 253-259, 2011. LINK


556. "Structural characterization of heparins from different commercial sources" F. Zhang, B. Yang, M. Ly, K. Solakyildirim, Z. Xiao, Z. Wang, J. M. Beaudet, A. Y. Torelli, J. S. Dordick, R. J. Linhardt, Analytical and Bioanalytical Chemistry, 401, 2793-2803, 2011. LINK


555. "Chemoenzymatic synthesis of structurally homogeneous ultra-low molecular weight heparins," Y. Xu, S. Masuko, M. Takieddin, H. Xu, R. Liu, J. Jing, S. Mousa, R. J. Linhardt, J. Liu, Science, 334, 498-501, 2011. LINK


554. "The proteoglycan bikunin has a defined sequence," M. Ly, F. E. Leach III, T. N. Laremore, T. Toida, I. J. Amster, R.J. Linhardt, Nature Chemical Biology, 7, 827-833, 2011. LINK


553. "Preparation of synthetic wood composites using ionic liquids," T.J. Simmons, S.H. Lee, J. Miao, M. Miyauchi, T.J. Park, S.S. Bale, R. Pangule, J. Bult, J.G. Martin, J.S. Dordick, R.J. Linhardt, Wood Science and Technology, 45, 719-733, 2011. LINK


552. "Response surface optimization of the heparosan N-deacetylation in producing bioengineered heparin," Z. Wang, J. Li, S. Cheong, U. Bhaskar, O. Akihiro, F. Zhang, J.S. Dordick, R.J. Linhardt, Journal of Biotechnology, 156, 188-196, 2011. LINK


551. "Lysostaphin-functionalized cellulose fibers with antistaphylococcal activity for wound healing applications," J. Miao, R. C. Pangule, E. E. Paskaleva, E. Hwang, R. S. Kane, R. J. Linhardt, J. S. Dordick, Biomaterials, 32, 9557-9567, 2011. LINK


550. "Synthesis, structural, and biological studies on a pseudodisaccharide containing a bicyclic, bridged carba-sugar," Z. Fejes, T. Kurtán, G. Raabe, J. Fleischhauer, L. Szilágyi, A. Bényei, Z. Gál, W. Zhao, R. J. Linhardt, M. Cygler, P. Herczegh, Tetrahedron: Asymmetry, 22, 1404-1410, 2011. LINK


549. "Polysaccharides and phytochemicals: a natural reservoir for the green synthesis of gold and silver nanoparticles," Y. Park, Y. N. Hong, A. Weyers, Y. S. Kim, R. J. Linhardt, IET Nanobiotechnology, 5, 69–78, 2011. LINK


548. "Comamonas testosteronan synthase, a bifunctional glycosyltransferase that produces a unique heparosan polysaccharide analog," N. J. Otto, K. Solakyildirim, R. J. Linhardt, P. L. DeAngelis, Glycobiology, 21, 1331–1340, 2011. LINK


547. "Ozonolysis of the double bond of the unsaturated uronate residue in low molecular weight heparin and K5 heparosan," S. Masuko, K. Higashi, Z. Wang, U. Bhaskar, A. M. Hickey, F. Zhang, T. Toida, J. S. Dordick, R. J. Linhardt, Carbohydrate Research, 346, 1962–1966, 2011. LINK


546. "Anti-proliferative effects of O-acyl-low-molecular-weight heparin derivatives on bovine pulmonary artery smooth muscle cells," H. G.Garg, H. Mrabat, L. Yu, C. A. Hales, B. Li, C. N. Moore, F. Zhang, R. J. Linhardt, Glycoconjugate Journal, 28, 419–426, 2011. LINK


545. "Electrospray ionization Fourier transform mass spectrometric analysis of intact bikunin glycosaminoglycan from normal human plasma," T. N. Laremore, F. E. Leach III, I. J. Amster, R. J. Linhardt, International Journal of Mass Spectrometry, 305, 109–115, 2011. LINK


544. "Controlled Photochemical Depolymerization of K5 Heparosan, a Bioengineered Heparin Precursor," K. Higashi, M. Ly, Z. Wang, S. Masuko, U. Bhaskar, E. Sterner, F. Zhang, T. Toida, J. S. Dordick, R. J. Linhardt, Carbohydrate Polymers, 86, 1365– 1370, 2011. LINK


543. "Asparagine 405 of heparin lyase II prevents the cleavage of glycosidic linkages proximate to a 3-O-sulfo glucosamine residue," W. Zhao, M.-L. Garron, B. Yang, Z. Xiao, J. D. Esko, M, Cygler, R. J. Linhardt, Febs Letters, 585, 2461–2466, 2011. LINK


542. "Electrospun polyvinylpyrrolidone fibers with high concentrations of ferromagnetic and superparamagnetic nanoparticles," M. Miyauchi, T. J. Simmons, J. Miao, Z. Shriver, U. Aich, J. S. Dordick, R. J. Linhardt, ACS Applied Materials & Interfaces, 3, 1958-1964, 2011. LINK


541. "Negative electron transfer dissociation Fourier transform mass spectrometry of glycosaminoglycan carbohydrates," F. E. Leach, J. J. Wolff, Z. Xiao, M. Ly, T. N. Laremore, S. Arungundram, K. Al-Mafraji, A. Venot, G.-J. Boons, R. J. Linhardt, I. Jonathan Amster, European Journal of Mass Spectrometry, 71, 167-176, 2011. LINK


540. "Control of the heparosan N-deacetylation leads to an improved bioengineered heparin, " Z. Wang, B. Yang, Z. Zhang, M. Ly, M. Takieddin, S. Mousa, J. Liu, J. S. Dordick, R. J. Linhardt Applied Microbiology and Biotechnology, 91, 91-99, 2011. LINK


539. "Impact of autoclave sterilization on the activity and structure of formulated heparin," J. M. Beaudet, A. Weyers, K. Solakyildirim, B. Yang, M. Takieddin, S. Mousa, F. Zhang, R. J. Linhardt, Journal of Pharmaceutical Science, 100, 3396–3404, 2011. LINK


538. "Ultraperformance ion-pairing liquid chromatography with on-line electrospray ion trap mass spectrometry for heparin disaccharide analysis," B. Yang, A. Weyers, J. Y. Baik, E. Sterner, S. Sharfstein, S. A. Mousa, F. Zhang, J. S. Dordick, R. J. Linhardt, Analytical Biochemistry, 415, 59–66, 2011. LINK


537. "Design and synthesis of unnatural heparosan and chondroitin building blocks," S. Bera, R. J. Linhardt, Journal of Organic Chemistry, 76, 3181-3189, 2011. LINK


536. "N,N,N-trimethyl chitosan nanoparticles for the delivery of monoclonal antibodies against hepatocellular carcinoma cells," P. Vongchan, Y. Wutti-In, W. Sajomsang, P. Gonil, S. Kothan, R. J. Linhardt, Carbohydrate Polymers, 85, 215-220, 2011. LINK


535. "Room Temperature Ionic Liquids as Emerging Solvents for the Pretreatment of Lignocellulosic Biomass," M. Mora-Pale, L. Meli, T. V. Doherty, R. J. Linhardt, J. S. Dordick, Biotechnology and Bioengineering, 108, 1229-1245, 2011. LINK


534. "HSulf-1 modulates FGF-2 and hypoxia mediated migration and invasion of breast cancer cells," A. Khurana, P. Liu, P. Mel1one, L. Lorenzon, B. Vincenzi, K. Datta, B. Yang, R. J. Linhardt, W. Lingle, J. Chien, A. Baldi, V. Shridhar, Cancer Research, 71, 2152-2161, 2011. LINK


533. Protein-associated water effects the removal of blood proteins from metallic substrates," G. Anand, F, Zhang, R. J. Linhardt, G. Belfort, Langmuir, 27, 1830–1836, 2011. LINK


532. "Heparin mapping using heparin lyases and the generation of a novel low molecular weight heparin," Z. Xiao, B. R. Tappen, M. Ly, W. Zhao, L. P. Canova, H. Guan, R. J. Linhardt, Journal of Medicinal Chemistry, 54, 603–610, 2011. 2011. LINK


531. "Host and pathogen glycosaminoglycan-binding proteins modulate antimicrobial peptide responses," Z. Wang, L. A. Flax, M. M. Kemp, R. J. Linhardt, M. J. Baron, Infection and Immunity, 79, 606-616, 2011. LINK


530. "E. coli K5 heparosan fermentation and improvement by genetic engineering," Z. Wang, J. S. Dordick, R. J. Linhardt, Bioengineered Bugs, 2, 1-15, 2011. LINK


529. "Conjugation of ginsenoside Rg3 with gold nanoparticles," Y. Park, A.-R. Im, E. J. Joo, J. Lee, H.-G. Park, R. J. Linhardt, Y. S. Kim, Bulletin of the Korean Chemical Society, 32, 286-290, 2011. LINK


528. "Analysis of E. coli K5 capsular polysaccharide heparosan," M. Ly, Z. Wang, T. N. Laremore, F. Zhang, W. Zhong, D. Pu, D. V. Zagorevski, J. S. Dordick, R. J. Linhardt, Analytical and Bioanalytical Chemistry, 399, 737-745, 2011. LINK


527. "Hyphenated techniques for the analysis of heparin and heparan sulfate," B. Yang, K. Solakyildirim, Y. Chang, R. J. Linhardt, Analytical and Bioanalytical Chemistry, 399, 541–557, 2011. LINK


526. "Heparinase I selectivity for the 3,6-di-O-sulfo-2-deoxy-2-sulfamido-a-D-glucopyranose (1,4) 2-O-sulfo-a-L-idopyranosyluronic acid (GlcNS3S6S-IdoA2S) linkages," Z. Xiao, W. Zhao, B. Yang, Z. Zhang, H. Guan, R. J. Linhardt, Glycobiology, 21, 13–22, 2011. LINK


525. "Analysis of glycosaminoglycans in stem cell glycomics," B. Li, H. Liu, Z. Zhang, H. Stansfield, J.S. Dordick, R.J. Linhardt, in Embryonic Stem Cell Therapy for Osteodegenerative Diseases. Nicole zur Nieden, Ed., Humana Press, Methods in Molecular Biology 690, 285-300, 2011. LINK


524. "Mass balance analysis of contaminated heparin product," Z. Liu, Z. Xiao, S. Masuko, W. Zhao, E. Sterner, V. Bansal, J. Fareed, J. S. Dordick, F. Zhang, R. J. Linhardt, Analytical Biochemistry, 408, 147-156, 2011. LINK


523. "Ionic Liquid Solvent Properties as Predictors of Lignocellulose Pretreatment Efficacy," T. V. Doherty, M. Mora-Pale, S. Foley, R. J. Linhardt, J. S. Dordick, Green Chemistry, 12, 1967-1975, 2010. LINK


522. "Preparation of biopolymer-based materials using ionic liquids for the biomedical applications," S. H. Lee, M. Miyauchi, J. S. Dordick, and R. J. Linhardt, ACS Symposium Series Ionic liquids application: Pharmaceutical, Therapeutics, and Biotechnology, Chapter 10, pp 115-134, 2010. LINK


521. "E. coli K5 fermentation and the preparation of heparosan, a bioengineered heparin precursor," Z. Wang, M. Ly, F. Zhang, W. Zhong, A. Suen, J. S. Dordick, R. J. Linhardt, Biotechnology and Bioengineering, 107, 968-977, 2010. LINK


520. "Glycosaminoglycans of the porcine central nervous system," Z. Liu, S. Masuko, K. Solakyildirim, D. Pu, R. J. Linhardt, F. Zhang, Biochemistry, 49, 9839–9847, 2010. LINK


519. "Electrospinning from room temperature ionic liquids for biopolymer fiber formation," L. Meli, J. Miao, J. S. Dordick, R, J. Linhardt, Green Chemistry, 12, 1883–1892, 2010. LINK


518. "Chemoenzymatic design of heparan sulfate oligosaccharides," R. Liu, Y. Xu, M. Chen, M. Weïwer, A. Bridges, P.L. DeAngelis, Q. Zhang, R. J. Linhardt, J. Liu, Journal of Biological Chemistry, 285, 34240-34249, 2010. LINK


517. "Domain structure elucidation of human decorin glycosaminoglycans," T. N. Laremore, M. Ly, Z. Zhang, K. Solakyildirim, S. McCallum, R. T. Owens, R. J. Linhardt, Biochemical Journal 431, 199-205, 2010. LINK


516. "Glycosaminoglycan characterization by electrospray ionization mass spectrometry including Fourier transform mass spectrometry," T. N. Laremore, F. E. Leach III, K. Solakyildirim, I. J. Amster, R. J. Linhardt, Methods in Enzymology, 478, 79-108, 2010. LINK


515. "Carrageenan-induced increase in interleukin-8 secretion is modified by pre-treatment with galactosidases and carrageenases," S. Bhattacharyya, H. Liu, Z. Zhang, M. Jam, P. K. Dudeja, G. Michel, R. J. Linhardt, J. Tobacman, Journal of Nutritional Biochemistry, 21, 906-913, 2010. LINK


514. "Conductive cable fibers with insulating surface prepared by coaxial electrospinning of multi-walled nanotubes and cellulose," M. Miyauchi, J. Miao, T. J. Simmons, J.-W. Lee, T. V. Doherty, J. S. Dordick, R. J. Linhardt, Biomacromolecules, 11, 2440–2445, 2010. LINK


513. "Proteoglycomics: Recent progress and future challenges," M. Ly, T. N. Laremore, R. J. Linhardt, Omics, 14, 389-399, 2010. LINK


512. "Identification of a novel structure in heparin generated by potassium permanganate oxidation," D. Beccati, S. Roy, F. Yu, N. S. Gunay, R. J. Linhardt I. Capila, G. Venkataraman, Carbohydrate Polymers, 82, 699–705, 2010. LINK


511. "Stereoselective Total Synthesis of (-)-Cleistenolide," C. Cai, J. Liu, Y. Du, R. J. Linhardt, Journal of Organic Chemistry, in 75, 5754–5756, 2010. LINK


510. "Induction of nucleolin translocation by acharan sulfate in A549 cells," E. J. Joo, Y. Hui, Y. Park, N. Y. Park, T. Toida, R. J. Linhardt, Y.S. Kim, Journal of Cellular Biochemistry, 110, 1272–1278, 2010. LINK


509. "Catalytic mechanism of heparinase II revealed by site-directed mutagenesis and the crystal structure with its substrate," D. Shaya, W. Zhao, M.-L. Garron, Z. Xiao, Q. Cui, Z. Zhang, T. Sulea, R. J. Linhardt, M. Cygler, Journal of Biological Chemistry, 285, 20051-20061, 2010. LINK


508. "Negative electron transfer dissociation of glycosaminoglycans," J. Wolff, F. Leach, T. Laremore, D. Kaplan, M. Easterling, R. J. Linhardt, J. Amster, Analytical Chemistry, 82, 3460-3466, 2010. LINK


507. "Partial depolymerization of pectin by photochemical reaction," J. Burana-osot, N. Soonthornchareonnon, S. Hosoyamac, R. J. Linhardt, T. Toida, Carbohydrate Research, 345, 1205–1210, 2010. LINK


506. "Artificial organelles: Digital microfluidic platform for proteoglycan and glycoprotein biosynthesis," J. G. Martin, J. M. Beaudet, J. S. Dordick, R. J. Linhardt, The World Scientific Journal, 10, 997-1000, 2010. LINK


505. "Effect of Carboxyl-Reduced Heparin on the Growth Inhibition of Bovine Pulmonary Artery Smooth Muscle Cells," H.G. Garg, H. Mrabat, L. Yu, C. Freeman, B. Li, F. Zhang, R. J. Linhardt, C. A. Hales, Carbohydrate Research, 345, 1084–1087, 2010. LINK


504. "High performance liquid chromatography-mass spectrometry for mapping and sequencing glycosaminoglycan-derived oligosaccharides," N. Volpi, R. J. Linhardt, Nature Protocols, 5, 993 - 1004, 2010. LINK


503. "Antitumor effect of butanoylated heparin with low anticoagulant activity on lung cancer growth in mice and rats," L. Yu, H. G. Garg, B. Li, R. J. Linhardt, C. A. Hales, Current Cancer Drug Targets, 10, 229-241, 2010. LINK


502. "Electrospinning of nanomaterials and applications in electronic components and devices," J. Miao, M. Miyauchi, T. J. Simmons, J. S. Dordick, R. J. Linhardt, Journal of Nanoscience and Nanotechnology, 10, 5507–5519, 2010. LINK


501. "High-resolution preparative separation of glycosaminoglycan oligosaccharides by polyacrylamide gel electrophoresis," T. N. Laremore, M. Ly, K. Solakyildirim, D.V. Zagorevski, R. J. Linhardt, Analytical Biochemistry, 401, 236–241, 2010. LINK


500. "Oversulfated chondroitin sulfate is the major contaminant in suspect heparin lots collected in February/March of 2008," M. Guerrini, Z. Shriver, A. Naggi, B. Casu, R. J. Linhardt, G. Torri, Ram Sasisekharan, Nature Biotechnology, 28, 207-211, 2010. LINK


499. "Unnatural polyketide analogs selectively target the HER2 signaling pathway in human breast cancer cells," S. J. Kwon, M. I. Kim, B. Ku, L. Coulombel, J.-H. Kim, R.J. Linhardt, and J. S. Dordick, ChemBioChem, 11, 573 – 580, 2010. LINK


498. "Glycosaminoglycans from earthworms (Eisenia andrei)," A.-R. Im, Y. Park, J.-S. Sim, Z. Zhang, Z. Liu, R. J. Linhardt, Y. S. Kim, Glycoconjugate Journal, 27, 249–257, 2010. LINK


497. "NMR quantification for monitoring heparosan K5 capsular polysaccharide production," Z. Wang, Z. Zhang, S. A. McCallum, R. J. Linhardt, Analytical Biochemistry, 398, 275–277, 2010. LINK


496. "Cellulose composites prepared using ionic liquids (ILs)-Blood compatibility to batteries," T.-J. Park , S. Murugesan, R. J. Linhardt, Kevin Edgar, Thomas Heinze, Charles Buchanan (eds.), ACS symposium Series, Polysaccharide Materials: Performance by Design, Chapter 7, pp 133-152, 2010. LINK


495. "Heparin-based nanoparticles," M. M. Kemp and R. J. Linhardt, Nanomedicine and Nanobiotechnology, 2, 77 – 87, 2010. LINK


494. "Ultraperformance liquid chromatography with electrospray ion trap mass spectrometry for chondroitin disaccharide analysis," K. Solakyildirim, Z. Zhang, R. J. Linhardt, Analytical Biochemistry, 397, 24–28, 2010. LINK


493. "Cell-Bound IL-8 Increases in Bronchial Epithelial Cells after Arylsulfatase B Silencing due to Sequestration with Chondroitin-4-Sulfate," S. Bhattacharyya, K. Solakyildirim Z. Zhang, R. J. Linhardt, J. K. Tobacman, American Journal of Respiratory Cell and Molecular Biology, 42, 51-61, 2010. LINK






492. "Glycosaminoglycans," F. Zhang, Z. Zhang, R.J. Linhardt, in Handbook of Glycomics: Glycoconjugate Structural Analysis, R.D. Cummings, M. Pierce (eds.) Academic Press/Elsevier, Chapter 3, 2009. LINK


491. "Enzymatic polymerization of phenols in room-temperature ionic liquids," B. Eker, D. Zagorevski, G. Zhu, R.J. Linhardt, J.S. Dordick, Journal of Molecular Catalysis B: Enzymatic, 59, 177–184, 2009. LINK


490. "Chloroquine reduces arylsulfatase B Activity and increases chondroitin 4-sulfate: Implications for mechanisms of action and resistance of chloroquine," S. Bhattacharyya, K. Solakyildirim, Z. Zhang, R. J. Linhardt, J. K. Tobacman, Malaria Journal, 8, 303, 2009. LINK


489. "Structural snapshots of heparin depolymerization by heparin lyase I," Y.-H. Han, M.-L. Garron, H.-Y. Kim, W.-S. Kim, Z. Zhang, K.-S. Ryu, D. Shaya, Z. Xiao, C. Cheong, Y.-S. Kim, R. J. Linhardt, Y. H. Jeon, M. Cygler, Journal of Biological Chemistry, 284, 34019–34027, 2009. LINK


488. "Recent progress and applications in glycosaminoglycan and heparin research," T. N. Laremore, F. Zhang, J. S. Dordick, J. Liu, R. J. Linhardt, Current Opinions in Chemical Biology, 13, 633–640, 2009. LINK


487. "Gold and silver nanoparticles conjugated with heparin-derivative possess anti-angiogenesis properties," M. M. Kemp, A. Kumar, S. Mousa, E. Dyskin, M. Yalcin, P. Ajayan, R. J. Linhardt, S.A. Mousa, Nanotechnology, 20, 455104, 2009. LINK


486. "Orthogonal analytical approaches to detect potential contaminants in heparin," M. Guerrini, Z. Zhang, Z. Shriver, S. Masuko, R. Langer, B. Casu, R. J. Linhardt, G. Torri, R. Sasisekharan, Proceedings of the National Academy of Sciences USA, 106, 16956–16961, 2009. LINK


485. " Control of promatrilysin (MMP7) activation and substrate-specific activity by sulfated glycosaminoglycans," H-J Ra, S. Harju-Baker, F. Zhang, R. J. Linhardt, C. L. Wilson, W. C. Parks, Journal of Biological Chemistry, 284, 27924-27932, 2009. LINK


484. "Analysis of pharmaceutical heparins and potential contaminants using 1H-NMR and PAGE," Z. Zhang, B. Li, J. Suwan, F. Zhang, Z. Wang, H. Liu, B. Mulloy, R. J. Linhardt, Journal of Pharmaceutical Science, 98, 4017-4026, 2009. LINK


483. "Photolytic depolymerization of alginate," J. Burana-osot, S. Hosoyama, Y. Nagamoto, S. Suzuki, R. J. Linhardt, T. Toida, Carbohydrate Research, 344, 2023–2027, 2009. LINK


482. "Changes in cultured endothelial cell glycosaminoglycans under hyperglycemic conditions and the effect of insulin and heparin," J. Han, F. Zhang, J. Xie, R. J. Linhardt and L. M. Hiebert, Cardiovascular Diabetology, 8, 46-58, 2009. LINK


481. "Compositional analysis of heparin/heparan sulfate interacting with fibroblast growth factor•fibroblast growth factor receptor complexes," F. Zhang, Z. Zhang, X. Lin, A. Beenken, A. V. Eliseenkova, M. Mohammadi, R. J. Linhardt, Biochemistry, 48, 8379–8386, 2009. LINK


480. "Towards an artificial Golgi: Redesigning the biological activities of heparan sulfate on a digital microfluidic chip," J. G. Martin, M. Gupta, Y. Xu, S. Akella, J. Liu, J. S. Dordick, R. J. Linhardt, Journal of the American Chemical Society, 131, 11041–11048, 2009. LINK


479. "Inhibition of human vascular NADPH oxidase by apocynin derived oligophenols," M. Mora-Pale, M. Weïwer, J. Yu, R.J. Linhardt, J.S. Dordick, Bioorganic Chemistry and Medicinal Chemistry, 17, 5146–5152, 2009. LINK


478. "Novel interactions of glycosaminoglycans and bacterial glycolipids mediate binding of enterococci to human cells," I. G. Sava, F. Zhang, I. Toma, C. Theilacker, B. Li, T. F. Baumert, O. Holst, R. J. Linhardt, J. Huebner, Journal of Biological Chemistry, 284, 18194 - 18201, 2009. LINK


477. "Sequence analysis of native oligosaccharides using negative ESI tandem MS," Z. Zhang, R. J. Linhardt, Current Analytical Chemistry, 5, 225-237, 2009. LINK


476. "Hyaluronan and Heparin Reduced Silver Nanoparticles Having Antimicrobial Properties," M. M. Kemp, A. Kumar, D. Clement, P. Ajayan, S. Mousa, R. J. Linhardt, Nanomedicine, 4, 421-429, 2009. LINK


475. "Sulfonation of papain treated chitosan and its mechanism for anticoagulant activity," J. Suwan, Z. Zhang, B. Li, P. Vongchan, P. Meepowpan, F. Zhang, S.A. Mousa, S. Mousa, B. Premanode, P. Kongtawelert, R. J. Linhardt, Carbohydrate Research, 344, 1190–1196, 2009. LINK


474. "Thin Layer Chromatography for the Separation and Analysis of Acidic Carbohydrates," Z. Zhang, Z. Xiao, R.J. Linhardt, Journal of Liquid Chromatography & Related Technologies, 32, 1711–1732, 2009. LINK


473. "Quantitification of Heparan Sulfate and Heparin Disaccharides Using Ion-pairing, Reverse-Phase, Micro-flow, High Performance Liquid Chromatography Coupled with Electrospray Ionization Trap Mass Spectrometry," Z. Zhang, J. Xie, H. Liu, J. Liu, R. J. Linhardt, Analytical Chemistry, 81, 4349–4355, 2009. LINK


472. "Oversulfated chondroitin sulfate interaction with heparin-binding proteins: New insights into adverse reactions from contaminated heparins," B. Li, J.Suwan, J.G. Martin, F. Zhang, Z. Zhang, D. Hoppensteadt, M. Clark, J. Fareed, R.J. Linhardt, Biochemical Pharmacology, 78, 292–300, 2009. LINK


471. "Synthesis and biological evaluation of 1,2,3-triazole linked sialic acid derivatives as neuraminidase inhibitors," M. Weïwer, C.-C. Chen, M. M. Kemp, R. J. Linhardt, European Journal of Organic Chemistry, 2611–2620, 2009. LINK


470. "Non-covalent functionalization as an alternative to oxidative acid treatment of single wall carbon nanotubes," T. J. Simmons, J. Bult, D. P. Hashim, R. J. Linhardt, P.M. Ajayan, ACS Nano, 3, 865-870, 2009. LINK


469. "Solvolytic depolymerization of chondroitin and dermatan sulfates," T. Toida, K. Sato, N. Sakamoto, S. Sakai, S. Hosoyama, R. J. Linhardt, Carbohydrate Research, 344, 888-893, 2009. LINK


468. "Antiseptic single wall carbon nanotube bandages", T.J. Simmons, S.-H. Lee, T.-J. Park, D.P. Hashim, P.M. Ajayan, R.J. Linhardt, Carbon, 47, 1561-1564, 2009. LINK


467. "Quantitative capillary electrophoresis determination of oversulfated chondroitin sulfate as a contaminant in heparin preparations," N. Volpi, F. Maccari, R. J. Linhardt, Analytical Biochemistry, 388, 140-145, 2009. LINK


466. "Synthesis of Gold and Silver Nanoparticles Stabilized with Glycosaminoglycans having Distinctive Biological Activities," M. M. Kemp, A. Kumar, S. Mousa, T.-J, Park, N. Kubotera, S. Mousa, P. Ajayan, R. J. Linhardt, Biomacromolecules, 10, 589–595, 2009. LINK


465. "Green glycosylation using ionic liquid to prepare alkyl glycosides for studying carbohydrate-protein interactions by SPR," F. J. Muñoz, J. Pérez, S. André, H.-J. Gabius, J. V. Sinisterra, M. J. Hernáiz, and R. J. Linhardt, Green Chemistry, 11, 373-379, 2009. LINK


464. "Lessons learned from the contamination of heparin," H. Liu, Z. Zhang, R.J. Linhardt, Natural Product Reports, 26, 313–321, 2009. LINK


463. "Structural Characterization of Glycosaminoglycans from Zebrafish in Different Ages," F. Zhang, Z. Zhang, R. Thistle, L. McKeen, S. Hosoyama, T. Toida, R. J. Linhardt, P. Page-McCaw, Glycoconjugate Journal, 26, 211-218, 2009. LINK


462. "Ionic liquid-mediated selective extraction of lignin from wood leading to enhanced enzymatic cellulose hydrolysis," S.-H. Lee, T. V. Doherty, R. J. Linhardt, J. S. Dordick, Biotechnology and Bioengineering, 102, 1368-1376, 2009. LINK


461. "Electron Capture Dissociation, Electron Detachment Dissociation, and Infrared Multiphoton Dissociation of Sucrose Octasulfate," J. J.Wolff, T. N.Laremore, F. E.Leach, R. J. Linhardt, I. Amster, European Journal of Mass Spectrometry, 15, 275–281, 2009. LINK


460. "Biological profile of hyper/oversulfated chondroitin sulfate contaminant isolated from recalled heparin," J. Fareed, J.M. Walenga, W. Jeske, D. Hoppensteadt, M. Prechel, O. Iqbal, C. Adiuzel, M. Clark, E. Latinas, J. Cunanan, R. J. Linhardt, J Harenberg, Seminars in Thrombosis and Hemostasis, 34, 119-127, 2008. LINK


459. "Liquid Chromatography-Mass Spectrometry to Study Chondroitin Lyase Action Pattern," Z. Zhang, Y. Park, M. M. Kemp, W. Zhao, A.-R. Im, D. Shaya, M. Cygler, Y. S. Kim, R. J. Linhardt, Analytical Biochemistry, 385, 57-64, 2008. LINK


458. "Stereoselective Synthesis of a C-linked Neuraminic Acid Disaccharide: Potential Building Block for the Synthesis of C-Analogs of Polysialic Acids," J.-H. Kim, F. Huang, M. Ly, R. J. Linhardt, Journal of Organic Chemistry, 73, 9497–9500, 2008. LINK


457. "Significance of 2-O-Sulfonate Group of L-Iduronic Acid Residues in Heparin on the Growth Inhibition of Bovine Pulmonary Artery Smooth Muscle Cells," H. G.Garg, H. Mrabat, L. Yu, C. Freeman, B. Li, F. Zhang, R. J. Linhardt, C. A. Hales, Carbohydrate Research, 343, 2406-2410, 2008. LINK


456. "Variation of Acharan Sulfate and Monosaccharide Composition and Analysis of Neutral N-Glycans in African Giant Snail (Acatina fulica)." Y. Park, Z. Zhang, T. N. Laremore, B. Li, J.-S. Sim, A.-R. Im, M. Y. Ahn, Y. S. Kim, R.J. Linhardt Glycoconjugate Journal, 25, 863-877, 2008. LINK


455. "Synthesis of Floridoside," M. Weïwer, T. Sherwood, R. J. Linhardt, Journal of Carbohydrate Chemistry, 27, 420 - 427, 2008. LINK


454. "Glycosaminoglycan Binding Proteins," J. D. Esko, R.J. Linhardt, In Essentials of Glycobiology, A. Varki, Ed., Cold Spring Harbor Laboratory, Chapter 35, Second Edition, 2008. LINK


453. "Synthesis of Uridine 5’-Diphosphoiduronic Acid: A Potential Substrate for the Chemoenzymatic Synthesis of Heparin," M.Weïwer, T. Sherwood, Dixy E. Green, M. Chen, P. L. DeAngelis, J. Liu, R. J. Linhardt, Journal of Organic Chemistry, 73, 7631-7637, 2008. LINK


452. "Biocompatible Activated Charcoal Composites For Drug Detoxification Prepared Using Room Temperature Ionic Liquids," T.-J. Park,a J. G. Martin, T. J. Simmons, S. Mousa, E. A. Snezhkova, V. V. Sarnatskaya, V. G. Nikolaev, R. J. Linhardt, Chemical Communications, 5022-5024, 2008. LINK


451. "Mass spectrometry for the characterization of unsulfated chondroitin oligosaccharides from 2-mers to 16-mers. Comparison with hyaluronic acid oligomers," N. Volpi, Z. Zhang, R. J. Linhardt, Rapid Communications in Mass Spectrometry, 22, 3526-3530, 2008. LINK


450. "Human Follicular Fluid Heparan Sulfate Contain Abundant 3-O-Sufated Chains with Anticoagulant Activity," A. I. de Agostini, J.-C. Dong, C. de Vantéry Arrighi, M.-A. Ramus, I. Dentand-Quadri, S. Thalmann, P. Ventura, V. Ibecheole, F. Monge,A.-M. Fischer, S. HajMohammadi, N. W. Shworak, L. Zhang, Z. Zhang, R. J. Linhardt, Journal of Biological Chemistry, 283, 28115-28124, 2008. LINK


449. "Evaluation of the Experimental Parameters which Control Electron Detachment Dissociation, and their Effect on the Fragmentation Efficiency of Glycosaminolgycan Carbohydrates," F. E. Leach III, J. J. Wolff, T. N. Laremore, R. J. Linhardt, I. J. Amster, International Journal of Mass Spectrometry, 276,110-115, 2008. LINK


448. "Signal Amplification of Target Protein on Heparin Glycan Microarray," T.-J. Park, M.-Y. Lee, J. S. Dordick, R. J. Linhardt, Analytical Biochemistry, 383, 116–121, 2008. LINK


447. "Solution Structures of Chemoenzymatically Synthesized Heparin and its Precursors," Z. Zhang, S. A. McCallum, J. Xie, L. Nieto, F. Corzana, J. Jiménez-Barbero, M. Chen, J. Liu, R. J. Linhardt, Journal of the American Chemical Society, 130, 12998-13007, 2008. LINK


446. "Electron Induced Dissociation of Glycosaminoglycan Tetrasaccharides," J. J. Wolff, T. N. Laremore, H. Aslam, R. J. Linhardt, I. J. Amster, Journal of the American Society of Mass Spectrometry, 19, 1449-1458, 2008. LINK


445. "Oversulfated Chondroitin Sulfate: Impact of a Heparin Impurity, Associated with Adverse Clinical Events, on Low Molecular Weight Heparin Preparation," Z. Zhang, M. Weïwer, B. Li, M. M. Kemp, T. H. Daman, R. J. Linhardt Journal of Medicinal Chemistry, 51, 5498-5501, 2008. LINK


444. "Pharmacological Applications of Biocompatible Carbon Nanotubes and their Emerging Toxicology Issues," T.-J. Park, J. G. Martin, R. J. Linhardt, In Medicinal Chemistry and Pharmacological Potential of Fullerenes and Carbon Nanotubes, Franco Cataldo and Tatiana Da Ros (Eds.), Springer Vol. 1, Capter 12, pp 283-316, Topics in Carbon Materials Chemistry and Physics, 2008. LINK


443. "Modification of solid phase red cell adherence assay for the detection of platelet alloantibodies in patients with thrombocytopenia, " P. Vongchan, W. Nawarawong, R. J. Linhardt, American Journal of Clinical Pathology, 130, 455-66, 2008. LINK


442. "Distinct Heparan Sulfate Compositions in Wild-Type and Pipe-Mutant Eggshell Matrix," Y. Park, Z. Zhang, R.J. Linhardt, E. K. LeMosy, Fly, 2, 1-5, 2008. LINK


441. . "The Role of the Methoxyphenol Apocynin, a Vascular NADPH Oxidase Inhibitor, as a Chemopreventative Agent in the Potential Treatment of Cardiovascular Diseases," J. Yu, M. Weiwer, R. J. Linhardt, J. S. Dordick, Current Vascular Pharmacology, 6, 204-217, 2008. LINK


440. "Capillary Electrophoresis of Complex Natural Polysaccharides, " N. Volpi, F. Maccari, R. J. Linhardt, Electrophoresis, 29, 3095–3106, 2008. LINK


439. "Physiological, Pathophysiological and Therapeutic Roles of Heparin/Heparan Sulfate," J. Xie, S. Murugesan, R. J. Linhardt, in Carbohydrate Chemistry, Biology and Medical Applications. Garg, H.G., Cowman, M.K., Hales, C.A., eds., , Chapter 10, 227-251, Elsevier, Oxford , UK, 2008. LINK


438. "The Effects of Culture Conditions on the Glycosylation of Secreted Human Placental Alkaline Phosphatase Produced in Chinese Hamster Ovary Cells," J. H. Nam, F. Zhang, M. Ermonval, R. J. Linhardt, S. T. Sharfstein, Biotechnology and Bioengineering, 100, 1178-1192, 2008. LINK


437. "Oversulfated Chondroitin Sulfate is a major contaminant in Heparin associated with Adverse Clinical Events," M. Guerrini, D. Beccati, Z. Shriver, A. M. Naggi, A. Bisio, I. Capila, J. Lansing, S. Guglieri, B. Fraser, A. Al-Hakim, S. Gunay, K. Viswanathan, Z. Zhang, L. Robinson, G. Venkataraman, L. Buhse, M. Nasr, J. Woodcock, R. Langer, R. Linhardt, B. Casu, G. Torri, R. Sasisekharan, Nature Biotechnology, 26, 669-775, 2008. LINK


436. "Is Human Placenta Proteoglycan Remodeling Involved in Pre-Eclampsia?" M. Warda, F. Zhang, M. Radwan, Z. Zhang, N. Kim, Y.N. Kim, R. J. Linhardt, J. Han, Glycoconjugate Journal, 25, 441–450, 2008. LINK


435. "Influence of charge state and sodium cationization on the electron detachment dissociation and infrared multiphoton dissociation of glycosaminoglycan oligosaccharides," J. J. Wolff, T. N. Laremore, A. M. Busch, R. J. Linhardt, I. J. Amster, Journal of the American Society Mass Spectrometry, 19, 790-798, 2008. LINK


434. "Using a 3-O-Sulfated Heparan Sulfate Octasaccharide to Inhibit the Entry of Herpes Simplex Virus 1", R. Copeland, A. Balasubramaniam, V. Tiwari, F. Zhang, A. Bridges, R. J. Linhardt, D. Shukla, J. Liu, Biochemistry, 47, 5774–5783, 2008. LINK


433. "Toll-like Receptor 4 Mediates Induction of Inflammatory Pathway by Food Additive Carrageenan," S. Bhattacharyya, R. Gill, M. L. Chen, F. Zhang, R. J. Linhardt, P. K. Dudeja, J. K. Tobacman, Journal of Biological Chemistry, 283, 10550-10558, 2008. LINK


432. "Structural Analysis of Bikunin Glycosaminoglycan," L. Chi, J. J. Wolff, T. N. Laremore, O. F. Restaino, J. Xie, C. Schiraldi, T. Toida, I. J. Amster, R. J. Linhardt, Journal of the American Chemical Society, 130, 2617-2625, 2008. LINK


431. "Electron Detachment Dissociation of Dermatan Sulfate Oligosaccharides," J. J. Wolff, T. N. Laremore, A. M. Busch, R. J. Linhardt, I. Jonathan Amster, Journal of American Society of Mass Spectrometry, 19, 294-304, 2008. LINK


430. "Synthesis and Evaluation of Anticancer Vaccine Candidate, C-Glycoside Analogs of sTn and PSA," M. Weïwer, F. Huang, C.-C. Chen, X. Yuan, K. Tokuzaki, H. Tomiyama, R. J. Linhardt, Chemical Glycobiology II: Glycopharmaceuticals and Glycovaccines, X. Chen, R. L. Halcomb, p. G. Wang, Eds., ACS Press, Chap. 10, pp. 175-195, 2008. LINK


429. "Conformational Analysis of a Dermatan Sulfate - Derived Tetrasaccharide by NMR, Molecular Modeling and Residual Dipolar Couplings," A. Silipo, Z. Zhang, F. J. Cañada, A. Molinaro, R. J. Linhardt, J. Jiménez-Barbero, ChemBiochem, 9, 240-252, 2008. LINK


428. "Tandem MS Can Distinguish Hyaluronic Acid from N-Acetylheparosan," Z. Zhang, J. Xie, J. Liu, R. J. Linhardt, Journal of American Society of Mass Spectrometry, 19, 82-89, 2008. LINK


427. "Immobilization of Heparin-Approaches and Applications," S. Murugesan, J. Xie, R. J. Linhardt, Current Topics in Medicinal Chemistry, 8, 80-100, 2008. LINK


426. "Pharmacokinetics and Pharmacodynamics of Oral Heparin Solid Dosage Form in Healthy Human Subjects," S. A. Mousa, F. Zhang, A. Aljada, S. Chaturvedi, M. Takieddin, H. Zhang, L. Chi, E. Arbit, M. C. Castelli, M.M. Goldberg, R. J. Linhardt, Journal of Clinical Pharmacology, 47, 1508-1520, 2007. LINK


425. "Enzyme-Carbon Nanotube Conjugates in Room Temperature Ionic Liquids," B. Eker, P. Asuri, S. Murugesan, R. J. Linhardt, J. S. Dordick, Applied Biochemistry and Biotechnology, 143, 153-163, 2007. LINK


424. "Glycomics of Proteoglycan Biosynthesis in Murine Embryonic Stem Cell Differentiation," A. V. Nairn, A. Kinoshita-Toyoda, H. Toyoda, J. Xie, K. Harris, S. Dalton, M. Kulik, J. M. Pierce, T. Toida, K. W. Moremen, R. J. Linhardt, Journal of Proteome Research 6, 4374-4387, 2007. LINK


423. "Synthesis of Glycosaminoglycans and their Oligosaccharides," M. Weiwer, R. J. Linhardt, in Comprehensive Glycosciences, G. J. Boons, Y. C. Lee, A. Suzuki, N. Taniguchi, A. G. J. Voragen, J.P. Kamerling (eds.) Elsevier BV, Amsterdam, The Netherlands, Chap 1.18, 713-745, 2007. LINK


422. "Binding Between the Integrin aXß2 (CD11c/CD18) and Heparin," T. Vorup-Jensen, L. Chi, L. C. Gjelstrup, U. B. Jensen, C. A. Jewett, C. Xie, M. Shimaoka, R. J. Linhardt, T. A. Springer, Journal of Biological Chemistry, 282, 30869-30877, 2007. LINK


421. "Thin Layer Chromatography for the Analysis of Glycosaminoglycan Oligosaccharides," Z. Zhang, J. Xie, F. Zhang, R. J. Linhardt, Analytical Biochemistry, 371, 118–120, 2007. LINK


420. "Combinatorial Enzymatic Synthesis of Heparan Sulfate, " J.-H. Kim, R. J. Linhardt, Chemistry & Biology, 14, 972-973, 2007. LINK


419. "Mosquito Heparan Sulfate and its Potential Role in Malaria Infection and Transmission," P. Sinnis, A. Coppi, T. Toida, H. Toyoda, A. Kinoshita-Toyoda, J. Xie M.M. Kemp, R. J. Linhardt, Journal of Biological Chemistry, 282, 25376-25384, 2007. LINK


418. "Flexible Nanocomposite Thin Film Energy Storage Devices," V. L Pushparaj, S. M. Manikoth, A. Kumar, S. Murugesan, L. Ci, R. Vajtai, R. J. Linhardt, O. Nalamasu, P. M. Ajayan, Proceedings of the National Academy of Science USA 104, 13574-13577, 2007. LINK


417. "Enzymatic Synthesis of Glycosaminoglycan Heparin," R. J. Linhardt, J. S. Dordick, P. L. DeAngelis, J. Liu, Seminars in Thrombosis and Hemostasis, 33, 453-465, 2007. LINK


416. "MALDI-TOFMS Analysis of Hyaluronan Oligosaccharides," S. Sakai, K. Hirano, H. Toyoda, R. J. Linhardt, T. Toida, Analytica Chimica Acta, 593, 207-213, 2007. LINK


415. "Heparin Oligosaccharides as Potential Therapeutic Agents in Senile Dementia," Q. Ma, U. Cornelli, I. Hanin, J. M. Lee, W. P. Jeske, R. J. Linhardt, J. M. Walenga, J. Fareed, Current Pharmaceutical Design, 13, 1607-1616, 2007. LINK


414. "Facile Synthesis of (±)-Paeonilide," Y. Du, J Liu, R. J. Linhardt, Journal of Organic Chemistry, 72, 3952-3954, 2007. LINK


413. "Molecular Insights into the Klotho-Dependent, Endocrine Mode of Action of FGF19 Subfamily Members," R. Goetz, A. Beenken, O. A. Ibrahimi, J. Kalinina, S. K. Olsen, A. V. Eliseenkova, C. F. Xu, T. Neubert, F. Zhang, R. J. Linhardt, X. Yu, K. E. White, T. Inagaki, S. A. Kliewer, M. Yamamoto, H. Kurosu, Y. Ogawa, M. Kuro-o, B. Lanske, M. S. Razzaque, M. Mohammadi, Molecular and Cellular Biology, 27, 3417-3428, 2007. LINK


412. "Synthesis of nor-C-linked neuraminic acid disaccharide: A versatile precursor of C-analogs of oligosialic acids and gangliosides," X. Yuan, D. K. Ress, R. J. Linhardt, Journal of Organic Chemistry, 72, 3085-3088, 2007. LINK


411. "Kinetic and Structural Studies on Interactions between Heparin/Heparan Sulfate and Proteins of the Hedgehog Signaling Pathway," F. Zhang, J. S. McLellan, A. M. A. Jiménez, D. J. Leahy, R. J. Linhardt, Biochemistry, 46, 3933-3941, 2007. LINK


410. "Enzymatic Synthesis of Glycosaminoglycans: Improving on Nature," F.Y. Avci, P.L. DeAngelis, J. Liu, R.J. Linhardt, in Frontiers in Carbohydrate Chemistry, ACS Symposium Series 960, A. Demchenko, Ed., Chapter 15, pp 253-284, 2007, Oxford University Press, London. LINK


409. "Distinguishing Glucuronic from Iduronic Acid in Glycosaminoglycan Tetrasaccharides by Using Electron Detachment Dissociation," J. J. Wolff, L. Chi, R. J. Linhardt, I. J. Amster, Analytical Chemistry, 79, 2015-2022, 2007. LINK


408. "Carbon Inhibits VEGF and FGF Promoted Angiogenesis," S. Murugesan, S. A. Mousa, L. J. O’Connor, D.W. Lincoln, R. J. Linhardt, FEBS Letters, 581, 1157-1160, 2007. LINK


407. "Molecular Weight Dependent Tissue Factor Pathway Inhibitor Release by Heparin and Heparin Oligosaccharides," Q. Ma, M. Tobu, C. Schultz, W. Jeske, D. Hoppensteadt, J. Walenga, U. Cornelli, J. Lee, R. Linhardt, I. Hanin, J. Fareed, Thrombosis Research, 119, 653-661, 2007. LINK


406. "Improved Matrix-Assisted Laser Desorption/Ionization Mass Spectrometric Detection of Glycosaminoglycan Disaccharides as Cesium Salts," T.N. Laremore, R.J. Linhardt, Rapid Communications in Mass Spectrometry, 21, 1315-1320, 2007. LINK


405. "Investigation of the Binding Mechanism between Internalin B and Heparin using Surface Plasmon Resonance," S. Lang, M. M. Kemp, E. M. Muñoz, O. Azizad, M. Banerjee, J. Kumaran, P. Ghosh, R. J. Linhardt, Biochemistry, 46, 2697 -2706, 2007. LINK


404. "New Ionic Liquid Matrix for Direct UV-MALDI-TOF-MS Analysis of Dermatan Sulfate and Chondroitin Sulfate Oligosaccharides," T.N. Laremore, F. Zhang, R. J. Linhardt, Analytical Chemistry, 79, 1604-1610, 2007. LINK


403. "Conducting Organic-Inorganic Submicron Rods Based on Ionic Liquids," A. Kumar, S. Murugesan, V. L. Pushparaj, C. Soldano, J. Xie, G. John, O. Nalamasu, P. M. Ajayan, R. J. Linhardt, Small, 3, 429-433, 2007. LINK


402. "Synthesis of Tin (II) Phosphate Open Frameworks Using Isomers of 1, 2-Diaminocyclohexane as Template," X. Yuan, Y. Xu, X. You, R. J. Linhardt, European Journal of Inorganic Chemistry, 858-864, 2007. LINK


401. "Quantitative Continuous Assay for Hyaluronan Synthase," J. C. Krupa, D. Shaya, L. Chi, R.J. Linhardt, M. Cygler, S. G. Withers, J. S. Mort, Analytical Biochemistry, 361, 218-225, 2007. LINK


400. "Electron Detachment Dissociation of Glycosaminoglycan Tetrasaccharides," J. J. Wolff, L. Chi, R. J. Linhardt, I. J. Amster, Journal of the American Society of Mass Spectrometry, 18, 234-244, 2007. LINK


399. "Expression of human liver HSPGs on myeloid leukemia," P. Vongchan, R. J. Linhardt, Clinical Immunology, 122, 194–206, 2007. LINK


398. "Glycosylation in Room Temperature Ionic Liquid using Unprotected and Unactivated Donors," T.-J. Park, M. Weiwer, X. Yuan, S. N. Baytas, E. M. Munoz, S. Murugesan, R. J. Linhardt, Carbohydrate Research, 342, 614-620, 2007. LINK


397. "Acceptor Specificity of the Pasteurella Hyaluronan and Chondroitin Synthases and Production of Chimeric Glycosaminoglycans," B. S. Tracy, F. Y. Avci, Robert J. Linhardt, and P. L. DeAngelis, Journal of Biological Chemistry, 282, 337–344, 2007. LINK


396. "Qualitative and Quantitative Determination of Ten Major Saponins in Platycodi Radix by High Performance Liquid Chromatography with Evaporative Light Scattering Detection and Mass Spectrometry," Y. W. Ha, Y.-C. Na, J.-J. Seo, S.-N. Kim, R. J. Linhardt, Y. S. Kim, Journal of Chromatography A, 1135, 27-35, 2006. LINK


395. "The First Total Synthesis of Sporiolide A," Y. Du, Q. Chen, R. J. Linhardt, Journal of Organic Chemistry, 71, 8446-8451, 2006. LINK


394. "Synthesis of Silica – Gold Nanocomposites and their Porous Nanoparticles by In – Situ Approach," A. Kumar, V. L. Pushparaj, S. Murugesan, G. Viswanathan, R. J. Linhardt, O. Nalamasu and P. M. Ajayan, Langmuir, 22, 8631-8634, 2006. LINK


393. "Anti-metastatic effect of non-anticoagulant low molecular weight heparin versus standard low molecular weight heparin, enoxaparain," S. A. Mousa, R. J. Linhardt, J. L. Francis, A. Amirkhosravi, Thrombosis and Haemostasis, 96, 816-821, 2006. LINK


392. "Ionic Liquid Derived Blood Compatible Composite Membranes For Kidney Dialysis," S. Murugesan, S. Mousa, A. Vijayaraghavan, P. M. Ajayan and R. J. Linhardt, Journal of Biomedical Materials Research: Part B - Applied Biomaterials, 79B, 298-304, 2006. LINK


391. "Crystallographic Analysis of Calcium-Dependent Heparin Binding to Annexin A2," C. Shao, F. Zhang, M. Kemp, R. J. Linhardt, J. F. Head, B, A. Seaton, Journal of Biological Chemistry, 281, 31689–31695, 2006. LINK


390. "Viral and Cellular Determinants of Hepatitis C Virus Envelope-Heparan Sulfate Interaction," H. Barth, E. K. Schnober, F. Zhang, R. J. Linhardt, E. Depla, B. Boson, F.-L. Cosset, A. Patel, H. E. Blum, T. F. Baumert, Journal of Virology, 80, 10579-10590, 2006. LINK


389. "Increase in the Growth Inhibition of Bovine Pulmonary Artery Smooth Muscle Cells by an O-Hexanoyl Low Molecular Weight Heparin Derivative," H. G. Garg, N. Cindhuchao, C. A. Hales, M. Butler, T. Islam, R. J. Linhardt, Carbohydrate Research, 341, 2607–2612, 2006. LINK


388. "Synthetic Oligosaccharide Stimulates and Stabilizes Angiogenesis: Structure-Function Relationships and Potential Mechanisms," S.A. Mousa, X. Feng, J. Xie, Y. Du, Y. Hua, H. He, L. O’Connor, R. J. Linhardt, The Journal of Cardiovascular Pharmacology, 48, 6-14, 2006. LINK


387. "Synthetic Sugars Point Towards Chemical Glycomics: Commentary," J. E. Turnbull, R. J. Linhardt, Nature Chemical Biology, 2, 449-450, 2006. LINK


386. "Chondroitin Sulfate Intake Inhibits the IgE-Mediated Allergic Response by Down Regulating Th2 Responses in Mice," S. Sakai, H. Akiyama, Y. Sato, Y. Yoshioka, R. J. Linhardt, Y. Goda, T. Maitani, T. Toida, Journal of Biological Chemistry, 281, 19872 - 19880, 2006. LINK


385. "CS Lyases: Structure, Activity and Applications in Analysis and the Treatment of Diseases, R.J. Linhardt," F.Y. Avci, T. Toida, Y.S. Kim, M. Cygler, Chondroitin Sulfate Structure, Role and Pharmacological Activity-Advances in Pharmacology, N. Volpi Ed., Elsevier, Chapter 9, 2006.


384. "Immunological Activity of Chondroitin Sulfate," T. Toida, S. Sakai, H. Akiyama, R. J. Linhardt, Chondroitin Sulfate Structure, Role and Pharmacological Activity-Advances in Pharmacology, N. Volpi Ed., Elsevier, Chapter 19, 2006. LINK


383. "Affinity, kinetic and structural study of the interaction of 3-O-sulfotransferase isoform 1 with heparan sulfate," E. Mu“oz, D. Xu, J. Liu, R. J. Linhardt, Biochemistry, 45, 5122-5118, 2006. LINK


382. "In Vivo Antithrombotic Synergy of Oral Heparin and Arginine: Endothelial Thromboresistance Without Systemic Anticoagulation," B. Daniels, R.J. Linhardt, F. Zhang, W. Mao, S. Wice, L. Hiebert, Thrombosis and Haemostasis, 95, 865-873, 2006. LINK


381. "Preparation and Structural Determination of Large Oligosaccharides Derived from Acharan Sulfate," L. Chi, E. M. Munoz, H. S. Choi, Y. W. Ha, Y. S. Kim, T. Toida, R. J. Linhardt, Carbohydrate Research, 341 864–869, 2006. LINK


380. "Nano-based Neoproteoglycans – Blood Compatible Carbon Nanotubes," S. Murugesan, T. Park, H. Yang, S. Mousa and R. J. Linhardt, Langmuir, 22,3461-3463, 2006. LINK


379. "Isolation and Characterization of Heparan Sulfate from Various Murine Tissues," M. Warda, T. Toida, F. Zhang, P. Sun, E. Munoz, R. J. Linhardt, Glycoconjugate Journal, 23, 553-561, 2006. LINK


378. "Microscale Isolation and Analysis of Heparin from Plasma using an Anion Exchange Spin Column," F. Zhang, P. Sun, E. Mu“oz, L.Chi, S. Sakai, T. Toida, H. Zhang, S. Mousa R. J. Linhardt, Analytical Biochemistry, 353, 284–286, 2006. LINK


377. "Preparation of Biopolymer Fibers Using Electrospinning from Room Temperature Ionic Liquids," G. Viswanathan, S. Murugesan, V. Pushparaj, O. Nalamasu, P. M. Ajayan and R. J. Linhardt, Biomacromolecules, 7, 415-418, 2006. LINK


376. "Matrix-Assisted Laser Desorption/Ionization Mass Spectrometric Analysis of Uncomplexed Highly Sulfated Oligosaccharides using Ionic Liquid Matrices. T.N. Laremore, S. Murugesan," T.-J. Park, F.Y. Avci, D. V. Zagorevski, R. J. Linhardt, Analytical Chemistry, 78, 1774-1779, 2006. LINK


375. "Heparin Accelerates Gelsolin Amyloidogenesis," J. Y. Suk, F. Zhang, W. E. Balch, R. J. Linhardt, J. W. Kelly, Biochemistry, 45, 2234-2242, 2006. LINK


374. "Structural Basis by which Alternative Splicing Modulates the Organizer Activity of FGF8 in the Brain," S. K. Olsen, J. Y. H. Li, C. Bromleigh, A. V. Eliseenkova, O. A. Ibrahimi, Z. Lao, F. Zhang, R. J. Linhardt, A. L. Joyner, Moosa Mohammadi, Genes and Development, 20, 185-198, 2006. LINK


373. "Benzoate-Based Room Temperature Ionic Liquids – Thermal Properties and Glycosaminoglycan Dissolution," S. Murugesan, J. M. Wiencek, R.X. Ren R.J. Linhardt, Carbohydrate Polymers,, 63, 268-271, 2006. LINK


372. "Stereoselective Synthesis of Cytotoxic Anhydrophytosphingosine Pachastrissamine (Jaspine B) from D-Xylose," Y. Du, J, Liu, R.J. Linhardt, Journal of Organic Chemistry, 71, 1251-1253, 2006. LINK


371. "Dromedary glycosaminoglycans: Molecular Characterization of Camel Lung and Liver Heparan Sulfate," M. Warda, R.J. Linhardt, Comparative Biochemistry and Physiology B, 143,37-43, 2006. LINK


370. "Enzymatic Synthesis of Heparin Related Polysaccharides on Sensor Chips: Rapid Screening of Heparin-Protein Interactions," E. Muñoz, D. Xu, F. Avci, M. Kemp, J. Liu, R. J. Linhardt, Biochemical and Biophysical Research Communications , 339, 597-602, 2006. LINK


369. "HClO4-SiO2 Catalyzed Glycosylation using Sugar Trichloroacetimidates as Glycosyl Donors," Y. Du, G. Wei, S. Cheng, Y. Hua, R. J. Linhardt, Tetrahedron Letters, 47, 307-310, 2005. LINK


368. "Enzymatic Redesigning of Biological Active Heparan Sulfate," J. Chen, F.Y. Avci, E. M. Muñoz, L. M. McDowell, M. Chen, L. C. Pedersen, L. Zhang, R. J. Linhardt, J. Liu, Journal of Biological Chemistry, 280, 42817-42825, 2005. LINK


367. "Chemistry and Biology of Heparin and Heparan Sulfate," H. G. Garg, R. J. Linhardt, C. A. Hales (Eds.), Elsevier Ltd., Oxford, 2005. (Google book link) LINK


366. "Influence of Heparin Chemical Modifications on Its Antiproliferative Properties," H. G. Garg, R. J. Linhardt, C. A. Hales, in the Chemistry and Biology of Heparin and Heparan Sulfate, Elsevier Ltd., Oxford, H. G. Garg, R. J. Linhardt, and C. A. Hales (Eds.), Chapter 18, pp 513-532, 2005. LINK


365. "Regulation Activity of Heparin in Complement System H.Yu, R.E. Edens, R. J. Linhardt," inin the Chemistry and Biology of Heparin and Heparan Sulfate, Elsevier Ltd., Oxford, H. G. Garg, R. J. Linhardt, and C. A. Hales (Eds.), Chapter 11, pp.313-343, 2005. LINK


364. "Recent Advances in the Synthesis of C-oligosaccharides, " X. Yuan, R. J. Linhardt, Current Topics in Medicinal Chemistry, 5, 1393-430, 2005. LINK


363. "Analysis of the Biochemical Mechanisms for the Endocrine Actions of FGF23," X. Yu, O. A. Ibrahimi, F. Zhang, S. I. Davis, H. J. Garringer, R. J. Linhardt, D. M. Ornitz, M. Mohammadi, K. E. White, Endocrinology, 146, 4647-4656, 2005. LINK


362. "Kinetic Studies on the Interaction of Heparin and Complement Proteins using Surface Plasmon Resonance," H. Yu, E.M. Muñoz, F. Zhang, R.E. Edens, R.J. Linhardt, Biochemica Biophysica Acta, Biochemica Biophysica Acta, 1726, 168-176, 2005. LINK


361. "Synthesis of Double C-Glycoside Analog of sTn," D.R. Ress, S.N. Baytas, H Tomiyama, E.M. Muñoz, R.J. Linhardt, Journal of Organic Chemistry, 70, 8197-8200, 2005. LINK


360. "Preparation of hyaluronan O-methylester and its enzymatic degradation," K. Hirano , S. Sakai, T. Ishikawa, F.Y. Avci, R. J. Linhardt, T. Toida, Carbohydrate Research, 340, 2297-2304, 2005. LINK


359. "Mass Spectrometry for the Analysis of Highly Charged Sulfated Carbohydrates," L. Chi, J. Amster, R.J. Linhardt, Current Analytical Chemistry,1, 223-240, 2005. LINK


358. "Poly(ethylene glycol)-Based Biosensor Chip to Study Heparin Protein Interactions," E.M. Muñoz, H. Yu, J. Hallock, R.E. Edens, R.J. Linhardt, 343, 176-178, 2005. Analytical Biochemistry, 343, 176-178, 2005. LINK


357. "Characterization of Heparan Sulfate from the Unossified Antler of Cervus elaphus, " Y. W. Ha, B. T. Jeon, S. H. Moon, H. Toyoda, T. Toida, R. J. Linhardt, Y. S. Kim, Carbohydrate Research, 340, 411-416, 2005. LINK


356. "Analysis Of Mutations in FGF and a Pathogenic Mutation in FGFR Provide Direct Evidence in Support of the Two-End Model for FGFR Dimerization," O.A. Ibrahimi, B.K. Yeh, A.V. Eliseenkova, F. Zhang, S.K. Olsen, M. Igarashi, S.A. Aaronson, R.J. Linhardt, M. Mohammadi, Molecular and Cell Biology, 25, 671-684, 2005. LINK


355. "Quantitative Analysis of Chondroitin Sulfate in Raw Materials, Ophthalmic Solutions, Soft Capsules and Liquid Preparations," J.-S. Sim, T. Toida, S. Y. Cho, D. W. Choi, S.-Y. Chang, R. J. Linhardt, Y. S. Kim, Journal of Chromatography B, 818, 133-139, 2005. LINK


354. "Ionic Liquids In Carbohydrate Chemistry – Current Trends And Future Directions," S. Murugesan, R. J. Linhardt, Current Organic Synthesis, 2, 437-451, 2005. LINK


353. "Structural Characterization of Human Liver Heparan Sulfate," P. Vongchan, M. Warda, H. Toyoda, T. Toida, R. M. Marks, R. J. Linhardt, Biochemica Biophysica Acta, 1721, 1-8, 2005. LINK


352. "Nucleolin: Acharan Sulfate-Binding Protein on the Surface of Cancer Cells," E. J. Joo, T. Toida, R. J. Linhardt, Y. S. Kim, Glycobiology, 15, 1-9, 2005. LINK


351. "Samarium Iodide-Mediated Synthesis of Neuraminic Acid C-Clycosides," C.-C. Chen, D. K. Ress, R. J. Linhardt, In Syntheses of Glycomimetics, R. Roy, Ed., ACS Symposium Series, 896, 53-80, 2004. (Fulltext in PDF format) LINK


350. "Synthetic and Natural Polysaccharides with Anticoagulant Properties," F. Zhang, P.G. Yoder, R.J. Linhardt, in Polysaccharides: Structural Diversity and Functional Versatility, 2nd Edition, S. Dumitriu, Ed., Marcel Dekker, New York, 773-794, 2004. LINK


349. "Structural Analysis of the Sulfotransferase (3-OST-3) Involved in the Biosynthesis of an Entry Receptor for Herpes Simplex Virus 1," A.F. Moon, S.C. Edavettal, J.M. Krahn, E.M. Munoz, M. Negishi, R.J. Linhardt, J. Liu, L.C. Pedersen, Journal of Biological Chemistry, 279, 45185-45193, 2004. LINK


348. "Metabolic alteration of the N-glycan structure of a protein from patients with a heterozygous protein deficiency," F. Zhang, A. D. Bries, S. C. Lang, Q. Wang, D. W. Murhammer, J. M. Weiler, R. J. Linhardt, Biochimica Biophysica Acta, 1739, 43-49, 2004. LINK


347. "Biochemical analysis of pathogenic ligand-dependent FGFR2 mutations suggests distinct pathophysiological mechanisms for craniofacial and limb abnormalities in human skeletal disorders," O. A. Ibrahimi, F. Zhang, A. V. Eliseenkova, N. Itoh, R. J. Linhardt, M. Mohammadi, Human Molecular Genetics, 13, 2313-2324, 2004. LINK


346. "New Potent Insecticidal Agent: 4’-Fucosyl Avermectin Derivative," G. Wei, Y. Du R.J. Linhardt, Tetrahedron Letters, 45, 6895-6898, 2004. LINK


345. "Solid-Phase Chemoenzymatic Synthesis of Neuraminic Acid Based C-glycosides," S.N. Baytas, Q. Wang, N.A. Karst, R.J. Linhardt, Journal of Organic Chemistry, 69, 6900-6903, 2004. LINK


344. "Chondroitin Sulfate Structure Impacts its Immunological Effects on Murine Splenocytes Sensitized with Ovalbumin," H. Akiyama, S. Sakai, R. J. Linhardt, Y. Goda, T. Toida, T. Maitani, Biochemical Journal, 382, 269-278 2004. LINK


343. "Facile Synthesis of Saponins Containing 2,3-Branched Oligosaccharides by Using Partially Protected Glycosyl Donors," G. Gu, Y. Du, R. J. Linhardt, Journal of Organic Chemistry, 69, 5497-5500, 2004. LINK


342. "Heparin Binding Domains in Vascular Biology," E. M. Munoz, R. J. Linhardt, Arteriosclerosis, Thrombosis and Vascular Biology, 24, 1549-1557, 2004. LINK


341. "Role of Glycosaminoglycans in Cellular Communication," R. J. Linhardt, T. Toida, Accounts of Chemical Research, 37, 431-438, 2004. LINK


340. "Previews: Heparin-Induced Cancer Cell Death," R. J. Linhardt, Chemistry & Biology, 11, 420-422, 2004. LINK


339. "Trifluoroethylsulfonate Protected Monosaccharides in Glycosylation Reactions," N. A. Karst, T. F. Islam, F. Avci, R. J. Linhardt, Tetrahedron Letters, 45, 6433-6437, 2004. LINK


338. "The structure of chondroitin B lyase complexed with glycosaminoglycan fragments unravels calcium-dependent catalytic machinery," G. Michel, Y. Li, T. Sulea, R. J. Linhardt, M. Cygler, Journal of Biological Chemistry, 279, 32882-32896, 2004. LINK


337. "Crystal Structure and Mutational Analysis of Heparan Sulfate 3-O-Sulfotransferase Isoform 1," S. Thorp, K.A. Lee, M. Negishi, R.J. Linhardt, J. Liu, L.C. Pedersen, Journal of Biological Chemistry, 279, 25789-25797, 2004. LINK


336. "Studies on the effect of calcium in interactions between heparin and heparin cofactor II using surface plasmon resonance," F. Zhang, Y. Wu, Q. Ma, D. Hoppensteadt, J. Fareed, R. J. Linhardt, Clinical and Applied Thrombosis/Hemostasis, 10, 249-257, 2004. LINK


335. "A Kinetic Model for FGF, FGFR and Proteoglycan Signal Transduction Complex Assembly," O. A. Ibrahimi, F. Zhang, S. C. Lang Hrstka, M. Mohammadi, R. J. Linhardt, Biochemistry, 43,4724-4730, 2004. LINK


334. "Long Duration of Anticoagulant Activity and Protective Effects of Acharan Sulfate in Vivo," D.-W. Li, I. S. Lee, J.-S. Sim, T. Toida, R. J. Linhardt, Y. S. Kim, Thrombosis Research, 113,67-73, 2004. LINK


333. "Combinatorial Carbohydrate Synthesis" S. N. Baytas, R. J. Linhardt, Mini-Reviews in Organic Chemistry, 1,27-39, 2004. LINK


332. "Structural Determinants Of Heparan Sulfate Interactions With Slit Proteins," F. Zhang, F. Ronca, R.J. Linhardt, R.U. Margolis, Biochemical Biophysical Research Communications, 317, 352-357, 2004. LINK


331. "Total Synthesis of Quercetin 3-Sophorotrioside," Y. Du, G. Wei, R. J. Linhardt, Journal of Organic Chemistry, 69, 2206-2209, 2004. LINK


330. "A Glycosaminoglycan Recognition Element of Lymphotactin Essential for In Vivo Chemokine Activity," F. C. Peterson, E. S. Elgin, T. J. Nelson, F. Zhang, T. J. Hoeger, R. J. Linhardt, B. F. Volkman, Journal of Biological Chemistry, 279, 12598-12604, 2004. LINK


329. "High Resolution Crystal Structure of Arthrobacter aurescens Chondroitinase AC Complexed with Chondroitin Sulfate Defines the Catalytic Mechanism," V. V. Lunin, Y. Li, R.J. Linhardt, H. Miyazono, M. Kyogashima, M. Cygler, Journal of Molecular Biology, 337, 367-386, 2004. LINK


328. "Isolation and Characterization of Raw Heparin from Dromedary Intestine: Evaluation of a New Source of Pharmaceutical Heparin," M. Warda, E. M. Gouda, T. Toida, L. Chi, R. J. Linhardt, Comparative Biochemistry and Physiology Part C, 136 357-365, 2004. LINK


327. "Sialic Acid Donors: Chemical Synthesis and Glycosylation," D. K. Ress, R. J. Linhardt, Current Organic Synthesis, 1, 31-46, 2004. LINK


326. "Insights Into the Molecular Basis for FGF Receptor Autoinhibition and Ligand Binding Promiscuity," S. K. Olsen, O. A. Ibrahimi, A. Raucci, F. Zhang, A. V. Eliseenkova, A. Yayon, C. Basilico, R. J. Linhardt, J. Schlessinger, M. Mohammadi, Proceedings of the National Academy of Sciences USA, 101, 935-940, 2004. LINK


325. "Proline to Arginine Mutations in FGF Receptors 1 and 3 Result in Pfeiffer and Muenke Craniosyntosis Syndromes Through the Enhancement of FGF Binding Affinity," O.A. Ibrahimi, F. Zhang, A. V. Eliseenkova, R. J. Linhardt, M. Mohammadi Human and Molecular Genetics, 13, 69-78, 2004. LINK


324. "LC/MS Sequencing of Highly Sulfated Heparin-Derived Oligosaccharides" C. Thanawiroon, K. G. Rice, T. Toida, R.J. Linhardt, Journal of Biological Chemistry, 279, 2608-2615 2004. LINK


323. "Enhancement of Heparin an Heparin Disaccharide Absorption by the Phytolacca Americana Saponins," S. Y. Cho, J.-S. Sim, C.-S. Jeong, S. S. Kang, R. J. Linhardt, Y. S. Kim, Archives of Pharmacal Research, 26, 1102-1108, 2003. LINK


322. "Engineering Interferon-Alpha for Targeted Delivery," S. C. L. Hrstka, P. Yoder, J. M. Weiler, and R. J. Linhardt, Proceedings of the Conference on Advances in Structure, Function and Stability in Pharmaceuticals and Biologics II, AIChE Meeting, November 16-21, 2003, Omnipress, Madison, WI. LINK


321. "Sulfo-Protected Hexosamine Monosaccharides: Potentially Versatile Building Blocks for Glycosaminoglycan Synthesis," N. Karst, T. F. Islam, R. J. Linhardt, Organic Letters, 5, 4839-4842, 2003. LINK


320. "Synthesis of Saponins Using Partially Protected Glycosyl Donors," Y. Du, G. Gu, G. Wei, Y. Hua, R. J. Linhardt, Organic Letters, 5, 3627-3630, 2003. LINK


319. "The First Total Synthesis of Calabricoside A," Y. Du, G. Wei, R. J. Linhardt, Tetrahedron Letters, 44, 6887-6890, 2003. LINK


318. "Sulfation Patterns in Heparin and Heparan Sulfate: Effects on the Proliferation of Bovine Pulmonary Artery Smooth Muscle Cells," H. G. Garg, L. Yu, C.A. Hales, T. Toida, T. Islam, R. J. Linhardt, Biochimical Biophysical Acta, 1639, 225-231, 2003. LINK


317. "Molecular Mechanism of Host Specificity in Plasmodium Falciparum Infection: Role of Circumsporozoite Protein," D. Rathore, S. C. L. Hrstka, J. B. Sacci, P. de la Vega, R.J. Linhardt, S. Kumar, T.F. McCutchan, Journal of Biological Chemistry, 278, 40905 – 40910, 2003. LINK


316. "Cellular Binding of Hepatitis C Virus Envelope Glycoprotein E2 Requires Cell Surface Heparan Sulfate," H. Barth, C. Schäfer, M.I. Adah, F. Zhang, R.J. Linhardt, H. Toyoda, A. Kinoshita-Toyoda, T. Toida, T. H. van Kuppevelt, E. Depla, F. von Weizsäcker, H.E. Blum, T.F. Baumert, Journal of Biological Chemistry, 278, 41003 – 41012, 2003. LINK


315. "Chondroitin O-Methyl Ester: An Unusual Substrate for Chondroitin AC Lyase, "F.Y. Avci, T. Toida, R. J. Linhardt, Carbohydrate Research, 338, 2101-2104, 2003. LINK


314. "Synthetic Oligosaccharides as Heparin-Mimetics Displaying Anticoagulant Properties," F. Y. Avci, N. A. Karst, R. J. Linhardt, Current Pharmaceutical Design, 9, 2323-2335, 2003. LINK


313. "CE Separation of Heparin-Delivered Oligosaccharides Under Conditions Amenable MS Detection," N.S. Gunay, R.J. Linhardt, Journal of Chromatography, 1014, 225-233, 2003. LINK


312. "Dialkyl Imidazolium Benzoates-- Room Temperature Ionic Liquids Useful in the Peracetylation and Perbenzoylation of Simple and Sulfated Saccharides," S. Murugesan, N. Karst, T. Islam, J.M. Wiencek, R.J. Linhardt, Synlett, 9, 1283-1286, 2003. LINK


311. "Chemistry, Biochemistry and Pharmaceutical Potential of Glycosaminoglycans and Related Saccharides," T. Islam, R.J. Linhardt, in Carbohydrate-Based Drug Discovery, C.H. Wong, Ed. Wiley-VCH Press, Weinheim, Germany, Chapter 15, pp. 407-439, 2003. LINK


310. "Seperation of a Complex Mixture of of Heparin-Derived Oligosaccharides Using Reveresed-Phase High Performance Liquid Chromatography," C. Thanawiroon, R.J. Linhardt, Journal of Chromatography, 114, 215-233, 2003. LINK


309. "Recent Chemical and Enzymatic Approaches to the Synthesis of Glycosaminoglycan Oligosaccharides," N.A. Karst, R.J. Linhardt, Current Medicinal Chemistry, 10, 1993-2031, 2003. LINK


308. "Structure and Bioactivity of Sulfated Polysaccharides," T. Toida, R.J. Linhardt, Trends in Glycosciences and Glycotechnology, 15, 29-46, 2003. LINK


307. "Distribution of N-Acetylneuraminic Acid and Sialylglycan in Eggs in Silky Fowl," M. Koketsu, E. Sakuragawa, R. J. Linhardt, H. Ishihara, British Journal of Poultry Science, 44, 145-148, 2003. LINK


306. "Perspective: 2003 Claude S. Hudson Award Address in Carbohydrate Chemistry. Heparin: Structure and Activity," R. J. Linhardt, Journal of Medicinal Chemistry, 46, 2551-2554, 2003. LINK


305. "Evaluation of Counter-Ions for Electrospray Ionization Mass Spectral Analysis of Highly Sulfated Carbohydrates," N.S. Gunay, K. Tadano-Aritomi, T. Toida, I. Ishizuka, R.J. Linhardt, Analytical Chemistry, 75, 3226-3231, 2003. LINK


304. "Synthesis of a C-Glycoside Analog of sTn: an HIV and Tumor Associated Antigen," B. Kuberan, S.A. Sikkandar, H. Tomiyama, R.J. Linhardt, Angewandte Chemie, Intl.ed., 42, 2073-2074, 2003. (Full Text in PDF format) LINK


303. "Suppression of Tumor Growth by a New Glycosaminoglycan Isolated from African Giant Snail Achatina fulica," Y.S. Lee, K.H. Shin, D.K. Oh, R.J. Linhardt, Y.S. Kim, European Journal of Pharmocology, 465, 191-198, 2003. LINK


302. "Synthesis of Serine-Based Neuraminic Acid C-Glycoside," Q. Wang, R.J. Linhardt, Journal of Organic Chemistry, 68, 2668-2672, 2003. LINK


301. "Chemoenzymatic Synthesis of Neuraminic Acid Containing C-Glycoside Polymers," Q. Wang, J.S. Dordick, R.J. Linhardt, Orgainic Letters, 5, 1187-1189, 2003. LINK


300. "Zinc Triflate-Benzoyl Bromide: A Versatile Reagent for the Conversion of Ether into Benzoate Protecting Groups and Ether Glycosides into Glycosyl Bromides," T. Polat, R. J. Linhardt, Carbohydrate Research, 338, 447-449, 2003. LINK


299. "Turkey Intestines as a Commercial Source of Heparin? Comparative Structural Studeis of Intestinal Avian and Mammalian Glycosaminoglycans," M. Warda, W. Mao, T. Toida, R.J. Linhardt, Comparative Biochemistry and Physiology B, 134, 189-197, 2003. LINK


298. "Heparin as a Potential Therapeutic Agent to Reverse Vascular Remodeling," H. Garg, B.T. Thompson, R.J. Linhardt, C.A. Hales, Proteoglycans and Lung Disease, H.G. Garg, P.J. Roughley, C.A. Hales (Eds.), Chapter 18, 377-398, 2003. LINK


297. "Characterization of Glycosaminoglycans by Capillary Electrophoresis," R.J. Linhardt, T. Toida, in Capillary Electrophoresis of Oligosaccharides and Complex Carbohydrates, S. Honda, P. Thibault, Eds. Humana Press, Totawa, NJ, 133-146, 2002. LINK


296. "Ultra-High Resolution Separation Comes of Age", R.J. Linhardt, T. Toida, Science, 298, 1141-1142, 2002. LINK


295. "Synthesis of Sulfosucrose Derivatives for Evaluation as Regulators of Fibroblast Growth Factor Activity," T. Polat, M. Mohammadi, R.J. Linhardt, Tetrahedron Letters, 43, 8047-8049, 2002. LINK


294. "Conductivity Detection for Molecular Mass Estimation of Per-O-Sulfonated Glycosaminoglycans Seperated by High-Performance Size Exclusion Chromatography," A. Chaidedgumjorn, A. Suzuki, H. Toyoda, T. Toida, T. Imanari and R.J. Linhardt, Journal of Chromatography A, 959, 95-102. 2002. LINK


293. "LaPSvS1 and its Anti-Angiogenic and Anti-inflammatory Effects Obtained in Various CAM-Assays," J. Bürgermeister, D.H. Paper, H. Vogl, R.J. Linhardt, G. Franz , Carbohydrate Research, 337, 1459-1466, 2002. LINK


292. "Preparation and anticoagulant activity of phosphosulfomannan PI-88", G. Yu, N.S Gunay, R.J Linhardt, T. Toida, J. Fareed, D.A. Hoppensteadt, H. Shadid, V. Ferro, C. Li, K. Fewings, M.C. Palermo, D. Podger, European Journal of Medicinal Chemistry, 37, 783-791, 2002. LINK


291. "Analysis of glycosaminoglycans and glycosaminoglycan-derived oligosaccharides by polyacrylamide gel electrophoresis", W. Mao, C. Thanawiroon, R.J. Linhardt,, in:Analytical Chemistry:Analytical Techniques to Evaluate the Structure and Function of Natural Polysaccharides, Glycosaminoglycans, N. Volgi (Ed.), Research signpost, Kerala, India, 53-78, 2002. LINK


290. "Characterization of Polysaccharide Interactions," C. Thanawiroon, W.J. Mao, R.J. Linhardt in Affinity Capillary Electrophoresis in Pharamaceuticals and Biopharmaceuticals, R. Neubert ed., Marcel Dekker, New York,, Chap. II, pp 265-3001, 2002. (full text in PDF format) LINK


289. "Identification of the Capsular Polysaccharides of Type D and F Pasteurella multocida as Unmodified Heparin and Chondroitin, Respectively. " P. L. DeAngelis, N. S. Gunay, T. Toida, W.-J. Mao, and R. J. Linhardt, Carbohydrate Research, 337, 1547-1552, 2002. LINK


288. "Characterization of Heparin Binding by a Peptide from Amyloid P Component Using Capillary Electrophoresis, Surface Plasmon Resonance, and Isothermal Titration Calorimetry," M.J. Hernaiz, L.A. LeBrun, Y. Wu, J.W. Sen, R.J. Linhardt, N.H.H. Heegaard, European Journal of Biochemistry, 269, 2860-2867. 2002. LINK


287. "Further evidence that periodate cleavage of heparin occurs primarily through the antithrombin binding site," T. Islam, M. Butler, S. A. Sikkander, T. Toida and R. J. Linhardt, Carbohydrate Research, 337, 2239-2243, 2002. LINK


286. "Patents related to Dengue Virus Infection," M. Warda, R. M. Marks. R. J. Linhardt, Expert Opinions on Therapeutic Patents, Expert Opinion, 12(8), 1127-1143, 2002. . LINK


285. "Heparin Oligosaccharide Sequence and Size Essential for Inhibition of Pulmonary Artery Smooth Muscle Cell Proliferation," H.G. Garg, N. Cindhuchao, C. A. Hales, C. Thanawiroon, I. Capila, R. J. Linhardt, Carbohydrate Research, 337, 2359-2364, 2002. LINK


284. "Structural Basis for Activation of Fibroblast Growth Factor Signaling by Sucrose Octasulfate", B.K. Yeh, A.V. Eliseenkova, A.N. Plotnikov, D. Green, J. Pinnell, T. Polat, A. Gritli-Linde, R.J. Linhardt, M. Mohammadi, Molecular and Cellular Biology, 22, 7184-7192, 2002. LINK


283. "Characterization of a Heparan Sulfate Octasaccharide that Binds to Herpes Simplex Viral Type 1 Glycoprotein D," J. Liu, Z. Shriver, R.M. Pope, S.C. Thorp, C.S. Raska, K. Yoshida, R.J. Eisenberg, G. Cohen, R.J. Linhardt, R. Sasisekharan, Journal of Biological Chemistry, 277,33456-33467. 2002. LINK


282. "Synthesis and Application of Carbohydrate-Containing Polymers," Q. Wang, J. S. Dordick, R. J. Linhardt, Chemistry of Materials, 14, 3232-3244, 2002. LINK


281. "A Highly Stable Covalent Conjugated Heparin Biochip for Heparin-Protein Interactions Studies," F. Zhang, M. Fath, R. Marks, R.J. Linhardt, Analytical Biochemistry, 304, 271-273, 2002. LINK


280. "Inhibition of Apolipoprotein E- Related Neurotoxicity by Glycosaminoglycans and their Oligosaccharides," H.G. Bazin, M.A. Marques, A.P. Owens, R.J. Linhardt, K.A. Krutcher, Biochemistry, 41, 8203-8211, 2002. LINK


279. "Role of Arginine 292 in the Catalytic Activity of Chondroitin AC Lyase from Flavobacterium heparinum," I. Capila, Y. Wu, D.W. Rethwisch, A. Matte, M. Cygler, R.J. Linhardt, Biochimica et Biophysica Acta, 1597, 260-270, 2002. LINK


278. "Enzyme Kinetics and Glycan Structural Characterization of Secreted Alkaline Phosphatase Prepared Using the Baculovirus Expression Vector System," F. Zhang, D.W. Murhammer, R.J. Linhardt, Applied Biochemistry and Biotechnology, 101, 197-210, 2002. LINK


277. "Tissue Distribution [14 C] Sucrose Octasulfate Following Oral Administration to Rats," L.M. Hiebert, S.M. Wice, T. Ping, R.E. Hileman, T. Polat, R.J. Linhardt, Pharmaceutical Research, 19, 838-844, 2002. LINK


276. "Molecular and biochemical profiling of a heparin-derived oligosaccharide, C3" Q. Ma, B. Dudas, A. Daud, O. Iqbal, D. Hoppensteadt, W. Jeske, U. Cornelli, J. Lee, S. Lorens, R. Mervis, I. Hanin, I. Capila, R. Linhardt, J. Fareed, Thrombosis Research, 105, 303-309, 2002. LINK


275. "Human Single Chain Antibodies Against Heparin: Selection, Characterization and Effect on Coagulation, " E.M.A. van de Westerlo, T.F.C.M. Smetsers, M.A.B.A. Dennissen, R.J. Linhardt, J.H. Veerkamp, G.N.P. van Muijen, T.H. van Kuppevelt, Blood, 99, 2427-2433, 2002. LINK


274. "Enhancement of Paracellular Transport of Heparin Disaccharide Across Caco-2 Cell Monolayers, " S. Y. Cho, J. S. Kim, H. Li, C. Shim, R. J. Linhardt, Y. S. Kim, Archives Pharmacal Research, 25, 86-92 2002. LINK


273. "Structural Studies on k-Carrageenan Derived Oligosaccharides," G. Yu, H. Guan, A.S. Ioanoviciu, S.A. Sikkander, C. Thanawiroon, J. K.Tobacman, T. Toida, R. J. Linhardt. Carbohydrate Research, 337, 433-440, 2002. LINK


272. "Determination of the Composition of the Oligosaccharide Phosphate Fraction of Pichia holstii NRRL Y-2448 Phosphomannan by Capillary Electrophoresis and HPLC," V. Ferro, C. Li, K. Fewings, M.C. Palermo, D. Podger, R.J. Linhardt, T. Toida, Carbohydrate Research, 337, 139-146, 2002. LINK


271. "Capillary Electrophoresis for the Analysis of Glycosaminoglycans and Glycosaminoglycan-Derived Oligosaccharides," W.J. Mao, C. Thanawiroon, R.J. Linhardt, Biomedical Chromatography, 16, 77-94, 2002. LINK


270. "Pretreatment Procedure for the Microdetermination of Chondroitin Sulfate in Plasma and Urine," S. Sakai, J. Onose, H. Nakamura, H. Toyoda, T. Toida, Toshio Imanari, R. J. Linhardt, Analytical Biochemistry, 302, 169-174, 2002. LINK


269. "Purification and Characterization of Heparan Sulfate Peptidoglycans from Bovine Liver," M.J. Hernáiz, H.O. Yang, N.S. Gunay, R.J. Linhardt, Carbohydrate Polymers, 48, 153-160, 2002. LINK


268. "Preparation of Bovine Lung Heparin Oligosaccharides," G. Yu, Q. Wang , G. Huashi, X. Jiamin, R. J. Linhardt, Journal of the Ocean University of Qingdao, 32, 231-235, 2002. LINK


267. "Heparin-Protein Interactions," I. Capila, R.J. Linhardt, Angewandte Chemie Int. Ed., 41, 390-412, 2002; Angewandte Chemie, 114, 426-450, 2002. (Full text in PDF format English) (Full text in PDF format German) LINK


266. "The Effect of Dissolved Oxygen (DO) Concentration on the Glycosylation of Recombinant Protein Produced by the Insect Cell-Baculovirus System," F. Zhang, M.A. Saarinen, L.J. Itle, S.C. Lang, D.W. Murhammer, R.J. Linhardt, Biotechnology & Bioengineering, 77, 219-224, 2002. LINK


265. "Esterase Mediated Regioselective Deacetylation of Ulosonic Acids," B. Kuberan, Q. Wang, M. Koketsu, R.J. Linhardt, Synthetic Communications, 32, 1421-1426, 2002. LINK


264. "Separation and Purification of Carbohydrates," H.G. Bazin, R.J. Linhardt, in Glycoscience: Chemistry and Chemical Biology, B. Fraser-Reid, K. Tatsuta, J. Thiem, eds., Springer-Verlag, Heidelberg, Chapter 1.3, pp 64-74, 2001. LINK


263. "Properties of Carbohydrates," H.G. Bazin, R.J. Linhardt, in Glycoscience: Chemistry and Chemical Biology, B. Fraser-Reid, K. Tatsuta, J. Thiem, eds., Springer-Verlag, Heidelberg, Chapter 1.2, pp 53-61, 2001. LINK


262. "Synthesis and Applications of Sucrose-Based Esters," T. Polat, R. J. Linhardt, Journal of Surfactants and Detergents, 4, 415-421, 2001. LINK


261. "Localization and Characterization of Acharan Sulfate in the Body of the Giant African Snail Achatina fulica", J. Jeong, T. Toida, I. Kosiishi, T. Imanari, R.J. Linhardt, S.J. Wu, Y.S. Kim, Comparative Biochemistry and Physiology (Part B), 130, 513-519, 2001. LINK


260. "Hydrolysis of Heparinase I to Synthetic Heparin-Pentasaccharide and Effect on its Anti-Factor Xa Activity," G. Yu, G. Huashi, R. J. Linhardt, J. Farred, Journal of the Ocean University of Qingdao, 31, 529-535, 2001. LINK


259. "Structural Basis for interaction of FGF-1, FGF-2 and FGF-7 with different heparan sulfate motifs", S. Ye, Y. Luo, W. Lu, R.B. Jones, K.A. Mohamedali, R.J. Linhardt, I. Capila, T. Toida, M. Kan, H. Pelletier, W.L. McKeehan, Biochemistry, 40, 14429-14439, 2001. LINK


258. "Preparation and Structure-Activity Differences of Low Molecular Weight Heparins (LMWH)," G. Yu, G. Huashi, X. Jiamin, Q. Wang, R.J. Linhardt, Journal of Ocean University of Qingdao, 31, 673-680, 2001. LINK


257. "New Insights into the Heparan Sulfate Proteoglycan binding Activity of Apolipoprotein E4," C. Peters-Libeu, S. Lund-Katz, M. Phillips, S. Wehrli, M. J. Hernaiz, I. Capila, R.J. Linhardt, R. Raffai, Y. M. Newhouse, M., F. Zhou, K. H. Weisgraber, Journal of Biological Chemistry, 276, 39138-39142, 2001. LINK


256. "Order out of complexity; protein structures that interact with heparin," B. Mulloy, R.J. Linhardt, Current Opinions in Structural Biology, 11, 623-628, 2001. LINK


255. "Anticoagulant and antiprotease profiles of a novel natural heparinomimetic mannopentaose phosphate sulfate (PI-88)," M. Demir, O. Iqbal, D.A. Hoppensteadt, P. Piccolo, S. Ahmad, C.L. Schultz, R.J. Linhardt, J. Fareed, Clinical Applications in Thrombosis and Hemostasis, 7, 131-140, 2001. LINK


254. "Direct Measurement of the Interaction of Glycosaminoglycans and a Heparin Decasaccharide with Malaria Circumsporozoite Protein," D. Rathore, T. F. McCutchan, M. J. Hernaiz, L.A. LeBrun, S.C. Lang, R.J. Linhardt, Biochemistry, 40, 11518-11524, 2001. LINK


253. "Certain High Molecular Weight Heparin Chains Have Affinity for Vitronectin," R.E. Edens, L.A. LeBrun, J.M. Weiler, R.J. Linhardt, P.R. Kaul, Archives in Biochemistry and Biophysics, 391, 278-285, 2001. LINK


252. "Isolation and Preparation of Dermatan Sulfate Oligosaccharides" G.Yu, G. Huashi, R. J. Linhardt, Q. Wang, H.-O. Yang, T. Toida, Journal of the Ocean University of Qingdao, 31, 849-854, 2001. LINK


251. "Expression of C1 Esterase Inhibitor by the Baculovirus Expression System: Preparation, Purification and Characterization," M.W. Wolff, F. Zhang, J.J. Roberg, E.E.O. Caldwell, P.R. Kaul, J.N. Serrahn, D.W. Murhammer, R.J. Linhardt, J.M. Weiler, Protein Expression and Purification, 22 414-421, 2001. LINK


250. "Enzymatic Preparation of Heparin Dissacharides as Building Blocks in Glycosaminoglycan Synthesis," Y.S. Kim, C. Thanawiroon, H.G. Bazin, R.J. Kerns, R.J. Linhardt, Preparative Biochemistry and Biotechnology, 31, 113-124, 2001. LINK


249. "Affinity Purification of Secreted Alkaline Phosphatase Produced by the Baculovirus Expression Vector System," F. Zhang, M.W. Wolff, D. Williams, K. Busch, S.C. Lang, D.W. Murhammer, R.J. Linhardt, Applied Biochemistry and Biotechnology, 90, 125-136, 2001. LINK


248. "Degradation of Chondroitin Sulfate and Dermatan Sulfate with Chondroitin Lyases," M.J. Hernáiz, R.J. Linhardt, in Methods in Molecular Biology, Proteoglycan Protocols: Current Methods and Applications, Vol. 171, R.V. Iozzo, ed., Humana Press, Totowa, NJ, Chap. 36, pp 363-371, 2001. LINK


247. "Degradation of Heparan Sulfate with Heparin Lyases," L.A. LeBrun, R.J. Linhardt, in Methods in Molecular Biology, Proteoglycan Protocols: Current Methods and Applications, Vol. 171, R.V. Iozzo, ed., Humana Press, Totowa, NJ, Chap. 35, pp 353-361, 2001. LINK


246. "Annexin V-Heparin Oligosaccharide Complex Suggests Heparan Sulfate-Mediated Assembly on Cell Surfaces," I. Capila, M.J. Hernaiz, Y.D. Mo, T.R. Mealy, B. Campos, R.J. Linhardt B.A. Seaton, Structure, 9, 57-64, 2001. LINK


245. "X-ray Diffraction and High-Resolution NMR Spectroscopic Analysis of 2,4,7,8-tetra-O-acetyl-3-deoxy-a-D-manno-2-octulopyranosidonon-1,5-lactone," M. Koketsu, R.J. Linhardt, Carbohydrate Research, 330, 145 - 147, 2001. LINK


244. "Interaction of the N-Terminal Domain of Apolipoprotein E4 with Heparin," J. Dong, C.A. Peters-Libeu, K.H. Weisgraber, B.W. Segelke, B. Rupp, I. Capila, M.J. Hernaiz, L.A. LeBrun, R.J. Linhardt, Biochemistry, 40, 2826-2834, 2001. LINK


243. "Active Site of Chondroitin AC Lyase Revealed by the Structure of Enzyme-Oligosaccharide Complexes and Mutagenesis," W. Huang, L. Boju, L. Tkalec, H. Su, H.O. Yang, N.S. Gunay, R.J. Linhardt, Y.S. Kim, A. Matte, M. Cygler, Biochemistry, 40, 2359-2372, 2001. LINK


242. "Probing the Interaction of Dengue Virus Envelope Protein with Heparin: Assessment of Glycosaminoglycan-Derived Inhibitors," R.M. Marks, H. Lu, R. Sundaresan, T. Toida, A. Suzuki, T. Imanari, M.J. Hernaiz, R. J. Linhardt, Journal of Medicinal Chemistry, 44, 2178-2187, 2001. LINK


241. "Chemoenzymatic Synthesis of Dermatan Sulfate Oligosaccharides as Arylsulfatase B and a-L-Iduronidase Inhibitors," F. Dasgupta, R.I. Masada, C.M. Starr, B. Kuberan, H.-O. Yang, R.J. Linhardt, Glycoconjugate Journal, 17, 827-832, 2000. LINK


240. "Heparinase I Acts on a Synthetic Heparin Pentasaccharide Corresponding to the Antithrombin III Binding Site," G. Yu, L. LeBrun, N.S. Gunay, D. Hoppensteadt, J. Walenga, J. Fareed, R.J. Linhardt, Thrombosis Research, 100, 549-556, 2000. LINK


239. "Crystal Structure of a Ternary FGF-FGFR-Heparin Complex Reveals a Dual Role for Heparin in FGFR Binding and Dimerization," J. Schlessinger, A.N. Plotnikov, O.A. Ibrahimi, A.V. Eliseenkova, B.K. Yeh, A. Yayon, R.J. Linhardt, M. Mohammadi, Molecular Cell, 6, 743-750, 2000. LINK


238. "Steroeselective Synthesis of the a-Glycoside of a KDO "C"-Disaccharides," M. Koketsu, B. Kuberan, R.J. Linhardt, Organic Letters, 2, 3361-3363, 2000. LINK


237. "Cleavage of the Antithrombin III Binding Site in Heparin by Heparinase and Its Implications in the Generation of Low Molecular Weight Heparin," Z. Shriver, M. Sundaram, G. Venkataraman, J. Fareed, R. Linhardt, K. Biemann, R. Sasisekharan, Proceedings of the National Academy of Sciences (USA), 97, 10365-10370, 2000. LINK


236. "Sequencing of 3-O-Sulfate Containing Heparin Decasaccharides with a Partial Antithrombin III Binding Site," Z. Shriver, R. Raman, G. Venkataraman, K. Drummond, J. Turnbull, T. Toida, R. Linhardt, K. Biemann, R. Sasisekharan, Proceedings of the National Academy of Sciences (USA), 97, 10359-10364, 2000. LINK


235. "Enzymatic Modification of Heparan Sulfate on a Biochip Promotes Its Interaction with Antithrombin III," M. Hernaiz, J. Liu, R.D. Rosenberg, R.J. Linhardt, Biochemical Biophysical Research Communications, 276, 292-297, 2000. LINK


234. "Preparation and Structural Determination of Dermatan Sulfate-Derived Oligosaccharides," H.O. Yang, N.S. Gunay, T. Toida, B. Kuberan, G. Yu, Y.S. Kim, R.J. Linhardt, Glycobiology, 10, 1033-1040, 2000. LINK


233. "Separation of a-Acid Glycoprotein Glycoforms Using Affinity-Based Reversed Micellar Extraction and Separation," J.-H. Choe, F. Zhang, M.W. Wolff, D.W. Murhammer, R.J. Linhardt, J.S. Dordick, Biotechnology and Bioengineering, 70, 484-490, 2000. LINK


232. "Electrophoresis for the Analysis of Acidic Oligosaccharides," M. Koketsu, R.J. Linhardt, Analytical Biochemistry, 283, 136-145, 2000. LINK


231. "Electrophoretic Analysis of Glycoprotein Glycans Produced by Lepidoteran Insect Cells Infected with an Immediate Early Recombinant Baculovirus Encoding Mammalian b1,4- Galactosyltransferase," M.W. Wolff, D. W. Murhammer, D.L. Jarvis, R.J. Linhardt, Glycoconjugate Journal, 16, 753-756, 2000. LINK


230. "Purification and Characterization of a Novel Heparinase from Bacteroides stercoris HJ-15, " B.-T. Kim, W.-S. Kim, Y.S. Kim, R.J. Linhardt, D.-H. Kim, Journal of Biochemistry (Tokyo), 128, 323-328, 2000. LINK


229. "Carbohydrate Based Vaccines," B. Kuberan, R.J. Linhardt, Current Organic Chemistry, 4, 653-677, 2000. LINK


228. "Inhibition of Neuraminidase with Neuraminic Acid C-Glycosides," Q. Wang, M. Wolff, T. Polat, R.J. Linhardt, Bioorganic & Medicinal Chemistry Letters, 10, 941-944, 2000. LINK


227. "Heparin-Binding Growth-Associated Molecule Contains Two Heparin Binding b-Sheet Domains That Are Homologous to the Thrombospondin Type I Repeat" I. Kilpeläinen, M. Kaksonen, T. Kinnunen, H. Avikainen, R.J. Linhardt, M. Fath, E. Raulo, H. Rauvala, Journal of Biological Chemistry, 275, 13564-13570, 2000. LINK


226. "Tissue Distribution and Antithrombotic Activity of Unlabeled or 14C-Labelled Porcine Intestinal Mucosal Heparin Following Administration to Rats by the Oral Route, " L.M. Hiebert, S.M. Wice, T. Ping, R.E. Hileman, I. Capila, R.J. Linhardt, Canadian Journal of Physiology and Pharmacology, 78, 307-320, 2000. LINK


225. "Conformational Behavoir of C-Glycosyl Analogues of Sialyl a-(2,3) Galactose," A. Poveda, J.L. Asensio, T. Polat, H. Bazin, R. J. Linhardt, J. Jiminez-Barbero, European Journal of Organic Chemistry, 1805-1813, 2000. LINK






224. "Analysis of fluorescently labeled oligosaccharides by capillary electrophoresis and electrospray ionization mass spectrometry. "H. G. Bazin, M.W. Wolff, R.J. Linhardt, Biotechnology Techniques,13,797-801, 1999. LINK


223. "Crystal Structure of Chondroitinase B from Flavobacterium heparinumand its Complex with a Disaccharide Product at 1.7 ÅResolution," W. Huang, A. Matte, Y. Li, Y.S. Kim, R.J. Linhardt, H. Su,M. Cygler, Journal of Molecular Biology, 294, 1257-1269, 1999. LINK


222. "Effect of Fully Sulfated Glycosaminoglycans on Pulmonary ArterySmooth Muscle Cell Proliferation," H. G. Garg, P.A.M. Joseph, T. Thompson,C.A. Hales, T. Toida, T. Imanari, I. Capila, R.J. Linhardt, Archivesin Biochemistry and Biophysics, 371, 228-233, 1999. LINK


221. "Affinity Chromatography Using Enzymatically Synthesized Nucleotide-ContainingDNA Binding Polymers," Q. Wang, R.J. Linhardt, J.S. Dordick BiotechnologyTechniques, 13, 463-467, 1999. LINK


220. "Purification and Characterization of Heparan Sulphate Proteoglycanfrom Bovine Brain, " Y. Park, G. Yu, N.S. Gunay, RJ. Linhardt, BiochemicalJournal 344, 723-730, 1999. LINK


219. "Heparin Dodecasaccharide Binding to Platelet Factor-4 and Growth-RelatedProtein-a: Transition through a Partially FoldedState and Implications for Heparin Induced Thrombocytopenia," D. Mikhailov,H. C. Young, R.J. Linhardt, K. H. Mayo, Journal of Biological Chemistry274,25317-25329, 1999. LINK


218. "A New Sulfated b-Galactan From Clamwith Anti-HIV Activity," C. Amornrut, T. Toida, T. Imanari, E.R. Woo, H.Park, S.J. Wu, R.J. Linhardt, Y.S. Kim, Carbohydrate Research, 321,121-127, 1999. LINK


217. "Production and Chemical Processing of Low Molecular Weight Heparins,"N. S. Gunay, R.J. Linhardt, Seminars in Thrombosis and Hemostasis,25,5-16, 1999. LINK


216. "Preparation and Isolation of Neoglycoconjugates Using Biotin-StreptavidinComplexes," B. Kuberan, N.S. Gunay, J.S. Dordick, R.J. Linhardt, GlycoconjugateJournal, 16, 271-281, 1999. LINK


215. "Synthesis of a Versatile Neuraminic Acid C-Disaccharideas Precursor for the Synthesis of C-Glycoside Analogs of Gangliosides"H.G. Bazin, Y. Du, T. Polat, R.J. Linhardt, Journal of Organic Chemistry,64,7254-7259, 1999. LINK


214. "Preparation and Anticoagulant Activity of Fully O-SulfonatedGlycosaminoglycans," T. Toida, T. Maruyama, Y. Ogita, A. Suzuki, H. Toyoda,T. Imanari, R.J. Linhardt, International Journal of Biological Macromolecules,26,233-241, 1999. LINK


213. "Interaction of Soluble and Surface-Bound Heparin Binding Growth-AssociatedMolecule with Heparin" M. Fath, V. VanderNoot, I. Kilpeläinen, T.Kinnunen, H. Rauvala, R.J. Linhardt, FEBS Letters, 454, 105-108, 1999. LINK


212. "Interaction of Heparin with Annexin V," I. Capila, V. A. VanderNoot,T. R. Mealy, B. A. Seaton, RJ. Linhardt, FEBS Letters, 446,327-330, 1999. LINK


211. "Release and Preparation of Intact and Unreduced N-linkedOligosaccharides from Sf-9 Insect Cells," M. W. Wolff, D. W. Murhammer,R.J. Linhardt, Preparative Biochemistry and Biotechnology, 29,1-21, 1999. LINK


210. "Regiospecific Synthesis of New Methyl Sufoglucopyranoside-BasedSurfactants: Nucleophilic Displacement of a Cyclic Sulfate," H. G. Bazin,R.J. Linhardt, Synthesis, 4, 621-624, 1999. LINK


209. "Heparinoids: Structure, Biological Activities and TherapeuticApplications," N. S. Gunay, R.J. Linhardt, Planta Medica, 65,301-306, 1999. LINK


208. "A Novel Fabrication of Poly (e-caprolactone)Microspheres from Blends of Poly (e-caprolactone)and Poly (ethylene glycol) s," W.J. Lin, D.R. Flanagan, R.J. Linhardt,Polymer40,1731-1735, 1999. LINK


207. "Heparin Binding and Augmentation of C1 Inhibitor Activity," E.E.O.Caldwell, A.M. Andreason, M.A. Blietz, J. N. Serrahn, V. VanderNoot, R.J.Linhardt, J.M. Weiler, Archives in Biochemistry and Biophysics,361,215-222, 1999. LINK


206. "Regio- and Stereoselective Synthesis of b-D-Gluco-, a -L-Ido-and a -L-Altro pyranosiduronicAcids from D 4-Uronates," H. G. Bazin,M.W. Wolff, R.J. Linhardt, Journal of Organic Chemistry, 64,144-152, 1999. LINK


205. "A General Method for the Stereospecific Synthesis of C-glycosidesof Ulosonic Acids by Samarium-Mediated Reductive Dechlorination," T. Polat,Y. Du, R.J. Linhardt, Synlett, 11, 1195-1196, 1998. LINK


204. "Diversity Does Make a Difference: Fibroblast Growth Factor - HeparinInteractions," S. Faham, R.J. Linhardt, D.C. Rees, Current Opinionsin Structural Biology, 8, 578-586 1998. LINK


203. "Resolution of Structurally Similar Glycoproteins by Affinity-BasedReversed Micellar Extraction and Separation," J.-H. Choe, V.A. VanderNoot,R.J. Linhardt, J.S. Dordick, AIChE Journal, 44, 2542-2548, 1998. LINK


202. "Circular Dichroism and Absolute Conformation of D4-UronateDerivatives: a Semi-empirical Rule for Inherent Chirala-Alkoxy Acrylates," I.R. Vlahov, H. G. Bazin, R.J. Linhardt, ChemicalCommunication, 1819-1820, 1998. LINK


201. "Thermodynamic Analysis of Heparin Interaction with a Basic CyclicProtein Using Isothermal Titration Calorimetry," R.E. Hileman, R. N. Jennings,R.J. Linhardt, Biochemistry, 37, 15231-15237, 1998. LINK


200. "Chemical Oversulfation and Anticoagulant Activity of Acharan Sulfate,"S.J. Wu, M. W. Chun, K. H. Shin, T. Toida, Y. Park, R.J. Linhardt, Y.S.Kim, Thrombosis Research, 92, 273-281, 1998. LINK


199. "Capillary Affinity Chromatography and Affinity Capillary Electrophoresisof Heparin Binding Proteins," X. Wu, R.J. Linhardt, Electrophoresis,19,2650-2653, 1998. LINK


198. "Isolation and Characterization of b-Cyclodextrin Sulfates by Preparative Gradient Polyacrylamide Gel Electrophoresis,Capillary Electrophoresis and Electrospray Ionization Mass Spectrometry,"R. E. Hileman, M. M. Siegel, K. Tabei, K. Balagurunathan, R.J. Linhardt,Electrophoresis,19,2677-2681, 1998. LINK


197. "The Stereospecific Synthesis of KDN a-C-glycosides by Samarium-Mediated Reductive Desulfonylation ofGlycosyl Phenylsulfone," Y. Du, T. Polat, R.J. Linhardt, TetrahedronLetters, 39, 5007-5010, 1998. LINK


196. "Tetrahedron Report Number 462 - Recent Advances in StereoselectiveC-Glycoside Synthesis," Y. Du, R.J. Linhardt, I.R. Vlahov, Tetrahedron,54,9913-9961, 1998. LINK


195. "Conformational Study of D 4-UronateMonosaccharide and Glycosaminoglycan-derived Disaccharide," H.G. Bazin,I. Capila, R.J. Linhardt, Carbohydrate Research, 309,135-144, 1998. LINK


194. "Synthesis of Sucrose-Based Surfactants Through RegioselectiveSulfonation of Acylsucrose and the Nucleophilic Opening of a Sucrose CyclicSulfate," H.G. Bazin, T. Polat, R.J. Linhardt, Carbohydrate Research,309,189-205, 1998. LINK


193. "Determination of the Structure of Oligosaccharides Prepared fromAcharan Sulfate," Y.S. Kim, M.Y. Ahn, S.J. Wu, D.-H. Kim, T. Toida, L.M.Teesch, Y. Park, G. Yu, J. Lin, R.J. Linhardt, Glycobiology, 8,869-877, 1998. LINK


192. "Stereospecific Synthesis of a -C-Glycosylderivatives ("a-C-Glycosides") of N-AcetylneuraminicAcid by Samarium-Mediated Reductive Desulfonylation of Glycosyl Phenylsulfone,"Y. Du, R.J. Linhardt, Carbohydrate Research, 308, 161-164, 1998. LINK


191. "Characterization of Bacteroides Species from Human Intestinethat Degrades Glycosaminoglycans, " M.Y. Ahn, K.H. Shin, D.-H. Kim, E.-A.Jung, T. Toida, R.J. Linhardt, Y.S. Kim, Canadian Journal of Microbiology,44,423-429, 1998. LINK


190. "Conformational Changes and Anticoagulant Activity of ChondroitinSulfate Following its O-Sulfonation," T. Maruyama, T. Toida, T.Imanari, G. Yu, R.J. Linhardt, Carbohydrate Research, 306,35-43, 1998. LINK


189. "Highly Swelling Hydrogels from Ordered Galactose-Based Poly (Acrylate)s,"B.D. Martin, R.J. Linhardt, J.S. Dordick, Biomaterials, 19,69-76, 1998. LINK


188. "A Sensitive Method for the Quantification of b-Glucuronidase Activity in Urine Using Capillary Electrophoresis with FluorescenceDetection," X. Wu, D. Loganathan, R.J. Linhardt, Journal of Chromatography,708,61-66, 1998. LINK


187. "Interaction of Secretory Leukocyte Protease Inhibitor with HeparinInhibits Proteases Involved in Asthma," M.A. Fath, X. Wu, R.E. Hileman,R.J. Linhardt, W.M. Abraham, M.A. Kashem, R.M. Nelson, and C.Wright, Journal of Biological Chemistry, 273, 13563-13569, 1998. LINK


186. "Differential Interactions of Heparin and Heparan Sulfate Glycosaminoglycanswith the Selectins. Implications for the Use of Unfractionated and LowMolecular Weight Heparins as Therapeutic Agents," A. Koenig, K. Norgard-Sumnicht,R.J. Linhardt, A. Varki, Journal of Clinical Investigation, 101,877-889, 1998. LINK


185. "Affinity Capillary Electrophoresis Employing Immobilized Glycosaminoglycanto Resolve Heparin-Binding Peptides," V.A. VanderNoot, R.E. Hileman, J.S.Dordick, R.J. Linhardt, Electrophoresis, 19, 437-441, 1998. LINK


184. "Glycosaminoglycan-Protein Interaction: Definition of ConsensusSites in Glycosaminoglycan Binding Proteins," R.E. Hileman, J.R. Fromm,J.M. Weiler, R.J. Linhardt, BioEssays, 20, 156-167, 1998. LINK


183. "Structural Analysis of Heparan Sulfate and Heparan Sulfate Oligosaccharides"T. Toida, R.J. Linhardt, Trends in Glycobiology and Glycotechnology,10,125-136, 1998. LINK


182. "New Strategy for the Synthesis of Differentially Protected D-GlucopyranuronicAcid Glycosyl Donors Containing a Latent C-4 Acceptor," Y. Du, I.R. Vlahov,R.J. Linhardt, Carbohydrate Letters, 3, 53-58, 1998. LINK


181. "NMR Solution Conformation of Heparin-Derived Hexasaccharide,"D. Mikhailov, R.J. Linhardt, K.H. Mayo, Biochemical Journal, 328, 51-61, 1997. LINK


180. "Detection of Glycosaminoglycans as a Copper (II) Complex in HPLC,"T. Toida, M. Shima, S. Azumaya, T. Maruyama, H. Toyoda, T. Imanari, R.J.Linhardt, Journal of Chromatography, 787, 266-270, 1997. LINK


179. "Regioselective Synthesis of L-Idopyranuronic Acid Derivatives:Intermolecular Aglycone Transfer Under Standard Glycosylation Conditions,"Y. Du, R.J. Linhardt, Journal of Carbohydrate Chemistry, 16,1327-1344, 1997. LINK


178. "Identification of a Heparin Binding Peptide on the ExtracellularDomain of the KDR VEGF Receptor," M. Dougher, L. Torley, H. Wasserstrom,L. Shridaran, P. Westdock, R.E. Hileman, J.R. Fromm, S. Lyman, R.J. Linhardt,J. Kaplan, B.I. Terman Growth Factors, 14, 257-268, 1997. LINK


177. "Enzyme Catalyzed Regioselective Synthesis of Sucrose Fatty AcidSurfactants," T. Polat, H. Bazin, R.J. Linhardt, Journal of CarbohydrateChemistry, 16, 1319-1325, 1997. LINK


176. "Interaction of Fibroblast Growth Factor-1 and Related Peptideswith Heparan Sulfate and Its Oligosaccharides," J. R. Fromm, R. E. Hileman,J. M. Weiler, R.J. Linhardt, Archives in Biochemistry and Biophysics,346,252-262, 1997. LINK


175. "Heparin-Dependent Fibroblast Growth Factor Activities: Effectsof Defined Heparin Oligosaccharides ," F.-Y. Zhou, M. Kan, R.T. Owens,W.L. McKeehan, J.A. Thompson, R.J. Linhardt, M. Höök , EuropeanJournal of Cell Biology, 73, 71-80, 1997. LINK


174. "Chemical Microdetermination of Heparin in Plasma " T. Toida, Y.Huang, T. Maruyama, H. Toyoda, T. Imanari, R.J. Linhardt, AnalyticalBiochemistry, 251, 219-226, 1997. LINK


173. "Glycosaminoglycans Can Influence Fibroblast Growth Factor-2 MitogenicityWithout Significant Growth Factor Binding, " H.M. Wang, T. Toida, Y.S.Kim, I Capila, R.E. Hileman, M. Bernfield, R.J. Linhardt, BiochemicalBiophysical Research Communications, 235, 369-373, 1997. Erratum242, 248, 1997. LINK


172. "Polysulfated Carbohydrates Analyzed as Ion-Paired Complexes withBasic Peptides and Proteins Using Electrospray Negative Ionization MassSpectrometry," Marshall M. Siegel, Kieko Tabei, M. Z. Kagan, I. R. Vlahov,R. E. Hileman, R.J. Linhardt, Journal of Mass Spectrometry, 32,760-772, 1997. LINK


171. "Parameters Affecting the Efficiency of Affinity-Based ReversedMicellar Extraction and Separation ," J.-H. Choe, V. A. VanderNoot R.J.Linhardt, J. S. Dordick, Biotechnology Progress, 13, 440-445, 1997. LINK


170. "Directional Immobilization of Heparin onto the Non-Porous Surfaceof Microtiter Plates," V. D. Nadkarni, R.J. Linhardt, BioTechniques,23,382-385, 1997. LINK


169. "Dengue Virus Infectivity Depends on Envelope Protein Binding toTarget Cell Heparan Sulfate," Y. Chen, T. Maguire, R. E. Hileman, J. R.Fromm, J. D. Esko, R.J. Linhardt, R. M. Marks, Nature Medicine,3,866-871, 1997. LINK


168. "Pattern and Spacing of Basic Amino Acids in Heparin Binding Sites,"J. R. Fromm, R. E. Hileman, E. E. O. Caldwell, J. M. Weiler, R.J. Linhardt,Archivesof Biochemistry and Biophysics, 343, 92-100, 1997. LINK


167. "Heparin Analogs-Development and Applications, " R.J. Linhardt,T. Toida, in Carbohydrates as Drugs, Z.B. Witczak, K.A. Nieforth,eds., Marcel Dekker, NY, Chapter 7, pp. 277-341, 1997. (Fulltext in PDF format Part A) (PartB) LINK


166. "Regioselective Synthesis of Sucrose Monoesters as Surfactants,"I. R. Vlahov, P. I. Vlahova, R.J. Linhardt, Journal of CarbohydrateChemistry, 16, 1-10, 1997. LINK


165. "Exploration of the Action Pattern of Streptomyces HyaluronateLyase Using High Resolution Capillary Electrophoresis," Y. Park, S. Cho,R.J. Linhardt, Biochimica et Biophysica Acta, 1337, 217-226,1997. LINK


164. "Regio and Stereoselective Synthesis of Derivatives of L-IdopyranuronicAcid and D-Glucopyranuronic Acid from D4-Uronates," H. G. Bazin, R.J. Kerns,R.J. Linhardt, Tetrahedron Letters, 38, 923-926, 1997. LINK


163. "Structural Differences and the Presence of Unsubstituted AminoGroups in Heparan Sulphates from Different Tissues and Species," T. Toida,H. Yoshida, H. Toyoda, I. Koshiishi, T. Imanari, R. E. Hileman, J. R. Fromm,R.J. Linhardt, Biochemical Journal, 322, 499-506, 1997. LINK


162. "Diastereocontrolled Synthesis of Carbon Glycosides of N-AcetylneuraminicAcid via Glycosyl Samarium(III) Intermediates," I. R. Vlahov, P. I. Vlahov,R.J. Linhardt, Journal of the American Chemical Society, 119,1480-1481, 1997. LINK


161. "Preparation and Structure of Heparin Lyase-Derived Heparan SulphateOligosaccharides," R. E. Hileman, T. Toida, A. E. Smith, R.J. Linhardt,Glycobiology,7,231-239, 1997. LINK


160. "Analysis of the Structure of Heparin and Heparan Sulfate by HighResolution Separation of Oligosaccharides, " R.J. Linhardt, T. Toida, A.E. Smith, R. E. Hileman, in A Laboratory Guide to Glycoconjugate Analysis,J. T. Gallagher, P. Jackson, eds., Birkhauser Verlag AG, Basel, 1997, Chapter10,pp 183-197. LINK


159. "An Unusual Ring Contraction of Silyl Glucopyranosides to Silyl Glucofuranosides," Y. G. Du, I. R. Vlahov, R.J. Linhardt, Carbohydrate Letters, 2,165-168, 1996. LINK


158. "Structure-Function Relationships in the Heparin Binding C-terminal Region of Insulin-Like Growth Factor Binding Protein-3," B.A. Booth, M. Boes, B.L. Dake, R.J. Linhardt, E. Caldwell, J. Weiler, R. S. Bar, Growth Regulation, 6, 206-213, 1996. LINK


157. "Enzymatic Preparation of Heparin Oligosaccharides Containing Antithrombin III Binding Sites," T. E. Toida, R. E. Hileman, A. E. Smith, P. I. Vlahova, R.J. Linhardt, Journal of Biological Chemistry, 271, 32040-32047, 1996. LINK


156. "Preparation and Biological Activity of N-Sulfated Chondroitin and Dermatan Sulfate Derivatives," V. D. Nadkarni, T. Toida, C.L. VanGorp, R.L. Schubert, J.M. Weiler, K.P. Hansen, E. E. O. Caldwell, R.J. Linhardt, Carbohydrate Research, 290, 87-96, 1996. LINK


155. "Heparin and Heparin Oligosaccharides: Preparation, Analysis, Applications and Biological Activities," R.J. Linhardt, R.J. Kerns, I. R. Vlahov, Biochemical Functions and Biotechnology of Natural and Artificial Polymers, M. Yalpani, ed., ATL Press, Science Publishers, Mt. Prospect, IL, 1996, pp 46-62. LINK


154. "NMR Solution Conformation of Heparin-Derived Tetrasaccharide," D. Mikhailov, K. Mayo, I. R. Vlahov, T.T. Toida, R.J. Linhardt, Biochemical Journal, 318, 93-102, 1996. LINK


153. "A New Glycosaminoglycan from the Giant African Snail Achatina fulica," Y.S. Kim, Y.T. Jo, I.M. Chang, T. E. Toida, Y. Park, R.J. Linhardt, Journal of Biological Chemistry, 271, 11750-11755, 1996. LINK


152. "Synthesis of the Bis-Tetrahydropyrano[2,3-b:2’,3’-e] Piperazine Ring System: A New Tricyclic Heterocycle from D-Glucosamine," R.J. Kerns, T. E. Toida, R.J. Linhardt, Journal of Carbohydrate Chemistry, 15, 581-590, 1996. LINK


151. "Selective N-Sulfation of Glucosamine Derivatives Using Phenyl Chlorosulfate in Non-Aqueous Solvent," R.J. Kerns, R.J. Linhardt, Synthetic Communications, 26, 2671-2680, 1996. LINK


150. "C-2 Epimerization of N-Acetylglucosamine in an Oligosaccharides Derived from Heparan Sulfate," T. E. Toida, I. R. Vlahov, A. E. Smith, R. E. Hileman, R.J. Linhardt, Journal of Carbohydrate Chemistry, 15, 351-360, 1996. LINK


149. "Crystallographic Analyses of Heparin Oligosaccharides Binding to Basic Fibroblast Growth Factor," S. Faham, R. E. Hileman, J. R. Fromm, R.J. Linhardt, D. C. Rees, Science, 271, 1116-1120, 1996. LINK


148. "Detection of Glycosaminoglycans as a Copper (II) Complex in Capillary Electrophoresis," T. E. Toida, R.J. Linhardt, Electrophoresis, 17, 341-346, 1996. LINK


147. "13C-NMR Relaxation Study of Heparin Disaccharide with Tripeptides GRG and GKG," D. Mikhailov, K. Mayo, R.J. Linhardt, A. Pervin Biochemical Journal, 315, 447-454, 1996. LINK


146. "Accelerated Heparin Stability Studies," K. Jandik, D. Kruep, M. Cartier, R.J. Linhardt, Journal of Pharmaceutical Science, 85, 45-51, 1996. LINK


145. "Importance of Basic Amino Acids in Heparin and Heparan Sulfate Protein Binding Sites," E. E. O. Caldwell, V. D. Nadkarni, J. R. Fromm, R.J. Linhardt, J. M. Weiler International Journal of Biochemistry and Cell Biology, 28, 203-216, 1996. LINK


144. "Separation of Acidic Carbohydrates by Capillary Electrophoresis," R.J. Linhardt, A. Pervin, Journal of Chromatography A, 720, 323-335, 1996. LINK


143. "Enzymatic and Chemoenzymatic Approaches to Synthesis of Sugar-Based Polymer and Hydrogels ," X. Chen, B. D. Martin, T. K. Neubauer, R. J. Linhardt, J. S. Dordick, D. G. Rethwisch, Carbohydrate Polymers, 28, 15-21, 1995. LINK


142. "Regioselective Synthesis of Derivatives of L-Idopyranuronic Acid: A Key Constituent of Glycosaminoglycans," I. R. Vlahov, R. J. Linhardt, Tetrahedron Letters, 36, 8379-8382, 1995. LINK


141. "Differences in the Interaction of Heparin with Arginine and Lysine and the Importance of Basic Amino Acids in the Binding of Heparin to aFGF," J. R. Fromm, R. E. Hileman, E. E. O. Caldwell, J. M. Weiler, R.J. Linhardt, Archives of Biochemistry and Biophysics, 323, 279-287, 1995. LINK


140. "Strategy for the Sequence Analysis of Heparin" J. Liu, U.R. Desai, X. Han, T. Toida, R.J. Linhardt, Glycobiology, 5, 765-774, 1995. LINK


139. "Isolation and Characterization of Heparan Sulfate from Crude Porcine Intestinal Mucosa Peptidoglycan Heparin," C. C. Griffin, R.J. Linhardt, C.L. VanGorp, T. Toida, R.E. Hileman, R.L. Schubert, S.E. Brown, Carbohydrate Research, 276, 183- 197, 1995. LINK


138. "Conformational Analysis of Sucrose Octasulfate by High Resolution Nuclear Magnetic Resonance Spectroscopy," U.R. Desai, I. R. Vlahov, A. Pervin, R. J. Linhardt, Carbohydrate Research, 275, 391-401, 1995. LINK


137. "Separation of Acidic Carbohydrates by Capillary Electrophoresis," R. J. Linhardt, A. Pervin, Journal of Chromatography A, 720, 323-335, 1995. LINK


136. "Purification, Characterization and Specificity of Chondroitin Lyases and Glucuronidase from Flavobacterium heparinum" K. Gu, R.J. Linhardt, M. Laliberte, K. Gu, J. Zimmerman, Biochemical Journal, 311, 569-577, 1995. LINK


135. "Carbohydrate-Protein Interactions in Vascular Biology," , R.M. Nelson, A. Venot, M.P. Bevilacqua, R.J. Linhardt, I. Stamenkovic, Annual Reviews in Cell and Developmental Biology, 11, 601-631, 1995. LINK


134. "Separation of Hydroxyl-Protected Heparin Derived Disaccharides using Reversed-Phase High Performance Liquid Chromatography," R. J. Kerns, R. J. Linhardt, Journal of Chromatography A, 705, 369-373, 1995. LINK


133. "Modified Assay for the Measurement of Biotin in the Presence of Heparin," V. D. Nadkarni, R. J. Linhardt, Analytical Biochemistry, 227, 402-404, 1995. LINK


132. "Two-Dimension Affinity Resolution Electrophoresis Demonstrates that Three Distinct Heparin Populations Interact with Antithrombin III" R. E. Edens, J. R. Fromm, S. J. Fromm, R.J. Linhardt, J. M. Weiler, Biochemistry, 34, 2400-2407, 1995. LINK


131. "Molecular Weight of Heparin Using 13C Nuclear Magnetic Resonance Spectroscopy," U.R. Desai, R.J. Linhardt, Journal of Pharmaceutical Science, 84, 212-215, 1995. LINK


130. "Measurement of the Antithrombin III Binding Site in Low Molecular Weight Heparins Using 13C NMR and Capillary Electrophoresis," U.R. Desai, D. Hoppensteadt, J. Fareed, R.J. Linhardt, Pharmaceutical Science, 1, 349-353, 1995. LINK


129. "Dermatan Sulfate as a Potential Therapeutic Agent," R. J. Linhardt, R. E. Hileman, General Pharmacology, 26, 443-451, 1995. LINK


128. "Lectin Affinity Electrophoresis," R. J. Linhardt, X.J. Han, J. R. Fromm, Molecular Biotechnology, 3, 191-197, 1995. LINK


127. "Capillary Electrophoresis for Monitoring Chemical Reactions: Sulfation and Synthetic Manipulation of Sulfated Carbohydrates," R. J. Kerns, I. R. Vlahov, R. J. Linhardt, Carbohydrate Research, 267, 143-152, 1995. LINK


126. "Analysis of Fluorescently Labeled Sugars by Reversed-Phase Ion-Pairing High Performance Liquid Chromatography," Y. S. Kim, J. Liu, X.J. Han, A. Pervin, R. J. Linhardt, Journal of Chromatographic Science, 33, 162-167 1995. LINK


125. "Preparation and Structural Characterization of Large Heparin-Derived Oligosaccharides," A. Pervin, C. Gallo, K. Jandik, X.-J. Han, R. J. Linhardt, Glycobiology, 5, 83-95, 1995. LINK


124. "IGFBP-3 and IGFBP-5 Association with Endothelial Cells: Role of C-terminal Heparin Binding Domain," B.A. Booth, M. Boes, D.L. Andress, B.L. Dake, M.C. Kiefer, C. Maack, R.J. Linhardt, K. Bar, E.E.O. Caldwell, J. Weiler, R.S. Bar, Growth Regulations, 5, 1-17, 1995. LINK


123. "Human Milk Glycosaminoglycans Inhibit HIV Glycoprotein GP120 Binding to Its Host Cell CD4 Receptor " D.S. Newburg, R.J. Linhardt, S.A. Ampofo, R.H. Yolken, Journal of Nutrition, 125, 419-424, 1995. LINK


122. "Directional Immobilization of Heparin to Beaded Supports," V. D. Nadkarni, A. Pervin , R. J. Linhardt, Analytical Biochemistry, 222, 59-67, 1994. LINK


121. "Separation of Glycosaminoglycan Derived Oligosaccharides by Capillary Electrophoresis Using Reverse Polarity," A. Pervin, A. Al-Hakim, R. J. Linhardt, Analytical Biochemistry, 221, 182-188, 1994. LINK


120. "Chemical and biochemical catalysis to make swellable polymers. " J. S. Dordick, R.J. Linhardt, D.G. Rethwisch, Chemtech, 24, 33-39, 1994. LINK


119. "New Approaches for the Preparation of Hydrophobic Heparin Derivatives," J. Liu, A. Pervin, C. M. Gallo, U.R. Desai, C.L. VanGorp, R.J. Linhardt, Journal of Pharmaceutical Science , 83, 1034-1039, 1994. LINK


118. "Accelerated Degradation of Poly(e-caprolactone) by Organic Amines," W.-J. Lin, D.R. Flanagan, R.J. Linhardt, Pharmaceutical Research, 11, 1030-1034, 1994. LINK


117. "Action Pattern of Polysaccharide Lyases on Glycosaminoglycans" K.A. Jandik, K. Gu, R.J. Linhardt, Glycobiology, 4, 289-296, 1994. LINK


116. "Importance of Distinct Water Environments in the Hydrolysis of Poly(D,L-lactide-co-glycolide)," E.A. Schmitt, D.R. Flanagan, R.J. Linhardt, Macromolecules, 27, 743-748, 1994. LINK


115. "Capillary Electrophoresis of Oligosaccharides" R.J. Linhardt, in Methods in Enzymology, Guide to Techniques in Glycobiology, W.J. Lennarz, G.W. Hart (eds.), Volume 230, Chapter 16, pp 265-280, Academic Press, San Diego, 1994. LINK


114. "Interaction of Heparin with Synthetic Antithrombin III Peptide Analogues," J. Bae, U.R. Desai, A. Pervin, E.O. Caldwell, J.M. Weiler, R. J. Linhardt, Biochemical Journal, 301, 121-129, 1994. LINK


113. "Low Molecular Weight Dermatan Sulfate as an Antithrombotic Agent: Structure Activity Relationship Studies" R.J. Linhardt, U.R. Desai, J. Liu, A. Pervin, D. Hoppensteadt, J. Fareed, Biochemical Pharmacology, 47, 1241-1252 (1994). LINK


112. "Molecular Weight of Low Molecular Heparins by 13C NMR Spectroscopy," U.R. Desai, R.J. Linhardt, Carbohydrate Research, 255, 193-212 (1994). LINK


111. "Analysis of Glycosaminoglycans with Polysaccharide Lyases" R. J. Linhardt, in Current Protocols in Molecular Biology, Analysis of Glycoconjugates, A. Varki (ed.), V 2, 17.13.17-17.13.32, Wiley Interscience, 1994. LINK


110. "Biodegradable Polymers for the Controlled Delivery of Vaccines," E. Schmitt, D.R. Flanagan, R.J. Linhardt, in Biotechnology and Bioactive Polymers, Plenum Publishing Company, New York, C.G. Gebelein (Ed.), pp 249-259, 1994. LINK


109. "Heparin and Derivatized Heparin Inhibit Cobra Venom Factor Activation of Complement in Serum," R.E. Edens, R.J. Linhardt, J.M. Weiler, Immunopharmacology, 27, 145-153, 1994. LINK


108. "Capillary Electrophoresis to Measure Sulfoesterase Activity on Chondroitin Sulfate and Heparin Derived Disaccharides," A. Pervin, K. Gu, R. J. Linhardt, Applied and Theoretical Electrophoresis, 3, 297-303 (1993). LINK


107. "Substrate Specificity of the Heparin Lyases from Flavobacterium heparinum," U.R. Desai, H.M. Wang, R.J. Linhardt, Archives of Biochemistry and Biophysics, 306, 461-468 (1993). LINK


106. "Specificity Studies on the Heparin Lyases from Flavobacterium heparinum," U.R. Desai, H.M. Wang, R.J. Linhardt, Biochemistry, 32, 8140-8145 (1993). LINK


105. "Oligosaccharide Compositional Analysis of Heparin and Low Molecular Weight Heparins by Capillary Electrophoresis," U.R. Desai, H.M. Wang, S.A. Ampofo, R.J. Linhardt, Analytical Biochemistry, 213, 120-127 (1993). LINK


104. "Heparin Oligosaccharides Bind P- and L-Selectin and Inhibit Acute Inflammation," R.M. Nelson, O. Cecconi, W.G. Roberts, A. Aruffo, R.J. Linhardt, M.P. Bevilacqua, Blood, 82, 3253-3258 (1993). LINK


103. "Mapping and Sequencing of Oligosaccharides by Electrophoresis" R.J. Linhardt, J. Liu, X. -J. Han, Trends in Glycoscience and Glycotechnology, 5, 181-192 (1993). LINK


102. "Comparison of the Activity of Two Chondroitin AC Lyases on Dermatan Sulfate," K. Gu, J. Liu, A. Pervin, R.J. Linhardt, Carbohydrate Research, 244, 369-377 (1993). LINK


101. "Monoclonal Antibodies Prepared Against Heparin Lyase I and their Reactivity Towards Heparin Lyases I, II and III," K. Gu., R.E. Edens, K.A. Jandik, R.J. Linhardt, International Journal of Biochemistry, 25, 331-336 (1993). LINK


100. "Heparin, Not Just an Anticoagulant Anymore: Six and One Half Decades of Studies on the Ability of Heparin to Regulate Complement Activation," R.E. Edens, J.M. Weiler, R.J. Linhardt, Complement Profiles, 1, 96-120 (1993). LINK


99. "Structure Elucidation of a Novel Acidic Tetrasaccharide and Hexasaccharide Derived From a Chemically Modified Heparin," U.R. Desai, H.M. Wang, T.R. Kelly, R.J. Linhardt, Carbohydrate Research, 241, 249-259 (1993). LINK


98. "Nature of the Interaction of Heparin with Acidic Fibroblast Growth Factor," H. Mach, D.B. Volkin, C.J. Burke, C.R. Middaugh, R.J. Linhardt, J. Fromm, D. Loganathan, L. Mattsson, Biochemistry, 32, 5480-5489 (1993). LINK


97. "Degradation and Release Properties of Poly (D,L-Lactide-co-Glycolide, 50:50) Pellets Fabricated From Three Commercial Polymers," E.A. Schmitt, D.R. Flanagan, R.J. Linhardt, Journal of Pharmaceutical Sciences, 82, 326-329 (1993). LINK


96. "Physical Stabilization of Acidic Fibroblast Growth Factor by Polyanions," D.B. Volkin, P.K. Tsai, J.M. Dabora, J.O. Gress, C.J. Burke, R.J. Linhardt, C.R. Middaugh, Archives in Biochemistry and Biophysics, 300, 30-41, (1993). LINK


95. "Biocatalytic Synthesis of Sugar-Containing Polyacrylates," B.D. Martin, S.A. Ampofo, R.J. Linhardt, J.S. Dordick, Macromolecules, 25, 7081-7085 (1992). LINK


94. "Purification and Characterization of Heparin Lyases from Flavobacterium heparinum," D.L. Lohse, R.J. Linhardt, Journal of Biological Chemistry, 267, 24347-24355, (1992). LINK


93. "Negative-Ion Fast Atom Bombardment Tandem Mass Spectrometry to Determine Sulfate and Linkage Position in Glycosaminoglycan-Derived Disaccharides," D.J. Lamb, H.M. Wang, L.M. Mallis, R.J. Linhardt, Journal of the American Society for Mass Spectrometry, 3, 797-803 (1992). LINK


92. "Heparin and Modified Heparin Inhibit C Activation In Vivo," J.M. Weiler, R.E. Edens, R.J. Linhardt, D.P. Kapelanski, Journal of Immunology, 148, 3210-3215 (1992). LINK


91. "Fundamental Studies on the Hydration, Erosion and Release Properties of Biodegradable Poly(esters)," E. Schmitt, D.R. Flanagan, R.J. Linhardt, Proceedings of the ACS Division of Polymeric Materials: Science and Engineering, 66, 95-96 (1992). LINK


90. "Biodegradable Polymers for the Controlled Delivery of Vaccines," E. Schmitt, D.R. Flanagan, R.J. Linhardt, Proceedings of the ACS Division of Polymeric Materials: Science and Engineering, 66, 493-494 (1992). LINK


89. "Lectin Affinity Electrophoresis for the Separation of Fluorescently Labeled Sugar Derivatives," K.B. Lee, Y.S. Kim, R.J. Linhardt, Analytical Biochemistry, 203, 206-210 (1992). LINK


88. "An Electrophoresis-Based Assay For Glycosyltransferase Activity," K.B. Lee, U.R. Desai, M.M. Palcic, O. Hindsgaul, R.J. Linhardt, Analytical Biochemistry, 205, 108-114 (1992). LINK


87. "New Methodologies in Heparin Structure Analysis and the Generation of Low Molecular Weight Heparins," R.J. Linhardt, H.M. Wang, S.A. Ampofo, in Heparin and Related Polysaccharides, Plenum Press, New York, D. Lane and U. Lindahl (Eds.), pp. 37-47, 1992. LINK


86. "Search for the Heparin Antithrombin III Binding Site Precursor," R.J. Linhardt, H.M. Wang, D. Loganathan, J.H. Bae, The Journal of Biological Chemistry, 267, 2380-2387 (1992). LINK


85. "Isolation and Characterization of a Human Heparin," R.J. Linhardt, S.A. Ampofo, J. Fareed, D. Hoppensteadt, J. B. Mulliken, J. Folkman, Biochemistry, 31, 12441-12445 (1992). LINK


84. "Gradient Polyacrylamide Gel Electrophoresis for Determination of the Molecular Weight of Heparin and Low Molecular Weight Heparin Derivatives," R.E. Edens, A. Al-Hakim, J.M. Weiler, D.G. Rethwisch, J. Fareed, R.J. Linhardt, Journal of Pharmaceutical Sciences, 81, 823-827 (1992). LINK


83. "Analysis of Glycosaminoglycan-Derived Oligosaccharides Using Fast Atom Bombardment Mass Spectrometry," R.J. Linhardt, H.M. Wang, D. Loganathan, D. Lamb, L.M. Mallis, Carbohydrate Research, 225, 137-145 (1992). LINK


82. "Chemical and Enzymatic Methods for the Depolymerization and Modification of Heparin," R.J. Linhardt, in Carbohydrates-Synthetic Methods and Applications in Medicinal Chemistry, Kodansha/VCH Publishers, Tokyo/Weinheim, H. Ogura, A. Hasegawa, T. Suami (Eds.), Chap. 20, pp 385-401, 1992. LINK


81. "Controlled Release of Protein and Vaccines from Poly(Ester) Microspheres In Vitro," H.T. Wang, H. Palmer, R.J. Linhardt, D.R. Flanagan, E. Schmitt, Proceedings of the ACS Symposium on Polymers Cosmetics and Pharmaceutical Applications, 239-253 (1991). LINK


80. "Controlled Release of Protein and Vaccines from Poly(Ester) Microspheres In Vitro," H.T. Wang, H. Palmer, R.J. Linhardt, D.R. Flanagan, E. Schmitt, in Cosmetic and Pharmaceutical Applications of Polymers, Plenum Publishing Company, New York, C.G. Gebelein, T.C. Cheng, V.C. Yang (Eds.), pp 239-253, 1991. LINK


79. "Detection of Chitinase Activity Using a Fluorescently Labelled Substrate on Polyacrylamide Gel," Y.S. Kim, K.B. Lee, R.J. Linhardt, Korean Biochemical Journal, 24, 466-471 (1991). LINK


78. "Disaccharide Compositional Analysis of Heparin and Heparan Sulfate Using Capillary Zone Electrophoresis," S.A. Ampofo, H.M. Wang, R.J. Linhardt, Analytical Biochemistry, 199, 249-255, (1991). LINK


77. "Capillary Zone Electrophoresis for the Quantitation of Oligosaccharides Formed Through the Action of Chitinase", K.B. Lee, Y.S. Kim, R.J. Linhardt, Electrophoresis, 12, 636-640 (1991). LINK


76. "Capillary Electrophoresis for the Analysis of Chondroitin Sulfate and Dermatan Sulfate-Derived Disaccharides," A. Al-Hakim, R.J. Linhardt, Analytical Biochemistry, 195, 68-73 (1991). LINK


75. "Structural Features of Dermatan Sulfates and their Relationship to Anticoagulant and Antithrombotic Activities," R.J. Linhardt, A. Al-Hakim, J. Liu, D. Hoppensteadt, J. Fareed, G. Mascellani, P. Bianchini, Biochemical Pharmacology, 42, 1609-1619 (1991). LINK


74. "Determination of the pKa of Glucuronic Acid and Heparin's Carboxyl Groups by 13C NMR," H.M. Wang, D. Loganathan, R.J. Linhardt, Biochemical Journal, 278, 689-695 (1991). LINK


73. "Antithrombin III Regulates Complement Activity," J.M. Weiler, R.J. Linhardt, Journal of Immunology, 146, 3889-3894 (1991). LINK


72. "Heparin: An Important Drug Enters its Seventh Decade," R.J. Linhardt, Chemistry & Industry, 2, 45-50 (1991). LINK


71. "Rhamnose from the Products of Microbial Fermentation," R.J. Linhardt,SIM Industrial Microbiology News, 41, 113-118 (1991). LINK


70. "Influence of Formulation Methods on the In Vitro Controlled Release of Protein from Poly(Ester) Microspheres," H.T. Wang, E. Schmitt, D.R. Flanagan, R.J. Linhardt, Journal of Controlled Release, 17, 23-32 (1991). LINK


69. "Acidic Polysaccharides, Their Modification and Uses," R.J. Linhardt, A. Al-Hakim, J. Liu, in Polymers from Biotechnology, Plenum Publishing Company, New York, C.G. Gebelein (Ed.) 1991, pp. 115-165. LINK


68. "A New Method for Sequencing Linear Oligosaccharides on Gels Using Charged, Fluorescent Conjugates," K.B. Lee, A. Al-Hakim, D. Loganathan, R.J. Linhardt, Carbohydrate Research, 214, 155-168 (1991). LINK


67. "Molecular Profile of Dermatan Sulfates from Different Origins," R.J. Linhardt, A. Al-Hakim, S.Y. Liu, Y.S. Kim, J. Fareed, Seminars in Thrombosis and Hemostasis, 17, 15-22 (1991). LINK


66. "Biocatalysts for the Synthesis and Modification of Biopolymers," R.J. Linhardt and A. Al-Hakim in Biocatalysts for Industry, Topics in Applied Chemistry, Plenum Publishing Company, New York, J.S. Dordick (Ed.), Chapter 5, pp. 83-112, 1991. LINK


65. "Electrophoresis and Detection of Nanogram Quantities of Exogenous and Endogenous Glycosaminoglycans in Biological Fluids," A. Al-Hakim, R.J. Linhardt, Applied and Theoretical Electrophoresis, 1, 305-312 (1991). LINK


64. "Immobilization of C3b with Retention of Functional Activity," R.E. Edens, R.J. Linhardt, J.M. Weiler, Journal of Immunological Methods, 133, 67-70 (1990). LINK


63. "Biodegradable Poly(Esters) for the Controlled Delivery of Vaccines," R.J. Linhardt, H.T. Wang, D.R. Flanagan, E. Schmitt, H. Palmer, Proceedings of the ACS Division of Polymeric Materials: Science and Engineering, 63, 39-42 (1990). LINK


62. "Structure and Metabolism of Glycosaminoglycans," R.J. Linhardt, A. Al-Hakim, S. Ampofo, D. Loganathan, in New Trends in Haemostasis: Coagulation Proteins, Endothelium, and Tissue Factors, Springer Verlag Publishers, Heidelberg, G. Schettler, L. Heene, J. Harenberg (Eds.), pp. 12-26, 1990. LINK


61. "Low Molecular Weight Heparin and Heparinoids in Cerebrovascular Disease," D.L. Gordon, R. Linhardt, H.P. Adams, Clinical Neuropharmacology, 13, 522-543 (1990). LINK


60. "Degradation of Poly(Ester) Microspheres," H.T. Wang, H. Palmer, R.J. Linhardt, D.R. Flanagan, E. Schmitt, Biomaterials, 11, 679-685 (1990). LINK


59. "Randomness in the Heparin Polymer: Computer Simulations of Alternative Action Patterns of Heparin Lyase," D.M. Cohen, R.J. Linhardt, Biopolymers, 30, 733-741 (1990). LINK


58. "Oligosaccharide Mapping of Low Molecular Weight Heparins: Structural Differences and their Relationship to Activity," R.J. Linhardt, D. Loganathan, A. Al-Hakim, H.M. Wang, J.M. Walenga, D. Hoppensteadt, J. Fareed, Journal of Medicinal Chemistry, 33, 1639-1645 (1990). LINK


57. "Biodegradable Poly(Esters) for the Delivery of Bioactive Agents," R.J. Linhardt, D.R. Flanagan, H.T. Wang, E. Schmitt, Polymer Preprints, 31, 249-250 (1990). LINK


56. "Modification and Potential Uses of Heparin and Other Acidic Polysaccharides," R.J. Linhardt, Proceedings of the ACS Division of Polymeric Materials: Science and Engineering, 62, 488-491 (1990). LINK


55. "Examination of the Substrate Specificity of Heparin and Heparan Sulfate Lyases," R.J. Linhardt, J.E. Turnbull, H.M. Wang, D. Loganathan, J.T. Gallagher, Biochemistry, 29, 2611-2617 (1990). LINK


54. "Structural Variation of the Antithrombin III Binding Site and its Occurrence in Heparin from Different Sources," D. Loganathan, H.M. Wang, L.M. Mallis, R.J. Linhardt, Biochemistry, 29, 4362-4368 (1990). LINK


53. "Isolation and Recovery of Acidic Oligosaccharides from Polyacrylamide Gels by Semi-Dry Electrotransfer," A. Al-Hakim, R.J. Linhardt, Electrophoresis, 11, 23-28 (1990). LINK


52. "Carbohydrate Analysis of Glycoproteins," K.B. Lee, D. Loganathan, Z.M. Merchant, R.J. Linhardt, Applied Biochemistry and Biotechnology, 23, 53-80 (1990). LINK


51. "Heparin, Heparinoids and Heparin Oligosaccharides: Structure and Biological Activities," R.J. Linhardt and D. Loganathan, in Biomimetic Polymers, G. Gebelein (ed.), Plenum Press, New York, pp. 135-175, (1990). LINK


50. "Structure of Therafectin, A Novel Anti-Inflammatory Agent," R.J. Linhardt, N.C. Baenziger, B. Ronsen, Journal of Pharmaceutical Science, 79, 158-162 (1990). LINK






49. "Analysis of Glycosaminoglycan-Derived Oligosaccharides Using Reversed Phase Ion-Pairing HPLC and Ion Exchange Chromatography With Suppressed Conductivity Detection," R.J. Linhardt, K.N. Gu, D. Loganathan, S.R. Carter, Analytical Biochemistry, 181, 288-296 (1989). LINK


48. "Sequence Analysis of Highly Sulfated Heparin-Derived Oligosaccharides Using Fast Atom Bombardment Mass Spectrometry," L.M. Mallis, H.M. Wang, D. Loganathan, R.J. Linhardt, Analytical Chemistry, 61, 1453-1458 (1989). LINK


47. "Comparison of the Activity of Polyanions and Polycations on the Classical and Alternative-Amplification Pathways of Complement," J.M. Weiler, R.J. Linhardt, Immunopharmacology, 17, 65-72 (1989). LINK


46. "Quantitative Analysis of the Monomer Products Formed on the Hydrolysis of Poly(Esters) and Poly(Anhydrides)," R.J. Linhardt, D.R. Flanagan, E. Schmitt, H.T. Wang, Polymer Preprints, 30, 464-465 (1989). LINK


45. "Structural Features of Heparin and Their Effect on Heparin Cofactor II Mediated Inhibition of Thrombin," Y.S. Kim and R.J. Linhardt, Thrombosis Research, 53, 55-71 (1989). LINK


44. "Non-Random Structural Features in the Heparin Polymer," R.J. Linhardt, D.M. Cohen, K.G. Rice, Biochemistry, 28, 2888-2894 (1989). LINK


43. "Biodegradable Polymers For Controlled Release of Drugs," R.J. Linhardt, in Controlled Release of Drugs: Polymers and Aggregate Systems, Verlag Chemie Critical Review Series, M. Rosoff (Ed.), Chapter 2, pp 53-95, 1989. LINK


42. "Resistance of Heparinase-Derived Heparin Fragments to Biotransformation," A.K. Larsen, R.J. Linhardt, K.G. Rice, G. Wogan, R. Langer, The Journal of Biological Chemistry, 264, 1570-1577. (1989). LINK


41. "A Dose Escalation Study or Org 10172 (Low Molecular Weight Heparinoid) in Stroke," J. Biller, E.W. Massey, J.R. Marler, H.P. Adams, J.N. Davis, A. Bruno, R.A. Henriksen, R.J. Linhardt, L.B. Goldstein, M. Alberts, C.T. Kisker, G.J. Toffol, C.S. Greenberg, K.J. Banwart, C. Bertels, D.W. Beck, M. Walker, H.N. Maganani, Neurology, 39, 262-265 (1989). LINK


40. "Study of Defined Oligosaccharide Substrates of Heparin and Heparan Monosulfate Lyases," K.G. Rice and R.J. Linhardt, Carbohydrate Research, 190, 219-233 (1989). LINK


39. "Microbially Produced Rhamnolipid as a Source of Rhamnose," R.J. Linhardt, R. Bakhit, L. Daniels, F. Mayerl, and W. Pickenhagen, Biotechnology and Bioengineering, 33, 365-368 (1989). LINK


38. "Mapping and Quantification of the Major Oligosaccharide Components of Heparin," R.J. Linhardt, K.G. Rice, Y.S. Kim, D.L. Lohse, H.M. Wang, D. Loganathan," Biochemical Journal, 254, 781-787 (1988). LINK


37. "Microheterogeneity of Plasma Glycoproteins Antithrombin III and Heparin Cofactor II and Their Carbohydrate Analysis," Y.S. Kim, K.B. Lee and R.J. Linhardt, Thrombosis Research, 51, 97-104 (1988). LINK


36. "Homogeneous, Structurally Defined Heparin-Oligosaccharides With Low Anticoagulant Activity Inhibit the Generation of the Amplification Pathway C3 Convertase In Vitro," R.J. Linhardt, K.G. Rice, Y.S. Kim, J. Engelken, J. Weiler, The Journal of Biological Chemistry, 263, 13090-13096 (1988). LINK


35. "Use of Computer Simulation on the Massively Parallel Processor to Study the Structural Features of Heparin," D.M. Cohen, R.J. Linhardt, Proceedings of the Third International Conference on Super-computing: Supercomputing Projects, Applications and Artificial Intelligence, Volume 1, pp 210-213, L.P. Kartashev and S.I. Kartashev (Eds.), International Supercomputing Institute, St. Petersburg, FL, 1988. LINK


34. "Fractionation of Heparin-Derived Oligosaccharides by Gradient Polyacrylamide-Gel Electrophoresis," K.G. Rice, M.K. Rottink, R.J. Linhardt, Biochemical Journal, 244, 515-522 (1987). LINK


33. "New Approaches for Anticoagulation in Extracorporeal Therapy," R.J. Linhardt, R. Langer, Journal of Biomaterials, Artificial Cells and Artificial Organs, 15, 91-100 (1987). LINK


32. "Structure and Activity of a Unique Heparin-Derived Hexasaccharide," R.J. Linhardt, K.G. Rice, Z.M. Merchant, Y.S. Kim, D.L. Lohse, The Journal of Biological Chemistry, 261, 14448-14454 (1986). LINK


31. "Effect of Very Low Molecular Weight Heparin-Derived Oligosaccharides on Lipoprotein Lipase Release in Rabbits," Z.M. Merchant, E.E. Erbe, W.P. Eddy, D. Patel, R.J. Linhardt, Atherosclerosis, 62, 151-158 (1986). LINK


30. "Variation in Composition and Yield of Exopolysaccharides Produced by Klebsiella Serotype K32 and Acinetobacter calcoaceticus BD4," B.A. Bryan, R.J. Linhardt, L. Daniels, Applied and Environmental Microbiology, 51, 1304-1308 (1986). LINK


29. "Effect of Heparin, Heparin Fragments, and Cortisone on Cerebral Endothelial Cell Growth In Vitro and In Vivo," D.W. Beck, J.J. Olson, R.J. Linhardt, Journal of Neuropathology and Experimental Neurology, 45, 503-512 (1986). LINK


28. "Polysaccharide Lyases," R.J. Linhardt, P.M. Galliher, C.L. Cooney, Applied Biochemistry and Biotechnology, 12, 135-177 (1986). LINK


27. "Evidence of Random Structural Features in the Heparin Polymer," R.J. Linhardt, Z.M. Merchant, K.G. Rice, Y.S. Kim, G.L. Fitzgerald, A.C. Grant, R. Langer, Biochemistry, 24, 7805-7810 (1985). LINK


26. "High-Performance Liquid Chromatographic Separation of Heparin Derived Oligosaccharides," K.G. Rice, Y.S. Kim, A.C. Grant, Z.M. Merchant, R.J. Linhardt, Analytical Biochemistry, 150, 325-331 (1985). LINK


25. "Immuno-Affinity Purification of Heparinase," R.J. Linhardt, Z.M. Merchant, D.W. Persinger, The International Journal of Biochemistry, 17, 1179-1183 (1985). LINK


24. "Structure of Heparin Derived Tetrasaccharides," Z.M. Merchant, Y.S. Kim, K.G. Rice, R.J. Linhardt, Biochemical Journal, 229, 369-377 (1985). LINK


23. "Small Heparin Fragments Regulate the Amplification Pathway of Complement," M.D. Sharath, J.M. Weiler, Z.M. Merchant, Y.S. Kim, K.G. Rice, R.J. Linhardt, Immunopharmacology, 9, 73-80 (1985). LINK


22. "Purification and Characterization of Heparinase from Flavobacterium heparinum," V.C. Yang, R.J. Linhardt, H. Bernstein, C.L. Cooney, R. Langer, The Journal of Biological Chemistry, 260, 1849-1857 (1985). LINK


21. "Polymer Based Drug Delivery: Magnetic Modulation and Bioerodible Systems," E. Edelmen, R.J. Linhardt, H. Bobeck, J. Kost, H.B. Rosen, R. Langer, Polymers as Biomaterials, pp. 279-292, S.W. Shalaby, A.S. Hoffman, B.D. Ratner and T.A. Horbett (Eds.) Plenum Press, 1984. LINK


20. "The Effect of Extracorporeal Enzymatic Deheparinization on the Formed Blood Components," A. Larsen, R.J. Linhardt, M. Klein, D. Tapper, R. Langer, Artificial Organs, 8, 198-203 (1984). LINK


19. "Metachromatic Activity of Heparin and Heparin Fragments," A.C. Grant, R.J. Linhardt, G.. Fitzgerald, J.J. Park, R. Langer, Analytical Biochemistry, 137, 25-32 (1984). LINK


18. "An Immobilized Microbial Heparinase for Blood Deheparinization," R.J. Linhardt, C.L. Cooney, A. Larsen, C.A. Zannetos, D. Tapper, R. Langer, Applied Biochemistry and Biotechnology, 9, 41-55 (1984). LINK


17. "Bioerodable Polyanhydrides for Controlled Drug Delivery," R.J. Linhardt, H.B. Rosen, R. Langer, Polymer Preprints, 24, 47-48 (1983). LINK


16. "Angiogenesis Inhibition and Tumor Regression Caused by Heparin or a Heparin Fragment in the Presence of Cortisone," J. Folkman, R. Langer, R.J. Linhardt, C. Haudenschild, S. Taylor, Science, 221, 719-725 (1983). LINK


15. "Heparinase: In Vivo Activity and Immunogenicity in Rabbits," M.D. Klein, R.A. Drongowski, R.J. Linhardt, C.L. Cooney, R.S. Langer, Journal of Clinical and Laboratory Medicine, 102, 828-837 (1983). LINK


14. "Bioerodible Polyanhydrides For Controlled Drug Delivery," H. Rosen, J. Chang, G. Wenik, R.J. Linhardt, R. Langer, Biomaterials, 4, 131-133 (1983). LINK


13. "In Vivo Activity of Microbial Heparinase," R. Langer, R.J. Linhardt, A.K. Larsen, C.L. Cooney, D. Tapper, M. Klein, Transactions of the American Society for Artificial Internal Organs, 28, 387-390 (1982). LINK


12. "A Colorimetric Assay for Chemical Heparin in Plasma," M. Klein, R.A. Drongowski, R.J. Linhardt, R. Langer, Analytical Biochemistry, 124, 59-64 (1982). LINK


11. "Differential Anticoagulant Activity of Heparin Fragments Prepared Using Microbial Heparinase," R.J. Linhardt, A. Grant, C.L. Cooney, R. Langer, The Journal of Biological Chemistry, 257, 7310-7313 (1982). LINK


10. "The Regulation of Heparinase Production in Flavobacterium heparinum," P.M. Galliher, R.J. Linhardt, L.J. Conway, R. Langer, C.L. Cooney, European Journal of Applied Microbiology and Biotechnology, 15, 252-257 (1982). LINK


9. "An Enzymatic System for Removing Heparin in Extracorporeal Therapy," R. Langer, R.J. Linhardt, C.L. Cooney, M. Klein, D. Tapper, S.M. Hoffberg, A. Larsen, Science, 217, 261-263 (1982). LINK


8. "Mode of Action of Heparin Lyase On Heparin," R.J. Linhardt, G.L. Fitzgerald, C.L. Cooney, R. Langer, Biochimica et Biophysica Acta, 702, 197-203 (1982). LINK


7. "Immobilized Heparinase: Productions, Purification, and Application In Extracorporeal Therapy," R. Langer, R.J. Linhardt, C.L. Cooney, D. Tapper, M.D. Klein, Enzyme Engineering Vol. 6, pp. 433-441, I. Chibata, S. Fukui and L. Wingard (Eds.), Plenum Press, New York, 1982. LINK


6. "A System for Heparin Removal," R. Langer, R.J. Linhardt, M. Klein, P.M. Galliher, C.L. Cooney and M.M. Flanagan, Biomaterials: Inter-facial Phenomenon and Applications, Advances in Chemistry Symposium Series, Chapter 31, pp. 493-509, S. Cooper, A. Hoffman, N. Pepas and B. Ratner (Eds.), Washington, D.C. 1982. LINK


5. "Mechanism of Diacyl Peroxide Decomposition," R.J. Linhardt, B.L. Murr, E. Montgomery, J. Osby and J. Sherbine, The Journal of Organic Chemistry, 47, 2242-2251 (1982). LINK


4. "Blood Deheparinization Using Immobilized Microbial Heparinase," R.J. Linhardt, R. Langer, C.L. Cooney, P.M. Galliher, M.M. Flanagan, S.M. Hoffberg, Proceedings of the Second World Congress of Chemical Engineering, Montreal, Canada, Vol. I, pp. 183-185, 1981. LINK


3. "Heparinase Production by Flavobacterium heparinum," P.M. Galliher, C.L. Cooney, R. Langer and R.J. Linhardt, Applied and Environmental Microbiology, 41, 360-365 (1981). LINK






2. "The Mechanism of Diacyl Peroxide Decomposition," R.J. Linhardt, Ph.D. Dissertation, The Johns Hopkins University, 1979. (Abstract in PDF format) LINK


1. "Mechanism of Decomposition for Diacyl Peroxides and Related Carboxy Inversion Products in Aqueous Acetone," R.J. Linhardt and B.L. Murr, Tetrahedron Letters, 12, 1007-1010 (1979). LINK