Current Publications by Decade
1039. “Xylosyltransferase 2 deficiency and organ homeostasis,” B. Ferencz, E. Condac, N. Poudel, M.C. Munteanu, P. Sivasami, B. Choudhury, N.N. Naidu, F. Zhang, M. Breshears, R.J. Linhardt, M.E. Hinsdale, Glycoconjugate Journal, in press, 2020.
1038. “Expression and functional identification of two homologous nicotine dehydrogenases, NicA2 and Nox, from Pseudomonas sp. JY-Q,” J. Li, M. Shen, Z. Chen, F. Pan, Y. Yang, M. Shu, G. Chen, Y. Jiao, F. Zhang, R. J. Linhardt, W. Zhong, Protein Expression and Purification, in press, 2020.
1037. “The structure-activity relationship of the interactions of SARS-CoV-2 spike glycoproteins with glucuronomannan and sulfated galactofucan from Saccharina japonica,” W. Jin, W. Zhang, D. Mitra, M. G. McCandless, P. Sharma, R. Tandon, F. Zhang, R. J. Linhardt, International Journal of Biomarcromolecules, In press, 2020.
1036. “Advances in preparation and synthesis of heparin and related products,” S. N. Baytas, R. J. Linhardt, Drug Discovery Today, in press, 2020.
1035. “Synthesis of selected unnatural sugar nucleotides for biotechnological applications,” M. Qiao, B. Li, Y. Ji, L. Lin, R. J. Linhardt, X. Zhang, Critical Reviews in Biotechnology, in press, 2020.
1034. “Extraction temperature is a decisive factor for the properties of a pectin,” J. Chen, H. Cheng, Z. Zhi, H. Zhang, R. J. Linhardt, F. Zhang, S. Chen, X. Ye, Food Hydrocolloids, in press, 2020.
1033. "Mapping the Structural and Dynamic Determinants of pH-sensitive Heparin Binding to Granulocyte Macrophage-colony Stimulating Factor," J. Y. Cui, F. Zhang, L. Nierzwicki, G. Palermo, R. J. Linhardt, G. P. Lisia, Biochemistry, in press, 2020.
1032. "MAPK/HOG signaling pathway induced stress-responsive damage repair a mechanism for Pichia pastoris to survive from hyperosmotic stress," R. Wang, T. Zhao, J. Zhuo, C. Zhan, F. Zhang, R. J. Linhardt, Z. Baia, Y. Yang, Journal of Chemical Technology & Biotechnology, in press, 2020.
1031. “Combined genomic and transcriptomic analysis of Dibutyl phthalate metabolic pathway in Arthrobacter sp. ZJUTW,” T. Liu, J. Li, L. Qiu, F. Zhang, R. J. Linhardt, W. Zhong, Biotechnology and Bioengineering, in press, 2020.
1030. "Bioengineered production of glycosaminoglycans and their analogues," W. Jin, F. Zhang, R. J. Linhardt, Systems Microbiology and Biomanufacturing, in press, 2020.
1029. "Construction of heparan sulfate microarray for investigating the binding of specific saccharide sequences to proteins," M. Horton, G. Su, L. Yi, Y. Xu, V. Pagadala, F. Zhang, K. Pierce, R. J Linhardt, J. Liu, Glycobiology, in press, 2020.
1028. “Oral administration of fucosylated chondroitin sulfate oligomers in gastro-resistant microcapsules exhibits a safe antithrombotic activity,” L. Yan, M. Zhu, D. Wang, W. Tao, D. Liu, F. Zhang, R. J. Linhardt, X. Ye, S. Chen, Thrombosis and Haemostasis, in press, 2020.
1027. "Analysis of the glycosaminoglycan chains of proteoglycans," Y. Song, F. Zhang, R. J. Linhardt, Journal of Histochemistry & Cytochemistry, in press 2020.
1026. "Elucidating the Unusual Reaction Kinetics of D-Glucuronyl C5-Epimerase," D. Vaidyanathan, E. Paskaleva, T. Vargason, X. Ke, S. McCallum, R. J. Linhardt, J. S. Dordick, Glycobiology, in press, 2020.
1025. "Effects of glycosaminoglycan supplementation in the chondrogenic differentiation of bone marrow- and synovial- derived mesenchymal stem/stromal cells on 3D-extruded poly (ε-caprolactone) scaffolds," J C. Silva, C. S. Moura, G. Borrecho, A. P. Alves de Matos, Joaquim M. S. Cabral, R. J. Linhardt, F. C. Ferreira, International Journal of Polymeric Materials and Polymeric Biomaterials, in press, 2020.
1024. "Fermented cassava residue lignin prepared by sequential acid steam-explosion and hot-alkaline treatment and its antioxidant properties," W. Wang, S. Wanga, Y. Pana, X. Ouyang, R. J. Linhardt, Waste and Biomass Valorization, in press, 2020.
1023. “Structural insight into the binding of human galectins to corneal keratan sulfate, its desulfated form and related saccharides,” M. C. Miller, C. Cai, K. Wichapong, S. Bhaduri, N. L.B. Pohl, R. J. Linhardt, H. -J. Gabius, K. H. Mayo, Science Reports, 10, 15708, 2020. LINK
1022. "Structural characteristics and anti-complement activities of polysaccharides from Sargassum hemiphyllum," W. Jin, Q. Fang, D. Jiang, T. Li, B. Wei, J. Sun, W. Zhang, Z. Zhang, F. Zhang, R. J. Linhardt, H. Wang, W. Zhong, Glycoconjugate Journal, 37, 553–563, 2020. LINK
1021. “Chemical O-sulfation of N-sulfoheparosan: A route to rare N-sulfo-3-O-sulfoglucosamine and 2-O-sulfoglucuronic acid,” L. Yan, P. Brodfueher, L. Fu, F. Zhang, S. Chen, J. S. Dordick, R. J. Linhardt, Glycoconjugate Journal, 37, 589–597, 2020. LINK
1020. “Identification, Repair and Characterization of a Benzyl Alcohol-Inducible Promoter for Recombinant Proteins Overexpression in Corynebacterium glutamicum,” X. Liu, Z. Zhao, G. Dong, Y. Li, F. Peng, C. Liu, F. Zhang, R. J. Linhardt, Y. Yang, Z. Bai, Enzyme and Microbial Technology,141, 109651, 2020. LINK
1019. Prominent members of the human gut microbiota express endo-acting O-glycanases to initiate mucin breakdown, L. I. Crouch, M. V. Liberato, P. A. Urbanowicz, A. Baslé, C. A. Lamb, C. Stewart, K. Cooke, M. Doona, S. Needham, R. R. Brady, J. E. Berrington, K. Madunic, P. Chater, F. Zhang, R. J. Linhardt, D. I. R. Spencer, D. N. Bolam, Nature Communications, 11, 4017, 2020. LINK
1018. “Fabrication of homotypic neural ribbons as a multiplex platform optimized for spinal cord delivery,” Z. T . Olmsted, C. Stigliano, A. Badri, F. Zhang, A. Williams, M. A. G. Koffas, Y. Xie, R. J. Linhardt, J. Cibelli, P. Horner, J. L. Paluh, Science Reports,10, 12939, 2020. LINK
1017. “Fucosylated chondroitin sulfate 9-18 oligomers exhibit molecular size-independent potent antithrombotic activity during circulating in the blood,” L. Yan, D. Wang, Y. Yu, F. Zhang, X. Ye, R. J. Linhardt, S. Chen, ACS Chemical Biology, 15, 2232-2246, 2020. LINK
1016. “Highly branched RG-I domain enrichment are indispensable for pectin mitigating against high-fat diet-induced obesity,” K. Zhu, G. Mao, D. Wu, C. Yu, H. Xiao, X. Ye, R. J. Linhardt, C. Orfila, S. Chen, Journal of Agriculture and Food Chemistry, 68, 8688-8701, 2020. LINK
1015. "Enzymatic polymerization of poly(glycerol-1,8-octanediol-sebacate): versatile PGS analogs that form mono-component biodegradable fiber scaffolds," K. Lang, S. Bhattacharya, Z. Ning, R. J. Sánchez-Leija, M.T. K. Bramson, R. Centore, D. T. Corr, R. J. Linhardt, R.A. Gross, Biomacromolecules, 21, 3197-3206, 2020. LINK
1014. “N-glycolyl chondroitin synthesis using metabolically engineered E. coli," A. E. Awofiranye, S. N. Baytas, K. Xia, A. Badri, W. He, A. Varki, M. Koffas, R. J. Linhardt, Applied Microbiology and Biotechnology Express,10, 144, 2020. LINK
1013. "Loss and rescue of osteocalcin and osteopontin modulate osteogenic and angiogenic features of mesenchymal stem/stromal cells," M. S. Carvalho, J. C. Silva, C. Hoff, J.M. S. Cabral, R. J. Linhardt, C. Lobato da Silva, D. Vashishth, Journal of Cellular Physiology, 235, 7496–7515, 2020. LINK
1012. “Developing a quantitative method to analyze heparan sulfate using isotopically labeled calibrants,” Z. Wang, K. Arnold, Y. Xu, V. Pagadala, G. Su, H. Myatt, R.J. Linhardt, J. Liu, Communications Biology, 3, 425, 2020. LINK
1011. “End-functionalised glycopolymers as glycosaminoglycan mimetics inhibit HeLa cell proliferation,” C. Yang, L. Gao, C. Cai, L. Wang, M. Shao, F. Fan, J. Li, M. Liu, R. J. Linhardt, G. Yu, Polymer Chemistry, 11, 4714, 2020. LINK
1010. "Characterization and application of a putative transcription factor SUT2 in Pichia pastoris," Y. Yang, Y. Zheng, P. Wang, X. Li, C. Zhan, X. Liu, C. Liu, Y. Li, Z. Bai, F. Zhang, R. J. Linhardt, Molecular Genetics and Genomics, 295, 1295–1304, 2020. LINK
1009. “Fabrication of homotypic neural ribbons as a multiplex platform optimized for spinal cord delivery,” Z. T. Olmsted, C. Stigliano, A. Badri, F. Zhang, A. Williams, M. A. G. Koffas, Y. Xie, R. J. Linhardt, J. Cibelli, P. J. Horner, J. L. Paluh, Scientific Reports 10, 12939, 2020 LINK
1008. "Inhibition of glucuronomannan hexamer on the proliferation of lung cancer through binding with immunoglobulin G," W. Jin, X. He, J. Zhu, Q. Fang, B. Wei, J. Sun, W. Zhang, Z. Zhang, F. Zhang, R. J. Linhardt, H. Wang, W. Zhong, Carbohydrate Polymers, 248, 116785, 2020. LINK
1007. “Polysaccharide Sequence Influences the Specificity and Catalytic Activity of Glucuronyl C5-Epimerase,” Deepika Vaidyanathan, Xia Ke, Yanlei Yu, Robert J. Linhardt, Jonathan S. Dordick, Biochemistry, 59, 2576-2584, 2020. LINK
1006. "Enzymatic synthesis of chondroitin sulfate E to attenuate bacterial lipopolysaccharide-induced organ damage" J. Li, E. Sparkenbaugh, G. Su, F. Zhang, Y. Xu, K. Xia, P. He, S. Baytas, S. Pechauer, A. Padmanabhan, R. J. Linhardt, R. Pawlinski, J. Liu, ACS Central Science, 6, 1199−1207, 2020. LINK
1005. "Expression of enzymes for 3'-phosphoadenosine-5'-phosphosulfate (PAPS) biosynthesis and their preparation for PAPS synthesis and regeneration," P. Datta, L. Fu, W. He, M. A. G. Koffas, J.S. Dordick, R.J. Linhardt, Applied Microbiology and Biotechnology,104, 7067–7078, 2020. LINK
1004. “Sulfated polysaccharides effectively inhibit SARS-CoV-2 in vitro,” P. S. Kwon, H. Oh, S.-J. Kwon, W. Jin, F. Zhang, K. Fraser, J. Hong, R. J. Linhardt, J. S. Dordick, Cell Discovery 6, 50, 2020. LINK
1003. “Structural analysis of a glucoglucuronan derived from laminarin and the mechanisms of its anti-lung cancer activity,” W. Jin, X. He, W. Wu, Y. Bao, S. Wang, M. Cai, W. Zhang, C. Wang, F. Zhang, R. J. Linhardt, G. Mao, W. Zhong, International Journal of Biological Macromolecules, 163, 776–787, 2020. LINK
1002. “Antimicrobial effects of positively charged, conductive electrospun polymer fibers,” S. Bhattacharya, D. Kim, S. Gopal, A. Tice, K. Lang, J. S. Dordick, J. L. Plawsky, R. J. Linhardt, Materials Science & Engineering C, 116 ,111247, 2020. LINK
1001. “Characterization of heparin and severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) spike glycoprotein binding interactions,” S.-Y. Kim, W. Jin, A. Sood, D. W. Montgomery, O. C. Grant, M. M. Fuster, L. Fu, J. S. Dordick, R. J. Woods, F. Zhang, R. J. Linhardt, Antiviral Research, 181, 104873, 2020. LINK
1000. "FAM20B-catalyzed glycosaminoglycans control murine tooth number by restricting FGFR2b signaling," J. Wu, Y. Tian, L. Han, C. Liu, T. Sun, L. Li, Y. Yu, B. Lamichhane, R. N. D’Souza, S. E. Millar, R. Krumlauf, D. M. Ornitz, J. Q. Feng, O. Klein, H. Zhao, F. Zhang, R. J. Linhardt, X. Wang, BMC Biology, 18, 87, 2020. LINK
999. "Colon-targeted delivery systems for nutraceuticals: A review of current vehicles, evaluation methods and future prospects," K. Feng, Y.-S. Wei, T.-G. Hu, R. J. Linhardt, M.-H. Zong, H. Wu, Trends in Food Science & Technology, 102, 203-222, 2020. LINK
998. "Structure-activity relationship of citrus segment membrane RG-I pectin against galectin-3: The galactan is not the only important factor," D. Wu, J. Zheng, W. Hu, X. Zheng, Q. He, R. J. Linhardt, X. Ye, S. Chen, Carbohydrate Polymers, 245, 116526, 2020. LINK
997. "Increased CHST15 Expression follows Decline in Arylsulfatase B (ARSB) and Disinhibition of Non-Canonical WNT Signaling: Potential for Epithelial-Mesenchymal Transition," S. Bhattacharyya, L. Feferman, X. Han, K. Xia, F. Zhang, R. J. Linhardt, J. K. Tobacman, Oncotarget, 11, 2327-2344, 2020. LINK
996. "Recent advances in biotechnology for heparin and heparan sulfate analysis," Meng Qiao, Lei Lin, Ke Xia, Jun Lid, Xing Zhang, Robert J. Linhardt, Talanta 219, 121270, 2020. LINK
995. "Autophagic degradation of HAS2 in endothelial cells: A novel mechanism to regulate angiogenesis," C. G. Chen, M. A. Gubbiotti, X. Han, Y. Yu, R. J. Linhardt, R. V. Iozzo, Matrix Biology, 90, 1-19, 2020. LINK
994. "Filter-entrapment enrichment pull-down assay for glycosaminoglycan structural characterization and protein interaction," Y. Yu, F. Zhang, G. Renois-Predelus, I. J. Amster, R. J. Linhardt, Carbohydrate Polymers, 245, 116623, 2020. LINK
993. “Glycosaminoglycan remodeling during chondrogenic differentiation of human bone marrow−/synovial-derived mesenchymal stem/stromal cells under normoxia and hypoxia,” J. C. Silva, X. Han, T. P. Silva, K. Xia, P. E. Mikael, J. M. S. Cabral, F. C. Ferreira, R. J. Linhardt, Glycoconjugate Journal, 37, 345–360, 2020. LINK
992. "Interactions of Fibroblast Growth Factors with Sulfated Galactofucan from Saccharina japonica," W. Jin, D. Jiang, W. Zhang, C. Wang, K. Xia, F. Zhang, R. J. Linhardt, International Journal of Biological Macromolecules, 160, 26–34, 2020. LINK
991. "Structural characterization of a clinically described heparin-like substance in plasma causing bleeding, " Y. Yu, K. Bruzdoski, V. Kostousov, L. Hensch, S. Hui, F. Siddiqui, A. Farooqui, A. Kouta, F. Zhang, J. Fareed, J. Teruya, R. J. Linhardt, Carbohydrate Polymers, 244, 116443, 2020. LINK
990. "Alveolar heparan sulfate shedding impedes recovery from bleomycin-induced lung injury," W. LaRiviere, S. Liao, S. McMurtry, K. Oshima, X. Han, F. Zhang, S. Yan, S. Haeger, M. Ransom, J. Bastarache, R. J. Linhardt, E. Schmidt, Y. Yang, American Journal of Physiology-Lung Cellular and Molecular Physiology, 318, L1198–L1210, 2020. LINK
989. "High Conductivity and High Capacitance Electrospun Fibers for Supercapacitor Applications," S. Bhattacharya, I. Roy, A. Tice, C. Chapman, R. Udangawa, V. Chakrapani, J. L. Plawsky, R. J. Linhardt, ACS Applied Materials & Interfaces, 12, 19369−19376, 2020. LINK
988. "Unique cell surface mannan of yeast pathogen Candida auris with selective binding to IgG," L. Yan, K. Xia, Y. Yu, A. Miliakos, S. Chaturvedi, F. Zhang, Shiguo Chen,; V. Chaturvedi,; R. J. Linhardt, ACS Infectious Diseases, 6, 1018−1031, 2020. LINK
987. "Rational identification and characterisation of peptide ligands for targeting polysialic acid," D. G. Shastry, F. J. Irudayanathan, A. Williams, M. Koffas, R. J. Linhardt, S. Nangiac, P. Karande, Scientific Reports, 10, 7697-7712, 2020. LINK
986. "Design of anti-inflammatory heparan sulfate to protect against acetaminophen-induced acute liver failure," K. Arnold, Y. Xu, E. M. Sparkenbaugh, M. Li, X. Han, X. Zhang, K. Xia, M. Piegore, F. Zhang, X. Zhang, M. Henderson, V. Pagadala, G. Su, L. Tan, P. W. Park, R. T. Stravitz, N. S. Key, R. J. Linhardt, R. Pawlinski, D. Xu, J. Liu, Science Translational Medicine, 12, eaav8075, 2020. LINK
985. "Biotechnology for removal of indoor gaseous formaldehyde," Y. Shao, Y. Wang, R. Zhao, J. Chen, F. Zhang, R. J. Linhardt, W. Zhong, Applied Microbiology and Biotechnology, 104, 3715–3727, 2020. LINK
984. "Chondrogenic differentiation of mesenchymal stem/stromal cells on 3D porous poly (ε-caprolactone) scaffolds: effects of material alkaline treatment and chondroitin sulfate supplementation," C. S. Moura, J. C. Silva, S. Faria, P. R.Fernandes, J. M. S. Cabral, R. J. Linhardt, P. J. Bártolo, F. C. Ferreira, Journal of Bioscience and Bioengineering, 129, 756-764, 2020. LINK
983. "Comprehensive glycomic analysis reveals that human serum albumin glycation specifically affects the pharmacokinetics and efficacy of different anticoagulant drugs in diabetes," H. Qiu, L. Jin, J. Chen, M. Shi, F. Shi, M. Wang, D. Li, X. Xu, X. Su, X. Yin, W. Li, X. Zhou, R. J. Linhardt, Z. Wang, L.Chi, Q. Zhang, Diabetes, 69, 760-770, 2020. LINK
982. "Extraction, structure and bioactivities of the polysaccharides from Pleurotus eryngii: A Review," B. Zhang, Y. Li, F. Zhang, R. J. Linhardt, G. Zeng, A. Zhang, International Journal of Biological Macromolecules, 150, 1342–1347 2020. LINK
981. "A novel laminin-binding protein mediates microbial-endothelial cell interactions and facilitates dissemination of Lyme disease pathogens," S. Bista, P. Singh, Q. Bernard, X. Yang, T. Hart, Y.-P. Lin, C. Kitsou, V. S. Rana, F. Zhang, R. J. Linhardt, K. Zhang, D. R. Akins, L. Hritzo, Y. Kim, D. J. Grab, J. S. Dumler, U. Pal, Journal of Infectious Diseases, 221, 1438–1447, 2020. LINK
980. "Glycosaminoglycan disaccharide compositional analysis of cell-derived extracellular matrices using liquid chromatography-tandem mass spectrometry," J. C. Silva, M. S. Carvalho, K. Xia, J. M. S. Cabral, C. L. da Silva, F. C. Ferreira, D. Vashishth, R. J. Linhardt, In Methods in Cell Biology, Chapter 5, Volume 156, pp 85-106, Cell-derived Matrices, Part A, Elsevier, 2020. LINK
979. "Structural characterization and anti-lung cancer activity of a sulfated glucurono-xylo-rhamnan from Enteromorpha prolifera," W. Jin, X. He, L. Long, Q. Fang, B. Wei, J. Sun, W. Zhang, H. Wang, F. Zhang, R. J. Linhardt, Carbohydrate Polymers, 237, 116143, 2020. LINK
978. "Molecular mechanisms of bioactive polysaccharides from Ganoderma lucidum (Lingzhi), a review," J. Lu, R. He, P. Sun, F. Zhang, R. J. Linhardt, A. Zhang, International Journal of Biological Macromolecules,150, 765–774, 2020. LINK
977. "Non-anticoagulant heparin as a pre-exposure prophylaxis prevents Lyme disease infection," Y.-P. Lin, , Y. Yu, A. Marcinkiewicz, P. Lederman, T. Hart, F. Zhang, R. J. Linhardt, ACS Infectious Diseases,6, 503−514, 2020. LINK
976. "Chemical, enzymatic and biological synthesis of hyaluronic acids," J. Li, M. Qiao, Y. Ji, L. Lin, X. Zhang, R. J. Linhardt, International Journal of Biological Macromolecules, 152, 199–206, 2020. LINK
975. "Structural analysis of urinary glycosaminoglycans from healthy human subjects," X. Han, P. Sanderson, S. Nesheiwat, L. Lin, Y. Yu, F. Zhang, I. J. Amster, R. J. Linhardt, Glycobiology,30, 143–151, 2020. LINK
974. "Encapsulation of phycocyanin by prebiotics and polysaccharides-based electrospun fibers and improved colon cancer prevention effects," Y. Wen, P. Wen, T.-G. Hu, R. J. Linhardt, M.-H. Zong , H. Wu, Z.-Y. Chen, International Journal of Biological Macromolecules 149, 672–681, 2020. LINK
973. "Extraction Methods Affect the Structure and Bioactivity of Goji (Lycium barbarum) Polysaccharides," S. Zhou, R. Md Atikur, J. Li, D. Wu, C. Wei, J. Chen, R. J. Linhardt, X. Ye, Sh. Chen, Molecules, 25, 936, 2020. LINK
972. "Chemoenzymatic Synthesis of Glycosaminoglycans," X. Zhang, L. Lin, H. Huang, R. J. Linhardt, Accounts of Chemical Research, 53, 335−346, 2020. LINK
971. "Digestibility of squash polysaccharide under simulated salivary, gastric and intestinal conditions and its impact on short chain fatty acid production in type-2 diabetic rats," L. Liang, G. Liu, F. Zhang, Q. Li, R. J. Linhardt, Carbohydrate Polymers, 235, 115904, 2020. LINK
970. "Mass spectrometric evidence for the mechanism of free-radical depolymerization of various types of glycosaminoglycans," N. Zhang, G. Li, S. Li, C. Cai, F. Zhang, R. J. Linhardt, Guangli Yu, Carbohydrate Polymers,233, 115847, 2020. LINK
969. "Interactions between sclerostin and glycosaminoglycans," F. Zhang, J. Zhao, X. Liu, R. J. Linhardt, Glycoconjugate Journal, 37, 119–128, 2020. LINK
968. "Structural analysis of a novel sulfated galacto-fuco-xylo-glucurono-mannan from Sargassum fusiforme and its anti-lung cancer activity," W. Jin, H. Tang, J. Zhang, B. Wei, J. Sun, W. Zhang, F. Zhang, H. Wang, R. J. Linhardt, W. Zhong, International Journal of Biological Macromolecules, 149, 450–458, 2020. LINK
967. "Regulation of PTP1B activation through disruption of redox-complex formation," A. D. Londhe, A. Bergeron, S. M. Curley, F. Zhang, K. D. Rivera, A. Kannan, G. Coulis, S. H. M. Rizvi, S. J. Kim, D. J. Pappin, N. K. Tonks, R. J. Linhardt, B. Boivin, Nature Chemical Biology, 16, 122-125, 2020. LINK
966. "Evaluating heparin products for heparin-induced thrombocytopenia using surface plasmon resonance," F. Zhang, P. Datta, J. S. Dordick, R. J. Linhardt, Journal of Pharmaceutical Sciences,109, 975-980, 2020. LINK
965. "Extracellular matrix decorated polycaprolactone scaffolds for improved mesenchymal stem/stromal cell osteogenesis towards a patient-tailored bone tissue engineering approach," J. C. Silva, M. S. Carvalho, R. N. Udangawa, C. S. Moura, J. M. S. Cabral, C. L. da Silva, F. C. Ferreira, D. Vashishth, R. J. Linhardt, Journal of Biomedical Materials Research Part B – Applied Biomaterials, 1-14, 2020. LINK
964. "Site-selective reactions for the synthesis of glycoconjugates in polysaccharide vaccine development," L. Lin, M. Qiao, X. Zhang, R. J. Linhardt, Carbohydrate Polymers, 230, 115643, 2020. LINK
963. "Functional role of glycosaminoglycans in decellularized lung extracellular matrix," F. E. Uhl, F. Zhang, R. A. Pouliot, J. J. Uriarte, S. Rolandsson Enes, X. Han, Y. Ouyang, K. Xia, G. Westergren-Thorsson, A. Malmström, O. Hallgren, R. J. Linhardt, D. J. Weiss, Acta Biomateriala, 102, 231-246, 2020. LINK
962. "A novel route for double-layered encapsulation of probiotics with improved viability under adverse conditions," K. Feng, R.-M. Huang, R.-Q. Wu, Y.-S. Wei, M.-H. Zong, R. J. Linhardt, H. Wu, Food Chemistry, 310, 125977, 2020. LINK
961. "Designer DNA architecture offers precise and multivalent spatial pattern-recognition for viral sensing and inhibition," P. S. Kwon, S. Ren1, S.-J. Kwon, M. E. Kizer, L. Kuo, M. Xie, D. Zhu, F. Zhou, F. Zhang, D. Kim, K. Fraser, L. D. Kramer, N. C. Seeman, J. S. Dordick, R. J. Linhardt, J. Chao, X. Wang, Nature Chemistry, 12, 26–35, 2020. LINK
960. "Urinary metabolomics analysis reveals the anti-diabetic effect of stachyose in high-fat diet/ streptozotocin - induced type 2 diabetic rats," L. Liang, G. Liu, F. Zhang, R. J. Linhardt, Q. Li, Carbohydrate Polymers, 229, 115534, 2020. LINK
959. "Gelling mechanism of RG-I enriched citrus pectin: Role of arabinose side-chains in cation- and acid-induced gelation," J. Zheng, J. Chen, H. Zhang, D. Wu, X. Ye, R. J. Linhardt, S. Chen, Food Hydrocolloids, 101, 105536, 2020. LINK
958. "Storage stability studies on interesterified blend-based fast-frozen special fats for oxidative stability, crystallization characteristics and physical properties," T.-W. Zhu, X. Zhang, M.-H. Zong; R. J. Linhardt. H. Wu, B. Li, Food Chemistry 306, 125563, 2020. LINK
957. "Kartogenin-loaded coaxial PGS/PCL aligned nanofibers for cartilage tissue engineering," J. C. Silva, R. N. Udangawa, J. Chen, C. D. Mancinelli, F. F. F. Garrudo, P. E. Mikael, J. M. S. Cabral, F. C. Ferreira, R. J. Linhardt, Materials Science & Engineering C, 107, 110291, 2020. LINK
956. "3-O-sulfation of Heparan Sulfate Enhances Tau Interaction and Cellular Uptake," J. Zhao, Y. Zhu, X. Song, Y. Xiao, G. Su, X. Liu, Z. Wang, Y. Xu, J. Liu, D. Eliezer, T. F. Ramlall, G. Lippens, J. Gibson, F. Zhang, R. J. Linhardt, L. Wang, C. Wang, Angewandte Chemie Int. Ed., 59, 1818-1827, 2020. LINK
955. "Enzymatic Bioconversion of Cycloastragenol-6-O-β-D-glucoside into Cycloastragenol by a Novel Recombinant β-Glucosidase from Phycicoccus sp. Soil748," L. Cheng, H. Zhang, H. Liang, X. Sun, X. Shen, J. Wang, W. Wang, Q. Yuan, H.-I. Ri, T.-M. Kim, M.-S. Kang, R. J. Linhardt, Process Biochemistry, 90, 81–88, 2019. LINK
954. "Production and characterization of recombinant collagen binding resilin nanocomposite for regenerative medicine applications," P. E. Mikael, R. Udangawa, M. Sorci, B. Cress, Z. Shtein, G. Belfort, O. Shoseyov, J. S. Dordick, R. J. Linhardt, Regenerative Engineering and Translational Medicine, 5, 362–372, 2019. LINK
953. "Expedient synthesis of core disaccharide building blocks from natural polysaccharides for heparan sulfate oligosaccharide assembly," N. Pawar, L. Wang, T. Higo, C. Bhattacharya, P. K. Kancharla, F. Zhang, K. Baryal, C. -X. Huo, J. Liu, R. J. Linhardt, X. Huang, L. Hsieh-Wilson, Angewandte Chemie, 58, 18577 – 18583, 2019. LINK
952. "Depolymerized RG-I enriched pectin from citrus segment membrane modulates gut microbiota, increases SCFAs production, promotes the growth of Bifidobacterium spp., Lactobacillus spp. and Faecalibaculum spp.," G. Mao, S. Li, C. Orfila, X. Shen, S. Zhou, R. J. Linhardt, X. Ye, S. Chen, Food & Function, 10, 7828–7843, 2019. LINK
951. “Reconsidering conventional and innovative methods for pectin extraction from fruit and vegetable waste: Targeting rhamnogalacturonan I,” G. Mao, D. Wu, C. Wei, W. Tao, X. Ye, R. J. Linhardt, C. Orfila, S. Chen, Trends in Food Science & Technology, 94, 65-78, 2019. LINK
950. "Loss of endothelial sulfatase-1 after experimental sepsis attenuates subsequent pulmonary inflammatory responses", K. Oshima, X. Han, Y. Ouyang, R. el Masri, Y. Yang, S. Haeger, S. McMurtry, T. Lane, P. Davizon-Castillo, F. Zhang, X. Yue, R. Vivès, R. J. Linhardt, E. Schmidt, American Journal of Physiology-Lung Cellular and Molecular Physiology 317, L667–L677, 2019. LINK
949. "Bottom-up analysis using liquid chromatography-Fourier transform mass spectrometry to characterize fucosylated chondroitin sulfates from sea cucumbers," L. Yan, L. Li, J. Li, Y. Yu, X. Liu, X. Ye, R. J. Linhardt, S. Chen, Glycobiology 29, 755–764, 2019. LINK
948. "Extruded bioreactor perfusion culture supports the chondrogenic differentiation of human mesenchymal stem/stromal cells in 3D porous poly (ε-caprolactone) scaffolds," J. C. Silva, C. S. Moura, G. Borrecho, A. P. Alves de Matos, C. L. da Silva, J. M. S. Cabral, P. J. Bártolo, R. J. Linhardt, F. C. Ferreira, Biotechnology Journal, 14, 1900078, 2019. LINK
947. "Interesterified blend-based and physical blend-based special fats: Storage stability under fluctuating temperatures," T.-W. Zhu, X. Zhang, M.-H. Zong, R. J. Linhardt, B. Li, H. Wu, Journal of the Science of Food and Agriculture, 99, 6219-6226, 2019. LINK
946. "Rethinking the impact of RG-I mainly from fruits and vegetables on dietary health," D. Wu, J. Zheng, G. Mao, W. Hu, X. Ye, R. J. Linhardt, S. Chen, Critical Reviews in Food Science and Nutrition, 59, 1-23, 2019. LINK
945. "Glycan Markers of Human Stem Cells Reassigned with Beam Search Arrays," N. Wu, L. M. Silva, Y. Liu, Y. Zhang, C. Gao, F. Zhang, L. Fu, Y. Peng, R. J. Linhardt, T. Kawasaki, B. Mulloy, W. Chai, T. Feizi, Molecular and Cellular Proteomics, 18, 1981–2002, 2019. LINK
944. "Polybenzimidazole nanofibers for neural stem cell culture," F. F. F. Garrudo, R. N. Udangawa, P. R. Hoffman, L. Sordini, C. A. Chapman, P. E. Mikael, F. A. Ferreira, J. C. Silva, C. A. V. Rodrigues, J. M. S. Cabral, J. M. F. Morgado, F. C. Ferreira, R J. Linhardt, Materials Today Chemistry, 14, 100185, 2019. LINK
943. "Online capillary zone electrophoresis negative electron transfer dissociation tandem mass spectrometry of glycosaminoglycan mixtures," M. Stickney, P. Sanderson, F. E. Leach III, F. Zhang, R. J. Linhardt, I. J. Amster, International Journal of Mass Spectrometry, 445, 116209, 2019. LINK
942. "Comparison of the interactions of different growth factors and glycosaminoglycans," F. Zhang, L. Zheng, S. Cheng, Y. Peng, L. Fu, X. Zhang, R.J. Linhardt, Molecules, 24, 3360, 2019 LINK
941. "High-throughput method for in process monitoring of 3-O-sulfotransferase catalyzed sulfonation in bioengineered heparin synthesis," L. Lin, Y. Yu, F. Zhang, X. Zhang, R. J. Linhardt, Analytical Biochemistry, 586, 113419, 2019. LINK
940. "Bottom-up and top-down profiling of pentosan polysulfate," L. Lin, Y. Yu, F. Zhang, K. Xia, X. Zhang, R. J. Linhardt, Analyst,144, 4781-4786, 2019. LINK
939. "Highly purified fucosylated chondroitin sulfate oligomers with selective intrinsic factor Xase complex inhibition," L. Yan, D. Wang, M. Zhu, Y. Yu, F. Zhang, X. Ye, R. J. Linhardt, S. Chen, Carbohydrate Polymers,222, 115025, 2019. LINK
938. "Recovery of high value-added nutrients from fruit and vegetable industrial wastewater," H. Chen, X. Ye, H. Zhang, J. Tian, J. Shi, R. J. Linhardt, S. Chen, Comprehensive Reviews in Food Science and Food Safety, 18, 1388-1402, 2019. LINK
937. "Increased 3’-phosphoadenosine-5’-phosphosulfate levels in engineered Escherichia coli cell lysate facilitates in vitro synthesis of chondroitin sulfate A," A. Badri, A. Williams, K. Xia, R. J. Linhardt, M. A.G. Koffas, Biotechnology Journal, 14, 1800436, 2019. LINK
936. "Metabolic Engineering of Bacillus megaterium for Heparosan Biosynthesis using Pasteurella multocida Heparosan Synthase, PmHS2," A. Williams, K. S. Gedeon; D. Vaidyanathan, Y. Yu; C. H. Collins, J. S. Dordick, R. J. Linhardt, M. Koffas, Microbial Cell Factories, 18, 132, 2019. LINK
935. "Specificity and action pattern of heparanase Bp, a β-glucuronidase from Burkholderia pseudomallei," Y. Yu, A. Williams, X. Zhang, L. Fu, K. Xia, Y. Xu, F. Zhang, J. Liu, M. Koffas, R. J. Linhardt, Glycobiology, 29, 572–581, 2019. LINK
934. "Intravenous fluid resuscitation is associated with septic endothelial glycocalyx degradation," J. A. Hippensteel, R. Uchimido, P. D. Tyler, R. C. Burke, X. Han, F. Zhang, S. A. McMurtry, J. F. Colbert, C. J. Lindsell, D. C. Angus, J. A. Kellum, D. M. Yealy, R. J. Linhardt, N. I. Shapiro, E. P. Schmidt, Critical Care, 23, 259, 2019. LINK
933. "Major differences between the self-assembly and seeding behavior of heparin-induced- and in-vitro-phosphorylated tau and their modulation by potential inhibitors," C. Despres, J. Di, F.-X. Cantrelle, Z. Li,; I. Huvent, B. Chambraud, J. Zhao, J. Chen, S. Chen, G. Lippens, F. Zhang, R. J. Linhardt, C. Wang, F.-G. Klärner, T. Schrader, I. Landrieu, G. Bitan, C. Smet-Nocca, ACS Chemical Biology, 14, 1363−1379, 2019. LINK
932. "1D and 2D-HSQC NMR: two methods to distinguish and characterize heparin from different animal and tissue sources," L. Mauri, M. Marinozzi, N. Phatak, M. Karfunkle, K. StAnge, M. Guerrini, D. Keire, R. J. Linhardt, Frontiers in Medicine, 6, 1-9, 2019. LINK
931. "Endothelial glycocalyx shedding predicts donor organ acceptability and is associated with primary graft dysfunction in lung transplant recipients," T. M Sladden, S. Yerkovich, M. Grant, F. Zhang, X. Liu, M. Trotter, P. Hopkins, R. J. Linhardt, D. C. Chambers, Transplantation, 103, 1277-1285, 2019. LINK
930. "A Molecular Hero Suit for In Vitro and In Vivo DNA Nanostructures.," M. Kizer, R.J. Linhardt, A.R. Chandrasekaran, X. Wang, Small, 1805386, 2019. LINK
929. "Systematic analysis of enoxaparins from different sources with online one- and two-dimensional chromatography," Y. Ouyang, M. Zhu, X. Wang, L. Yi, J. Fareed, R.J. Linhardt, Z. Zhang, Analyst,144, 3746–3755, 2019. LINK
928. "Dose-dependent neuroprotective effect of oriental phyto-derived glycyrrhizin on experimental neuroterminal norepinephrine depletion in a rat brain model," O. A. Ahmed-Farid, S. A. Haredy, R. M. Niazy, R. J. Linhardt, M. Warda, Chemico-Biological Interactions, 308, 279–287, 2019. LINK
927. "Determination of cerebrospinal fluid leakage by selective deletion of transferrin glycoform using an immunochromatographic assay," J. Oh, S.-J. Kwon, J. S. Dordick, W. J. Sonstein, R. J. Linhardt, M.-G. Kim, Theranostics, 9, 4182-4191, 2019. LINK
926. "Characterization and comparative analysis of toxin–antitoxin systems in Acetobacter pasteurianus," K. Xia, H. Bao, F. Zhang, R. J. Linhardt, X. Liang, Journal of Industrial Microbiology & Biotechnology, 46, 869–882, 2019. LINK
925. "Fast preparation of rhamnogalacturonan I enriched low molecular weight pectic polysaccharide by ultrasonically accelerated metal-free Fenton reaction," J. Li, S. Li, H. Zhang, Y. Zheng, J. Chen, L. Yan, T. Ding, R.J. Linhardt, C. Orfila, D. Liu, X. Ye, S. Chen, Food Hydrocolloids, 95, 551-561, 2019. LINK
924. "Physicochemical properties and conformations of water-soluble peach gums via different preparation methods," C. Wei, Y. Zhang, H. Zhang, J. Li, W. Tao, R. J. Linhardt, S. Chen, X. Ye, Food Hydrocolloids, 95, 571-579, 2019. LINK
923. "Preparation of salidroside with n-butyl β-D-glucoside as the glycone donor via a two-step enzymatic synthesis catalyzed by an immobilized β-glucosidase from bitter almond," F. Wang, D. Huang, Y. Ma, F. Zhang, R. J. Linhardt, Biocatalysis and Biotransformation, 37, 246–260, 2019. LINK
922. "Heparin Contamination and Issues Related to Raw Materials and Controls," Y. Zhu, F. Zhang, R. J. Linhardt, In The Science and Regulations of Naturally Derived Complex Drugs, Sasisekharan, R., Lee, S.L., Rosenberg, A., Walker, L.A. (Eds.), AAPS Advances in the Pharmaceutical Sciences Series 39, Chapter 11, pp 191-206, Springer Nature, NY, 2019. LINK
921. "Circulating heparin oligosaccharides rapidly target the hippocampus in sepsis potentially impacting cognitive functions," X. Zhang, X. Han, K. Xia, Y. Xu, Y. Yang, K. Oshima, S. M. Haeger, M. J. Perez, S. A. McMurtry, J. A. Hippensteel, J. A. Ford P. S. Herson, J. Liu, E. P. Schmidt, R. J. Linhardt, Proceedings of the National Academy of Sciences (USA), 116, 9208–9213, 2019. LINK
920. "Polyaniline-polycaprolactone blended nanofibers for neural cell culture," F. F. F. Garrudo, C. A. Chapman, P. Hoffman, R. W. Udangawa, J. C. Silva, P. E. Mikael, C. A. V. Rodrigues, J.M. S. Cabral, J. M. F. Morgado, F. C. Ferreira, R. J. Linhardt, European Polymer Journal, 117, 28–37, 2019. LINK
919. "Novel Cellulose – Halloysite Hemostatic Nanocomposite Fibers with a Dramatic Reduction in Human Plasma Coagulation Time", R. Udangawa, P. Mikael, C. Mancinelli, C. Chapman, C. Willard, T.J. Simmons, R. J. Linhardt, ACS Applied Materials & Interfaces, 11, 15447−15456, 2019. LINK
918. "Comparison of low-molecular-weight heparins prepared from ovine heparins with enoxaparin," J. Chen, Y. Yu, J. Fareed, D. Hoppensteadt, W. Jeske, A. Kouta, C. Jin, Y. Jin, Y. Yao, K. Xia, F. Zhang, S. Chen, X. Ye, R. J. Linhardt, Clinical and Applied Thrombosis/Hemostasis, 25, 1-9, 2019. LINK
917. "Glycosaminoglycans compositional analysis of urodele axolotl (Ambystoma mexicanum) and porcine retina," S. Y. Kim, J. Kundu, A. Williams, A. S. Yandulskaya, J. R. Monaghan, R. L. Carrier, R. J. Linhardt, Glycoconjugate Journal, 36, 165–174, 2019. LINK
916. "Development of low molecular weight heparin by H2O2/ascorbic acid with ultrasonic power and its anti-metastasis property," X. Shen, Z. Liu, J. Li, D. Wu, M. Zhu, L. Yan, G. Mao, X. Ye, R.J. Linhardt, S. Chen, International Journal of Biological Macromolecules, 133, 101–109, 2019. LINK
915. "Compositional and structural analysis of glycosaminoglycans in cell-derived extracellular matrices," J. C. Silva, M. S. Carvalho, X. Han, K. Xia, P. E. Mikael, J. M. S. Cabral, F. Castelo Ferreira, R. J. Linhardt, Glycoconjugate Journal, 36, 141–154, 2019. LINK
914. "Heavy heparin: A stable isotope-enriched, chemoenzymatically-synthesized, poly-component drug," B. F. Cress, U. Bhaskar, D. Vaidyanathan, A. Williams, C. Cai, X. Liu, L. Fu, V. M-Chari, F. Zhang, S. A. Mousa, J. S. Dordick, M. A. G. Koffas, R. J. Linhardt, Angewandte Chemie, 58, 5962 –5966, 2019. LINK
913. "Circulating heparan sulfate fragments mediate septic cognitive dysfunction," J.A Hippensteel, B.J. Anderson, J. E. Orfila, S. A. McMurtry, R. Dietz, G. Su, J. A Ford, F. Zhang, J. Liu, R. J. Linhardt, N. J. Meyer, P. S. Herson, E. P. Schmidt, Journal of Clinical Investigation, 129, 1779-1784, 2019. LINK
912. "Preparation of low molecular weight heparin using an ultrasound-assisted Fenton-system," Z. Zhi, J. Li, J. Chen, S. Li, H. Cheng, D. Liu, X. Ye, R. J. Linhardt, S. Chen, Ultrasonics Sonochemistry, 52, 184–192, 2019. LINK
911. "Chemically modified polysaccharides: Synthesis, characterization, structure activity relationships of action," Y. Xu, Y.-J. Wu, P.-L. Sun, F. Zhang, R. J. Linhardt, A. Zhang, International Journal of Biological Macromolecules, 132, 970–977, 2019. LINK
910. "Targeted delivery of phycocyanin for prevention of colon cancer using electrospun fibers," P. Wen, T.-G. Hu, Y. Wen, R. J. Linhardt, M.-H. Zong, Y.-X. Zou, H. Wu, Food & Function, 10, 1816–1825, 2019. LINK
909. "Chemoenzymatic synthesis of heparan sulfate tetrasaccharide from a N-acetyl-α-D-glucosamine-O-methylglycoside acceptor," X. Zhang, D. M. Dickinson, L. Lin, M. Suflita, S. Baytas, R. J. Linhardt, Tetrahedron Letters, 60, 911–915, 2019. LINK
908. "Glycosaminoglycan compositional analysis of relevant tissues in ZIKV pathogenesis and in vitro evaluation of heparin as antiviral against ZIKV infection," S.Y. Kim, C.A. Koetzner, A.F. Payne, G.J. Nierode, Y. Yu, R. Wang, E. Barr, J.S. Dordick, L.D. Kramer, F. Zhang, R.J. Linhardt, Biochemistry, 58, 1155–1166, 2019. LINK
907. "IO4-- stimulated crosslinking of catechol-conjugated hydroxyethylchitosan as a tissue adhesive," X. Peng, Y. Peng, B. Han, W. Liu, F. Zhang, R. J Linhardt, Journal of Biomedical Materials Research Part B: Applied Biomaterials, 107B, 582-593, 2019. LINK
906. "Coconut oil-cellulose beaded microfibers by coaxial electrospinning: An eco-model system to study thermoregulation of confined phase change materials," W. M. R. N. Udangawa, C. F. Willard, C. Mancinelli, C. Chapman, R. J. Linhardt, T. J. Simmons, Cellulose, 26, 1855–1868, 2019. LINK
905. "Glycoconjugate synthesis using chemoselective ligation," S. Cheng, P.L. Wantuch, M.E. Kizer, D.R. Middleton, R. Wang, M. DiBello, M. Li, X. Wang, X. Li, V. Ramachandiran, F.Y. Avci, F. Zhang, Xing Zhang, R.J. Linhardt, Organic & Biomolecular Chemistry, 17, 2646-2650, 2019. LINK
904. "Remodeling of Glycosaminoglycans During Differentiation of Adult Human Bone Mesenchymal Stromal Cells toward Hepatocytes," P. E. Mikael, C. Willard, A. Koyee, C.-G. Barlao, X. Liu, X. Han, Y. Ouyang, K. Xia, R. J. Linhardt, J. S. Dordick, Stem Cells and Development, 28, 278-2898, 2019. LINK
903. "Effect of the sulfation pattern of sea cucumber-derived fucoidan oligosaccharides on modulating metabolic syndromes and gut microbiota dysbiosis caused by HFD in mice," S. Li, J.i Li, G. Mao, L. Yan, Y. Hu, X. Ye, D. Tian, R. J. Linhardt, S. Chen, Journal of Functional Foods, 55, 193-210, 2019. LINK
902. "The potential role of enzymatic catalysis and metabolic engineering in lignin valorization," W. Wang, C. Shi, R. J. Linhardt, in Lignin: Biosynthesis, Functions and Economic Significance, Chapter 7, pp 165-190, F. Lu and F. Yue (Eds.), Nova Science Publishers, NY, 2019. LINK
901. "Co-culture cell-derived extracellular matrix loaded electrospun microfibrous scaffolds for bone tissue engineering," M.S. Carvalho, J.C. Silva, R.N. Udangawa, J.M. S. Cabral, F. Castelo Ferreira, C. Lobato da Silva, R.J. Linhardt, D. Vashishth, Materials Science and Engineering: C, 99, 479-490, 2019. LINK
900. "Mechanism of enhanced oral absorption of Akebia saponin D by a self-nanoemulsifying drug delivery system loaded with phospholipid complex," Y. Wang, J. Shen, X. Yang, Y. Jin, Z. Yang, R. Wang, F. Zhang, R.J. Linhardt, Drug Development and Industrial Pharmacy, 45, 124-129, 2019. LINK
899. "Complete degradation of bisphenol A and nonylphenol by a composite of biogenic manganese oxides and Escherichia coli cells with surface-displayed multicopper oxidase CotA," Z. Zhang, Z. Ruan, J. Liu, C. Liu, F. Zhang, R.J. Linhardt, L. Li, Chemical Engineering Journal, 362, 897-908, 2019. LINK
898. "Non-anticoagulant low molecular weight heparins for pharmaceutical applications," Y. Ouyang, Y. Yu, F. Zhang, J. Chen, X. Han, K. Xia, Y. Yao, Z. Zhang, R. J. Linhardt, Journal of Medicinal Chemistry, 62, 1067-1073, 2019. LINK
897. "Chemical composition and biological activities of essential oil isolated by HS-SPME and UAHD from fruits of bergamot," C. Xing, C. Qin, X. Li, F. Zhang, R. J. Linhardt, P. Sun, A. Zhang, LWT - Food Science and Technology, 104, 38–44, 2019. LINK
896. "Tip-enhanced Raman imaging of single-stranded DNA with single base resolution," Z. He, Z. Han, M. Kizer, R. Linhardt, X. Wang, A. Sinyukov, J. Wang, V. Deckert, A. Sokolov, J. Hu, M. Scully, Journal of the American Chemical Society, 141, 753−757, 2019. LINK
895. "Ultrasound-assisted fast preparation of low molecular weight fucosylated chondroitin sulfate with antitumor activity," J. Li, S. Li, H. Yang, C. Wei, L. Yan, T. Ding, R. J. Linhardt, X. Zheng, X. Ye, S. Chen, Carbohydrate Polymers, 209, 82-91, 2019. LINK
894. "Negative-ion mode capillary isoelectric focusing-mass spectrometry for charge-based separation of acidic oligosaccharides," Y. Ouyang, X.Han, Q. Xia, J. Chen, S. Velagapudi, K. Xia, Z. Zhang, R. J Linhardt, Analytical Chemistry, 91, 846−853, 2019. LINK
893. "Glycosaminoglycans in human cerebrospinal fluid determined by LC-MS/MS MRM," Y. Yu, F. Zhang, W. Colón, R. J. Linhardt, Ke Xia, Analytical Biochemistry,567, 82–84, 2019. LINK
892. "Development of a method to analyze the complexes of enoxaparin and platelet factor 4 with size-exclusion chromatography," F. Wu, K. Dong, M. Zhu, Q. Zhang, B. Xie, D. Li, H. Gan, R.J. Linhardt, Z. Zhang, Journal of Pharmaceutical and Biomedical Analalysis 164, 668-671, 2019. LINK
891. "Pectic oligosaccharides hydrolyzed from citrus canning processing water by Fenton reaction and their antiproliferation potentials," S. Liu, S. Li, D. Liu, L. Yan, R.J. Linhardt, T. Ding, X. Ye, L. Junhui, C. Wei, S. Chen, International Journal of Biological Macromolecules,124, 1025–1032, 2019. LINK
890. "Metabolic engineering of cyanobacteria for photoautotrophic production of heparosan, a pharmaceutical precursor of heparin," A. Sarnaika, M. H. Abernathy, X. Han, Y. Ouyang, K. Xia, Y. Chen, B. Cress, F. Zhang, A. Lali, R. Pandita, R. J. Linhardt, Y. J. Tang, M. A.G. Koffas, Algal Research 37 57–63, 2019. LINK
889. "Fucosylated chondroitin sulfate from Isostichopus badionotus alleviates metabolic syndromes and gut microbiota dysbiosis induced by high-fat and high-fructose diet," S. Li, J. Li, G. Mao, T. Wu, D. Lin, Y. Hu, X. Ye, D. Tian, W. Chai, R.J. Linhardt, S. Chen, International Journal of Biological Macromolecules,124, 377–388, 2019 LINK
888. "Amphiphilic bromelain-synthesized oligo-phenylalanine grafted with methoxypolyethylene glycol possessing stabilizing thermo-responsive emulsion properties," F. Wang, J. Zhu, T. Yan, X. Pei, F. Zhang, R. J. Linhardt, Journal of Colloid and Interface Science, 538, 1-14, 2019. LINK
887. "Mulberry: A review of bioactive compounds and advanced processing technology," Y. Zou, S.-T. Liao, P. Wen, R. J. Linhardt, Hong Wu, Teng-gen Hu, Trends in Food Science & Technology, 83, 138–158, 2019. LINK
886. "Structure, bioactivities and applications of the polysaccharides from Tremella fuciformis mushroom: A review," Y. Wu, Z. Wei, F. Zhang, R. J. Linhardt, P. Sun, A. Zhang, International Journal of Biological Macromolecules, 121 1005–1010, 2019. LINK
885. "Structural characterization and anti-proliferative activities of partially degraded polysaccharides from peach gum," C. Wei, Y. Zhang, L. He, J. Cheng, J. Li, W. Tao, G. Mao, H. Zhang, R.J. Linhardt, X. Ye, S. Chen, Carbohydrate Polymers, 203, 193-202, 2019. LINK
884. "Chemometric analysis of porcine, bovine and ovine heparins," Y. Ouyang, X. Han, Y. Yu, J. Chen, F. Zhang, R. J. Linhardt, J. Fareed, D. Hoppensteadt, W. Jeske, A. Kouta, Z. Zhang, K. Xia, Journal of Pharmaceutical and Biomedical Analysis, 164, 345–352, 2019. LINK
883. "Polyamines stimulate the CHSY1 synthesis through the unfolding of the RNA G-quadruplex at the 5'-untraslated region," K. Yamaguchi, K. Asakura, M. Imamura, G. Kawai, T. Sakamoto, T. Furihata, R.J. Linhardt, K. Igarashi, T. Toida, K. Higashi, Biochemical Journal, 475 3797–3812, 2018. LINK
882. "Bacteriophage T7 transcription system: an enabling tool in synthetic biology," W. Wang, Y. Li, Y. Wang, C. Shi, C. Li, Q. Li, R. J. Linhardt, Biotechnology Advances, 36, 2129–2137, 2018. LINK
881. "Dimerization Interface of Osteoprotegerin Revealed by Hydrogen-deuterium Exchange Mass Spectrometry" Y. Xiao, M. Li, R. Larocque, F. Zhang, A. Malhotra, J. Chen, R. J. Linhardt, L. Konermann, D. Xu, Journal of Biological Chemistry, 293, 17523–17535, 2018. LINK
880. "A mutant cell library for systematic analysis of heparan sulfate," H. Qiu, S. Shi, J. Yue, M. Xin, A. V. Nairn, L. Lin, X. Liu, G. Li, S. A. Archer-Hartmann, M. Dela Rosa, M. Galizzi, S. Wang, F. Zhang, P. Azadi, T. H. van Kuppevelt, W. V. Cardoso, K. Kimata, X. Ai, K. W. Moremen, J. Esko, R. J. Linhardt, L. Wang, Nature Methods, 15, 889-899, 2018. LINK
879. "A Flexible Carbon/Sulfur-Cellulose Core-Shell Structure for Advanced Lithium–Sulfur Batteries," L. Li, L. Hou, J. Cheng, T. J. Simmons, F. Zhang, L. Zhang, R. J. Linhardt, N. Koratkar, Energy Storage Materials, 15, 388–395, 2018. LINK
878. "Metabolic engineering of capsular polysaccharides," A. Williams, R.J. Linhardt, M.A.G. Koffas, Emerging Topics in Life Science, 2, 337-348, 2018. LINK
877. "Metabolic bioengineering: Glycans and glycoconjugates," M. A. G. Koffas, R. J. Linhardt, Emerging Topics in Life Science,2, 333-335, 2018. LINK
876. "Improved viability and thermal stability of the probiotics encapsulated in a novel electrospun fiber mat," K Feng, M Zhai, Y Zhang, RJ Linhardt, M Zong, L Li, H. Wu, Journal of Agricultural and Food Chemistry, 66, 10890−10897, 2018. LINK
875. "RNA aptamers with specificity for heparosan and chondroitin glycosaminoglycans," M. Kizer, P. Li, B. F. Cress, L. Lin, T. T. Jing, X. Zhang, R. J. Linhardt, X. Wang, ACS Omega, 3, 13667−13675, 2018. LINK
874. "A fucoidan from sea cucumber Pearsonothuria graeffei with well-repeated structure alleviated gut microbiota dysbiosis and metabolic syndromes in HFD-fed mice," S. Li, J. Li, G. Mao, T. Wu, Y. Hu, X. Ye, D. Tian, R. J. Linhardt, S. Chen, Food & Function, 9, 5371-5380, 2018. LINK
873. "Copper regulates the interactions of antimicrobial piscidin peptides from fish mast cells with formyl peptide receptors and heparin," S. Y. Kim, F. Zhang, W. Gong, K. Chen, K. Xia, F. Liu, R.A. Gross, J. M. Wang, R.J. Linhardt, M. L. Cotton, Journal of Biological Chemistry, 293, 15381–15396, 2018. LINK
872. "Production of deuterated cyanidin 3-O-glucoside from recombinant Escherichia coli" M. Gupta, J. Zha, X. Zhang, G.-Y. Jung, R. J. Linhardt, M. Koffas, ACS Omega, 3, 11643−11648, 2018. LINK
871. "Cocaine exposure modulates perineuronal nets and synaptic excitability of fast-spiking interneurons in the medial prefrontal cortex" M. Slaker, E. Jorgensen, D. Hegarty, X. Liu, Y. Kong, F. Zhang, R. J. Linhardt, T. Brown, S. Aicher, B. Sorg, eNeuro, 5, 1–17, 2018. LINK
870. "Fucosylated chondroitin sulfate oligosaccharides from Isostichopus badionotus regulates lipid disorder in C57BL/6 mice fed a high-fat diet," S. Li, J. Li, G. Mao, Y. Hu, X. Ye, D. Tian, R. J. Linhardt, S. Chen, Carbohydrate Polymers, 201, 634-642, 2018. LINK
869. "Recent Progress of Marine Polypeptides as Anticancer Agents Marine Polypeptides as Anticancer Agents," L. Zheng, X. Lin, Z. Yuan, M. Liu, S. Cao, F. Zhang, R.J. Linhardt, Recent Patents on Anticancer Drug Discovery, 13, 2018. LINK
868. "PBN11-8, a cytotoxic polypeptide purified from marine Bacillus, suppresses invasion of human hepatocellular carcinoma cells by targeting focal adhesion kinase pathways," K. Yang, X. Zhu, M. Zhu, X. Lin, D. Kang, M. Sun, Y. Feng, F. Liang, F. Zhang, R. J. Linhardt, L. Zheng, Polymers, 10, 1043, 2018. LINK
867. "Epithelial Heparan Sulfate Contributes to Alveolar Barrier Function and is Shed during Lung Injury," S. M. Haeger, X. Liu, X. Han, J. B. McNeil, K. Oshima, S. A. McMurtry, Y. Yang, Y. Ouyang, F. Zhang, E. Nozik-Grayck, R. L. Zemans, R. M. Tuder, J. A. Bastarache, R. J. Linhardt, E. P. Schmidt, American Journal of Respiratory Cell and Molecular Biology, 59, 363–374, 2018. LINK
866. "Akebia saponin D reverses corticosterone hypersecretion in an Alzheimer's disease rat model." Y. Wang, J. Shen, X. Yang, Y. Jin, Z. Yang, R. Wang, F. Zhang, R.J. Linhardt, Biomedical Pharmacotherapy 107, 219-225, 2018. LINK
865. "Impact of temperature on heparin and protein interactions," J. Zhao, Y. Kong, F. Zhang, R. J. Linhardt, Biochemistry and Physiology, 7, 2, 2018. LINK
864. "B’reshith," R. A. Siegel, L. Brown, E. R. Edelman, R. J. Linhardt, Journal of Controlled Release, 285, 252–257, 2018. LINK
863. "Existing cell wall fragments modify the thermal properties and hydrolysis of potato starch," J. Tian, S. Chen, H. Zhang, H. Fang, Y. Sun, D. Liu, R. J. Linhardt, Xingqian Ye, Food Hydrocolloids 85, 229–232, 2018. LINK
862. "Decline in arylsulfatase B (N-acetylgalactosamine-4-sulfatase) leads to increased EGFR expression due to SHP2 inhibition and JNK activation in prostate," S. Bhattacharyya, L. Feferman, X. Han, Y. Ouya, F. Zhang, R. J. Linhardt, J. K. Tobacman, Journal of Biological Chemistry, 293, 11076–11087, 2018. LINK
861. "Effect of simultaneous steam explosion and alkaline depolymerization of corncob lignin and cellulose structure," X. Ouyan, L. Chen, S. Zhang, Q. Yuan, W. Wang, R. J. Linhardt, Chemical and Biochemical Engineering Quarterly, 32, 177–189, 2018. LINK
860. "Synthesis of coumarin derivatives and their cytoprotective effects on t-BHP-induced oxidative damage in HepG2 cells," T. Ando, M. Nagumo, M. Ninomiya, K. Tanaka, R. J. Linhardt, M. Koketsu, Bioorganic & Medicinal Chemistry Letters, 28, 2422-2425, 2018. LINK
859. "Preparation of low molecular weight heparins through nitrous acid degradation from bovine and ovine heparins," S. Xie, Y. Guan, P. Zhu, F. Li, M. Yu, R. J. Linhardt, L. Chi, L. Jin, Carbohydrate Polymers, 197, 83-91, 2018. LINK
858. "Structural and functional components of the skate sensory organ ampullae of Lorenzini," X. Zhang, K. Xia, L. Lin, F. Zhang, Y. Yu, K. St.Ange, X. Han, E. Edsinger, J. J. Sohn, R. J. Linhardt, ACS Chemical Biology, 13, 1677–1685, 2018. LINK
857. "Increased soluble heterologous expression of a rat brain 3-O-sulfotransferase 1 - A key enzyme for heparin biosynthesis," W. Jin, S. Li, J. Chen, B. Liu, J. Li, X. Li, F. Zhang, R.J. Linhardt, W. Zhong, Protein Expression and Purification, 151, 23-29, 2018. LINK
856. "Polymorphic factor H-binding activity of CspA protects Lyme disease borreliae from the host complement," T. Hart, N. T. T. Nguyen, N. Nowak, F. Zhang, R. J. Linhardt, M. Diuk-Wasser, S. Ram, P. Kraiczy, Y.-P. Lin, PLOS Pathogens, 14, e1007106, 2018. LINK
855. "Xylosyltransferase 1 and the GAG attachment site," Y. Yu, R. J. Linhardt, Structure, 26, 797-799, 2018. LINK
854. "On-line CE-LIF-MS analysis of glycans labeled with teal fluorescence dye using electrokinetic sheath liquid pump-based nanospray ion source," S. Khan, Z. Szabo, J. Liu, B. Kunnummal, X. Han, Y. Ouyang, R. J. Linhardt, Q. Xia, Rapid Communications in Mass Spectrometry, 32, 882–888, 2018. LINK
853. "Purification and structural elucidation of a water-soluble polysaccharide from the fruiting bodies of the Grifola frondosa." A. Zhang, J. Deng, S. Yu, F. Zhang, R. J. Linhardt, P. Sun, International Journal of Biological Macromolecules, 115, 221–226, 2018. LINK
852. "Antithrombin III Binding Site Analysis of Low Molecular Weight Heparin Fractions," Y Chen, J Zhao, Y Yu, X Liu, L Lin, F Zhang, R. J. Linhardt, Journal of Pharmaceutical Sciences, 107, 1290-1295, 2018. LINK
851. "Structural characterization and interaction with RCA120 of a highly sulfated keratan sulfate from blue shark (Prionace glauca) cartilage," Q. Li, G. Li, X.Zhao, X. Shan, C. Cai, J. Zhao, F. Zhang, R. J. Linhardt, G. Yu, Marine Drugs, 16, 128, 2018. LINK
850. "Extraction and characterization of RG-I enriched pectic polysaccharides from mandarin citrus peel," H. Zhang, J. Chen, J. Li, L. Yan, S. Li, X. Ye, D. Liu, T. Ding, R. J. Linhardt, C. Orfila, S. Chen, Food Hydrocolloids, 79, 579-586, 2018. LINK
849. "Structure and conformation of α-glucan extracted from Agaricus blazei Murill by high-speed shearing homogenization," A. Zhang, J. Deng, X. Liu, P. He, L. He, F. Zhang, R.J. Linhardt, P. Sun, International Journal of Biological Macromolecules, 113, 558–564, 2018. LINK
848. Heparin/heparan sulfate analysis by covalently modified reverse polarity capillary zone electrophoresis-mass spectrometry, P. Sanderson, M. Stickney, F. E. Leach III, Q. Xia, Y. Yu, F. Zhang R. J Linhardt, I. J. Amster, Journal of Chromatography A, 1545, 75–83, 2018. LINK
847. "Glycosaminoglycans from bovine eye vitreous humour and interaction with collagen type II," Y. Peng, Y. Yu, L. Lin, X. Liu, X. Zhang, P. Wang, P. Hoffman, S.-Y. Kim, F. Zhang, R. J. Linhardt, Glycoconjugate Journal, 35, 119–128, 2018. LINK
846. "Glycosaminoglycans from fish swim bladder: isolation, structural characterization and bioactive potential," Y. Pan, P. Wang, F. Zhang, Y. Yu, X. Zhang, L. Lin, R. J. Linhardt, Glycoconjugate Journal, 35, 87–94, 2018 LINK
845. "A method for characterizing human intervertebral disc glycosaminoglycan disaccharides using liquid chromatography- mass spectrometry with multiple reaction monitoring," X. Liu, D. Krishnamoorthy, L. Lin, P. Xue, F. Zhang, L. Chi, R. J. Linhardt, J. Iatridis, European Cells & Materials, 35, 117-131, 2018. LINK
844. "Stabilizing leaf and branch compost cutinase (LCC) withglycosylation: Mechanism and effect on PET hydrolysis," A. N. Shirke, C. White, J. A. Englaender, A. Sophie Zwarycz, G. L. Butterfoss, R. J. Linhardt, R. A. Gross, Biochemistry, 57, 1190−1200, 2018. LINK
843. "Repurposing paper by-product lignosulfonate as sulfur donor/acceptor for high performance lithium-sulfur batteries," L. Li, L. Huang, R. J. Linhardt, N. Koratkar, T. Simmons, Sustainable Energy & Fuels, 2, 422-429, 2018. LINK
842. "Comprehensive analysis of glycosaminoglycans from the edible shellfish," Y Okamoto, K Higashi, RJ Linhardt, T. Toida, Carbohydrate Polymers, 184, 269-276, 2018. LINK
841. "Interaction of Neisseria meningitidis group X N-acetylglucosamine-1-phosphotransferase with its donor substrate," S. Ming, E. Cottman-Thomas, N. C. Black, Y. Chen, V. Veeramachineni, D. C. Peterson, X. Chen, G. Wagner, C. Cai, R. J. Linhardt, W. F. Vann, Glycobiology, 28, 100–107, 2018. LINK
840. "Identification of the Streptococcus pneumoniae type 3 capsule-specific glycosyl hydrolase gene of Paenibacillus sp. 32352," D. R. Middleton, X. Zhang, P. L. Wantuch, A. Ozdilek, X. Liu, R. Lopilato, N. Gangasani, R. Bridger, L. Wells, R. J. Linhardt, F. Y. Avci, Glycobiology, 28, 90–99, 2018. LINK
839. "Structural elucidation of fucosylated chondroitin sulfates from sea cucumber using FTICR-MS/MS," I. Agyekum, L. Pepi, Y. Yu, J. Li, L. Yan, R.J. Linhardt, S. Chen, I. J. Amster, European Journal of Mass Spectrometry, 24, 157–167, 2018. LINK
838. "The Road to Animal-Free Glycosaminoglycan Production: Current Efforts and Bottlenecks," A. Williams, A. Badri, R.J. Linhardt, M. Koffas, Current Opinion in Biotechnology, 53, 85–92, 2018. LINK
837. "Full recovery of value-added compounds from citrus canning processing water," L. Yan, X. Ye, J. Chen, Dandan Yu, R. J. Linhardt, C. Orfila, F. Zhang, R. Huang, T. Dinga, D. Liua, S. Chen, Journal of Cleaner Production, 176, 959-965, 2018. LINK
836. "A novel structural fucosylated chondroitin sulfate from Holothuria mexicana and its effects on growth factors binding and anticoagulation," Q. Li, C. Cai, Y. Chang, F. Zhang, R. J. Linhardt, C. Xue, G. Li, G. Yu, Carbohydrate Polymers, 181, 1160-1168, 2018 LINK
835. "Sequencing the Oligosaccharide Pool in Dalteparin Sodium with Offline Strong Anion Exchange (SAX)-HPLC and ESI-MS/MS", Z. Wang, T. Zhang, S. Xie, X. Liu, H. Li, R. J. Linhardt, L. Chi, Carbohydrate Polymers, 183, 81-90, 2018. LINK
834. "Industrial production of glycosaminoglycans," P. Datta, R. J. Linhardt, S. T. Sharfstein, Reference Module in Life Sciences 2017, 1-10, 2018. LINK
833. "N-glycans released from glycoproteins using a commercial kit and comprehensively analyzed with a hypothetical database," X. Sun, L. Tao, L. Yi, Y. Ouyang, N. Xu, D. Li, R.J. Linhardt, Z. Zhang, Journal of Pharmaceutical Analysis, 7, 87-94, 2017 LINK
832. "Electrospinning: a novel nano-encapsulation approach for bioactive compounds," P. Wen, M.-H. Zong, R. J. Linhardt, K. Feng, H. Wu, Trends in Food Science and Technology, 70, 56-68, 2017. LINK
831. "Borrelia burgdorferi glycosaminoglycan binding proteins: Potential target of new therapeutics against Lyme disease," Y.-P. Lin, L. Li, F. Zhang, R. J. Linhardt, Microbiology, 163, 1759-1766, 2017. LINK
830. "Sequencing the dermatan sulfate chain of decorin," Yanlei Yu, Jiana Duan, Franklin E Leach III, Toshihiko Toida, Kyohei Higashi, Hong Zhang, Fuming Zhang, I Jonathan Amster, Robert J Linhardt, Journal of the American Chemical Society, 139, 16986–16995, 2017. LINK
829. "Chemoenzymatic synthesis of heparan sulfate and heparin oligosaccharides and NMR analysis: Paving the way to a diverse library for glycobiologists," X. Zhang, V. Pagadala, H. M. Jester, A. M. Lim, T. Q. Pham, A. M. P. Goulas, J. Liu, R. J. Linhardt, Chemical Sciences, 8, 7883–8466, 2017. LINK
828. "Encapsulation of bioactive compound in electrospun fibers and its potential application," P. Wen, Y. Wen, M.-H. Zong, R. J. Linhardt , H. Wu, Journal of Agricultural and Food Chemistry, 65, 9161-9179, 2017. LINK
827. "Comparative genomics reveals specific genetic architectures in nicotine metabolism of Pseudomonas sp. JY-Q," J. Li, S. Qian, L. Xiong, C. Zhu, J. Wang, Y. Jiao, H. He, F. Zhang, R. J. Linhardt, W. Zhong, Frontiers in Microbiology, 8, 2085, 2017. LINK
826. "Enzymatic generation of highly anticoagulant bovine intestinal heparin", L. Fu, K. Li, D. Mori, M. Hirakane, L. Lin, N. Grover, P. Datta, Y. Yu, J. Zhao, F. Zhang, M. Yalcin, S. Mousa, J.S. Dordick, R.J. Linhardt, Journal of Medicinal Chemistry, 60, 8673–8679 2017. LINK
825. "Cloning and expression of recombinant chondroitinase AC II and its comparison to the Arthrobacter aurescens enzyme," A. Williams, W. He, B. F. Cress, X. Liu, J. Alexandria, H. Yoshizawa, K. Nishimura, T. Toida, M. Koffas, R. J. Linhardt, Biotechnology Journal, 12, 1700239, 2017. LINK
824. Qualitative and quantitative analysis of heparin and low molecular weight heparins using size exclusion chromatography with multiple angle laser scattering/refractive index and inductively coupled plasma/mass spectrometry detectors, Y. Ouyang, Y. Zeng, L. Yi, H. Tang, D. Li, R. J. Linhardt, Zhenqing Zhang, Journal of Chromatography A, 1522, 56–61, 2017. LINK
823. "Isoflavonoid production by genetically engineered microorganisms," B. Cress, R.J. Linhardt, M.A.G. Koffas, in Handbook of Natural Products-Phytochemistry, Botany, Metabolism, edited by K.G. Ramawat, J.M. Merillon and M. Henry, Chapter 54, pp1647-1681, 2017 LINK
822. "Molecular size is important for the safety and selective inhibition of intrinsic factor Xase for fucosylated chondroitin sulfate," L. Yan, J. Li, D. Wang, D. Tian, Y. Hu, X. Ye, R. J. Linhardt, S. Chen, Carbohydrate Polymers, 178, 180-189, 2017. LINK
821. "Biodegradable and Bioactive Core-Shell Fibers for Tissue Engineering," L. Hou, X. Zhang, P.E. Mikael, L. Lin, W. Dong, Y. Zheng, T. J. Simmons, F. Zhang, R. J. Linhardt, ACS Omega, 2, 6321−6328, 2017. LINK
820. "Characteristics of global organic matrix in normal and pimpled chicken eggshells," Z. Liu, F. Zhang, W. He, R. J. Linhardt, Poultry Science, 96, 3775–3784, 2017. LINK
819. "Proteome analysis and selenium-binding peptide identification on proteins sequentially extracted from loach (Misgurnus anguillicaudatus)," Y. Yu, N. Zang, F. Zhang, R. J. Linhardt, H. Zhang, Biochemistry and Physiology, 6, 1000214, 2017. LINK
818. "Synthetic oligosaccharides can replace animal-sourced low-molecular weight heparins," Y. Xu, K. Chandarajoti, X. Zhang, V. Pagadala, W. Dou, D. M. Hoppensteadt, E. Sparkenbaugh, B. Cooley, S. Daily, N. S. Key, D. Severynse-Stevens, J. Fareed, R. J. Linhardt, R. Pawlinski, J. Liu, Science Translational Medicine, 9, eaan5954, 2017. LINK
817. "Synthesis of 4-azido-N-acetylhexosamine uridine diphosphate donors: Clickable glycosaminoglycans," X. Zhang, D.E. Green, V.L. Schultz, L. Lin, X.Han, R. Wang, A. Yaksic, S.Y. Kim, P. L. DeAngelis, R. J. Linhardt, Journal of Organic Chemistry 82, 9910−9915, 2017. LINK
816. "Glycosaminoglycans and glycolipids as potential biomarkers in lung cancer," G. Li, Lingyun Li, E. J. Joo, J. W. Son, Y. J. Kim, J. K. Kang, K. Bok Lee, F. Zhang, R. J. Linhardt, Glycoconjugate Journal, 34, 661–669, 2017. LINK
815. "Expression of chondroitin-4-O-sulfotransferase in Escherichia coli and Pichia pastoris," W. He, Y. Zhu, A. Shirke, X. Sun, J. Liu, R. A. Gross, M. A. G. Koffas, R. J. Linhardt, M. Li, Applied Microbiology and Biotechnology, 101, 6919–6928, 2017. LINK
814. "Construction and functional characterization of truncated versions of recombinant keratanase II from Bacillus circulans," H. Wang, W. He, P. Jiang, Y. Yu, L. Lin, X. Sun, M. Koffas, F. Zhang, Robert J. Linhardt, Glycoconjugate Journal, 34, 643–649, 2017. LINK
813. "Naringenin-Responsive Riboswitch-Based Fluorescent Biosensor Module for Escherichia coli Co-Cultures," Y. Xiu, S. Jang, J. A. Jones, N. A. Zill, R. J. Linhardt, Q. Yuan, G. Yeol Jung, M. A.G. Koffas, Biotechnology and Bioengineering, 114, 2235-2244, 2017. LINK
812. "Proteins that Bind Sulfated Glycosaminoglycans" J. D. Esko, J. Prestegard, R.J. Linhardt, In Essentials of Glycobiology, Varki A, Cummings RD, Esko JD, Stanley P, Hart GW, Aebi M, Darvill AG, Kinoshita T, Packer NH, Prestegard JH, Schnaar RL, Seeberger PH, Eds., Cold Spring Harbor Laboratory, Chapter 38, Third Edition, 2017. LINK
811. "Comparative proteomics of matrix fractions between pimpled and normal chicken eggshells," Z. Liu, L. Song, L. Lu, X. Zhang, F. Zhang, K. Wang, R. J. Linhardt, Journal of Proteomics, 167, 1–11, 2017. LINK
810. "Comparison of low molecular weight heparins prepared from bovine heparins with enoxaparin," X. Liu, K. St.Ange, J. Fareed, D. Hoppensteadt, W. Jeske, A. Kouta, L. Chi, C. Jin, Y. Jin, Y. Yao, R. J. Linhardt, Clinical and Applied Thrombosis and Hemostasis, 23, 542-553, 2017. LINK
809. "Improved octyl glucoside synthesis using immobilized β-glucosidase on PA-M with reduced glucose surplus inhibition". F. Wang, Y. Ma, Y. Liu, X. Zhang, F. Zhang, R. J. Linhardt, Biocatalysis and Biotransformation, 35, 349–362, 2017. LINK
808. "Structural and activity variability of fractions with different charge density and chain length from pharmaceutical heparins," Y. Yu, M. Hirakane, D. Mori, L. Lin, F. Zhang, H. Zhang, R. J. Linhardt, Glycoconjugate Journal, 34, 545–552, 2017. LINK
807. "Factors released from endothelial cells exposed to flow impact adhesion, proliferation, and fate choice in the adult NSC lineage," C. M. Dumont, J. Piselli, N. Kazi, E. Bowman, G. Li, R. J. Linhardt, S. Temple, G. Dai, D. M. Thompson, Stem Cells and Development, 26, 1199-1213, 2017. LINK
806. "Fucosylated chondroitin sulfate oligosaccharides exert anticoagulant activity by targeting at intrinsic tenase complex with low FXII activation: importance of sulfation pattern and molecular size," J. Li, S. Li, L. Yan, T. Ding, R. J. Linhardt, Y. Yu, X. Liu, D. Liu, X. Ye, S. Chen, European Journal of Medicinal Chemistry, 139, 191-200, 2017 LINK
805. "Structural characterization and bioactivity of exopolysaccharide synthesized by Geobacillus sp. TS3-9 isolated from radioactive radon hot spring," L. Wang, H. Zhang, L. Yang, X. Liang, F. Zhang, R. J. Linhardt, Advances in Biotechnology and Microbiology, 4, 1-8, 2017. LINK
804. "Sequencing analysis of β-glucan from highland barley with high performance anion exchange chromatography coupled to quadrupole time–of–flight mass spectrometry," Y. Rong, N. Xu, R. Cheng, B. Xie, J. Hao, L. Yi, D. Li, R. J. Linhardt, Z. Zhang, Food Hydrocolloids, 73, 235-242, 2017. LINK
803. "Glycan Activation of a Sheddase: Electrostatic Recognition between Heparin and proMMP-7," Y. G. Fulcher, S. H. Prior, S. Masuko, L. Li, D. Pu, F. Zhang, R. J. Linhardt, S. R. Van Doren, Structure, 25, 1100–1110, 2017. LINK
802. "Macromolecular properties and hypolipidemic effects of four sulfated polysaccharides from sea cucumbers," S. Li, J. Li, Z. Zhi, C. Wei, W. Wang, T. Ding, X. Ye, Y. Hu, R. J. Linhardt, S. Chen, Carbohydrate Polymers, 173, 330–337, 2017. LINK
801. "Expanding Glycosaminoglycan Chemical Space: Towards the Creation of Sulfated Analogs, and Novel and Chimeric Polymers," R. S. Lane, K. St. Ange, B. Zolghadr, X. Liu, C. Schäffer, R. J. Linhardt, P. L. DeAngelis, Glycobiology, 27, 646–656, 2017. LINK
800. "Complete biosynthesis of anthocyanins using E. coli polycultures" J. Jones, V. Vernacchio, S. Collins, A.Shirke, Y. Xiu, J. Englaender, B, Cress, C. McCutcheon, R. J. Linhradt, R. Gross, and M. Koffas, mBio, 8, e00621-17, 2017. LINK
799. "Fibroblast growth factor signaling mediates pulmonary endothelial glycocalyx reconstitution," Y. Yang, S. M. Haeger, M. A. Suflita, F. Zhang, K. L. Dailey, J. F. Colbert, J. A. Ford, M. A. Picon, R. Stearman, L. Lin, X. Liu, X. Han, R. J. Linhardt, E. P. Schmidt, American Journal of Respiratory Cell and Molecular Biology, 56, 727-737, 2017. LINK
798. "Efficient, environmentally-friendly and specific valorization of lignin: Promising role of non-radical lignolytic enzymes," W. Wang, C. Zhang, X. Sun, S. Su, Q. Li, R. J. Linhardt, World Journal of Microbiology and Biotechnology, 33, 125, 2017 LINK
797. "In vitro fermentation behaviors of fucosylated chondroitin sulfate from Pearsonothuria graeffei by human gut microflora," C. Wei, Y. Zhang, N. Liao, S. Li, R. Linhardt, X. Wang, X. Ye, S. Chen, International Journal of Biological Macromolecules, 102, 1195–1201, 2017. LINK
796. "The 2.8 Å Electron Microscopy Structure of Adeno-Associated Virus-DJ Bound by a Heparanoid Pentasaccharide" Q. Xie, J. Spear, A. Noble, D. Sousa, N. Meyer, O. Davulcu, F. Zhang, R. Linhardt, S. Stagg, M. Chapman, Molecular Therapy - Methods & Clinical Development, 5, 1-12, 2017. LINK
795. "Pathogenesis and inhibition of flaviviruses from a carbohydrate perspective," S. Y. Kim, B. Li, R. J. Linhardt, Pharmaceuticals,10(2), 44, 2017. LINK
794. "Effect of Genomic Integration Location on Heterologous Protein Expression and Metabolic Engineering in E. coli." J. Englaender, A. J. Jones, B. Cress, T. Kuhlman, R. J. Linhardt, M.A.G. Koffas, ACS Synthetic Biology, 6, 710−720, 2017. LINK
793. "Engineered heparins as new anticoagulant drugs," D. Vaidyanathan, A. Williams, J. S. Dordick, M. A.G. Koffas, Robert J. Linhardt, Bioengineering & Translational Medicine, 2, 17–30, 2016. LINK
792. "Fast preparation of RG-I enriched ultra-low molecular weight pectin by an ultrasound accelerated Fenton process," Z. Zhi, J. Chen, S. Li, W. Wang, R. Huang, D. Liu, Tian Ding, R. J. Linhardt, S. Chen, X. Ye, Scientific Reports, 7, 541, 2017. LINK
791. "Chemoenzymatic Synthesis of Low Molecular Weight Heparin and Heparan Sulfate," X. Zhang, R. J. Linhardt, Chapter 8, pp 233-252, in Chemical Biology of Glycoproteins: A tool for understanding and engineering glycans attached to proteins, Z. Tan and L.-X.Wang (Eds.), Royal Society of Chemistry, Cambridge, UK, 2017. LINK
790. "Expression and secretion of glycosylated heparin biosynthetic enzymes using Komagataella pastoris," J. A. Englaender, Y. Zhu, A.N. Shirke, L. Lin, X. Liu, F. Zhang, R.A. Gross, M.A.G. Koffas, R. J. Linhardt, Applied Microbiology and Biotechnology, 101, 2843–2851, 2017 LINK
789. "Heparin and homogeneous model heparin oligosaccharides form distinct complexes with protamine: Light scattering and zeta potential analysis," C. D. Sommers, H. Ye, J. Liu, R. J. Linhardt, D. A. Keire, Journal of Pharmaceutical and Biomedical Analysis, 140, 113–121, 2017. LINK
788. "Novel Method for Measurement of Heparin Anticoagulant Activity Using SPR," J. Zhao, X. Liu, A. Malnotra, Q. Li, F. Zhang, R. J. Linhardt, Analytical Biochemistry, 526, 39-42, 2017. LINK
787. "Glycan Determinants of Heparin-Tau Interaction," J. Zhao, I. Huvent, G. Lippens, D. Eliezer, A. Zhang, Q. Li, P. M. Tessier, R. J. Linhardt, F. Zhang, and C. Wang, Biophysical Journal, 112, 921–932, 2017. LINK
786. "Structural Analysis of Heparin-Derived 3-O-Sulfated Tetrasaccharides: Antithrombin Binding Site Variants," Y. Chen, L. Lin, I. Agyekum, X. Zhang, K. St.Ange, Y. Yu, J. Liu, I. J. Amster, R. J. Linhardt, Journal of Pharmaceutical Sciences, 106, 973-981, 2017. LINK
785. "EXTL3 mutation causes skeletal dysplasia with immune deficiency and unveils a critical role of heparan sulfate in thymopoiesis," S. Volpi, Y. Yamazaki, P. Brauer, A. Hayashida, L. Du, E. van Rooijen, K. Felgentreff, L. Ott de Bruin, K. Hayashida, K. Capuder, N. Luche, E. J. Hagedorn, A. Buoncompagni, M. Di Rocco, C. Rivolta, B. Royer-Bertrand, S. Giliani, P. Luigi Poliani, L. Imberti, K. Dobbs, F. E. Poulain, A. Martini, J. Manis, J. Carlos Zuniga-Pflucker, R. J. Linhardt, L. Zon, P. W. Park, A. Superti-Furga, L.i D. Notarangelo, Journal of Experimental Medicine, 214, 623–637, 2017. LINK
784. "Characterization of a new monoclonal anti-glypican-3 antibody specific for the hepatocellular carcinoma cell line, HepG2," P. Vongchan, R. J. Linhardt, World Journal of Hepatology, 9, 368-384, 2017. LINK
783. "4-O-Sulfation in sea cucumber fucodians contribute to reversing dyslipidiaemia caused by HFD," S. Li, J. Li, Z. Zhi, J. Ge, X. Ye, T. Ding, R. J. Linhardt, S. Chen, International Journal of Biological Macromolecules, 99, 96-104, 2017. LINK
782. "Chemoenzymatic Synthesis of 4-Fluoro-N-Acetylhexosamine Uridine Diphosphate Donors: Chain Terminators in Glycosaminoglycan Synthesis," V. L. Schultz, X. Zhang, K. Linkens, J. Rimel, D. E. Green, P. DeAngelis, and R. J. Linhardt, Journal of Organic Chemistry, 82, 2243–2248 2017. LINK
781. "Green recovery of pectic polysaccharides from citrus canning processing water," J. Chen, H. Cheng, D. Wu, R. J. Linhardt, Zi. Zhi, L. Yan, S. Chen, X. Ye, Journal of Cleaner Production, 144, 459-469, 2017. LINK
780. "A comparative secretome analysis of industrial Aspergillus oryzae and its spontaneous mutant ZJGS-LZ-21," Y. Zhu, H. Zhang, W. Feng, Y. Liu, F. Zhang, R. J Linhardt, X. Liang, International Journal of Food Microbiology, in 248, 1–9, 2017. LINK
779. "Intein-promoted cyclization of aspartic acid flanking the intein leads to atypical N-terminal cleavage," C. J. Minteer, N. M. Siegart, K. M. Colelli, X. Liu, R. J. Linhardt, C. Wang, A. V. Gomez, J. N. Reitter, K. V. Mills, Biochemistry, 56, 1042−1050, 2017 LINK
778. "Interaction of Zika Virus with Glycosaminoglycans," S. Y. Kim, J. Zhao, X. Liu, K. Fraser, L. Lin, F. Zhang, J. S. Dordick, R. J. Linhardt Biochemistry, 56, 1151−1162, 2017 LINK
777. "Parent heparin and daughter LMW heparin correlation analysis using LC-MS and NMR," X. Liu, K. St.Ange, X. Wang, L. Lin, F. Zhang, L. Chi, R. J. Linhardt, Analytical Chemica Acta, 961, 91-99, 2017. LINK
776. "Heparan Sulfate Domains Required for Fibroblast Growth Factor 1 and 2 Signaling through Fibroblast Growth Factor Receptor 1c," V. Schultz, M. Suflita, X. Liu, X. Zhang, Y. Yu, L. Li, D. E. Green, Y. Xu, F. Zhang, P. L. DeAngelis, J. Liu, R. J. Linhardt, Journal of Biological Chemistry, 292, 2495–2509, 2017. LINK
775. "A simple strategy for the separation and purification of water-soluble polysaccharides from the fresh Spirulina platensis," F. Wang, Y. Ma, Y. Liu, Z. Cui, X. Ying, F. Zhang, R. J. Linhardt, Separation Science and Technology, 52, 456-466, 2017. LINK
774. "Liquid to liquid extraction and liquid chromatography-tandem mass spectrometry determination of hainanmycin in feed," Z. P. Wang, J. Z. Shen, R. Linhardt, H. Jiang, L. L. Cheng, Journal of Chromatography B, 1046, 98–101, 2017. LINK
773. "Analysis of heparin oligosaccharides by capillary electrophoresis- negative-ion electrospray ionization mass spectrometry," L. Lin, X. Liu, F. Zhang, L. Chi, I. J. Amster, F. E. Leach III, Q. Xia, R. J. Linhardt, Analytical and Bioanalytical Chemistry,409, 411–420, 2017. LINK
772. "Construction and Characterization of Heparan Sulfate Heptasaccharide Microarray," J. Yang, P.-H.Hsieh, X. Liu, W. Zhou, X. Zhang, F. Zhang, R. J. Linhardt, J. Liu, Chemical Communications, 53, 1743-1746, 2017. LINK
771. "Chemoenzymatic synthesis of unmodified heparin oligosaccharides: Cleavage of p-nitrophenyl glucuronide by alkaline and Smith degradation," X. Zhang, Y. Xu, J. Liu, L. Lin, E. Schmidt, R.J. Linhardt, Organic and Biomolecular Chemistry, 15, 1222–1227, 2017. LINK
770. "Isolation of a lectin binding rhamnogalacturonan-I containing pectin from pumpkin," J. Zhao, F. Zhang, X. Liu, K. St.Ange, A. Zhang, Q. Li, R. J. Linhardt, Carbohydrate Polymers, 163, 330–336, 2017. LINK
769. "Nanostructured glycan architecture is important in the inhibition of influenza A virus infection," S.-J. Kwon, D. H. Na, J. H. Kwak, M. Douaisi, F. Zhang, E. J. Park, J.-H. Park, H. Youn, C.-S. Song, R. S. Kane, J. S. Dordick, K. B. Lee, R. J. Linhardt, Nature Nanotechnology, 12, 48-56, 2017. LINK
768. "Conformational Flexibility of Heparinases from PL12 family: Crystal Structure and Substrate Specificity of Heparinase III from Bacteroides thetaiotaomicron," T. S. Ulaganathan, R. Shi, D. Yao, Y. Li, M.-L. Garron, M. Cherney, R.-X. Gu, D. P. Tieleman, E. Sterner, G. Li, L. Li, R. J. Linhardt, M. Cygler, Glycobiology, 27, 176–187, 2017. LINK
767. "CRISPRi-mediated metabolic engineering of E. coli for O-methylated anthocyanin production," B. F. Cress, Q. D. Leitz, D. C. Kim, T. D. Amore, J. Y. Suzuki, R. J. Linhardt, Mattheos A. G. Koffas, Microbial Cell Factories, 16, (10), 1-15, 2017. LINK
766. "Glycosaminoglycans of the chicken muscular stomach or gizzard," Y. Chen, M. Reddy, Y. Yu, F. Zhang, R. J. Linhardt, Glycoconjugate Journal, 34, 119–126, 2017. LINK
765. "Surprising absence of heparin in the intestinal mucosa of baby pigs," Y. Yu, Y. Chen, P. Mikael, F. Zhang, A. M. Stalcup, R. German, F. Gould, J. Ohlemacher, H. Zhang, R. J. Linhardt, Glycobiology, 27, 57–63, 2017 LINK
764. "Hydrophilic interaction chromatography-multiple reaction monitoring mass spectrometry method for basic building block analysis of low molecular weight heparins prepared through nitrous acid depolymerization," X. Sun, Z. Guo, M. Yu, C. Lin, A. Sheng, Z. Wang, R. J. Linhardt, L. Chi, Journal of Chromatography A, 1479, 121–128, 2017. LINK
763. "Top-down and Bottom-up Analysis of Commercial Low Molecular Weight Heparins," X. Liu, K. St.Ange, L. Lin, F. Zhang, L. Chi, R. J. Linhardt, Journal of Chromatography A, 1480, 32–40, 2017. LINK
762. "Gas-Phase Examination of the Complex of Fibroblast Growth Factor 1 with Heparan Sulfate: a Traveling Wave Ion Mobility Spectrometry (TWIMS) and Molecular Modeling Study," Y. Zhao, A. Singh, Y. Xu, C. Zong, F. Zhang, G.-J. Boons, J. Liu, R. J. Linhardt, R. J. Woods, I. J. Amster, Journal of the American Society of Mass Spectrometry, 28, 96-109, 2017. LINK
761. "Mechanistic insights into the effect of imidazolium ionic liquids on the lipid production by Geotrichum fermentans," L. P. Liu, M. H. Zong, R. J. Linhardt, W. Y. Lou, N. Lia, H. Wu, Biotechnology for Biofuels, 9, 266, 2016. LINK
760. "Characteristics of glycosaminoglycans in chicken eggshells and the influence of disaccharide composition on eggshell properties," Z. Liu, X. Sun, C. Cai, W. He, F. Zhang, R. J. Linhardt, Poultry Science, 95, 2879–2888, 2016. LINK
759. "Structural Characterization of Oligochitosan Elicitor from Fusarium sambucinum and its Elicitation of Defensive Responses in Zanthoxylum bungeanum," P. Li, R. J. Linhardt, Z. Cao International Journal of Molecular Sciences, 17, 2076, 2016. LINK
758. "Draft genome sequence of Bacillus subtilis Ia1a, a new strain for poly-γ-glutamic acid and exopolysaccharides production." M. H. A. Ibrahim, B. F. Cress, R. J. Linhardt, M. A.G. Koffas, R. A. Gross, Genome Announcements, 4, e01361-16, 2016. LINK
757. "GlycCompSoft: Software for automated comparison of low molecular weight heparins using top-down LC/MS data," X. Wang, X. Liu, L. Li, F. Zhang, M. Hu, F. Ren, L. Chi, R. J. Linhardt, PlosOne, 0167727, 2016. LINK
756. "New insights into the action of bacterial chondroitinase AC I and hyaluronidase on hyaluronic acid," L. Tao, F. Song, N. Xu, D. Li, R. J. Linhardt, Z. Zhang, Carbohydrate Polymers, 158, 85–92, 2017.. LINK
755. "Impact of degree of oxidation on the physicochemical properties of microcrystalline cellulose," J. Hao, S.i Xu, N. Xu, D. Li, R. J. Linhardt, Z. Zhang, Carbohydrate Polymers, 155, 483–490, 2017. LINK
754. "Synthesis of heparin immobilized-magnetically addressable cellulose nanofibers for biomedical applications" L. Hou, W.M. R. Udangawa, A. Pochiraju, W. Dong, Y. Zheng, R. J. Linhardt, T. Simmons, ACS Biomaterials Science & Engineering, 2, 1905−1913, 2016. LINK
753. "Identification of Keratan Sulfate Disaccharide Unit at the C-3 position of Glucuronic Acid of Chondroitin Sulfate from Mactra chinensis," K. Higashi, K. Takeda, A. Mukuno, Y. Okamoto, S. Masuko, R. J. Linhardt, T. Toida, Biochemical Journal, 473 4145–4158, 2016. LINK
752. "Selective, switchable fluorescent probe for heparin based on aggregation-induced emission," Y.-J. Wang, L. Lin, X. Zhang, V. Schultz, F. Zhang, J.- Z. Sun, R. J. Linhardt, Analytical Biochemistry, 514, 48-54, 2016. LINK
751. "Quantitative analysis of the major linkage region tetrasaccharides in heparin," Y. Chen, K. St.Ange, Lei Lin, X. Liu, X. Zhang, R. J. Linhardt, Carbohydrate Polymers, 157, 244–250, 2017. LINK
750. "Highly active fucosylated chondroitin sulfate (FCS-pg) from Pearsonothuria graeffei affects human gut microflora," C. Wei, N. Liao, Y. Zhang, S. Li, X. Ye, Y. Hu, D. Liu, R. J. Linhardt, X. Wang, S. Chen, Marine Drugs, 14(9), 170, 2016. LINK
749. "Heparin's Solution Structure Determined by Small-Angle Neutron Scattering (SANS)," K. A. Rubinson, Y. Chen, B. F. Cress, F. Zhang, R. J. Linhardt, Biopolymers, 105, 905-913, 2016. LINK
748. "Polyamines release the let-7b-mediated suppression of initiation codon recognition during the protein synthesis of EXT2," M. Imamura, K. Higashi, K. Yamaguchi, K. Asakura, T. Furihata, Y. Terui, T. Satake, J. Maegawa, K. Yasumura, A. Ibuki, T. Akase, K. Nishimura, K. Kashiwagi, R. J. Linhardt, K. Igarashi, T. Toida, Scientific Reports, 6:33549, 2016. LINK
747. "Structural elucidation of polysaccharide containing 3-O-methyl galactose from fruiting bodies of Pleurotus citrinopileatus," P. He, A. Zhang, S. Zhou, F. Zhang, R. J. Linhardt, P. Sun, Carbohydrate Research, 434, 72-66, 2016. LINK
746. "New functional tools for anti-thrombogenic activity assessment of live surface glycocalyx," S. Dimitrievska, A. Weyers, T. Lin, C. Cai, W. Wu, C. T. Tuggle, S. Sundaram, J. L. Balestrini, D. Slattery, L. Tchouta, T. R. Kyriakides, J. M. Tarbell, R.J. Linhardt, L. E. Niklason, Arteriosclerosis, Thrombosis, and Vascular Biology, 36, 1847-1853, 2016. LINK
745. "Recombinant Escherichia coli K5 strain with the deletion of waaR gene decreases the molecular weight of the heparosan capsular polysaccharide," H. Huang, X. Liu, S. Lv, W. Zhong, F. Zhang, R.J. Linhardt, Applied Microbiology and Biotechnology, 100, 7877–7885, 2016 LINK
744. "Kinetic and Structural Studies on Interactions between Heparin/GAGs and Langerin," J. Zhao, X. Liu, C. Kao, E. Zhang, Q. Li, F. Zhang, R. J. Linhardt, Biochemistry, 55, 4552−4559, 2016. LINK
743. "Comprehensive identification and quantitation of basic building blocks for low molecular weight heparin," X. Sun, A. Sheng, X. Liu, F. Shi, L. Jin, S. Xie, F. Zhang, R. J. Linhardt, L. Chi, Analytical Chemistry, 88, 7738−7744, 2016. LINK
742. "Urinary glycosaminoglycans predict outcomes in septic shock and ARDS," E. P. Schmidt, K. H. Overdier, X. Sun, L. Lin, X. Liu, Y. Yang, L. A. Ammons, T. D. Hiller, M. A. Suflita, Y. Yu, Y. Chen, F. Zhang, C. Cothren Burlew, C. L. Edelstein, I. S. Douglas, R. J. Linhardt, American Journal of Respiratory and Critical Care Medicine, 194, 439–449, 2016. LINK
741. "Keratan sulfate glycosaminoglycan from chicken egg white," L. Fu, X. Sun, W. He, C. Cai, A. Onishi, F. Zhang, R. J. Linhardt, Z. Liu, Glycobiology, 26, 693–700, 2016. LINK
740. "Analysis of heparins derived from bovine tissues and comparison to porcine intestinal heparins," K. St.Ange, A. Onishi, L. Fu, X. Sun, L. Lin, D. Mori, F. Zhang, J. S. Dordick, J. Fareed, D. Hoppensteadt, Walter Jeske, R. J. Linhardt, Clinical and Applied Thrombosis and Hemostasis, 22, 520-527, 2016. LINK
739. "Structure and bioactivity of a polysaccharide containing uronic acid from Polyporus umbellatus sclerotia," P. He, A. Zhang, F. Zhang, R. J. Linhardt, P. Sun, Carbohydrate Polymers,152, 222–230, 2016. LINK
738. "Synthesis and Characterization of Adipic Acid Derived Epoxy Resin," A. Maiorana, G. Subramaniam, R. Centore, X. Han, R. J. Linhardt, R. A Gross, Journal of Polymer Science, Part A: Polymer Chemistry, 54, 2625–2631, 2016. LINK
737. "Heparin: Past, Present, and Future," E. Oduah, R. J. Linhardt, S. T. Sharfstein, Pharmaceuticals, 9, 38, 2016. LINK
736. "Abnormally high content of free glucosamine residues identified in a preparation of commercially available porcine intestinal heparan sulfate," B. Mulloy, N. Wu, F. Gyapon-Quast, L. Lin, F. Zhang, M. C. Pickering, R. J. Linhardt, T. Feizi, W. Chai, Analytical Chemistry, 88, 6648-6652, 2016. LINK
735. "Effect of sophorolipid n-alkyl ester chain length on its interfacial properties at the almond oil-water interface," A. Koh, R.J. Linhardt, R. Gross, Langmuir, 32, 5562–5572, 2016. LINK
734. "Synthesis and biological evaluation of 5,7-dihydroxyflavanone derivatives as antimicrobial agents," X. Zhang, O. Khalidi, S.-Y. Kim, R. Wang, V. Schultz, B. F. Cress, R. A. Gross, M. A.G. Koffas, R. J. Linhardt, Bioorganic & Medicinal Chemistry Letters, 26, 3089–3092, 2016 LINK
733. "The US regulatory and pharmacopeia response to the global heparin contamination crisis," A. Y. Szajek, E. Chess, K. Johansen, G. Gratzl, E. Gray, D. Keire, R. J. Linhardt, J. Liu, T. Morris, B. Mulloy, M. Nasr, Z. Shriver, P. Torralba, C. Viskov, R. Williams, J. Woodcock, W. Workman, A. Al-Hakim, Nature Biotechnology, 34, 625–630, 2016. LINK
732. "Comparison of Low Molecular Weight Heparins Prepared Using Bovine Lung Heparin and Porcine Intestine Heparin as Starting Materials," Y. Guan, X. Xu, X. Liu, A. Sheng, L. Jin, R. J. Linhardt, L. Chi, Journal of Pharmaceutical Sciences,105, 1843-1850, 2016. LINK
731. "Rapid generation of CRISPR/dCas9-regulated, orthogonally repressible hybrid T7-lac promoters for modular, tuneable control of metabolic pathway fluxes in E. coli," B. Cress, J. Jones, K. Daniel, Q. Leitz, J. Englaender, S. Collins, R. J. Linhardt, M. Koffas, Nucleic Acids Research, 44, 4472–4485, 2016. LINK
730. "Poly-ion Complex of Chondroitin Sulfate and Spermine and its Effect on Oral Chondroitin Sulfate Bioavailability," D. Ge, K. Higashi, D. Ito, Y. Terui K. Nagano, R. Ishikawa, K. Higashi, K. Moribe, R. J. Linhardt, T. Toida, Bulletins of the Japanese Pharmaceutical Society, 64, 390–398, 2016. LINK
729. "Specific oxidation pattern of soluble starch with TEMPO-NaBr-NaClO system," J. Hao, J. Lu, N. Xu, R. J. Linhardt, Z. Zhang, Carbohydrate Polymers, 146, 238–244, 2016. LINK
728. "Heparin and anticoagulation," A. Onishi, K. St. Ange, J. S. Dordick, R. J. Linhardt, Glycosaminoglycans and related disorders. Frontiers in Bioscience, 21, 1372-1392, 2016. LINK
727. "Phenylethanoid glycosides," S. Zhao, Z. Wang, M. Koffas, R. J. Linhardt, Fuming Zhang, Recent Progress in Medicinal Plants, Studium Press, V 43, Chapter 19, pp 427-457, 2016. LINK
726. "Examination of glycosaminoglycan binding sites on the XCL1 dimer," J. C. Fox, R. C. Tyler, F. C. Peterson, D. P. Dyer, F. Zhang, R. J. Linhardt, T. M. Handel, B. F. Volkman, Biochemistry, 55, 1214–1225, 2016. LINK
725. "Surface modification of a polyethylene film for anticoagulant and anti-microbial catheter," Y. Zheng, J. Miao, F. Zhang, C. Cai, A. Koh, T. J. Simmons, S. A. Mousa, R. J. Linhardt, Reactive & Functional Polymers,100, 142–150, 2016. LINK
724. "Capillary Electrophoresis-Mass Spectrometry for the Analysis of Heparin Oligosaccharides and Low Molecular Weight Heparin," X. Sun, L. Lin, F. Zhang, L. Chi, Q. Xia, R. J. Linhardt, Analytical Chemistry, 88, 1937-1943, 2016. LINK
723. "Bioengineered Heparins and Heparan Sulfates," L. Fu, M. Suflita, R. J. Linhardt, Advanced Drug Delivery Reviews, 97, 237–249, 2016. LINK
722. "Can natural fibers be a silver bullet? Antibacterial cellulose fibers through covalent bonding of silver nanotparticles to electrospun fibers," Y. Zheng, C. Cai, F. Zhang, J. Monty, R. J. Linhardt, T. Simmons, Nanotechnology, 27, 055102, 2016. LINK
721. "Changes in composition and sulfation patterns of glycoaminoglycans in renal cell carcinoma," E. Ucakturk, O. Akman, X. Sun, D. E. Baydar, A. Dolgun, F. Zhang, R. J. Linhardt, Glycoconjugate Journal, 33, 103–112, 2016. LINK
720. "Development of hydrophilic interaction chromatography with quadruple-time-of-flight mass spectrometry for heparin and low molecular weight heparin disaccharide analysis," C. Wu, Y. Ouyang, X. Sun, N. Xu, R. J. Linhardt, Z. Zhang, Rapid Communications in Mass Spectrometry, 30, 277-284, 2015. LINK
719. "The responses of hyperglycemic dividing mesangial cells to heparin is mediated by the non-reducing terminal trisaccharide." C.P. Wang, V.C. Hascall, F. Zhang, R.J. Linhardt, A. Abbadi, A Wang, Journal of Biological Chemistry, 290, 29045–29050, 2015. LINK
718. "Qualitative and quantitative analysis of branches in dextran using high-performance anion exchange chromatography coupled to quadrupole time-of-flight mass spectrometry," L. Yi, Y. Ouyang, X. Sun, N. Xu, R. J. Linhardt, Z. Zhang, Journal of Chromatography A, 1423, 79–85, 2015. LINK
717. "Interactions between heparin/GAGs and nattokinase" F. Zhang, J. Zhang, R. J. Linhardt, Glycoconjugate Journal, 32, 695–702, 2015. LINK
716. "Sensitive Cells: Enabling Tools for Static and Dynamic Control of Microbial Metabolic Pathways," B. F. Cress, E. A. Trantas, F. Ververidis, R. J. Linhardt, M. Koffas, Current Opinion in Biotechnology, 36, 205-214, 2015. LINK
715. "Antimicrobial mechanism of resveratrol-trans-dihydrodimer produced from peroxidase-mediated oligomerization of resveratrol," M. Mora-Pale, N. Bhan, S. Masuko, P. James, J. Wood, S. McCallum, R. J. Linhardt, J. S. Dordick, M. A.G. Koffas, Biotechnology and Bioengineering, 112, 2417-2428, 2015. LINK
714. "A purification process for heparin and precursor polysaccharides using the pH responsive behavior of chitosan," U. Bhaskar, A.M. Hickey, G. Li, C. Cai, L. Fu, Z. Ou, R. V. Mundra, F. Zhang, J. S. Dordick, R. J. Linhardt, Biotechnology Progress, 31, 1348–1359, 2015. LINK
713. "Detection of cerebrospinal fluid leakage by specific measurement of transferrin glycoforms," S.-J. Kwon, J. S. Dordick, W. J. Sonstein, R.. Linhardt, Electrophoresis, 36, 2425–2432, 2015. LINK
712. "Investigating changes in the gas-phase conformation of antithrombin III upon binding of Arixtra using traveling wave ion mobility spectrometry (TWIMS)," Y. Zhao, A. Singh, L. Li, R. J. Linhardt, Y. Xu, J. Liu, R. J. Woods, I. J. Amster, Analyst, 140, 6980–6989, 2015. LINK
711. "CRISPathBrick: Modular Combinatorial Assembly of Type II-A CRISPR Arrays for dCas9-Mediated Multiplex Transcriptional Repression in E. coli," B. F. Cress, Ö. D. Toparlak, S. Guleria, M. Lebovich, J. T. Stieglitz, J. A. Englaender, J. A. Jones, R. J. Linhardt, M. A. G. Koffas, ACS Synthetic Biology, 4, 987–1000, 2015. LINK
710. "The effect of surface modification of aligned poly-L-lactic acid electrospun fibers on fiber degradation and neurite extension," N. J. Schaub, C. Le Beux, J. Miao, R. Linhardt, J. G. Alauzun, D. Laurencin, R. J. Gilbert, PLoS One, 10, 0136780, 2015. LINK
709. "Profiling Analysis of Low Molecular Weight Heparins by Multiple Heart-Cutting Two Dimensional Chromatography with Quadruple Time-of-Flight Mass Spectrometry," Y. Ouyang, Y. Zeng, Y. Rong, Y. Song, L. Shi, N. Xu, R. J. Linhardt, Z. Zhang, Analytical Chemistry, 87, 8957−8963, 2015. LINK
708. "Production of a low molecular weight heparin using recombinant unsaturated glycuronidase," G. Sua, L. Lia, W. Zhong, F. Zhang, R.J. Linhardt, Carbohydrate Polymers, 134, 151–157, 2015. LINK
707. "Functional chondroitin sulfate from Enteroctopus dofleini containing a 3-O-sulfo glucuronic acid residue," K. Higashi, Y. Okamoto, A. Mukuno, J. Wakai, S. Hosoyama, R.J. Linhardt, T. Toida, Carbohydrate Polymers, 134, 557–565, 2015. LINK
706. "Heparin and related polysaccharides: Synthesis using recombinant enzymes and metabolic engineering," M. Suflita, L. Fu, W. He, M. Koffas, R. J. Linhardt, Applied Microbiology and Biotechnology, 99, 7465–7479, 2015. LINK
705. "Differentiating chondroitin sulfate glycosaminoglycans using collision- induced dissociation; uronic acid cross-ring diagnostic fragments in a single stage of tandem mass spectrometry," M. J. Kailemia, A. B. Patel, D. T. Johnson, L. Li, R. J. Linhardt, I. J. Amster, European Journal of Mass Spectrometry, 21, 275–285, 2015 LINK
704. "SPR Biosensor Probing the Interactions between TIMP-3 and Heparin/GAGs," F. Zhang, K.B. Lee, R. J. Linhardt Biosensors, 5, 500-512, 2015 LINK
703. "Green solvents in carbohydrate chemistry: from raw materials to fine chemicals," A. Farrán, C. Cai, M. Sandoval, Y. Xu, J. Liu, M. J. Hernáiz, R. J. Linhardt, Chemical Reviews 115, 6811-6853, 2015. LINK
702. "Optimization of bioprocess conditions improves production of a CHO cell-derived, bioengineered heparin," J. Y. Baik, H. Dahodwala, E. Oduah, L. Talman, T. R. Gemmill, L. Gasimli, P. Datta, B. Yang, G. Li, F. Zhang, L. Li, R. J. Linhardt, A. M. Campbell, S.F. Gorfien, S. T. Sharfstein, Biotechnology Journal,10, 1067–1081, 2015. LINK
701. "ePathOptimize: A Combinatorial Approach for Transcriptional Balancing of Metabolic Pathways," J. A. Jones, V. Vernacchio, D.Lachance, M. Lebovich, L. Fu, A. Shirke, V. Schultz, B. Cress, R. J. Linhardt, M. Koffas, Scientific Reports, 5, 11301, 2015. LINK
700. "2-O-Sulfated domains in syndecan-1 heparan sulfate inhibit neutrophil cathelicidin and promote S. aureus corneal infection," A. Hayashida, S. Amano, R. L. Gallo, R. J. Linhardt, J. Liu, P.-W. Park, Journal of Biological Chemistry, 290, 16157–16167, 2015. LINK
699. "Analysis of total human urinary glycosaminoglycan disaccharides by liquid chromatography-tandem mass spectrometry," X. Sun, L. Li, K. H. Overdier, L. A. Ammons, I. S. Douglas, C. C. Burlew, F. Zhang, E.P. Schmidt, L. Chi, R. J. Linhardt, Analytical Chemistry, 87, 6220−6227, 2015. LINK
698. "Expanding the chemical space of polyketides through structure-guided mutagenesis of Vitis vinifera stilbene synthase," N. Bhan, B. Cress, R. J. Linhardt, M. Koffas, Biochemie, 115, 136-143, 2015. LINK
697. "UP-HILIC-MS/MS to determine the action pattern of Penicillium sp. dextranase," L. Yi, X. Sun, K. Du, Y. Ouyang, C. Wu, N. Xu, R. J. Linhardt, Z. Zhang, Journal of the American Society of Mass Spectrometry, 26, 1174-1185 2015. LINK
696. "Glycosaminoglycanomics of cultured cells using a rapid and sensitive LC-MS/MS approach," G. Li, F. Tian, L. Zhang, C. Xue, L. Li, R. J. Linhardt, ACS Chemical Biology,10, 1303-1310, 2015. LINK
695. "Profiling pneumococcal type 3-derived oligosaccharides by high resolution liquid chromatography-tandem mass spectrometry," G. Li, L. Li, C. Xue, D. Middleton, R. J. Linhardt, F. Y. Avci, Journal of Chromatography A, 1397, 43–51, 2015. LINK
694. "Intact glycosaminoglycans from intervertebral disc-derived notochordal cell-conditioned media inhibit neurite growth while maintaining neuronal cell viability," D. Purmessur; M. C Cornejo; S. K Cho; P. J Roughley; R. J. Linhardt, James C Iatridis, The Spine Journal,15, 1060–1069, 2015. LINK
693. "Regulating malonyl-CoA metabolism via synthetic antisense RNAs for enhanced biosynthesis of natural products," Y. Yang, Y. Lin, L. Li, R. J. Linhardt, Y. Yan, Metabolic Engineering, 29: 217–226, 2015. LINK
692. "High structural resolution hydroxyl radical protein footprinting reveals an extended Robo1-heparin binding interface," Z. Li, H. Moniz, S. Wang, A. Ramiah, F. Zhang, K. W. Moremen, R. J. Linhardt, J. S. Sharp, Journal of Biological Chemistry, 290, 10729-10740, 2015. LINK
691. "Breast cyst fluid heparan sulfate is distinctively n-sulfated depending on apocrine or flattened type," F. Mannello, F. Maccari, D. Ligi, M. Canale, F. Gatto, R. Linhardt, F. Galeotti, N. Volpi, Cell Biochemistry and Function, 33, 128–133, 2015. LINK
690. "Bolometric properties of semiconducting and metallic single-walled carbon nanotube composite films," T. Simmons, G. Vera-Reveles, G. González, J. Gutierrez, R. J. Linhardt, H. Navarro-Contreras, F. González, ACS Photonics, 2, 334-340, 2015. LINK
689. "Composition of glycosaminoglycans in elasmobranchs including several deep-sea sharks: Identification of chondroitin/dermatan sulfate from the dried fins of Isurus oxyrinchus and Prionace glauca," K. Higashi, Y. Takeuchi, A. Mukuno, H. Tomitori, M. Miya, R. J. Linhardt, T. Toida, PLOS ONE, 0120860, 2015. LINK
688. "Combinatorial one-pot chemoenzymatic synthesis of heparin," U. Bhaskar, G. Li, L. Fu, A. Onishi, M. Suflita, J. S. Dordick, R. J. Linhardt, Carbohydrate Polymers, 122, 399–407, 2015. LINK
687. "High cell density cultivation of recombinant Escherichia coli strains expressing 2-O-sulfotransferase and C5-epimerase for the production of bioengineering heparin," J. Zhang, M. Suflita, G. Li, W. Zhong, L. Li, F. Zhang, J. S. Dordick, R. J. Linhardt, Applied Biochemistry and Biotechnology, 175, 2986–2995, 2015. LINK
686. "Polysaccharide-based nanocomposites and their applications," Y. Zheng, J. Monty, R. J. Linhardt, Carbohydrate Research, 405, 23–32, 2015. LINK
685. "Heavy chain transfer by tumor-necrosis-factor-stimulated-gene-6 to the bikunin proteoglycan," E. Lamkin, A. Calabro, V. C. Hascall, E. J. Joo, L. Li, R. J. Linhardt, M.E. Lauer, Journal of Biological Chemistry, 290, 5156–5166, 2015. LINK
684. "Modulation of heparan sulfate biosynthesis by sodium butyrate in recombinant CHO cells," P. Datta, B. Yang, R. J. Linhardt, S.T. Sharfstein, Cytotechnology, 67, 223–235, 2015. LINK
683. "Enzymatic formation of novel resorcylic acid by creating a structure guided single point mutation in stilbene synthase," N. Bhan, L. Li, P. Xu, R. J. Linhardt, M. Koffas, Protein Science, 24,167-173, 2015. LINK
682. "Stable-isotopic analysis of porcine, bovine, and ovine heparins," J. P. Jasper, F. Zhang, R. B. Poe, R. J. Linhardt, Journal of Pharmaceutical Sciences,104, 457–463, 2015 LINK
681. "Impact of hydrolysis conditions on detection of mannuronic to guluronic acids ratio in alginate and its derivatives," J. Lu, H. Yang, J. Hai, C. Wu, L. Liu, N. Xu, R. J. Linhardt, Z. Zhang, Carbohydrate Polymers, 122, 180–188 2015. LINK
680. "Click-coated, heparinized, decellularized vascular grafts," S. Dimitrievska, C. Cai, A. Weyers, T. Lin, S. Sundaram, D. A. Spiegel, T. R. Kyriakides, J. Miao, G. Li, L. Niklason, R. J. Linhardt, Acta Biomateriala, 13, 177–187, 2015. LINK
679. "Production of chondroitin in metabolically engineered E. coli," W. He, L. Fu, G. Li, J. A. Jones, R. J. Linhardt, M. Koffas, Metabolic Engineering, 27, 92-100, 2015. LINK
678. "Rapid and accurate determination of the lignin content of lignocellulosic biomass by solid-state NMR," L. Fu, S.A. McCallum, J. Miao, C. Hart, G. Tudryn, F. Zhang, R. J. Linhardt, Fuel, 141 39–45, 2015. LINK
677. "Apparent Digestibility of Diet Dominantly Comprised of Phyllostachys Vivax Bamboo Shoots for Captive Giant Pandas," Z.G. Liu, C.D. Wang, J.L. Hu, F.M. Zhang, R.J. Linhardt, X.C. Lin, Journal of Animal and Plant Sciences 25, 612-617, 2015. LINK
676. "Chemoenzymatic synthesis of heparin," D. M. Dickinson, J. Liu, R. J. Linhardt, Glycoscience: Biology and Medicine, N. Taniguchi, T. Endo, G. Hart, P. Seeberger, C.-H. Wong (Eds.), Springer, pp 419-426, 2015. LINK
675. "High cell density cultivation of a recombinant Escherichia coli strain expressing a 6-O-sulfotransferase for the production of bioengineered heparin," J. Zhang, M. Suflita, C.M. Fiaschetti, G. Li, L. Li, F. Zhang, J.S. Dordick, R. J. Linhardt, Journal of Applied Microbiology, 118, 92-98, 2014. LINK
674. "Chemoenzymatic synthesis of heparan sulfate and heparin," J. Liu, R.J. Linhardt, Natural Product Reports, 31, 1676–1685, 2014. LINK
673. "Compositional analysis and structural elucidation of glycosaminoglycans in chicken eggs," Z. Liu, F. Zhang, L. Li, G. Li, W. He, R. J. Linhardt, Glycoconjugate Journal, 31, 593–602, 2014. LINK
672. "Isolation and structural characterization of glycosaminoglycans from heads of red salmon (Oncorhynchus nerka)," F. Zhang, J. Xie, R. J. Linhardt, Journal of Biotechnology and Bioengineering, 1, 1-5, 2014. LINK
671. "Uniform nanoparticle coating of cellulose fibers during wet electrospinning," Y. Zheng, J. Miao, R. J. Linhardt, T. J. Simmons, Journal of Materials Chemistry A, 2, 15029–15034, 2014. LINK
670. "Divergent effect of glycosaminoglycans on the in vitro aggregation of serum amyloid A," J. J. Aguilera, J. Beaudet, F. Zhang, R. J. Linhardt, W. Colón, Biochemie, 104, 70-80, 2014 LINK
669. "Masquerading microbial pathogens: Capsular polysaccharides mimic host-tissue molecules." B. F. Cress, J. A. Englaender, W. He, D. Kasper, R. J. Linhardt, M. A. G. Koffas, FEMS Microbiology Reviews, 38, 660–697, 2014. LINK
668. "Capillary electrophoresis for total glycosaminoglycan analysis," E. Ucakturk, C. Cai, L. Li, G. Li, F. Zhang, R. J. Linhardt, Analytical and Bioanalytical Chemistry, 406, 4617–4626, 2014. LINK
667. "Bottom-up LMWH analysis using LC-FTMS for extensive characterization," G. Li, J. Steppich, Z. Wang, Y. Sun, C. Xue, R. J. Linhardt, L. Li, Analytical Chemistry, 86, 6626−6632, 2014. LINK
666. "Heparin stability by determining unsubstituted amino groups using HILIC-MS," L. Fu, L. Li, C. Cai, G. Li, F. Zhang, Robert J. Linhardt, Analytical Biochemistry, 461, 46–48, 2014. LINK
665. "The effects of metal ions on heparin/heparin sulfate-protein interactions," F. Zhang, X. Liang, J. M. Beaudet, Y. Lee, R. J. Linhardt, Journal of Biomedical Technology and Research, 1, 1-7, 2014 LINK
664. "Impact of GFP tagging on Robo1-heparin interaction," F. Zhang, B. Walcott, H. A. Moniz, K. W. Moremen, L. Wang, R. J. Linhardt, Glycoconjugate Journal, 31, 299–307, 2014. LINK
663. "Three Dimensional Cellular Microarray Platform for Human Neural Stem Cell Differentiation and Toxicology," L. Meli, H. S.C. Barbosa, A. M. Hickey, L. Gasimli, G. Nierode, M. M. Diogo, R. J. Linhardt, J.M.S. Cabral, Jonathan S. Dordick, Stem Cell Research, 12, 36–47, 2014. LINK
662. "Analysis of 3-O-sulfo group containing heparin tetrasaccharides in heparin by liquid chromatography-mass spectrometry," G. Li, B. Yang, L. Li, F. Zhang, C. Xue, R. J. Linhardt, Analytical Biochemistry,455, 3–9, 2014. LINK
661. "Fluorous-assisted chemoenzymatic synthesis of heparan sulfate oligosaccharides," C. Cai, D. M. Dickinson, L. Li, S. Masuko, M. Suflita, V. Schultz, U. Bhaskar, S. D. Nelson, J. Liu, R. J. Linhardt, Organic Letters, 16, 2240−2243, 2014. LINK
660. "Heparinoids activate a tumor-secreted protease via tethering and V-type allostery," Y. G. Fulcher, R.R.S. Gari, N.C. Frey, F. Zhang, R.J. Linhardt, G.M. King, S.R. Van Doren, ACS Chemical Biology, 9, 957−966, 2014. LINK
659. "Fibroblast growth factor-based signaling through synthetic heparan sulfate block copolymers studied using high-cell density 3D cell printing," E. Sterner, S. Masuko, G. Li, L. Li, D. E. Green, N. J. Otto, Y. Xu, P. L. DeAngelis, J. Liu, J. S. Dordick, R. J. Linhardt, Journal of Biological Chemistry, 289, 9754–9765, 2014. LINK
658. "Carbohydrate-containing molecules as potential biomarkers in colon cancer," E.-J. Joo, A. Weyers, G. Li, L. Gasimli, L. Li, W. J. Choi, K. B. Lee, R. J. Linhardt, Omics, 18, 231-241, 2014.. LINK
657. "Quantitative analysis of free and covalent anions in glycosaminoglycans and application in heparin stability studies," L. Liu, R.J. Linhardt, Z. Zhang, Carbohydrate Polymers, 106, 343–350, 2014. LINK
656. "Structure and activity of a new low molecular weight heparin produced by enzymatic ultrafiltration," L. Fu, F. Zhang, G. Li, A. Onishi, U. Bhaskar, P. Sun, R. J. Linhardt, Journal of Pharmaceutical Sciences, 103, 1375–1383, 2014. LINK
655. "Changes in glycosaminoglycan structure on differentiation of human embryonic stem cells towards mesoderm and endoderm lineages," L. Gasimli, A. M. Hickey, B. Yang, G. Li, M. dela Rosa, A. V. Nairn, M. J. Kulik, J. S. Dordick, K. W. Moremen, S. Dalton, R. J. Linhardt, Biochemica et Biophysica Acta, 1840, 1993–2003, 2014. LINK
654. "The Circulating Glycosaminoglycan Signature of Respiratory Failure in Critically Ill Adults," E. P. Schmidt, G. Li, L. Li, L. Fu, Y. Yang, K. H. Overdier, I. S. Douglas, R. J. Linhardt, Journal of Biological Chemistry, 289, 8194–8202, 2014. LINK
653. "Design of homogeneous and reversible low molecular weight heparins," Y. Xu, C. Cai, K. Chandarajoti, P.-H. Hsieh, L.Li, T. Q. Pham, E. M. Sparkenbaugh, J. Sheng, N. S. Key, R. Pawlinski, E. N. Harris, R.J. Linhardt, Jian Liu, Nature Chemical Biology, 10, 248-250, 2014. LINK
652. Proteomics of old world camelid (Camelus dromedarius): Better understanding the interplay between homeostasis and desert environment, M. Warda, A. Prince, H. Kyu Kim, N. Khafaga, T. Scholkamy, R. J. Linhardt, H. Jin, Journal of Advanced Research, 5, 219–242, 2014. LINK
651. "High Sensitivity Detection of Active Botulinum Neurotoxin (BoNT) by Glyco-qPCR," S. J. Kwon, E.J. Jeong, Y.C. Yoo, G.-H. Yang, J.C. Lee, J.S. Dordick, R.J. Linhardt, K.B. Lee, Analytical Chemistry, 86, 2279−2284, 2014. LINK
650. "Microarray platform affords improved product analysis in mammalian cell growth studies," P. Datta, L. Meli, L. Li, N. Migliore, E. Schaefer, S. T. Sharfstein, J. S. Dordick, R. J. Linhardt, Biotechnology Journal, 9, 386–395, 2014. LINK
649. "Bioengineering murine mastocytoma cells to produce anticoagulant heparin," L. Gasimli, C. A. Glass, P. Datta, B. Yang, G. Li, T. R. Gemmill, J. Y. Baik, S. T. Sharfstein, J. D. Esko, R. J. Linhardt, Glycobiology, 24, 272-280, 2014 LINK
648. "Mapping of glycosaminoglycan-derived, pre-column 2-aminoacridone-labeled disaccharides using liquid chromatography-fluorescence and -mass spectrometric detection," N. Volpi, F. Galeotti, B. Yang, R. J. Linhardt, Nature Protocols, 9, 541-558, 2014. LINK
647. "Characterization of human placental glycosaminoglycans and regional binding to VAR2CSA in malaria infected erythrocytes, " J. M. Beaudet, L. Mansur, E.-J. Joo, E. Kamhi, B. Yang, T. M Clausen, A. Salanti, F. Zhang, R. J. Linhardt, Glycoconjugate Journal, 31, 109–116, 2014. LINK
646. "Composite polysaccharide fibers prepared by electrospinning and coating," N. Maeda, J. Miao, T.J. Simmons, J.S. Dordick, R.J. Linhardt, Carbohydrate Polymers, 102, 950– 955, 2014. LINK
645. "New contaminant in heparin and determination by radical depolymerization and liquid chromatography-mass spectrometry," G. Li, C. Cai, L. Li, L. Fu, Y. Chang, F. Zhang, T. Toida, C. Xue, R. J. Linhardt, Analytical Chemistry, 86, 326−330, 2014. LINK
644. "High-field asymmetric-waveform ion mobility spectrometry and electron detachment dissociation of isobaric mixtures of glycosaminoglycans," M. J. Kailemia, M. Park, D.A. Kaplan, A. Venot, G.-J.Boons, L. Li, R. J. Linhardt, I. J. Amster, Journal of American Society for Mass Spectrometry, 25, 258-268, 2014. LINK
643. "Assays for determining heparan sulfate and heparin O-sulfotransferase activity and specificity," E. Sterner, L. Li, P. Paul, J. M. Beaudet, J. Liu, R. J. Linhardt, J. S. Dordick, Analytical and Bioanalytical Chemistry, 406, 525–536, 2014 LINK
642. "Congenital-diaphragmatic-hernia results from disruption of heparan sulfate-Slit3-Robo4 signaling-elicited developmental angiogenesis," B. Zhang, W. Xiao, H. Qiu, F. Zhang, H. Moniz, A. Jaworski, E. Condac, G. Gutierrez-Sanchez, C. Heiss, R. Clugston, P. Azadi, J. J. Greer, C. Bergmann, K. Moremen, D. Y. Li, R. J. Linhardt, J. D. Esko, L. Wang, Journal of Clinical Investigation, 124, 209-221, 2014. LINK
641. "Quantitation of heparosan with heparin lyase III and spectrophotometry," H. Huang, Y. Zhao, S. Lv, W. Zhong, F. Zhang，R. J. Linhardt, Analytical Biochemistry, 447, 46–48, 2014 LINK
640. "Biochemical strategies for enhancing the in vivo production of natural products with pharmaceutical potential," M. Mora-Pale, S.P. Sanchez-Rodriguez, R. J. Linhardt, J. S. Dordick, M. Koffas, Current Opinion in Biotechnology, 25, 86–94, 2014. LINK
639. "Bioengineered Chinese hamster ovary cells with Golgi-targeted 3-O-sulfotransferase-1 biosynthesize heparan sulfate with an antithrombin binding site," P. Datta, G. Li, B. Yang, X. Zhao, J.- Y. Baik, T. R. Gemmill, S. T. Sharfstein, R. J. Linhardt, Journal of Biological Chemistry, 288, 37308–37318, 2013. LINK
638. "FGF-FGFR signaling mediated through glycosaminoglycans in microtiter plate and cell-based microarray platforms," E. Sterner, L. Meli, J. S. Dordick, R. J. Linhardt, Biochemistry, 52, 9009−9019, 2013. LINK
637. "Characterization of the interaction between Robo1 and heparin/glycosaminoglycans," F. Zhang, H. A. Moniz, B. Walcott, K. W. Moremen, R. J. Linhardt, L. Wang, Biochemie, 95, 2345-2353, 2013. LINK
636. "Isoflavonoid Production by Genetically Engineered Microorganisms," B. F. Cress, R. J. Linhardt, M. A. G. Koffas, in Natural Products: Phytochemistry, Botany and Metabolism of Alkaloids, Phenolics and Terpenes, K.G. Ramawat, J.-M. Merillon (eds.), Springer Verlag, Chapter 54 pp 1647-1681, 2013. LINK
635. "Ultrasensitive detection and quantification of acidic disaccharides using capillary electrophoresis and quantum dot-based fluorescence resonance energy transfer," Y.Chang, C. Cai, L. Li, J. Miao, E. Ucakturk, G. Li, M. Ly, R.J. Linhardt, Analytical Chemistry, 85, 9356−9362, 2013 LINK
634. "Glycosaminoglycans in infectious disease," E. Kamhi, E. J. Joo, J. S. Dordick, R. J. Linhardt, Biological Reviews, 88, 928–943, 2013. LINK
633. "Expression of low endotoxin 3-O-sulfotransferase in Bacillus subtilis," W. Wang, P. Xu, J. Dordick, F. Zhang, Q. Yuan, M. Koffas, R.J. Linhardt, Applied Biochemistry and Biotechnology, 171, 954–962, 2013. LINK
632. "Characterization of Interactions between Heparin/Glycosaminoglycan and Adeno-associated Virus," F. Zhang, J.M. Beaudet, J. Aguilera, Q. Xie, T. F. Lerch, O. Davulcu, W. Colón, M. S. Chapman, R. J. Linhardt, Biochemistry, 52, 6275–6285, 2013. LINK
631. "Microanalysis of stomach cancer glycosaminoglycans," A. Weyers, B. Yang, J.-H. Park, Y.-S. Kim, S.-M. Kim, S.-E. Lee, F. Zhang, K. B. Lee, R. J. Linhardt, Glycoconjugate Journal, 30, 701–707, 2013. LINK
630. "Internal disulfide bond acts as a switch for intein activity," M.C. Nicastri, K. Xega, L. Li, J.Xie, C. Wang, R.J. Linhardt, J.N. Reitter, K. V. Mills, Biochemistry, 52, 5920–5927, 2013. LINK
629. "Structure of protein related to DAN and Cerberus (PRDC): Insights into the mechanism of BMP antagonism," K. Nolan, C. Kattamuri, D.M. Luedeke, A. Deng, A. Jagpal, F. Zhang, R. J. Linhardt, A. P. Kenny, A. M. Zorn, T. B. Thompson, Structure, 21, 1417–1429, 2013. LINK
628. "Immobilized enzymes to convert N-sulfo, N-acetyl heparosan to a critical intermediate in the production of bioengineered heparin," J. Xiong, U. Bhaskar, G. Li, L. Fu, L. Li, F. Zhang, J. S. Dordick, R. J. Linhardt, Journal of Biotechnology,167, 241– 247, 2013. LINK
627. "Effect of a variety of carbon nanotubes on the iodide-triiodide redox couple," T. J. Simmons, N. Maeda, M. Miyauchi, J. Miao, D. P. Hashim, P. M. Ajayan, J.S. Dordick, R. J. Linhardt, Carbon 62, 177–181, 2013. LINK
626. "Metabolic engineering and in vitro biosynthesis of natural and non-natural analogues of plant metabolites," M. Mora-Pale, S. P. Sanchez-Rodriguez, R. J. Linhatrdt, J. S. Dordick, M. A. G. Koffas, Plant Science, 210, 10–24, 2013. LINK
625. "N-sulfotestosteronan, a novel substrate for heparan sulfate 6-O-sulfotransferases and its analysis by oxidative degradation," G. Li, S. Masuko, D. E. Green, Y. Xu, L. Li, F. Zhang, C. Xue, J. Liu, P. L. DeAngelis, R. J. Linhardt, Biopolymers 99, 675-685, 2013 LINK
624. "Toward the chemoenzymatic synthesis of heparan sulfate oligosaccharides: Oxidative cleavage of p-nitrophenyl group with ceric ammonium salts," C. Cai, L. Li, C. Harvey, J. Liu, R.J. Linhardt, Tetrahedron Letters, 54, 4471–4474, 2013. LINK
623. "Chemoenzymatic synthesis of glycosaminoglycans: Re-creating, re-modeling, and re-designing nature’s longest or most complex carbohydrate chains," P. L. DeAngelis, J. Liu, R. J. Linhardt, Glycobiology, 23, 764–777, 2013. LINK
622. "Structural remodeling of proteoglycans on retinoic acid-induced differentiation of NCCIT cells," H. E. Stansfield, L. Gasimli, A. V. Nairn, H. Liu, J. L. Paluh, B. Yang, M. J. Saunders, J. S. Dordick, K. W. Moremen, R. J. Linhardt, Glycoconjugate Journal, 30, 497–510, 2013. LINK
621. "On-line separation and characterization of hyaluronan oligosaccharides derived from radical depolymerization," X. Zhao, B. Yang, L. Li, F. Zhang, R. J. Linhardt, Carbohydrate Polymers, 96, 503– 509, 2013. LINK
620. "Effect of eliminase gene (elmA) deletion on heparosan production and shedding in Escherichia coli K5," A. M. Hickey, U. Bhaskar, R. J. Linhardt, J. S. Dordick, Journal of Biotechnology, 165, 175–177, 2013. LINK
619. "Structurally informative tandem mass spectrometry of highly sulfated natural and chemo-enzymatically synthesized heparin and heparan sulfate glycosaminoglycans," M. J. Kailemia, L. Li, Y. Xu, J. Liu, R. J. Linhardt, I. J. Amster, Molecular and Cellular Proteomics, 12, 979-90, 2013. LINK
618. "Structural studies on the interaction of Crataeva tapia bark protein with heparin and other glycosaminoglycans," F. Zhang, B. Wacott, D. Zhou, A. Gustchina, Y. Lasanajak, D. F. Smith, R. S. Ferreira, M T. S. Correia, P. M.G. Paiva, N. V. Bovin, A. Wlodawer, M.L.V. Oliva, R. J. Linhardt, Biochemistry, 52, 2148−2156, 2013 LINK
617. "Sequence analysis and domain motifs in the decorin glycosaminoglycan chain," X. Zhao, B. Yang, K. Solakylidirim, E.-J. Joo, T. Toida, K. Higashi, R. J. Linhardt, L. Li, Journal of Biological Chemistry, 288, 9226-9237, 2013. LINK
616. "Self-assembly of carbon nanotube films from room temperature ionic liquids," T. J. Simmons, N. Maeda, J. S. Dordick, R. J. Linhardt, Carbon, 58, 226–231, 2013. LINK
615. "Structural characterization of pharmaceutical heparins prepared from different animal tissues," L. Fu, G. Li, B. Yang, A. Onishi, L. Li, P. Sun, F. Zhang, R.J. Linhardt, Journal of Pharmaceutical Science, 102, 1447-1457, 2013. LINK
614. "Neoproteoglycans in tissue engineering," A. Weyers, R. J. Linhardt, FEBS Journal, 280, 2511–2522, 2013. LINK
613. "Neutralizing the anticoagulant activity of ultra-low molecular weight heparins using N-acetylglucosamine 6-sulfatase," X. Zhou, L. Li, R. J. Linhardt, J. Liu, FEBS Journal, 280, 2523–2532, 2013. LINK
612. "Isolation of bovine corneal keratan sulfate and its growth factor and morphogen binding,"A. Weyers, B. Yang, K. Solakyildirim, V. Yee, L. Li, F. Zhang, R. J. Linhardt, FEBS Journal, 280, 2285–2293, 2013. LINK
611. "Impact of high salt diet on N-acetylgalactosamine-4-sulfatase activity, glycosaminoglycans, and kininogen in rat kidney," K. Kotlo, S. Bhattacharyya, B. Yang, S. Tejaskumar, R. J. Linhardt, R. Danziger, J. K. Tobacman, Glycoconjugate Journal, 30, 667–676, 2013. LINK
610. "High cell density cultivation of a recombinant E. coli strain expressing a key enzyme in bioengineered heparin production," O. F. Restaino, U. Bhaskar, P. Paul, L. Lin, M. De Rosa, J. S. Dordick, R. J. Linhardt, Applied Microbiology and Biotechnology, 97, 3893–3900, 2013. LINK
609. "Tunable thermo-responsive poly(N-vinylcaprolactam) cellulose nanofibers: Synthesis, characterization, and fabrication of potential affinity membranes" M. Webster, J. Miao, B. Lynch, D. Green, R. Linhardt, J. Mendenhall, Biomacromolecules, 298, 447–453, 2013. LINK
608. "An ‘omics approach towards CHO cell engineering," P. Datta, R. J. Linhardt, S. T. Sharfstein, Biotechnology and Bioengineering, 110, 1255–1271, 2013. LINK
607. "Capillary electrophoresis for the analysis of glycosaminoglycan-derived disaccharides," Y. Chang, B. Yang, A. Weyers, R. J. Linhardt, Chapter 7, In Capillary Electrophoresis of Biomolecules, Methods in Molecular Biology, 984:67-77, F. Maccari, N. Volpi eds., Humana Press, 2013. LINK
606. "Preparation and application of a “clickable” acceptor for enzymatic synthesis of heparin oligosaccharides," C. Cai, K. Edgar, J. Liu, R.J. Linhardt, Carbohydrate Research, 372, 30–34, 2013. LINK
605. "Draft Genome Sequence of Escherichia coli Strain ATCC #23506 (Serovar 1 O10:K5(L):H4)," B. F. Cress, Z.R. Greene, R. J. Linhardt, M.A.G. Koffas, Genome Announcements, 1, e00049-13, 2013. LINK
604. "Draft Genome Sequence of Escherichia coli Strain Nissle 1917 1 (Serovar O6:K5:H1)," B. F. Cress, R. J. Linhardt, M.A.G. Koffas, Genome Announcements, 1, e00047-13, 2013. LINK
603. "Draft Genome Sequence of Escherichia coli Strain ATCC #23502 (1 Serovar O5:K4(L):H4)," B. F. Cress, Z. R. Greene, R. J. Linhardt, M.A.G. Koffas, Genome Announcements, 1, e00046-13, 2013. LINK
602. "New type of sulfonated aramides nanoparticles and their copper complexes with anomalous electrical behavior: A simple method for the preparation of a microporous film-like layer," H. H. A. M. Hassan, A. F. Elhusseiny, A. M. Sweyllam, R. J. Linhardt, Journal of Applied Polymer Science, 128, 310–321, 2013. LINK
601. "Microscale separation of heparosan, heparan sulfate and heparin," X. Zhao, B. Yang, K. Linkens, P. Datta, A. Onishi, F. Zhang, R. J. Linhardt, Analytical Biochemistry, 434, 215–217, 2013. LINK
600. "Heparin oligosaccharides inhibit chemokine (C-X-C motif) ligand 12 (CXCL12) cardioprotection by binding orthogonal to the dimerization interface, promoting oligomerization, and competing with the chemokine (C-X-C motif) receptor 4 (CXCR4) amino-terminus," J. J. Ziarek, C. T. Veldkamp, F. Zhang, N.J. Murray, G. A. Kartz, X. Liang, J. Su, J. E. Baker, R. J. Linhardt, B.F. Volkman, Journal of Biological Chemistry, 288, 737–746, 2013. LINK
599. "Application of Carbon Nanotubes to Wound Healing Biotechnology," T. J. Simmons, C. J. Rivet, G. Singh, J. Beaudet, E. Sterner, D. Guzman, D. P. Hashim, S.-H. Lee, G. Qian, K. M. Lewis, R. Rosales, P. Karande, P. M. Ajayan, R. J. Gilbert, J. S. Dordick, R. J. Linhardt, Chapter 7, pp. 155-174, in Nanomaterials for Biomedicine (R. Nagarajan, ed.) ACS Symposium Series, 2012. LINK
598. "Addressing endotoxin issues in bioengineered heparin," J. Suwan, A. Torelli, A. Onishi, J. S. Dordick, R. J. Linhardt, Biotechnology and Applied Biochemistry, 59, 420-428, 2012. LINK
597. "Signal amplification by Glyco-qPCR for ultrasensitive detection of carbohydrates: Applications in glycobiology," S.-J. Kwon, K.-B. Lee, K. Solakyildirim, S. Masuko, M. Ly, F. Zhang, L. Li, J. S. Dordick, R. J. Linhardt, Angewandte Chemie, 51, 11800 –11804, 2012. LINK
596. "Top-down approach for the direct characterization of low molecular weight heparins using LC-FT-MS," L. Li, F. Zhang, J. Zaia, R. J. Linhardt, Analytical Chemistry, 84, 8822−8829, 2012. LINK
595. "Influence of a 3D microarray environment on human cell culture in drug screening systems," L. Meli, E. T. Jordan, D. Clark, R. J. Linhardt, J. S. Dordick, Biomaterials, 33, 9087-9096, 2012. LINK
594. "Molecular weight characterization for glycosaminoglycans with different degrees of sulfation by size exclusion chromatography," Z. Wang, F. Zhang, J. S. Dordick, R. J. Linhardt, Current Analytical Chemistry, , 8, 506-511, 2012. LINK
593. "Analysis of the Interaction between Heparin and Follistatin/Follistatin-ligand complexes Using Surface Plasmon Resonance" F. Zhang, J. Beaudet, D. Luedeke, R. Waker, T. Thompson, R. J. Linhardt, Biochemistry, 51, 6797−6803, 2012. LINK
592. "Functionalization of nitrogen-doped carbon nanotubes with gallium to form Ga-CN(x)-multi-wall carbon nanotube hybrid materials." T.J. Simmons, D.P. Hashim, X. Zhan, M. Bravo-Sanchez, M.G. Hahm, E. López-Luna, R.J. Linhardt, P.M. Ajayan, H. Navarro-Contreras, M.A. Vidal, Nanotechnology, 23, (325601) 1-9, 2012. LINK
591. "Hexuronic acid stereochemistry determination in chondroitin sulfate glycosaminoglycan oligosaccharides by electron detachment dissociation," F. E. Leach, M. Ly, T. N. Laremore, J. J. Wolff, J. Perlow, R. J. Linhardt, I. J. Amster, Journal of American Society of Mass Spectrometry, 23, 1488-1497, 2012. LINK
590. "Inhibitory effect of non-anticoagulant heparin (S-NACH) on pancreatic cancer cell adhesion and invasion in human umbilical cord vessel segment," T. Sudha, P. Phillips, C. Kanaan, R. J. Linhardt, L. Borsig, S.A. Mousa, Clinical & Experimental Metastasis, 29, 431-439, 2012. LINK
589. "Cell-based microscale isolation of glycoaminoglycans for glycomics study," X. Zhao, B. Yang, P. Dutta, L. Gasmili, F. Zhang, R. J. Linhardt, Journal of Carbohydrate Chemistry, 31, 420-435, 2012. LINK
588. "Towards a bioengineered heparin: challenges and strategies for metabolic engineering of mammalian cells," J.Y. Baik, C. L. Wang, B. Yang, R. J. Linhardt, S. T. Sharfstein, Bioengineered, 3, 225-229, 2012. LINK
587. "Complete mass spectral characterization of a synthetic ultralow molecular weight heparin using collision induced dissociation," M. J. Kailemia, L. Li, M. Ly, R. J. Linhardt, J. Amster, Analytical Chemistry, 84, 5475-5478, 2012. LINK
586. "Electrophoresis for the analysis of heparin purity and quality," N. Volpi, F. Maccari, R. J. Linhardt, Electrophoresis, 33, 1531-1537, 2012. LINK
585. "Analysis of glycosaminoglycan-derived disaccharides by capillary electrophoresis using laser-induced fluorescence detection," Y. Chang, B. Yang, X. Zhao, R. J. Linhardt, Analytical Biochemistry, 427, 91–98, 2012. LINK
584. "Synthetic heparin," R. J. Linhardt, J. Liu, Current Opinion in Pharmacology, 12, 217–219, 2012. LINK
583. "Effect of high aspect ratio filler on dielectric properties of polymer composites: A study on barium titanate fibers and graphene platelets," Z. Wang, J. K. Nelson, J. Miao, R.J. Linhardt, L. S. Schadler, H. Hillborg, S. Zhao, IEEE Transactions on Dielectrics and Electrical Insulation, 19, 960-967, 2012. LINK
582. "Recent advances in sulfotransferase enzyme activity assays," P. Paul, J. Liu, J. S. Dordick, R. J. Linhardt, Analytical and Bioanalytical Chemistry, 403, 1491–1500, 2012. LINK
581. "Preparation and characterization of electrospun core sheath nanofibers from multiwall carbon nanotubes and poly(vinyl pyrrolidone)," J. Miao, M. Miyauchi, J. S. Dordick, R. J. Linhardt, Journal of Nanoscience and Nanotechnology, 12, 2387-2393, 2012. LINK
580. "Exposure to common food additive carrageenan leads to reduced sulfatase activity and increase in sulfated glycosaminoglycans in human epithelial cells," B. Yang, S. Bhattacharyya, R. J. Linhardt, Tobacman, Biochemie, 94, 1309-1316, 2012. LINK
579. "Proteoglycans in stem cells," L. Gasimli, R. J. Linhardt, J. S. Dordick, Biotechnology and Applied Biochemistry, 59, 65–76, 2012. LINK
578. "Proteoglycan Sequence," L. Li, M. Ly, R. J. Linhardt, Molecular BioSystems, 8, 1613–1625, 2012. LINK
577. "Dissecting the substrate recognition of 3-O-sulfotransferase for the biosynthesis of anticoagulant heparin," A. F. Moon, Y. Xu, S. M. Woody, J. M. Krahn, R. J. Linhardt, J. Liu, L. C. Pedersen, Proceedings of the National Academy of Sciences USA, 109, 5265–5270, 2012. LINK
576. "Structure/function analysis of the Pasteurella multocida heparosan synthases: towards defining enzyme specificity and engineering novel catalysts," N. J. Otto, S. Masuko, A. Mayer, M. E. Tanner, Robert J. Linhardt, P. L. DeAngelis, Journal of Biological Chemistry, 287, 7203–7212, 2012. LINK
575. "A structural analysis of glycosaminoglycans from lethal and non-lethal breast cancer tissues: Towards a novel class of theragnostics for personalized medicine in oncology," A. Weyers, B. Yang, D. S. Yoon, J.-H. Park, F. Zhang, K. B. Lee, R. J. Linhardt, Omics, 16, 79-89, 2012. LINK
574. "Chemoenzymatic synthesis of the next generation of ultralow molecular weight heparin therapeutics, " S. Masuko, R. J. Linhardt, Future Medicinal Chemistry, 4, 289–296, 2012.. LINK
573. "Adsorption of doxorubicin on poly(methyl methacrylate)−chitosan−heparin-coated activated carbon beads," J. Miao, F. Zhang, M. Takieddin, S. Mousa, R. J. Linhardt, Langmuir, 28, 4396-403, 2012. LINK
572. "Metabolic engineering of Chinese hamster ovary cells: Towards a bioengineered heparin," J. Y. Baik, L. Gasimli, B. Yang, P. Datta, F. Zhang, C. A Glass, J. D. Esko, R.J. Linhardt, S. Sharfstein, Metabolic Engineering, 14, 81–90, 2012. LINK
571. "Intramolecular Disulfide Bond between Catalytic Cysteines in an Intein Precursor," W. Chen, L. Li, Z. Du, J. Liu, J. Reitter, K. Mills, R. J. Linhardt, C. Wang, Journal of the American Chemical Society, 134, 2500-2503, 2012. LINK
570. "Trimer hydroxylated quinone (IIIHyQ) derived from apocynin targets cysteine residues of p47phox preventing the activation of human vascular NADPH oxidase," M.Mora-Pale, S.J. Kwon, R. J. Linhardt, J. S. Dordick, Free Radical Biology and Medicine, 52, 962-969, 2012. LINK
569. "Chemoenzymatic synthesis of UDP-GlcNAc and UDP-GalNAc analogs for the preparation of unnatural glycosaminoglycans," S. Masuko, S. Bera, D. E. Green, M. Weïwer, P. L. DeAngelis, R. J. Linhardt, Journal of Organic Chemistry, 77, 1449-1456, 2012. LINK
568. "Disaccharide analysis of glycosaminoglycan mixtures by ultra-performance liquid chromatography-mass spectrometry," B. Yang, Y. Chang, A. M. Weyers, E. Sterner, R. J. Linhardt, Journal of Chromatography A,1225, 91– 98, 2012. LINK
567. "Engineering of routes to heparin and related polysaccharides," U. Bhaskar, E. Sterner, A. M. Hickey, A. Onishi, F. Zhang, J. S. Dordick, R.J. Linhardt, Applied Microbiology and Biotechnology, 93, 1–16, 2012. LINK
566. "Biophysical characterization of glycosaminoglycan-IL-7 interactions using SPR," F. Zhang, X. Liang, D. Pu, K. I. George, P. J. Holland, S. T. Walsh, R. J Linhardt, Biochemie, 94, 242-249, 2012. LINK
565. "Photochemical preparation of a novel low molecular weight heparin," K. Higashi, S. Hosoyama, A. Ohno, S. Masuko, B. Yang, E. Sterner, Z. Wang, R. J. Linhardt, T. Toida, Carbohydrate Polymers, 87, 1737-1743, 2012. LINK
564. "Semi-synthesis of chondroitin sulfate-E from chondroitin sulfate-A," C. Cai, K. Solakyildirim, B. Yang, J. M. Beaudet, A. Weyers, R. J. Linhardt, F. Zhang, Carbohydrate Polymers, 87, 822-829, 2012. LINK
563. "Binding affinities of vascular endothelial growth factor (VEGF) for heparin-derived oligosaccharides," W. Zhao, S. McCallum, Z. Xiao, F. Zhang, R. J. Linhardt, Bioscience Reports, 32, 71-81, 2012. LINK
562. "Stereoselective synthesis of a-C-sialyl compounds," J.-H. Kim, F. Huang, S. Masuko, D. Sail, R. J. Linhardt, Carbohydrate Chemistry, Proven Methods, CRC Press, Volume 1, CRC Press, Chapter 26, pp. 239-243, 2012. LINK
561. "Inhibition of human tumor xenograft growth in nude mice by a novel monoclonal anti-HSPG isolated from human liver," P. Vongchan, S. Kothan, Y. Wutti-In, N. Janejad, R.J. Linhardt, Anticancer Research, 31, 4067-4074, 2011. LINK
560. "Flexible electrospun cellulose fibers as an affinity packing material for the separation of bovine serum albumin," M. Miyauchi, J. Miao, T. J. Simmons, J. S. Dordick, R.J. Linhardt, Journal of Chromatography and Separation Techniques, 2,1-4, 2011. LINK
559. "Facile pretreatment of lignocellulosic biomass at high loadings in room temperature ionic liquids," H. Wu, J. Miao, M. Mora-Pale, T. V. Doherty, R. J. Linhardt, J. S. Dordick, Biotechnology and Bioengineering, 108, 2865-2875, 2011. LINK
558. "Electron detachment dissociation and infrared multiphoton dissociation of heparin tetrasaccharides," F. E. Leach, Z. Xiao, T. N. Laremore, R. J. Linhardt, I. J. Amster, International Journal of Mass Spectrometry, 308, 253-259, 2011. LINK
557. "Structural characterization of heparins from different commercial sources" F. Zhang, B. Yang, M. Ly, K. Solakyildirim, Z. Xiao, Z. Wang, J. M. Beaudet, A. Y. Torelli, J. S. Dordick, R. J. Linhardt, Analytical and Bioanalytical Chemistry, 401, 2793-2803, 2011. LINK
556. "Chemoenzymatic synthesis of structurally homogeneous ultra-low molecular weight heparins," Y. Xu, S. Masuko, M. Takieddin, H. Xu, R. Liu, J. Jing, S. Mousa, R. J. Linhardt, J. Liu, Science, 334, 498-501, 2011. LINK
555. "The proteoglycan bikunin has a defined sequence," M. Ly, F. E. Leach III, T. N. Laremore, T. Toida, I. J. Amster, R.J. Linhardt, Nature Chemical Biology, 7, 827-833, 2011. LINK
554. "Preparation of synthetic wood composites using ionic liquids," T.J. Simmons, S.H. Lee, J. Miao, M. Miyauchi, T.J. Park, S.S. Bale, R. Pangule, J. Bult, J.G. Martin, J.S. Dordick, R.J. Linhardt, Wood Science and Technology, 45, 719-733, 2011. LINK
553. "Response surface optimization of the heparosan N-deacetylation in producing bioengineered heparin," Z. Wang, J. Li, S. Cheong, U. Bhaskar, O. Akihiro, F. Zhang, J.S. Dordick, R.J. Linhardt, Journal of Biotechnology, 156, 188-196, 2011. LINK
552. "Lysostaphin-functionalized cellulose fibers with antistaphylococcal activity for wound healing applications," J. Miao, R. C. Pangule, E. E. Paskaleva, E. Hwang, R. S. Kane, R. J. Linhardt, J. S. Dordick, Biomaterials, 32, 9557-9567, 2011. LINK
551. "Synthesis, structural, and biological studies on a pseudodisaccharide containing a bicyclic, bridged carba-sugar," Z. Fejes, T. Kurtán, G. Raabe, J. Fleischhauer, L. Szilágyi, A. Bényei, Z. Gál, W. Zhao, R. J. Linhardt, M. Cygler, P. Herczegh, Tetrahedron: Asymmetry, 22, 1404-1410, 2011. LINK
550. "Polysaccharides and phytochemicals: a natural reservoir for the green synthesis of gold and silver nanoparticles," Y. Park, Y. N. Hong, A. Weyers, Y. S. Kim, R. J. Linhardt, IET Nanobiotechnology, 5, 69–78, 2011. LINK
549. "Comamonas testosteronan synthase, a bifunctional glycosyltransferase that produces a unique heparosan polysaccharide analog," N. J. Otto, K. Solakyildirim, R. J. Linhardt, P. L. DeAngelis, Glycobiology, 21, 1331–1340, 2011. LINK
548. "Ozonolysis of the double bond of the unsaturated uronate residue in low molecular weight heparin and K5 heparosan," S. Masuko, K. Higashi, Z. Wang, U. Bhaskar, A. M. Hickey, F. Zhang, T. Toida, J. S. Dordick, R. J. Linhardt, Carbohydrate Research, 346, 1962–1966, 2011. LINK
547. "Anti-proliferative effects of O-acyl-low-molecular-weight heparin derivatives on bovine pulmonary artery smooth muscle cells," H. G.Garg, H. Mrabat, L. Yu, C. A. Hales, B. Li, C. N. Moore, F. Zhang, R. J. Linhardt, Glycoconjugate Journal, 28, 419–426, 2011. LINK
546. "Electrospray ionization Fourier transform mass spectrometric analysis of intact bikunin glycosaminoglycan from normal human plasma," T. N. Laremore, F. E. Leach III, I. J. Amster, R. J. Linhardt, International Journal of Mass Spectrometry, 305, 109–115, 2011. LINK
545. "Controlled Photochemical Depolymerization of K5 Heparosan, a Bioengineered Heparin Precursor," K. Higashi, M. Ly, Z. Wang, S. Masuko, U. Bhaskar, E. Sterner, F. Zhang, T. Toida, J. S. Dordick, R. J. Linhardt, Carbohydrate Polymers, 86, 1365– 1370, 2011. LINK
544. "Asparagine 405 of heparin lyase II prevents the cleavage of glycosidic linkages proximate to a 3-O-sulfo glucosamine residue," W. Zhao, M.-L. Garron, B. Yang, Z. Xiao, J. D. Esko, M, Cygler, R. J. Linhardt, Febs Letters, 585, 2461–2466, 2011. LINK
543. "Electrospun polyvinylpyrrolidone fibers with high concentrations of ferromagnetic and superparamagnetic nanoparticles," M. Miyauchi, T. J. Simmons, J. Miao, Z. Shriver, U. Aich, J. S. Dordick, R. J. Linhardt, ACS Applied Materials & Interfaces, 3, 1958-1964, 2011. LINK
542. "Negative electron transfer dissociation Fourier transform mass spectrometry of glycosaminoglycan carbohydrates," F. E. Leach, J. J. Wolff, Z. Xiao, M. Ly, T. N. Laremore, S. Arungundram, K. Al-Mafraji, A. Venot, G.-J. Boons, R. J. Linhardt, I. Jonathan Amster, European Journal of Mass Spectrometry, 71, 167-176, 2011. LINK
541. "Control of the heparosan N-deacetylation leads to an improved bioengineered heparin, " Z. Wang, B. Yang, Z. Zhang, M. Ly, M. Takieddin, S. Mousa, J. Liu, J. S. Dordick, R. J. Linhardt Applied Microbiology and Biotechnology, 91, 91-99, 2011. LINK
540. "Impact of autoclave sterilization on the activity and structure of formulated heparin," J. M. Beaudet, A. Weyers, K. Solakyildirim, B. Yang, M. Takieddin, S. Mousa, F. Zhang, R. J. Linhardt, Journal of Pharmaceutical Science, 100, 3396–3404, 2011. LINK
539. "Ultraperformance ion-pairing liquid chromatography with on-line electrospray ion trap mass spectrometry for heparin disaccharide analysis," B. Yang, A. Weyers, J. Y. Baik, E. Sterner, S. Sharfstein, S. A. Mousa, F. Zhang, J. S. Dordick, R. J. Linhardt, Analytical Biochemistry, 415, 59–66, 2011. LINK
538. "Design and synthesis of unnatural heparosan and chondroitin building blocks," S. Bera, R. J. Linhardt, Journal of Organic Chemistry, 76, 3181-3189, 2011. LINK
537. "N,N,N-trimethyl chitosan nanoparticles for the delivery of monoclonal antibodies against hepatocellular carcinoma cells," P. Vongchan, Y. Wutti-In, W. Sajomsang, P. Gonil, S. Kothan, R. J. Linhardt, Carbohydrate Polymers, 85, 215-220, 2011. LINK
536. "Room Temperature Ionic Liquids as Emerging Solvents for the Pretreatment of Lignocellulosic Biomass," M. Mora-Pale, L. Meli, T. V. Doherty, R. J. Linhardt, J. S. Dordick, Biotechnology and Bioengineering, 108, 1229-1245, 2011. LINK
535. "HSulf-1 modulates FGF-2 and hypoxia mediated migration and invasion of breast cancer cells," A. Khurana, P. Liu, P. Mel1one, L. Lorenzon, B. Vincenzi, K. Datta, B. Yang, R. J. Linhardt, W. Lingle, J. Chien, A. Baldi, V. Shridhar, Cancer Research, 71, 2152-2161, 2011. LINK
534. Protein-associated water effects the removal of blood proteins from metallic substrates," G. Anand, F, Zhang, R. J. Linhardt, G. Belfort, Langmuir, 27, 1830–1836, 2011. LINK
533. "Heparin mapping using heparin lyases and the generation of a novel low molecular weight heparin," Z. Xiao, B. R. Tappen, M. Ly, W. Zhao, L. P. Canova, H. Guan, R. J. Linhardt, Journal of Medicinal Chemistry, 54, 603–610, 2011. 2011. LINK
532. "Host and pathogen glycosaminoglycan-binding proteins modulate antimicrobial peptide responses," Z. Wang, L. A. Flax, M. M. Kemp, R. J. Linhardt, M. J. Baron, Infection and Immunity, 79, 606-616, 2011. LINK
531. "E. coli K5 heparosan fermentation and improvement by genetic engineering," Z. Wang, J. S. Dordick, R. J. Linhardt, Bioengineered Bugs, 2, 1-15, 2011. LINK
530. "Conjugation of ginsenoside Rg3 with gold nanoparticles," Y. Park, A.-R. Im, E. J. Joo, J. Lee, H.-G. Park, R. J. Linhardt, Y. S. Kim, Bulletin of the Korean Chemical Society, 32, 286-290, 2011. LINK
529. "Analysis of E. coli K5 capsular polysaccharide heparosan," M. Ly, Z. Wang, T. N. Laremore, F. Zhang, W. Zhong, D. Pu, D. V. Zagorevski, J. S. Dordick, R. J. Linhardt, Analytical and Bioanalytical Chemistry, 399, 737-745, 2011. LINK
528. "Hyphenated techniques for the analysis of heparin and heparan sulfate," B. Yang, K. Solakyildirim, Y. Chang, R. J. Linhardt, Analytical and Bioanalytical Chemistry, 399, 541–557, 2011. LINK
527. "Heparinase I selectivity for the 3,6-di-O-sulfo-2-deoxy-2-sulfamido-a-D-glucopyranose (1,4) 2-O-sulfo-a-L-idopyranosyluronic acid (GlcNS3S6S-IdoA2S) linkages," Z. Xiao, W. Zhao, B. Yang, Z. Zhang, H. Guan, R. J. Linhardt, Glycobiology, 21, 13–22, 2011. LINK
526. "Analysis of glycosaminoglycans in stem cell glycomics," B. Li, H. Liu, Z. Zhang, H. Stansfield, J.S. Dordick, R.J. Linhardt, in Embryonic Stem Cell Therapy for Osteodegenerative Diseases. Nicole zur Nieden, Ed., Humana Press, Methods in Molecular Biology 690, 285-300, 2011. LINK
525. "Mass balance analysis of contaminated heparin product," Z. Liu, Z. Xiao, S. Masuko, W. Zhao, E. Sterner, V. Bansal, J. Fareed, J. S. Dordick, F. Zhang, R. J. Linhardt, Analytical Biochemistry, 408, 147-156, 2011. LINK
524. "Ionic Liquid Solvent Properties as Predictors of Lignocellulose Pretreatment Efficacy," T. V. Doherty, M. Mora-Pale, S. Foley, R. J. Linhardt, J. S. Dordick, Green Chemistry, 12, 1967-1975, 2010. LINK
523. "Preparation of biopolymer-based materials using ionic liquids for the biomedical applications," S. H. Lee, M. Miyauchi, J. S. Dordick, and R. J. Linhardt, ACS Symposium Series Ionic liquids application: Pharmaceutical, Therapeutics, and Biotechnology, Chapter 10, pp 115-134, 2010. LINK
522. "E. coli K5 fermentation and the preparation of heparosan, a bioengineered heparin precursor," Z. Wang, M. Ly, F. Zhang, W. Zhong, A. Suen, J. S. Dordick, R. J. Linhardt, Biotechnology and Bioengineering, 107, 968-977, 2010. LINK
521. "Glycosaminoglycans of the porcine central nervous system," Z. Liu, S. Masuko, K. Solakyildirim, D. Pu, R. J. Linhardt, F. Zhang, Biochemistry, 49, 9839–9847, 2010. LINK
520. "Electrospinning from room temperature ionic liquids for biopolymer fiber formation," L. Meli, J. Miao, J. S. Dordick, R, J. Linhardt, Green Chemistry, 12, 1883–1892, 2010. LINK
519. "Chemoenzymatic design of heparan sulfate oligosaccharides," R. Liu, Y. Xu, M. Chen, M. Weïwer, A. Bridges, P.L. DeAngelis, Q. Zhang, R. J. Linhardt, J. Liu, Journal of Biological Chemistry, 285, 34240-34249, 2010. LINK
518. "Domain structure elucidation of human decorin glycosaminoglycans," T. N. Laremore, M. Ly, Z. Zhang, K. Solakyildirim, S. McCallum, R. T. Owens, R. J. Linhardt, Biochemical Journal 431, 199-205, 2010. LINK
517. "Glycosaminoglycan characterization by electrospray ionization mass spectrometry including Fourier transform mass spectrometry," T. N. Laremore, F. E. Leach III, K. Solakyildirim, I. J. Amster, R. J. Linhardt, Methods in Enzymology, 478, 79-108, 2010. LINK
516. "Carrageenan-induced increase in interleukin-8 secretion is modified by pre-treatment with galactosidases and carrageenases," S. Bhattacharyya, H. Liu, Z. Zhang, M. Jam, P. K. Dudeja, G. Michel, R. J. Linhardt, J. Tobacman, Journal of Nutritional Biochemistry, 21, 906-913, 2010. LINK
515. "Conductive cable fibers with insulating surface prepared by coaxial electrospinning of multi-walled nanotubes and cellulose," M. Miyauchi, J. Miao, T. J. Simmons, J.-W. Lee, T. V. Doherty, J. S. Dordick, R. J. Linhardt, Biomacromolecules, 11, 2440–2445, 2010. LINK
514. "Proteoglycomics: Recent progress and future challenges," M. Ly, T. N. Laremore, R. J. Linhardt, Omics, 14, 389-399, 2010. LINK
513. "Identification of a novel structure in heparin generated by potassium permanganate oxidation," D. Beccati, S. Roy, F. Yu, N. S. Gunay, R. J. Linhardt I. Capila, G. Venkataraman, Carbohydrate Polymers, 82, 699–705, 2010. LINK
512. "Stereoselective Total Synthesis of (-)-Cleistenolide," C. Cai, J. Liu, Y. Du, R. J. Linhardt, Journal of Organic Chemistry, in 75, 5754–5756, 2010. LINK
511. "Induction of nucleolin translocation by acharan sulfate in A549 cells," E. J. Joo, Y. Hui, Y. Park, N. Y. Park, T. Toida, R. J. Linhardt, Y.S. Kim, Journal of Cellular Biochemistry, 110, 1272–1278, 2010. LINK
510. "Catalytic mechanism of heparinase II revealed by site-directed mutagenesis and the crystal structure with its substrate," D. Shaya, W. Zhao, M.-L. Garron, Z. Xiao, Q. Cui, Z. Zhang, T. Sulea, R. J. Linhardt, M. Cygler, Journal of Biological Chemistry, 285, 20051-20061, 2010. LINK
509. "Negative electron transfer dissociation of glycosaminoglycans," J. Wolff, F. Leach, T. Laremore, D. Kaplan, M. Easterling, R. J. Linhardt, J. Amster, Analytical Chemistry, 82, 3460-3466, 2010. LINK
508. "Partial depolymerization of pectin by photochemical reaction," J. Burana-osot, N. Soonthornchareonnon, S. Hosoyamac, R. J. Linhardt, T. Toida, Carbohydrate Research, 345, 1205–1210, 2010. LINK
507. "Artificial organelles: Digital microfluidic platform for proteoglycan and glycoprotein biosynthesis," J. G. Martin, J. M. Beaudet, J. S. Dordick, R. J. Linhardt, The World Scientific Journal, 10, 997-1000, 2010. LINK
506. "Effect of Carboxyl-Reduced Heparin on the Growth Inhibition of Bovine Pulmonary Artery Smooth Muscle Cells," H.G. Garg, H. Mrabat, L. Yu, C. Freeman, B. Li, F. Zhang, R. J. Linhardt, C. A. Hales, Carbohydrate Research, 345, 1084–1087, 2010. LINK
505. "High performance liquid chromatography-mass spectrometry for mapping and sequencing glycosaminoglycan-derived oligosaccharides," N. Volpi, R. J. Linhardt, Nature Protocols, 5, 993 - 1004, 2010. LINK
504. "Antitumor effect of butanoylated heparin with low anticoagulant activity on lung cancer growth in mice and rats," L. Yu, H. G. Garg, B. Li, R. J. Linhardt, C. A. Hales, Current Cancer Drug Targets, 10, 229-241, 2010. LINK
503. "Electrospinning of nanomaterials and applications in electronic components and devices," J. Miao, M. Miyauchi, T. J. Simmons, J. S. Dordick, R. J. Linhardt, Journal of Nanoscience and Nanotechnology, 10, 5507–5519, 2010. LINK
502. "High-resolution preparative separation of glycosaminoglycan oligosaccharides by polyacrylamide gel electrophoresis," T. N. Laremore, M. Ly, K. Solakyildirim, D.V. Zagorevski, R. J. Linhardt, Analytical Biochemistry, 401, 236–241, 2010. LINK
501. "Oversulfated chondroitin sulfate is the major contaminant in suspect heparin lots collected in February/March of 2008," M. Guerrini, Z. Shriver, A. Naggi, B. Casu, R. J. Linhardt, G. Torri, Ram Sasisekharan, Nature Biotechnology, 28, 207-211, 2010. LINK
500. "Unnatural polyketide analogs selectively target the HER2 signaling pathway in human breast cancer cells," S. J. Kwon, M. I. Kim, B. Ku, L. Coulombel, J.-H. Kim, R.J. Linhardt, and J. S. Dordick, ChemBioChem, 11, 573 – 580, 2010. LINK
499. "Glycosaminoglycans from earthworms (Eisenia andrei)," A.-R. Im, Y. Park, J.-S. Sim, Z. Zhang, Z. Liu, R. J. Linhardt, Y. S. Kim, Glycoconjugate Journal, 27, 249–257, 2010. LINK
498. "NMR quantification for monitoring heparosan K5 capsular polysaccharide production," Z. Wang, Z. Zhang, S. A. McCallum, R. J. Linhardt, Analytical Biochemistry, 398, 275–277, 2010. LINK
497. "Cellulose composites prepared using ionic liquids (ILs)-Blood compatibility to batteries," T.-J. Park , S. Murugesan, R. J. Linhardt, Kevin Edgar, Thomas Heinze, Charles Buchanan (eds.), ACS symposium Series, Polysaccharide Materials: Performance by Design, Chapter 7, pp 133-152, 2010. LINK
496. "Heparin-based nanoparticles," M. M. Kemp and R. J. Linhardt, Nanomedicine and Nanobiotechnology, 2, 77 – 87, 2010. LINK
495. "Ultraperformance liquid chromatography with electrospray ion trap mass spectrometry for chondroitin disaccharide analysis," K. Solakyildirim, Z. Zhang, R. J. Linhardt, Analytical Biochemistry, 397, 24–28, 2010. LINK
494. "Cell-Bound IL-8 Increases in Bronchial Epithelial Cells after Arylsulfatase B Silencing due to Sequestration with Chondroitin-4-Sulfate," S. Bhattacharyya, K. Solakyildirim Z. Zhang, R. J. Linhardt, J. K. Tobacman, American Journal of Respiratory Cell and Molecular Biology, 42, 51-61, 2010. LINK
493. "Studies on Glycosaminoglycans Isolated from Bivalves Molluscs Tridacna maxima and Perna viridis," M. Arumugam,T. Balasubramanian, M. Warda, R.J. Linhardt, Our Nature, 7, 10-17, 2009 LINK
492. "Glycosaminoglycans," F. Zhang, Z. Zhang, R.J. Linhardt, in Handbook of Glycomics: Glycoconjugate Structural Analysis, R.D. Cummings, M. Pierce (eds.) Academic Press/Elsevier, Chapter 3, 2009. LINK
491. "Enzymatic polymerization of phenols in room-temperature ionic liquids," B. Eker, D. Zagorevski, G. Zhu, R.J. Linhardt, J.S. Dordick, Journal of Molecular Catalysis B: Enzymatic, 59, 177–184, 2009. LINK
490. "Chloroquine reduces arylsulfatase B Activity and increases chondroitin 4-sulfate: Implications for mechanisms of action and resistance of chloroquine," S. Bhattacharyya, K. Solakyildirim, Z. Zhang, R. J. Linhardt, J. K. Tobacman, Malaria Journal, 8, 303, 2009. LINK
489. "Structural snapshots of heparin depolymerization by heparin lyase I," Y.-H. Han, M.-L. Garron, H.-Y. Kim, W.-S. Kim, Z. Zhang, K.-S. Ryu, D. Shaya, Z. Xiao, C. Cheong, Y.-S. Kim, R. J. Linhardt, Y. H. Jeon, M. Cygler, Journal of Biological Chemistry, 284, 34019–34027, 2009. LINK
488. "Recent progress and applications in glycosaminoglycan and heparin research," T. N. Laremore, F. Zhang, J. S. Dordick, J. Liu, R. J. Linhardt, Current Opinions in Chemical Biology, 13, 633–640, 2009. LINK
487. "Gold and silver nanoparticles conjugated with heparin-derivative possess anti-angiogenesis properties," M. M. Kemp, A. Kumar, S. Mousa, E. Dyskin, M. Yalcin, P. Ajayan, R. J. Linhardt, S.A. Mousa, Nanotechnology, 20, 455104, 2009. LINK
486. "Orthogonal analytical approaches to detect potential contaminants in heparin," M. Guerrini, Z. Zhang, Z. Shriver, S. Masuko, R. Langer, B. Casu, R. J. Linhardt, G. Torri, R. Sasisekharan, Proceedings of the National Academy of Sciences USA, 106, 16956–16961, 2009. LINK
485. " Control of promatrilysin (MMP7) activation and substrate-specific activity by sulfated glycosaminoglycans," H-J Ra, S. Harju-Baker, F. Zhang, R. J. Linhardt, C. L. Wilson, W. C. Parks, Journal of Biological Chemistry, 284, 27924-27932, 2009. LINK
484. "Analysis of pharmaceutical heparins and potential contaminants using 1H-NMR and PAGE," Z. Zhang, B. Li, J. Suwan, F. Zhang, Z. Wang, H. Liu, B. Mulloy, R. J. Linhardt, Journal of Pharmaceutical Science, 98, 4017-4026, 2009. LINK
483. "Photolytic depolymerization of alginate," J. Burana-osot, S. Hosoyama, Y. Nagamoto, S. Suzuki, R. J. Linhardt, T. Toida, Carbohydrate Research, 344, 2023–2027, 2009. LINK
482. "Changes in cultured endothelial cell glycosaminoglycans under hyperglycemic conditions and the effect of insulin and heparin," J. Han, F. Zhang, J. Xie, R. J. Linhardt and L. M. Hiebert, Cardiovascular Diabetology, 8, 46-58, 2009. LINK
481. "Compositional analysis of heparin/heparan sulfate interacting with fibroblast growth factor•fibroblast growth factor receptor complexes," F. Zhang, Z. Zhang, X. Lin, A. Beenken, A. V. Eliseenkova, M. Mohammadi, R. J. Linhardt, Biochemistry, 48, 8379–8386, 2009. LINK
480. "Towards an artificial Golgi: Redesigning the biological activities of heparan sulfate on a digital microfluidic chip," J. G. Martin, M. Gupta, Y. Xu, S. Akella, J. Liu, J. S. Dordick, R. J. Linhardt, Journal of the American Chemical Society, 131, 11041–11048, 2009. LINK
479. "Inhibition of human vascular NADPH oxidase by apocynin derived oligophenols," M. Mora-Pale, M. Weïwer, J. Yu, R.J. Linhardt, J.S. Dordick, Bioorganic Chemistry and Medicinal Chemistry, 17, 5146–5152, 2009. LINK
478. "Novel interactions of glycosaminoglycans and bacterial glycolipids mediate binding of enterococci to human cells," I. G. Sava, F. Zhang, I. Toma, C. Theilacker, B. Li, T. F. Baumert, O. Holst, R. J. Linhardt, J. Huebner, Journal of Biological Chemistry, 284, 18194 - 18201, 2009. LINK
477. "Sequence analysis of native oligosaccharides using negative ESI tandem MS," Z. Zhang, R. J. Linhardt, Current Analytical Chemistry, 5, 225-237, 2009. LINK
476. "Hyaluronan and Heparin Reduced Silver Nanoparticles Having Antimicrobial Properties," M. M. Kemp, A. Kumar, D. Clement, P. Ajayan, S. Mousa, R. J. Linhardt, Nanomedicine, 4, 421-429, 2009. LINK
475. "Sulfonation of papain treated chitosan and its mechanism for anticoagulant activity," J. Suwan, Z. Zhang, B. Li, P. Vongchan, P. Meepowpan, F. Zhang, S.A. Mousa, S. Mousa, B. Premanode, P. Kongtawelert, R. J. Linhardt, Carbohydrate Research, 344, 1190–1196, 2009. LINK
474. "Thin Layer Chromatography for the Separation and Analysis of Acidic Carbohydrates," Z. Zhang, Z. Xiao, R.J. Linhardt, Journal of Liquid Chromatography & Related Technologies, 32, 1711–1732, 2009. LINK
473. "Quantitification of Heparan Sulfate and Heparin Disaccharides Using Ion-pairing, Reverse-Phase, Micro-flow, High Performance Liquid Chromatography Coupled with Electrospray Ionization Trap Mass Spectrometry," Z. Zhang, J. Xie, H. Liu, J. Liu, R. J. Linhardt, Analytical Chemistry, 81, 4349–4355, 2009. LINK
472. "Oversulfated chondroitin sulfate interaction with heparin-binding proteins: New insights into adverse reactions from contaminated heparins," B. Li, J.Suwan, J.G. Martin, F. Zhang, Z. Zhang, D. Hoppensteadt, M. Clark, J. Fareed, R.J. Linhardt, Biochemical Pharmacology, 78, 292–300, 2009. LINK
471. "Synthesis and biological evaluation of 1,2,3-triazole linked sialic acid derivatives as neuraminidase inhibitors," M. Weïwer, C.-C. Chen, M. M. Kemp, R. J. Linhardt, European Journal of Organic Chemistry, 2611–2620, 2009. LINK
470. "Non-covalent functionalization as an alternative to oxidative acid treatment of single wall carbon nanotubes," T. J. Simmons, J. Bult, D. P. Hashim, R. J. Linhardt, P.M. Ajayan, ACS Nano, 3, 865-870, 2009. LINK
469. "Solvolytic depolymerization of chondroitin and dermatan sulfates," T. Toida, K. Sato, N. Sakamoto, S. Sakai, S. Hosoyama, R. J. Linhardt, Carbohydrate Research, 344, 888-893, 2009. LINK
468. "Antiseptic single wall carbon nanotube bandages", T.J. Simmons, S.-H. Lee, T.-J. Park, D.P. Hashim, P.M. Ajayan, R.J. Linhardt, Carbon, 47, 1561-1564, 2009. LINK
467. "Quantitative capillary electrophoresis determination of oversulfated chondroitin sulfate as a contaminant in heparin preparations," N. Volpi, F. Maccari, R. J. Linhardt, Analytical Biochemistry, 388, 140-145, 2009. LINK
466. "Synthesis of Gold and Silver Nanoparticles Stabilized with Glycosaminoglycans having Distinctive Biological Activities," M. M. Kemp, A. Kumar, S. Mousa, T.-J, Park, N. Kubotera, S. Mousa, P. Ajayan, R. J. Linhardt, Biomacromolecules, 10, 589–595, 2009. LINK
465. "Green glycosylation using ionic liquid to prepare alkyl glycosides for studying carbohydrate-protein interactions by SPR," F. J. Muñoz, J. Pérez, S. André, H.-J. Gabius, J. V. Sinisterra, M. J. Hernáiz, and R. J. Linhardt, Green Chemistry, 11, 373-379, 2009. LINK
464. "Lessons learned from the contamination of heparin," H. Liu, Z. Zhang, R.J. Linhardt, Natural Product Reports, 26, 313–321, 2009. LINK
463. "Structural Characterization of Glycosaminoglycans from Zebrafish in Different Ages," F. Zhang, Z. Zhang, R. Thistle, L. McKeen, S. Hosoyama, T. Toida, R. J. Linhardt, P. Page-McCaw, Glycoconjugate Journal, 26, 211-218, 2009. LINK
462. "Ionic liquid-mediated selective extraction of lignin from wood leading to enhanced enzymatic cellulose hydrolysis," S.-H. Lee, T. V. Doherty, R. J. Linhardt, J. S. Dordick, Biotechnology and Bioengineering, 102, 1368-1376, 2009. LINK
461. "Electron Capture Dissociation, Electron Detachment Dissociation, and Infrared Multiphoton Dissociation of Sucrose Octasulfate," J. J.Wolff, T. N.Laremore, F. E.Leach, R. J. Linhardt, I. Amster, European Journal of Mass Spectrometry, 15, 275–281, 2009. LINK
460. "Biological profile of hyper/oversulfated chondroitin sulfate contaminant isolated from recalled heparin," J. Fareed, J.M. Walenga, W. Jeske, D. Hoppensteadt, M. Prechel, O. Iqbal, C. Adiuzel, M. Clark, E. Latinas, J. Cunanan, R. J. Linhardt, J Harenberg, Seminars in Thrombosis and Hemostasis, 34, 119-127, 2008. LINK
459. "Liquid Chromatography-Mass Spectrometry to Study Chondroitin Lyase Action Pattern," Z. Zhang, Y. Park, M. M. Kemp, W. Zhao, A.-R. Im, D. Shaya, M. Cygler, Y. S. Kim, R. J. Linhardt, Analytical Biochemistry, 385, 57-64, 2008. LINK
458. "Stereoselective Synthesis of a C-linked Neuraminic Acid Disaccharide: Potential Building Block for the Synthesis of C-Analogs of Polysialic Acids," J.-H. Kim, F. Huang, M. Ly, R. J. Linhardt, Journal of Organic Chemistry, 73, 9497–9500, 2008. LINK
457. "Significance of 2-O-Sulfonate Group of L-Iduronic Acid Residues in Heparin on the Growth Inhibition of Bovine Pulmonary Artery Smooth Muscle Cells," H. G.Garg, H. Mrabat, L. Yu, C. Freeman, B. Li, F. Zhang, R. J. Linhardt, C. A. Hales, Carbohydrate Research, 343, 2406-2410, 2008. LINK
456. "Variation of Acharan Sulfate and Monosaccharide Composition and Analysis of Neutral N-Glycans in African Giant Snail (Acatina fulica)." Y. Park, Z. Zhang, T. N. Laremore, B. Li, J.-S. Sim, A.-R. Im, M. Y. Ahn, Y. S. Kim, R.J. Linhardt Glycoconjugate Journal, 25, 863-877, 2008. LINK
455. "Synthesis of Floridoside," M. Weïwer, T. Sherwood, R. J. Linhardt, Journal of Carbohydrate Chemistry, 27, 420 - 427, 2008. LINK
454. "Glycosaminoglycan Binding Proteins," J. D. Esko, R.J. Linhardt, In Essentials of Glycobiology, A. Varki, Ed., Cold Spring Harbor Laboratory, Chapter 35, Second Edition, 2008. LINK
453. "Synthesis of Uridine 5’-Diphosphoiduronic Acid: A Potential Substrate for the Chemoenzymatic Synthesis of Heparin," M.Weïwer, T. Sherwood, Dixy E. Green, M. Chen, P. L. DeAngelis, J. Liu, R. J. Linhardt, Journal of Organic Chemistry, 73, 7631-7637, 2008. LINK
452. "Biocompatible Activated Charcoal Composites For Drug Detoxification Prepared Using Room Temperature Ionic Liquids," T.-J. Park,a J. G. Martin, T. J. Simmons, S. Mousa, E. A. Snezhkova, V. V. Sarnatskaya, V. G. Nikolaev, R. J. Linhardt, Chemical Communications, 5022-5024, 2008. LINK
451. "Mass spectrometry for the characterization of unsulfated chondroitin oligosaccharides from 2-mers to 16-mers. Comparison with hyaluronic acid oligomers," N. Volpi, Z. Zhang, R. J. Linhardt, Rapid Communications in Mass Spectrometry, 22, 3526-3530, 2008. LINK
450. "Human Follicular Fluid Heparan Sulfate Contain Abundant 3-O-Sufated Chains with Anticoagulant Activity," A. I. de Agostini, J.-C. Dong, C. de Vantéry Arrighi, M.-A. Ramus, I. Dentand-Quadri, S. Thalmann, P. Ventura, V. Ibecheole, F. Monge,A.-M. Fischer, S. HajMohammadi, N. W. Shworak, L. Zhang, Z. Zhang, R. J. Linhardt, Journal of Biological Chemistry, 283, 28115-28124, 2008. LINK
449. "Evaluation of the Experimental Parameters which Control Electron Detachment Dissociation, and their Effect on the Fragmentation Efficiency of Glycosaminolgycan Carbohydrates," F. E. Leach III, J. J. Wolff, T. N. Laremore, R. J. Linhardt, I. J. Amster, International Journal of Mass Spectrometry, 276,110-115, 2008. LINK
448. "Signal Amplification of Target Protein on Heparin Glycan Microarray," T.-J. Park, M.-Y. Lee, J. S. Dordick, R. J. Linhardt, Analytical Biochemistry, 383, 116–121, 2008. LINK
447. "Solution Structures of Chemoenzymatically Synthesized Heparin and its Precursors," Z. Zhang, S. A. McCallum, J. Xie, L. Nieto, F. Corzana, J. Jiménez-Barbero, M. Chen, J. Liu, R. J. Linhardt, Journal of the American Chemical Society, 130, 12998-13007, 2008. LINK
446. "Electron Induced Dissociation of Glycosaminoglycan Tetrasaccharides," J. J. Wolff, T. N. Laremore, H. Aslam, R. J. Linhardt, I. J. Amster, Journal of the American Society of Mass Spectrometry, 19, 1449-1458, 2008. LINK
445. "Oversulfated Chondroitin Sulfate: Impact of a Heparin Impurity, Associated with Adverse Clinical Events, on Low Molecular Weight Heparin Preparation," Z. Zhang, M. Weïwer, B. Li, M. M. Kemp, T. H. Daman, R. J. Linhardt Journal of Medicinal Chemistry, 51, 5498-5501, 2008. LINK
444. "Pharmacological Applications of Biocompatible Carbon Nanotubes and their Emerging Toxicology Issues," T.-J. Park, J. G. Martin, R. J. Linhardt, In Medicinal Chemistry and Pharmacological Potential of Fullerenes and Carbon Nanotubes, Franco Cataldo and Tatiana Da Ros (Eds.), Springer Vol. 1, Capter 12, pp 283-316, Topics in Carbon Materials Chemistry and Physics, 2008. LINK
443. "Modification of solid phase red cell adherence assay for the detection of platelet alloantibodies in patients with thrombocytopenia, " P. Vongchan, W. Nawarawong, R. J. Linhardt, American Journal of Clinical Pathology, 130, 455-66, 2008. LINK
442. "Distinct Heparan Sulfate Compositions in Wild-Type and Pipe-Mutant Eggshell Matrix," Y. Park, Z. Zhang, R.J. Linhardt, E. K. LeMosy, Fly, 2, 1-5, 2008. LINK
441. . "The Role of the Methoxyphenol Apocynin, a Vascular NADPH Oxidase Inhibitor, as a Chemopreventative Agent in the Potential Treatment of Cardiovascular Diseases," J. Yu, M. Weiwer, R. J. Linhardt, J. S. Dordick, Current Vascular Pharmacology, 6, 204-217, 2008. LINK
440. "Capillary Electrophoresis of Complex Natural Polysaccharides, " N. Volpi, F. Maccari, R. J. Linhardt, Electrophoresis, 29, 3095–3106, 2008. LINK
439. "Physiological, Pathophysiological and Therapeutic Roles of Heparin/Heparan Sulfate," J. Xie, S. Murugesan, R. J. Linhardt, in Carbohydrate Chemistry, Biology and Medical Applications. Garg, H.G., Cowman, M.K., Hales, C.A., eds., , Chapter 10, 227-251, Elsevier, Oxford , UK, 2008. LINK
438. "The Effects of Culture Conditions on the Glycosylation of Secreted Human Placental Alkaline Phosphatase Produced in Chinese Hamster Ovary Cells," J. H. Nam, F. Zhang, M. Ermonval, R. J. Linhardt, S. T. Sharfstein, Biotechnology and Bioengineering, 100, 1178-1192, 2008. LINK
437. "Oversulfated Chondroitin Sulfate is a major contaminant in Heparin associated with Adverse Clinical Events," M. Guerrini, D. Beccati, Z. Shriver, A. M. Naggi, A. Bisio, I. Capila, J. Lansing, S. Guglieri, B. Fraser, A. Al-Hakim, S. Gunay, K. Viswanathan, Z. Zhang, L. Robinson, G. Venkataraman, L. Buhse, M. Nasr, J. Woodcock, R. Langer, R. Linhardt, B. Casu, G. Torri, R. Sasisekharan, Nature Biotechnology, 26, 669-775, 2008. LINK
436. "Is Human Placenta Proteoglycan Remodeling Involved in Pre-Eclampsia?" M. Warda, F. Zhang, M. Radwan, Z. Zhang, N. Kim, Y.N. Kim, R. J. Linhardt, J. Han, Glycoconjugate Journal, 25, 441–450, 2008. LINK
435. "Influence of charge state and sodium cationization on the electron detachment dissociation and infrared multiphoton dissociation of glycosaminoglycan oligosaccharides," J. J. Wolff, T. N. Laremore, A. M. Busch, R. J. Linhardt, I. J. Amster, Journal of the American Society Mass Spectrometry, 19, 790-798, 2008. LINK
434. "Using a 3-O-Sulfated Heparan Sulfate Octasaccharide to Inhibit the Entry of Herpes Simplex Virus 1", R. Copeland, A. Balasubramaniam, V. Tiwari, F. Zhang, A. Bridges, R. J. Linhardt, D. Shukla, J. Liu, Biochemistry, 47, 5774–5783, 2008. LINK
433. "Toll-like Receptor 4 Mediates Induction of Inflammatory Pathway by Food Additive Carrageenan," S. Bhattacharyya, R. Gill, M. L. Chen, F. Zhang, R. J. Linhardt, P. K. Dudeja, J. K. Tobacman, Journal of Biological Chemistry, 283, 10550-10558, 2008. LINK
432. "Structural Analysis of Bikunin Glycosaminoglycan," L. Chi, J. J. Wolff, T. N. Laremore, O. F. Restaino, J. Xie, C. Schiraldi, T. Toida, I. J. Amster, R. J. Linhardt, Journal of the American Chemical Society, 130, 2617-2625, 2008. LINK
431. "Electron Detachment Dissociation of Dermatan Sulfate Oligosaccharides," J. J. Wolff, T. N. Laremore, A. M. Busch, R. J. Linhardt, I. Jonathan Amster, Journal of American Society of Mass Spectrometry, 19, 294-304, 2008. LINK
430. "Synthesis and Evaluation of Anticancer Vaccine Candidate, C-Glycoside Analogs of sTn and PSA," M. Weïwer, F. Huang, C.-C. Chen, X. Yuan, K. Tokuzaki, H. Tomiyama, R. J. Linhardt, Chemical Glycobiology II: Glycopharmaceuticals and Glycovaccines, X. Chen, R. L. Halcomb, p. G. Wang, Eds., ACS Press, Chap. 10, pp. 175-195, 2008. LINK
429. "Conformational Analysis of a Dermatan Sulfate - Derived Tetrasaccharide by NMR, Molecular Modeling and Residual Dipolar Couplings," A. Silipo, Z. Zhang, F. J. Cañada, A. Molinaro, R. J. Linhardt, J. Jiménez-Barbero, ChemBiochem, 9, 240-252, 2008. LINK
428. "Tandem MS Can Distinguish Hyaluronic Acid from N-Acetylheparosan," Z. Zhang, J. Xie, J. Liu, R. J. Linhardt, Journal of American Society of Mass Spectrometry, 19, 82-89, 2008. LINK
427. "Immobilization of Heparin-Approaches and Applications," S. Murugesan, J. Xie, R. J. Linhardt, Current Topics in Medicinal Chemistry, 8, 80-100, 2008. LINK
426. "Pharmacokinetics and Pharmacodynamics of Oral Heparin Solid Dosage Form in Healthy Human Subjects," S. A. Mousa, F. Zhang, A. Aljada, S. Chaturvedi, M. Takieddin, H. Zhang, L. Chi, E. Arbit, M. C. Castelli, M.M. Goldberg, R. J. Linhardt, Journal of Clinical Pharmacology, 47, 1508-1520, 2007. LINK
425. "Enzyme-Carbon Nanotube Conjugates in Room Temperature Ionic Liquids," B. Eker, P. Asuri, S. Murugesan, R. J. Linhardt, J. S. Dordick, Applied Biochemistry and Biotechnology, 143, 153-163, 2007. LINK
424. "Glycomics of Proteoglycan Biosynthesis in Murine Embryonic Stem Cell Differentiation," A. V. Nairn, A. Kinoshita-Toyoda, H. Toyoda, J. Xie, K. Harris, S. Dalton, M. Kulik, J. M. Pierce, T. Toida, K. W. Moremen, R. J. Linhardt, Journal of Proteome Research 6, 4374-4387, 2007. LINK
423. "Synthesis of Glycosaminoglycans and their Oligosaccharides," M. Weiwer, R. J. Linhardt, in Comprehensive Glycosciences, G. J. Boons, Y. C. Lee, A. Suzuki, N. Taniguchi, A. G. J. Voragen, J.P. Kamerling (eds.) Elsevier BV, Amsterdam, The Netherlands, Chap 1.18, 713-745, 2007. LINK
422. "Binding Between the Integrin aXß2 (CD11c/CD18) and Heparin," T. Vorup-Jensen, L. Chi, L. C. Gjelstrup, U. B. Jensen, C. A. Jewett, C. Xie, M. Shimaoka, R. J. Linhardt, T. A. Springer, Journal of Biological Chemistry, 282, 30869-30877, 2007. LINK
421. "Thin Layer Chromatography for the Analysis of Glycosaminoglycan Oligosaccharides," Z. Zhang, J. Xie, F. Zhang, R. J. Linhardt, Analytical Biochemistry, 371, 118–120, 2007. LINK
420. "Combinatorial Enzymatic Synthesis of Heparan Sulfate, " J.-H. Kim, R. J. Linhardt, Chemistry & Biology, 14, 972-973, 2007. LINK
419. "Mosquito Heparan Sulfate and its Potential Role in Malaria Infection and Transmission," P. Sinnis, A. Coppi, T. Toida, H. Toyoda, A. Kinoshita-Toyoda, J. Xie M.M. Kemp, R. J. Linhardt, Journal of Biological Chemistry, 282, 25376-25384, 2007. LINK
418. "Flexible Nanocomposite Thin Film Energy Storage Devices," V. L Pushparaj, S. M. Manikoth, A. Kumar, S. Murugesan, L. Ci, R. Vajtai, R. J. Linhardt, O. Nalamasu, P. M. Ajayan, Proceedings of the National Academy of Science USA 104, 13574-13577, 2007. LINK
417. "Enzymatic Synthesis of Glycosaminoglycan Heparin," R. J. Linhardt, J. S. Dordick, P. L. DeAngelis, J. Liu, Seminars in Thrombosis and Hemostasis, 33, 453-465, 2007. LINK
416. "MALDI-TOFMS Analysis of Hyaluronan Oligosaccharides," S. Sakai, K. Hirano, H. Toyoda, R. J. Linhardt, T. Toida, Analytica Chimica Acta, 593, 207-213, 2007. LINK
415. "Heparin Oligosaccharides as Potential Therapeutic Agents in Senile Dementia," Q. Ma, U. Cornelli, I. Hanin, J. M. Lee, W. P. Jeske, R. J. Linhardt, J. M. Walenga, J. Fareed, Current Pharmaceutical Design, 13, 1607-1616, 2007. LINK
414. "Facile Synthesis of (±)-Paeonilide," Y. Du, J Liu, R. J. Linhardt, Journal of Organic Chemistry, 72, 3952-3954, 2007. LINK
413. "Molecular Insights into the Klotho-Dependent, Endocrine Mode of Action of FGF19 Subfamily Members," R. Goetz, A. Beenken, O. A. Ibrahimi, J. Kalinina, S. K. Olsen, A. V. Eliseenkova, C. F. Xu, T. Neubert, F. Zhang, R. J. Linhardt, X. Yu, K. E. White, T. Inagaki, S. A. Kliewer, M. Yamamoto, H. Kurosu, Y. Ogawa, M. Kuro-o, B. Lanske, M. S. Razzaque, M. Mohammadi, Molecular and Cellular Biology, 27, 3417-3428, 2007. LINK
412. "Synthesis of nor-C-linked neuraminic acid disaccharide: A versatile precursor of C-analogs of oligosialic acids and gangliosides," X. Yuan, D. K. Ress, R. J. Linhardt, Journal of Organic Chemistry, 72, 3085-3088, 2007. LINK
411. "Kinetic and Structural Studies on Interactions between Heparin/Heparan Sulfate and Proteins of the Hedgehog Signaling Pathway," F. Zhang, J. S. McLellan, A. M. A. Jiménez, D. J. Leahy, R. J. Linhardt, Biochemistry, 46, 3933-3941, 2007. LINK
410. "Enzymatic Synthesis of Glycosaminoglycans: Improving on Nature," F.Y. Avci, P.L. DeAngelis, J. Liu, R.J. Linhardt, in Frontiers in Carbohydrate Chemistry, ACS Symposium Series 960, A. Demchenko, Ed., Chapter 15, pp 253-284, 2007, Oxford University Press, London. LINK
409. "Distinguishing Glucuronic from Iduronic Acid in Glycosaminoglycan Tetrasaccharides by Using Electron Detachment Dissociation," J. J. Wolff, L. Chi, R. J. Linhardt, I. J. Amster, Analytical Chemistry, 79, 2015-2022, 2007. LINK
408. "Carbon Inhibits VEGF and FGF Promoted Angiogenesis," S. Murugesan, S. A. Mousa, L. J. O’Connor, D.W. Lincoln, R. J. Linhardt, FEBS Letters, 581, 1157-1160, 2007. LINK
407. "Molecular Weight Dependent Tissue Factor Pathway Inhibitor Release by Heparin and Heparin Oligosaccharides," Q. Ma, M. Tobu, C. Schultz, W. Jeske, D. Hoppensteadt, J. Walenga, U. Cornelli, J. Lee, R. Linhardt, I. Hanin, J. Fareed, Thrombosis Research, 119, 653-661, 2007. LINK
406. "Improved Matrix-Assisted Laser Desorption/Ionization Mass Spectrometric Detection of Glycosaminoglycan Disaccharides as Cesium Salts," T.N. Laremore, R.J. Linhardt, Rapid Communications in Mass Spectrometry, 21, 1315-1320, 2007. LINK
405. "Investigation of the Binding Mechanism between Internalin B and Heparin using Surface Plasmon Resonance," S. Lang, M. M. Kemp, E. M. Muñoz, O. Azizad, M. Banerjee, J. Kumaran, P. Ghosh, R. J. Linhardt, Biochemistry, 46, 2697 -2706, 2007. LINK
404. "New Ionic Liquid Matrix for Direct UV-MALDI-TOF-MS Analysis of Dermatan Sulfate and Chondroitin Sulfate Oligosaccharides," T.N. Laremore, F. Zhang, R. J. Linhardt, Analytical Chemistry, 79, 1604-1610, 2007. LINK
403. "Conducting Organic-Inorganic Submicron Rods Based on Ionic Liquids," A. Kumar, S. Murugesan, V. L. Pushparaj, C. Soldano, J. Xie, G. John, O. Nalamasu, P. M. Ajayan, R. J. Linhardt, Small, 3, 429-433, 2007. LINK
402. "Synthesis of Tin (II) Phosphate Open Frameworks Using Isomers of 1, 2-Diaminocyclohexane as Template," X. Yuan, Y. Xu, X. You, R. J. Linhardt, European Journal of Inorganic Chemistry, 858-864, 2007. LINK
401. "Quantitative Continuous Assay for Hyaluronan Synthase," J. C. Krupa, D. Shaya, L. Chi, R.J. Linhardt, M. Cygler, S. G. Withers, J. S. Mort, Analytical Biochemistry, 361, 218-225, 2007. LINK
400. "Electron Detachment Dissociation of Glycosaminoglycan Tetrasaccharides," J. J. Wolff, L. Chi, R. J. Linhardt, I. J. Amster, Journal of the American Society of Mass Spectrometry, 18, 234-244, 2007. LINK
399. "Expression of human liver HSPGs on myeloid leukemia," P. Vongchan, R. J. Linhardt, Clinical Immunology, 122, 194–206, 2007. LINK
398. "Glycosylation in Room Temperature Ionic Liquid using Unprotected and Unactivated Donors," T.-J. Park, M. Weiwer, X. Yuan, S. N. Baytas, E. M. Munoz, S. Murugesan, R. J. Linhardt, Carbohydrate Research, 342, 614-620, 2007. LINK
397. "Acceptor Specificity of the Pasteurella Hyaluronan and Chondroitin Synthases and Production of Chimeric Glycosaminoglycans," B. S. Tracy, F. Y. Avci, Robert J. Linhardt, and P. L. DeAngelis, Journal of Biological Chemistry, 282, 337–344, 2007. LINK
396. "Qualitative and Quantitative Determination of Ten Major Saponins in Platycodi Radix by High Performance Liquid Chromatography with Evaporative Light Scattering Detection and Mass Spectrometry," Y. W. Ha, Y.-C. Na, J.-J. Seo, S.-N. Kim, R. J. Linhardt, Y. S. Kim, Journal of Chromatography A, 1135, 27-35, 2006. LINK
395. "The First Total Synthesis of Sporiolide A," Y. Du, Q. Chen, R. J. Linhardt, Journal of Organic Chemistry, 71, 8446-8451, 2006. LINK
394. "Synthesis of Silica – Gold Nanocomposites and their Porous Nanoparticles by In – Situ Approach," A. Kumar, V. L. Pushparaj, S. Murugesan, G. Viswanathan, R. J. Linhardt, O. Nalamasu and P. M. Ajayan, Langmuir, 22, 8631-8634, 2006. LINK
393. "Anti-metastatic effect of non-anticoagulant low molecular weight heparin versus standard low molecular weight heparin, enoxaparain," S. A. Mousa, R. J. Linhardt, J. L. Francis, A. Amirkhosravi, Thrombosis and Haemostasis, 96, 816-821, 2006. LINK
392. "Ionic Liquid Derived Blood Compatible Composite Membranes For Kidney Dialysis," S. Murugesan, S. Mousa, A. Vijayaraghavan, P. M. Ajayan and R. J. Linhardt, Journal of Biomedical Materials Research: Part B - Applied Biomaterials, 79B, 298-304, 2006. LINK
391. "Crystallographic Analysis of Calcium-Dependent Heparin Binding to Annexin A2," C. Shao, F. Zhang, M. Kemp, R. J. Linhardt, J. F. Head, B, A. Seaton, Journal of Biological Chemistry, 281, 31689–31695, 2006. LINK
390. "Viral and Cellular Determinants of Hepatitis C Virus Envelope-Heparan Sulfate Interaction," H. Barth, E. K. Schnober, F. Zhang, R. J. Linhardt, E. Depla, B. Boson, F.-L. Cosset, A. Patel, H. E. Blum, T. F. Baumert, Journal of Virology, 80, 10579-10590, 2006. LINK
389. "Increase in the Growth Inhibition of Bovine Pulmonary Artery Smooth Muscle Cells by an O-Hexanoyl Low Molecular Weight Heparin Derivative," H. G. Garg, N. Cindhuchao, C. A. Hales, M. Butler, T. Islam, R. J. Linhardt, Carbohydrate Research, 341, 2607–2612, 2006. LINK
388. "Synthetic Oligosaccharide Stimulates and Stabilizes Angiogenesis: Structure-Function Relationships and Potential Mechanisms," S.A. Mousa, X. Feng, J. Xie, Y. Du, Y. Hua, H. He, L. O’Connor, R. J. Linhardt, The Journal of Cardiovascular Pharmacology, 48, 6-14, 2006. LINK
387. "Synthetic Sugars Point Towards Chemical Glycomics: Commentary," J. E. Turnbull, R. J. Linhardt, Nature Chemical Biology, 2, 449-450, 2006. LINK
386. "Chondroitin Sulfate Intake Inhibits the IgE-Mediated Allergic Response by Down Regulating Th2 Responses in Mice," S. Sakai, H. Akiyama, Y. Sato, Y. Yoshioka, R. J. Linhardt, Y. Goda, T. Maitani, T. Toida, Journal of Biological Chemistry, 281, 19872 - 19880, 2006. LINK
385. "CS Lyases: Structure, Activity and Applications in Analysis and the Treatment of Diseases, R.J. Linhardt," F.Y. Avci, T. Toida, Y.S. Kim, M. Cygler, Chondroitin Sulfate Structure, Role and Pharmacological Activity-Advances in Pharmacology, N. Volpi Ed., Elsevier, Chapter 9, 2006.
384. "Immunological Activity of Chondroitin Sulfate," T. Toida, S. Sakai, H. Akiyama, R. J. Linhardt, Chondroitin Sulfate Structure, Role and Pharmacological Activity-Advances in Pharmacology, N. Volpi Ed., Elsevier, Chapter 19, 2006. LINK
383. "Affinity, kinetic and structural study of the interaction of 3-O-sulfotransferase isoform 1 with heparan sulfate," E. Mu“oz, D. Xu, J. Liu, R. J. Linhardt, Biochemistry, 45, 5122-5118, 2006. LINK
382. "In Vivo Antithrombotic Synergy of Oral Heparin and Arginine: Endothelial Thromboresistance Without Systemic Anticoagulation," B. Daniels, R.J. Linhardt, F. Zhang, W. Mao, S. Wice, L. Hiebert, Thrombosis and Haemostasis, 95, 865-873, 2006. LINK
381. "Preparation and Structural Determination of Large Oligosaccharides Derived from Acharan Sulfate," L. Chi, E. M. Munoz, H. S. Choi, Y. W. Ha, Y. S. Kim, T. Toida, R. J. Linhardt, Carbohydrate Research, 341 864–869, 2006. LINK
380. "Nano-based Neoproteoglycans – Blood Compatible Carbon Nanotubes," S. Murugesan, T. Park, H. Yang, S. Mousa and R. J. Linhardt, Langmuir, 22,3461-3463, 2006. LINK
379. "Isolation and Characterization of Heparan Sulfate from Various Murine Tissues," M. Warda, T. Toida, F. Zhang, P. Sun, E. Munoz, R. J. Linhardt, Glycoconjugate Journal, 23, 553-561, 2006. LINK
378. "Microscale Isolation and Analysis of Heparin from Plasma using an Anion Exchange Spin Column," F. Zhang, P. Sun, E. Mu“oz, L.Chi, S. Sakai, T. Toida, H. Zhang, S. Mousa R. J. Linhardt, Analytical Biochemistry, 353, 284–286, 2006. LINK
377. "Preparation of Biopolymer Fibers Using Electrospinning from Room Temperature Ionic Liquids," G. Viswanathan, S. Murugesan, V. Pushparaj, O. Nalamasu, P. M. Ajayan and R. J. Linhardt, Biomacromolecules, 7, 415-418, 2006. LINK
376. "Matrix-Assisted Laser Desorption/Ionization Mass Spectrometric Analysis of Uncomplexed Highly Sulfated Oligosaccharides using Ionic Liquid Matrices. T.N. Laremore, S. Murugesan," T.-J. Park, F.Y. Avci, D. V. Zagorevski, R. J. Linhardt, Analytical Chemistry, 78, 1774-1779, 2006. LINK
375. "Heparin Accelerates Gelsolin Amyloidogenesis," J. Y. Suk, F. Zhang, W. E. Balch, R. J. Linhardt, J. W. Kelly, Biochemistry, 45, 2234-2242, 2006. LINK
374. "Structural Basis by which Alternative Splicing Modulates the Organizer Activity of FGF8 in the Brain," S. K. Olsen, J. Y. H. Li, C. Bromleigh, A. V. Eliseenkova, O. A. Ibrahimi, Z. Lao, F. Zhang, R. J. Linhardt, A. L. Joyner, Moosa Mohammadi, Genes and Development, 20, 185-198, 2006. LINK
373. "Benzoate-Based Room Temperature Ionic Liquids – Thermal Properties and Glycosaminoglycan Dissolution," S. Murugesan, J. M. Wiencek, R.X. Ren R.J. Linhardt, Carbohydrate Polymers,, 63, 268-271, 2006. LINK
372. "Stereoselective Synthesis of Cytotoxic Anhydrophytosphingosine Pachastrissamine (Jaspine B) from D-Xylose," Y. Du, J, Liu, R.J. Linhardt, Journal of Organic Chemistry, 71, 1251-1253, 2006. LINK
371. "Dromedary glycosaminoglycans: Molecular Characterization of Camel Lung and Liver Heparan Sulfate," M. Warda, R.J. Linhardt, Comparative Biochemistry and Physiology B, 143,37-43, 2006. LINK
370. "Enzymatic Synthesis of Heparin Related Polysaccharides on Sensor Chips: Rapid Screening of Heparin-Protein Interactions," E. Muñoz, D. Xu, F. Avci, M. Kemp, J. Liu, R. J. Linhardt, Biochemical and Biophysical Research Communications , 339, 597-602, 2006. LINK
369. "HClO4-SiO2 Catalyzed Glycosylation using Sugar Trichloroacetimidates as Glycosyl Donors," Y. Du, G. Wei, S. Cheng, Y. Hua, R. J. Linhardt, Tetrahedron Letters, 47, 307-310, 2006. LINK
368. "Enzymatic Redesigning of Biological Active Heparan Sulfate," J. Chen, F.Y. Avci, E. M. Muñoz, L. M. McDowell, M. Chen, L. C. Pedersen, L. Zhang, R. J. Linhardt, J. Liu, Journal of Biological Chemistry, 280, 42817-42825, 2005. LINK
367. "Chemistry and Biology of Heparin and Heparan Sulfate," H. G. Garg, R. J. Linhardt, C. A. Hales (Eds.), Elsevier Ltd., Oxford, 2005. (Google book link) LINK
366. "Influence of Heparin Chemical Modifications on Its Antiproliferative Properties," H. G. Garg, R. J. Linhardt, C. A. Hales, in the Chemistry and Biology of Heparin and Heparan Sulfate, Elsevier Ltd., Oxford, H. G. Garg, R. J. Linhardt, and C. A. Hales (Eds.), Chapter 18, pp 513-532, 2005. LINK
365. "Regulation Activity of Heparin in Complement System H.Yu, R.E. Edens, R. J. Linhardt," inin the Chemistry and Biology of Heparin and Heparan Sulfate, Elsevier Ltd., Oxford, H. G. Garg, R. J. Linhardt, and C. A. Hales (Eds.), Chapter 11, pp.313-343, 2005. LINK
364. "Recent Advances in the Synthesis of C-oligosaccharides, " X. Yuan, R. J. Linhardt, Current Topics in Medicinal Chemistry, 5, 1393-430, 2005. LINK
363. "Analysis of the Biochemical Mechanisms for the Endocrine Actions of FGF23," X. Yu, O. A. Ibrahimi, F. Zhang, S. I. Davis, H. J. Garringer, R. J. Linhardt, D. M. Ornitz, M. Mohammadi, K. E. White, Endocrinology, 146, 4647-4656, 2005. LINK
362. "Kinetic Studies on the Interaction of Heparin and Complement Proteins using Surface Plasmon Resonance," H. Yu, E.M. Muñoz, F. Zhang, R.E. Edens, R.J. Linhardt, Biochemica Biophysica Acta, Biochemica Biophysica Acta, 1726, 168-176, 2005. LINK
361. "Synthesis of Double C-Glycoside Analog of sTn," D.R. Ress, S.N. Baytas, H Tomiyama, E.M. Muñoz, R.J. Linhardt, Journal of Organic Chemistry, 70, 8197-8200, 2005. LINK
360. "Preparation of hyaluronan O-methylester and its enzymatic degradation," K. Hirano , S. Sakai, T. Ishikawa, F.Y. Avci, R. J. Linhardt, T. Toida, Carbohydrate Research, 340, 2297-2304, 2005. LINK
359. "Mass Spectrometry for the Analysis of Highly Charged Sulfated Carbohydrates," L. Chi, J. Amster, R.J. Linhardt, Current Analytical Chemistry,1, 223-240, 2005. LINK
358. "Poly(ethylene glycol)-Based Biosensor Chip to Study Heparin Protein Interactions," E.M. Muñoz, H. Yu, J. Hallock, R.E. Edens, R.J. Linhardt, 343, 176-178, 2005. Analytical Biochemistry, 343, 176-178, 2005. LINK
357. "Characterization of Heparan Sulfate from the Unossified Antler of Cervus elaphus, " Y. W. Ha, B. T. Jeon, S. H. Moon, H. Toyoda, T. Toida, R. J. Linhardt, Y. S. Kim, Carbohydrate Research, 340, 411-416, 2005. LINK
356. "Analysis Of Mutations in FGF and a Pathogenic Mutation in FGFR Provide Direct Evidence in Support of the Two-End Model for FGFR Dimerization," O.A. Ibrahimi, B.K. Yeh, A.V. Eliseenkova, F. Zhang, S.K. Olsen, M. Igarashi, S.A. Aaronson, R.J. Linhardt, M. Mohammadi, Molecular and Cell Biology, 25, 671-684, 2005. LINK
355. "Quantitative Analysis of Chondroitin Sulfate in Raw Materials, Ophthalmic Solutions, Soft Capsules and Liquid Preparations," J.-S. Sim, T. Toida, S. Y. Cho, D. W. Choi, S.-Y. Chang, R. J. Linhardt, Y. S. Kim, Journal of Chromatography B, 818, 133-139, 2005. LINK
354. "Ionic Liquids In Carbohydrate Chemistry – Current Trends And Future Directions," S. Murugesan, R. J. Linhardt, Current Organic Synthesis, 2, 437-451, 2005. LINK
353. "Structural Characterization of Human Liver Heparan Sulfate," P. Vongchan, M. Warda, H. Toyoda, T. Toida, R. M. Marks, R. J. Linhardt, Biochemica Biophysica Acta, 1721, 1-8, 2005. LINK
352. "Nucleolin: Acharan Sulfate-Binding Protein on the Surface of Cancer Cells," E. J. Joo, T. Toida, R. J. Linhardt, Y. S. Kim, Glycobiology, 15, 1-9, 2005. LINK
351. "Samarium Iodide-Mediated Synthesis of Neuraminic Acid C-Clycosides," C.-C. Chen, D. K. Ress, R. J. Linhardt, In Syntheses of Glycomimetics, R. Roy, Ed., ACS Symposium Series, 896, 53-80, 2004. (Fulltext in PDF format) LINK
350. "Synthetic and Natural Polysaccharides with Anticoagulant Properties," F. Zhang, P.G. Yoder, R.J. Linhardt, in Polysaccharides: Structural Diversity and Functional Versatility, 2nd Edition, S. Dumitriu, Ed., Marcel Dekker, New York, 773-794, 2004. LINK
349. "Structural Analysis of the Sulfotransferase (3-OST-3) Involved in the Biosynthesis of an Entry Receptor for Herpes Simplex Virus 1," A.F. Moon, S.C. Edavettal, J.M. Krahn, E.M. Munoz, M. Negishi, R.J. Linhardt, J. Liu, L.C. Pedersen, Journal of Biological Chemistry, 279, 45185-45193, 2004. LINK
348. "Metabolic alteration of the N-glycan structure of a protein from patients with a heterozygous protein deficiency," F. Zhang, A. D. Bries, S. C. Lang, Q. Wang, D. W. Murhammer, J. M. Weiler, R. J. Linhardt, Biochimica Biophysica Acta, 1739, 43-49, 2004. LINK
347. "Biochemical analysis of pathogenic ligand-dependent FGFR2 mutations suggests distinct pathophysiological mechanisms for craniofacial and limb abnormalities in human skeletal disorders," O. A. Ibrahimi, F. Zhang, A. V. Eliseenkova, N. Itoh, R. J. Linhardt, M. Mohammadi, Human Molecular Genetics, 13, 2313-2324, 2004. LINK
346. "New Potent Insecticidal Agent: 4’-Fucosyl Avermectin Derivative," G. Wei, Y. Du R.J. Linhardt, Tetrahedron Letters, 45, 6895-6898, 2004. LINK
345. "Solid-Phase Chemoenzymatic Synthesis of Neuraminic Acid Based C-glycosides," S.N. Baytas, Q. Wang, N.A. Karst, R.J. Linhardt, Journal of Organic Chemistry, 69, 6900-6903, 2004. LINK
344. "Chondroitin Sulfate Structure Impacts its Immunological Effects on Murine Splenocytes Sensitized with Ovalbumin," H. Akiyama, S. Sakai, R. J. Linhardt, Y. Goda, T. Toida, T. Maitani, Biochemical Journal, 382, 269-278 2004. LINK
343. "Facile Synthesis of Saponins Containing 2,3-Branched Oligosaccharides by Using Partially Protected Glycosyl Donors," G. Gu, Y. Du, R. J. Linhardt, Journal of Organic Chemistry, 69, 5497-5500, 2004. LINK
342. "Heparin Binding Domains in Vascular Biology," E. M. Munoz, R. J. Linhardt, Arteriosclerosis, Thrombosis and Vascular Biology, 24, 1549-1557, 2004. LINK
341. "Role of Glycosaminoglycans in Cellular Communication," R. J. Linhardt, T. Toida, Accounts of Chemical Research, 37, 431-438, 2004. LINK
340. "Previews: Heparin-Induced Cancer Cell Death," R. J. Linhardt, Chemistry & Biology, 11, 420-422, 2004. LINK
339. "Trifluoroethylsulfonate Protected Monosaccharides in Glycosylation Reactions," N. A. Karst, T. F. Islam, F. Avci, R. J. Linhardt, Tetrahedron Letters, 45, 6433-6437, 2004. LINK
338. "The structure of chondroitin B lyase complexed with glycosaminoglycan fragments unravels calcium-dependent catalytic machinery," G. Michel, Y. Li, T. Sulea, R. J. Linhardt, M. Cygler, Journal of Biological Chemistry, 279, 32882-32896, 2004. LINK
337. "Crystal Structure and Mutational Analysis of Heparan Sulfate 3-O-Sulfotransferase Isoform 1," S. Thorp, K.A. Lee, M. Negishi, R.J. Linhardt, J. Liu, L.C. Pedersen, Journal of Biological Chemistry, 279, 25789-25797, 2004. LINK
336. "Studies on the effect of calcium in interactions between heparin and heparin cofactor II using surface plasmon resonance," F. Zhang, Y. Wu, Q. Ma, D. Hoppensteadt, J. Fareed, R. J. Linhardt, Clinical and Applied Thrombosis/Hemostasis, 10, 249-257, 2004. LINK
335. "A Kinetic Model for FGF, FGFR and Proteoglycan Signal Transduction Complex Assembly," O. A. Ibrahimi, F. Zhang, S. C. Lang Hrstka, M. Mohammadi, R. J. Linhardt, Biochemistry, 43,4724-4730, 2004. LINK
334. "Long Duration of Anticoagulant Activity and Protective Effects of Acharan Sulfate in Vivo," D.-W. Li, I. S. Lee, J.-S. Sim, T. Toida, R. J. Linhardt, Y. S. Kim, Thrombosis Research, 113,67-73, 2004. LINK
333. "Combinatorial Carbohydrate Synthesis" S. N. Baytas, R. J. Linhardt, Mini-Reviews in Organic Chemistry, 1,27-39, 2004. LINK
332. "Structural Determinants Of Heparan Sulfate Interactions With Slit Proteins," F. Zhang, F. Ronca, R.J. Linhardt, R.U. Margolis, Biochemical Biophysical Research Communications, 317, 352-357, 2004. LINK
331. "Total Synthesis of Quercetin 3-Sophorotrioside," Y. Du, G. Wei, R. J. Linhardt, Journal of Organic Chemistry, 69, 2206-2209, 2004. LINK
330. "A Glycosaminoglycan Recognition Element of Lymphotactin Essential for In Vivo Chemokine Activity," F. C. Peterson, E. S. Elgin, T. J. Nelson, F. Zhang, T. J. Hoeger, R. J. Linhardt, B. F. Volkman, Journal of Biological Chemistry, 279, 12598-12604, 2004. LINK
329. "High Resolution Crystal Structure of Arthrobacter aurescens Chondroitinase AC Complexed with Chondroitin Sulfate Defines the Catalytic Mechanism," V. V. Lunin, Y. Li, R.J. Linhardt, H. Miyazono, M. Kyogashima, M. Cygler, Journal of Molecular Biology, 337, 367-386, 2004. LINK
328. "Isolation and Characterization of Raw Heparin from Dromedary Intestine: Evaluation of a New Source of Pharmaceutical Heparin," M. Warda, E. M. Gouda, T. Toida, L. Chi, R. J. Linhardt, Comparative Biochemistry and Physiology Part C, 136 357-365, 2004. LINK
327. "Sialic Acid Donors: Chemical Synthesis and Glycosylation," D. K. Ress, R. J. Linhardt, Current Organic Synthesis, 1, 31-46, 2004. LINK
326. "Insights Into the Molecular Basis for FGF Receptor Autoinhibition and Ligand Binding Promiscuity," S. K. Olsen, O. A. Ibrahimi, A. Raucci, F. Zhang, A. V. Eliseenkova, A. Yayon, C. Basilico, R. J. Linhardt, J. Schlessinger, M. Mohammadi, Proceedings of the National Academy of Sciences USA, 101, 935-940, 2004. LINK
325. "Proline to Arginine Mutations in FGF Receptors 1 and 3 Result in Pfeiffer and Muenke Craniosyntosis Syndromes Through the Enhancement of FGF Binding Affinity," O.A. Ibrahimi, F. Zhang, A. V. Eliseenkova, R. J. Linhardt, M. Mohammadi Human and Molecular Genetics, 13, 69-78, 2004. LINK
324. "LC/MS Sequencing of Highly Sulfated Heparin-Derived Oligosaccharides" C. Thanawiroon, K. G. Rice, T. Toida, R.J. Linhardt, Journal of Biological Chemistry, 279, 2608-2615 2004. LINK
323. "Enhancement of Heparin an Heparin Disaccharide Absorption by the Phytolacca Americana Saponins," S. Y. Cho, J.-S. Sim, C.-S. Jeong, S. S. Kang, R. J. Linhardt, Y. S. Kim, Archives of Pharmacal Research, 26, 1102-1108, 2003. LINK
322. "Engineering Interferon-Alpha for Targeted Delivery," S. C. L. Hrstka, P. Yoder, J. M. Weiler, and R. J. Linhardt, Proceedings of the Conference on Advances in Structure, Function and Stability in Pharmaceuticals and Biologics II, AIChE Meeting, November 16-21, 2003, Omnipress, Madison, WI. LINK
321. "Sulfo-Protected Hexosamine Monosaccharides: Potentially Versatile Building Blocks for Glycosaminoglycan Synthesis," N. Karst, T. F. Islam, R. J. Linhardt, Organic Letters, 5, 4839-4842, 2003. LINK
320. "Synthesis of Saponins Using Partially Protected Glycosyl Donors," Y. Du, G. Gu, G. Wei, Y. Hua, R. J. Linhardt, Organic Letters, 5, 3627-3630, 2003. LINK
319. "The First Total Synthesis of Calabricoside A," Y. Du, G. Wei, R. J. Linhardt, Tetrahedron Letters, 44, 6887-6890, 2003. LINK
318. "Sulfation Patterns in Heparin and Heparan Sulfate: Effects on the Proliferation of Bovine Pulmonary Artery Smooth Muscle Cells," H. G. Garg, L. Yu, C.A. Hales, T. Toida, T. Islam, R. J. Linhardt, Biochimical Biophysical Acta, 1639, 225-231, 2003. LINK
317. "Molecular Mechanism of Host Specificity in Plasmodium Falciparum Infection: Role of Circumsporozoite Protein," D. Rathore, S. C. L. Hrstka, J. B. Sacci, P. de la Vega, R.J. Linhardt, S. Kumar, T.F. McCutchan, Journal of Biological Chemistry, 278, 40905 – 40910, 2003. LINK
316. "Cellular Binding of Hepatitis C Virus Envelope Glycoprotein E2 Requires Cell Surface Heparan Sulfate," H. Barth, C. Schäfer, M.I. Adah, F. Zhang, R.J. Linhardt, H. Toyoda, A. Kinoshita-Toyoda, T. Toida, T. H. van Kuppevelt, E. Depla, F. von Weizsäcker, H.E. Blum, T.F. Baumert, Journal of Biological Chemistry, 278, 41003 – 41012, 2003. LINK
315. "Chondroitin O-Methyl Ester: An Unusual Substrate for Chondroitin AC Lyase, "F.Y. Avci, T. Toida, R. J. Linhardt, Carbohydrate Research, 338, 2101-2104, 2003. LINK
314. "Synthetic Oligosaccharides as Heparin-Mimetics Displaying Anticoagulant Properties," F. Y. Avci, N. A. Karst, R. J. Linhardt, Current Pharmaceutical Design, 9, 2323-2335, 2003. LINK
313. "CE Separation of Heparin-Delivered Oligosaccharides Under Conditions Amenable MS Detection," N.S. Gunay, R.J. Linhardt, Journal of Chromatography, 1014, 225-233, 2003. LINK
312. "Dialkyl Imidazolium Benzoates-- Room Temperature Ionic Liquids Useful in the Peracetylation and Perbenzoylation of Simple and Sulfated Saccharides," S. Murugesan, N. Karst, T. Islam, J.M. Wiencek, R.J. Linhardt, Synlett, 9, 1283-1286, 2003. LINK
311. "Chemistry, Biochemistry and Pharmaceutical Potential of Glycosaminoglycans and Related Saccharides," T. Islam, R.J. Linhardt, in Carbohydrate-Based Drug Discovery, C.H. Wong, Ed. Wiley-VCH Press, Weinheim, Germany, Chapter 15, pp. 407-439, 2003. LINK
310. "Seperation of a Complex Mixture of of Heparin-Derived Oligosaccharides Using Reveresed-Phase High Performance Liquid Chromatography," C. Thanawiroon, R.J. Linhardt, Journal of Chromatography, 114, 215-233, 2003. LINK
309. "Recent Chemical and Enzymatic Approaches to the Synthesis of Glycosaminoglycan Oligosaccharides," N.A. Karst, R.J. Linhardt, Current Medicinal Chemistry, 10, 1993-2031, 2003. LINK
308. "Structure and Bioactivity of Sulfated Polysaccharides," T. Toida, R.J. Linhardt, Trends in Glycosciences and Glycotechnology, 15, 29-46, 2003. LINK
307. "Distribution of N-Acetylneuraminic Acid and Sialylglycan in Eggs in Silky Fowl," M. Koketsu, E. Sakuragawa, R. J. Linhardt, H. Ishihara, British Journal of Poultry Science, 44, 145-148, 2003. LINK
306. "Perspective: 2003 Claude S. Hudson Award Address in Carbohydrate Chemistry. Heparin: Structure and Activity," R. J. Linhardt, Journal of Medicinal Chemistry, 46, 2551-2554, 2003. LINK
305. "Evaluation of Counter-Ions for Electrospray Ionization Mass Spectral Analysis of Highly Sulfated Carbohydrates," N.S. Gunay, K. Tadano-Aritomi, T. Toida, I. Ishizuka, R.J. Linhardt, Analytical Chemistry, 75, 3226-3231, 2003. LINK
304. "Synthesis of a C-Glycoside Analog of sTn: an HIV and Tumor Associated Antigen," B. Kuberan, S.A. Sikkandar, H. Tomiyama, R.J. Linhardt, Angewandte Chemie, Intl.ed., 42, 2073-2074, 2003. (Full Text in PDF format) LINK
303. "Suppression of Tumor Growth by a New Glycosaminoglycan Isolated from African Giant Snail Achatina fulica," Y.S. Lee, K.H. Shin, D.K. Oh, R.J. Linhardt, Y.S. Kim, European Journal of Pharmocology, 465, 191-198, 2003. LINK
302. "Synthesis of Serine-Based Neuraminic Acid C-Glycoside," Q. Wang, R.J. Linhardt, Journal of Organic Chemistry, 68, 2668-2672, 2003. LINK
301. "Chemoenzymatic Synthesis of Neuraminic Acid Containing C-Glycoside Polymers," Q. Wang, J.S. Dordick, R.J. Linhardt, Orgainic Letters, 5, 1187-1189, 2003. LINK
300. "Zinc Triflate-Benzoyl Bromide: A Versatile Reagent for the Conversion of Ether into Benzoate Protecting Groups and Ether Glycosides into Glycosyl Bromides," T. Polat, R. J. Linhardt, Carbohydrate Research, 338, 447-449, 2003. LINK
299. "Turkey Intestines as a Commercial Source of Heparin? Comparative Structural Studeis of Intestinal Avian and Mammalian Glycosaminoglycans," M. Warda, W. Mao, T. Toida, R.J. Linhardt, Comparative Biochemistry and Physiology B, 134, 189-197, 2003. LINK
298. "Heparin as a Potential Therapeutic Agent to Reverse Vascular Remodeling," H. Garg, B.T. Thompson, R.J. Linhardt, C.A. Hales, Proteoglycans and Lung Disease, H.G. Garg, P.J. Roughley, C.A. Hales (Eds.), Chapter 18, 377-398, 2003. LINK
297. "Characterization of Glycosaminoglycans by Capillary Electrophoresis," R.J. Linhardt, T. Toida, in Capillary Electrophoresis of Oligosaccharides and Complex Carbohydrates, S. Honda, P. Thibault, Eds. Humana Press, Totawa, NJ, 133-146, 2002. LINK
296. "Ultra-High Resolution Separation Comes of Age", R.J. Linhardt, T. Toida, Science, 298, 1141-1142, 2002. LINK
295. "Synthesis of Sulfosucrose Derivatives for Evaluation as Regulators of Fibroblast Growth Factor Activity," T. Polat, M. Mohammadi, R.J. Linhardt, Tetrahedron Letters, 43, 8047-8049, 2002. LINK
294. "Conductivity Detection for Molecular Mass Estimation of Per-O-Sulfonated Glycosaminoglycans Seperated by High-Performance Size Exclusion Chromatography," A. Chaidedgumjorn, A. Suzuki, H. Toyoda, T. Toida, T. Imanari and R.J. Linhardt, Journal of Chromatography A, 959, 95-102. 2002. LINK
293. "LaPSvS1 and its Anti-Angiogenic and Anti-inflammatory Effects Obtained in Various CAM-Assays," J. Bürgermeister, D.H. Paper, H. Vogl, R.J. Linhardt, G. Franz , Carbohydrate Research, 337, 1459-1466, 2002. LINK
292. "Preparation and anticoagulant activity of phosphosulfomannan PI-88", G. Yu, N.S Gunay, R.J Linhardt, T. Toida, J. Fareed, D.A. Hoppensteadt, H. Shadid, V. Ferro, C. Li, K. Fewings, M.C. Palermo, D. Podger, European Journal of Medicinal Chemistry, 37, 783-791, 2002. LINK
291. "Analysis of glycosaminoglycans and glycosaminoglycan-derived oligosaccharides by polyacrylamide gel electrophoresis", W. Mao, C. Thanawiroon, R.J. Linhardt,, in:Analytical Chemistry:Analytical Techniques to Evaluate the Structure and Function of Natural Polysaccharides, Glycosaminoglycans, N. Volgi (Ed.), Research signpost, Kerala, India, 53-78, 2002. LINK
290. "Characterization of Polysaccharide Interactions," C. Thanawiroon, W.J. Mao, R.J. Linhardt in Affinity Capillary Electrophoresis in Pharamaceuticals and Biopharmaceuticals, R. Neubert ed., Marcel Dekker, New York,, Chap. II, pp 265-3001, 2002. (full text in PDF format) LINK
289. "Identification of the Capsular Polysaccharides of Type D and F Pasteurella multocida as Unmodified Heparin and Chondroitin, Respectively. " P. L. DeAngelis, N. S. Gunay, T. Toida, W.-J. Mao, and R. J. Linhardt, Carbohydrate Research, 337, 1547-1552, 2002. LINK
288. "Characterization of Heparin Binding by a Peptide from Amyloid P Component Using Capillary Electrophoresis, Surface Plasmon Resonance, and Isothermal Titration Calorimetry," M.J. Hernaiz, L.A. LeBrun, Y. Wu, J.W. Sen, R.J. Linhardt, N.H.H. Heegaard, European Journal of Biochemistry, 269, 2860-2867. 2002. LINK
287. "Further evidence that periodate cleavage of heparin occurs primarily through the antithrombin binding site," T. Islam, M. Butler, S. A. Sikkander, T. Toida and R. J. Linhardt, Carbohydrate Research, 337, 2239-2243, 2002. LINK
286. "Patents related to Dengue Virus Infection," M. Warda, R. M. Marks. R. J. Linhardt, Expert Opinions on Therapeutic Patents, Expert Opinion, 12(8), 1127-1143, 2002. . LINK
285. "Heparin Oligosaccharide Sequence and Size Essential for Inhibition of Pulmonary Artery Smooth Muscle Cell Proliferation," H.G. Garg, N. Cindhuchao, C. A. Hales, C. Thanawiroon, I. Capila, R. J. Linhardt, Carbohydrate Research, 337, 2359-2364, 2002. LINK
284. "Structural Basis for Activation of Fibroblast Growth Factor Signaling by Sucrose Octasulfate", B.K. Yeh, A.V. Eliseenkova, A.N. Plotnikov, D. Green, J. Pinnell, T. Polat, A. Gritli-Linde, R.J. Linhardt, M. Mohammadi, Molecular and Cellular Biology, 22, 7184-7192, 2002. LINK
283. "Characterization of a Heparan Sulfate Octasaccharide that Binds to Herpes Simplex Viral Type 1 Glycoprotein D," J. Liu, Z. Shriver, R.M. Pope, S.C. Thorp, C.S. Raska, K. Yoshida, R.J. Eisenberg, G. Cohen, R.J. Linhardt, R. Sasisekharan, Journal of Biological Chemistry, 277,33456-33467. 2002. LINK
282. "Synthesis and Application of Carbohydrate-Containing Polymers," Q. Wang, J. S. Dordick, R. J. Linhardt, Chemistry of Materials, 14, 3232-3244, 2002. LINK
281. "A Highly Stable Covalent Conjugated Heparin Biochip for Heparin-Protein Interactions Studies," F. Zhang, M. Fath, R. Marks, R.J. Linhardt, Analytical Biochemistry, 304, 271-273, 2002. LINK
280. "Inhibition of Apolipoprotein E- Related Neurotoxicity by Glycosaminoglycans and their Oligosaccharides," H.G. Bazin, M.A. Marques, A.P. Owens, R.J. Linhardt, K.A. Krutcher, Biochemistry, 41, 8203-8211, 2002. LINK
279. "Role of Arginine 292 in the Catalytic Activity of Chondroitin AC Lyase from Flavobacterium heparinum," I. Capila, Y. Wu, D.W. Rethwisch, A. Matte, M. Cygler, R.J. Linhardt, Biochimica et Biophysica Acta, 1597, 260-270, 2002. LINK
278. "Enzyme Kinetics and Glycan Structural Characterization of Secreted Alkaline Phosphatase Prepared Using the Baculovirus Expression Vector System," F. Zhang, D.W. Murhammer, R.J. Linhardt, Applied Biochemistry and Biotechnology, 101, 197-210, 2002. LINK
277. "Tissue Distribution [14 C] Sucrose Octasulfate Following Oral Administration to Rats," L.M. Hiebert, S.M. Wice, T. Ping, R.E. Hileman, T. Polat, R.J. Linhardt, Pharmaceutical Research, 19, 838-844, 2002. LINK
276. "Molecular and biochemical profiling of a heparin-derived oligosaccharide, C3" Q. Ma, B. Dudas, A. Daud, O. Iqbal, D. Hoppensteadt, W. Jeske, U. Cornelli, J. Lee, S. Lorens, R. Mervis, I. Hanin, I. Capila, R. Linhardt, J. Fareed, Thrombosis Research, 105, 303-309, 2002. LINK
275. "Human Single Chain Antibodies Against Heparin: Selection, Characterization and Effect on Coagulation, " E.M.A. van de Westerlo, T.F.C.M. Smetsers, M.A.B.A. Dennissen, R.J. Linhardt, J.H. Veerkamp, G.N.P. van Muijen, T.H. van Kuppevelt, Blood, 99, 2427-2433, 2002. LINK
274. "Enhancement of Paracellular Transport of Heparin Disaccharide Across Caco-2 Cell Monolayers, " S. Y. Cho, J. S. Kim, H. Li, C. Shim, R. J. Linhardt, Y. S. Kim, Archives Pharmacal Research, 25, 86-92 2002. LINK
273. "Structural Studies on k-Carrageenan Derived Oligosaccharides," G. Yu, H. Guan, A.S. Ioanoviciu, S.A. Sikkander, C. Thanawiroon, J. K.Tobacman, T. Toida, R. J. Linhardt. Carbohydrate Research, 337, 433-440, 2002. LINK
272. "Determination of the Composition of the Oligosaccharide Phosphate Fraction of Pichia holstii NRRL Y-2448 Phosphomannan by Capillary Electrophoresis and HPLC," V. Ferro, C. Li, K. Fewings, M.C. Palermo, D. Podger, R.J. Linhardt, T. Toida, Carbohydrate Research, 337, 139-146, 2002. LINK
271. "Capillary Electrophoresis for the Analysis of Glycosaminoglycans and Glycosaminoglycan-Derived Oligosaccharides," W.J. Mao, C. Thanawiroon, R.J. Linhardt, Biomedical Chromatography, 16, 77-94, 2002. LINK
270. "Pretreatment Procedure for the Microdetermination of Chondroitin Sulfate in Plasma and Urine," S. Sakai, J. Onose, H. Nakamura, H. Toyoda, T. Toida, Toshio Imanari, R. J. Linhardt, Analytical Biochemistry, 302, 169-174, 2002. LINK
269. "Purification and Characterization of Heparan Sulfate Peptidoglycans from Bovine Liver," M.J. Hernáiz, H.O. Yang, N.S. Gunay, R.J. Linhardt, Carbohydrate Polymers, 48, 153-160, 2002. LINK
268. "Preparation of Bovine Lung Heparin Oligosaccharides," G. Yu, Q. Wang , G. Huashi, X. Jiamin, R. J. Linhardt, Journal of the Ocean University of Qingdao, 32, 231-235, 2002. LINK
267. "Heparin-Protein Interactions," I. Capila, R.J. Linhardt, Angewandte Chemie Int. Ed., 41, 390-412, 2002; Angewandte Chemie, 114, 426-450, 2002. (Full text in PDF format English) (Full text in PDF format German) LINK
266. "The Effect of Dissolved Oxygen (DO) Concentration on the Glycosylation of Recombinant Protein Produced by the Insect Cell-Baculovirus System," F. Zhang, M.A. Saarinen, L.J. Itle, S.C. Lang, D.W. Murhammer, R.J. Linhardt, Biotechnology & Bioengineering, 77, 219-224, 2002. LINK
265. "Esterase Mediated Regioselective Deacetylation of Ulosonic Acids," B. Kuberan, Q. Wang, M. Koketsu, R.J. Linhardt, Synthetic Communications, 32, 1421-1426, 2002. LINK
264. "Separation and Purification of Carbohydrates," H.G. Bazin, R.J. Linhardt, in Glycoscience: Chemistry and Chemical Biology, B. Fraser-Reid, K. Tatsuta, J. Thiem, eds., Springer-Verlag, Heidelberg, Chapter 1.3, pp 64-74, 2001. LINK
263. "Properties of Carbohydrates," H.G. Bazin, R.J. Linhardt, in Glycoscience: Chemistry and Chemical Biology, B. Fraser-Reid, K. Tatsuta, J. Thiem, eds., Springer-Verlag, Heidelberg, Chapter 1.2, pp 53-61, 2001. LINK
262. "Synthesis and Applications of Sucrose-Based Esters," T. Polat, R. J. Linhardt, Journal of Surfactants and Detergents, 4, 415-421, 2001. LINK
261. "Localization and Characterization of Acharan Sulfate in the Body of the Giant African Snail Achatina fulica", J. Jeong, T. Toida, I. Kosiishi, T. Imanari, R.J. Linhardt, S.J. Wu, Y.S. Kim, Comparative Biochemistry and Physiology (Part B), 130, 513-519, 2001. LINK
260. "Hydrolysis of Heparinase I to Synthetic Heparin-Pentasaccharide and Effect on its Anti-Factor Xa Activity," G. Yu, G. Huashi, R. J. Linhardt, J. Farred, Journal of the Ocean University of Qingdao, 31, 529-535, 2001. LINK
259. "Structural Basis for interaction of FGF-1, FGF-2 and FGF-7 with different heparan sulfate motifs", S. Ye, Y. Luo, W. Lu, R.B. Jones, K.A. Mohamedali, R.J. Linhardt, I. Capila, T. Toida, M. Kan, H. Pelletier, W.L. McKeehan, Biochemistry, 40, 14429-14439, 2001. LINK
258. "Preparation and Structure-Activity Differences of Low Molecular Weight Heparins (LMWH)," G. Yu, G. Huashi, X. Jiamin, Q. Wang, R.J. Linhardt, Journal of Ocean University of Qingdao, 31, 673-680, 2001. LINK
257. "New Insights into the Heparan Sulfate Proteoglycan binding Activity of Apolipoprotein E4," C. Peters-Libeu, S. Lund-Katz, M. Phillips, S. Wehrli, M. J. Hernaiz, I. Capila, R.J. Linhardt, R. Raffai, Y. M. Newhouse, M., F. Zhou, K. H. Weisgraber, Journal of Biological Chemistry, 276, 39138-39142, 2001. LINK
256. "Order out of complexity; protein structures that interact with heparin," B. Mulloy, R.J. Linhardt, Current Opinions in Structural Biology, 11, 623-628, 2001. LINK
255. "Anticoagulant and antiprotease profiles of a novel natural heparinomimetic mannopentaose phosphate sulfate (PI-88)," M. Demir, O. Iqbal, D.A. Hoppensteadt, P. Piccolo, S. Ahmad, C.L. Schultz, R.J. Linhardt, J. Fareed, Clinical Applications in Thrombosis and Hemostasis, 7, 131-140, 2001. LINK
254. "Direct Measurement of the Interaction of Glycosaminoglycans and a Heparin Decasaccharide with Malaria Circumsporozoite Protein," D. Rathore, T. F. McCutchan, M. J. Hernaiz, L.A. LeBrun, S.C. Lang, R.J. Linhardt, Biochemistry, 40, 11518-11524, 2001. LINK
253. "Certain High Molecular Weight Heparin Chains Have Affinity for Vitronectin," R.E. Edens, L.A. LeBrun, J.M. Weiler, R.J. Linhardt, P.R. Kaul, Archives in Biochemistry and Biophysics, 391, 278-285, 2001. LINK
252. "Isolation and Preparation of Dermatan Sulfate Oligosaccharides" G.Yu, G. Huashi, R. J. Linhardt, Q. Wang, H.-O. Yang, T. Toida, Journal of the Ocean University of Qingdao, 31, 849-854, 2001. LINK
251. "Expression of C1 Esterase Inhibitor by the Baculovirus Expression System: Preparation, Purification and Characterization," M.W. Wolff, F. Zhang, J.J. Roberg, E.E.O. Caldwell, P.R. Kaul, J.N. Serrahn, D.W. Murhammer, R.J. Linhardt, J.M. Weiler, Protein Expression and Purification, 22 414-421, 2001. LINK
250. "Enzymatic Preparation of Heparin Dissacharides as Building Blocks in Glycosaminoglycan Synthesis," Y.S. Kim, C. Thanawiroon, H.G. Bazin, R.J. Kerns, R.J. Linhardt, Preparative Biochemistry and Biotechnology, 31, 113-124, 2001. LINK
249. "Affinity Purification of Secreted Alkaline Phosphatase Produced by the Baculovirus Expression Vector System," F. Zhang, M.W. Wolff, D. Williams, K. Busch, S.C. Lang, D.W. Murhammer, R.J. Linhardt, Applied Biochemistry and Biotechnology, 90, 125-136, 2001. LINK
248. "Degradation of Chondroitin Sulfate and Dermatan Sulfate with Chondroitin Lyases," M.J. Hernáiz, R.J. Linhardt, in Methods in Molecular Biology, Proteoglycan Protocols: Current Methods and Applications, Vol. 171, R.V. Iozzo, ed., Humana Press, Totowa, NJ, Chap. 36, pp 363-371, 2001. LINK
247. "Degradation of Heparan Sulfate with Heparin Lyases," L.A. LeBrun, R.J. Linhardt, in Methods in Molecular Biology, Proteoglycan Protocols: Current Methods and Applications, Vol. 171, R.V. Iozzo, ed., Humana Press, Totowa, NJ, Chap. 35, pp 353-361, 2001. LINK
246. "Annexin V-Heparin Oligosaccharide Complex Suggests Heparan Sulfate-Mediated Assembly on Cell Surfaces," I. Capila, M.J. Hernaiz, Y.D. Mo, T.R. Mealy, B. Campos, R.J. Linhardt B.A. Seaton, Structure, 9, 57-64, 2001. LINK
245. "X-ray Diffraction and High-Resolution NMR Spectroscopic Analysis of 2,4,7,8-tetra-O-acetyl-3-deoxy-a-D-manno-2-octulopyranosidonon-1,5-lactone," M. Koketsu, R.J. Linhardt, Carbohydrate Research, 330, 145 - 147, 2001. LINK
244. "Interaction of the N-Terminal Domain of Apolipoprotein E4 with Heparin," J. Dong, C.A. Peters-Libeu, K.H. Weisgraber, B.W. Segelke, B. Rupp, I. Capila, M.J. Hernaiz, L.A. LeBrun, R.J. Linhardt, Biochemistry, 40, 2826-2834, 2001. LINK
243. "Active Site of Chondroitin AC Lyase Revealed by the Structure of Enzyme-Oligosaccharide Complexes and Mutagenesis," W. Huang, L. Boju, L. Tkalec, H. Su, H.O. Yang, N.S. Gunay, R.J. Linhardt, Y.S. Kim, A. Matte, M. Cygler, Biochemistry, 40, 2359-2372, 2001. LINK
242. "Probing the Interaction of Dengue Virus Envelope Protein with Heparin: Assessment of Glycosaminoglycan-Derived Inhibitors," R.M. Marks, H. Lu, R. Sundaresan, T. Toida, A. Suzuki, T. Imanari, M.J. Hernaiz, R. J. Linhardt, Journal of Medicinal Chemistry, 44, 2178-2187, 2001. LINK
241. "Chemoenzymatic Synthesis of Dermatan Sulfate Oligosaccharides as Arylsulfatase B and a-L-Iduronidase Inhibitors," F. Dasgupta, R.I. Masada, C.M. Starr, B. Kuberan, H.-O. Yang, R.J. Linhardt, Glycoconjugate Journal, 17, 827-832, 2000. LINK
240. "Heparinase I Acts on a Synthetic Heparin Pentasaccharide Corresponding to the Antithrombin III Binding Site," G. Yu, L. LeBrun, N.S. Gunay, D. Hoppensteadt, J. Walenga, J. Fareed, R.J. Linhardt, Thrombosis Research, 100, 549-556, 2000. LINK
239. "Crystal Structure of a Ternary FGF-FGFR-Heparin Complex Reveals a Dual Role for Heparin in FGFR Binding and Dimerization," J. Schlessinger, A.N. Plotnikov, O.A. Ibrahimi, A.V. Eliseenkova, B.K. Yeh, A. Yayon, R.J. Linhardt, M. Mohammadi, Molecular Cell, 6, 743-750, 2000. LINK
238. "Steroeselective Synthesis of the a-Glycoside of a KDO "C"-Disaccharides," M. Koketsu, B. Kuberan, R.J. Linhardt, Organic Letters, 2, 3361-3363, 2000. LINK
237. "Cleavage of the Antithrombin III Binding Site in Heparin by Heparinase and Its Implications in the Generation of Low Molecular Weight Heparin," Z. Shriver, M. Sundaram, G. Venkataraman, J. Fareed, R. Linhardt, K. Biemann, R. Sasisekharan, Proceedings of the National Academy of Sciences (USA), 97, 10365-10370, 2000. LINK
236. "Sequencing of 3-O-Sulfate Containing Heparin Decasaccharides with a Partial Antithrombin III Binding Site," Z. Shriver, R. Raman, G. Venkataraman, K. Drummond, J. Turnbull, T. Toida, R. Linhardt, K. Biemann, R. Sasisekharan, Proceedings of the National Academy of Sciences (USA), 97, 10359-10364, 2000. LINK
235. "Enzymatic Modification of Heparan Sulfate on a Biochip Promotes Its Interaction with Antithrombin III," M. Hernaiz, J. Liu, R.D. Rosenberg, R.J. Linhardt, Biochemical Biophysical Research Communications, 276, 292-297, 2000. LINK
234. "Preparation and Structural Determination of Dermatan Sulfate-Derived Oligosaccharides," H.O. Yang, N.S. Gunay, T. Toida, B. Kuberan, G. Yu, Y.S. Kim, R.J. Linhardt, Glycobiology, 10, 1033-1040, 2000. LINK
233. "Separation of a-Acid Glycoprotein Glycoforms Using Affinity-Based Reversed Micellar Extraction and Separation," J.-H. Choe, F. Zhang, M.W. Wolff, D.W. Murhammer, R.J. Linhardt, J.S. Dordick, Biotechnology and Bioengineering, 70, 484-490, 2000. LINK
232. "Electrophoresis for the Analysis of Acidic Oligosaccharides," M. Koketsu, R.J. Linhardt, Analytical Biochemistry, 283, 136-145, 2000. LINK
231. "Electrophoretic Analysis of Glycoprotein Glycans Produced by Lepidoteran Insect Cells Infected with an Immediate Early Recombinant Baculovirus Encoding Mammalian b1,4- Galactosyltransferase," M.W. Wolff, D. W. Murhammer, D.L. Jarvis, R.J. Linhardt, Glycoconjugate Journal, 16, 753-756, 2000. LINK
230. "Purification and Characterization of a Novel Heparinase from Bacteroides stercoris HJ-15, " B.-T. Kim, W.-S. Kim, Y.S. Kim, R.J. Linhardt, D.-H. Kim, Journal of Biochemistry (Tokyo), 128, 323-328, 2000. LINK
229. "Carbohydrate Based Vaccines," B. Kuberan, R.J. Linhardt, Current Organic Chemistry, 4, 653-677, 2000. LINK
228. "Inhibition of Neuraminidase with Neuraminic Acid C-Glycosides," Q. Wang, M. Wolff, T. Polat, R.J. Linhardt, Bioorganic & Medicinal Chemistry Letters, 10, 941-944, 2000. LINK
227. "Heparin-Binding Growth-Associated Molecule Contains Two Heparin Binding b-Sheet Domains That Are Homologous to the Thrombospondin Type I Repeat" I. Kilpeläinen, M. Kaksonen, T. Kinnunen, H. Avikainen, R.J. Linhardt, M. Fath, E. Raulo, H. Rauvala, Journal of Biological Chemistry, 275, 13564-13570, 2000. LINK
226. "Tissue Distribution and Antithrombotic Activity of Unlabeled or 14C-Labelled Porcine Intestinal Mucosal Heparin Following Administration to Rats by the Oral Route, " L.M. Hiebert, S.M. Wice, T. Ping, R.E. Hileman, I. Capila, R.J. Linhardt, Canadian Journal of Physiology and Pharmacology, 78, 307-320, 2000. LINK
225. "Conformational Behavoir of C-Glycosyl Analogues of Sialyl a-(2,3) Galactose," A. Poveda, J.L. Asensio, T. Polat, H. Bazin, R. J. Linhardt, J. Jiminez-Barbero, European Journal of Organic Chemistry, 1805-1813, 2000. LINK
224. "Analysis of fluorescently labeled oligosaccharides by capillary electrophoresis and electrospray ionization mass spectrometry. "H. G. Bazin, M.W. Wolff, R.J. Linhardt, Biotechnology Techniques,13,797-801, 1999. LINK
223. "Crystal Structure of Chondroitinase B from Flavobacterium heparinumand its Complex with a Disaccharide Product at 1.7 ÅResolution," W. Huang, A. Matte, Y. Li, Y.S. Kim, R.J. Linhardt, H. Su,M. Cygler, Journal of Molecular Biology, 294, 1257-1269, 1999. LINK
222. "Effect of Fully Sulfated Glycosaminoglycans on Pulmonary ArterySmooth Muscle Cell Proliferation," H. G. Garg, P.A.M. Joseph, T. Thompson,C.A. Hales, T. Toida, T. Imanari, I. Capila, R.J. Linhardt, Archivesin Biochemistry and Biophysics, 371, 228-233, 1999. LINK
221. "Affinity Chromatography Using Enzymatically Synthesized Nucleotide-ContainingDNA Binding Polymers," Q. Wang, R.J. Linhardt, J.S. Dordick BiotechnologyTechniques, 13, 463-467, 1999. LINK
220. "Purification and Characterization of Heparan Sulphate Proteoglycanfrom Bovine Brain, " Y. Park, G. Yu, N.S. Gunay, RJ. Linhardt, BiochemicalJournal 344, 723-730, 1999. LINK
219. "Heparin Dodecasaccharide Binding to Platelet Factor-4 and Growth-RelatedProtein-a: Transition through a Partially FoldedState and Implications for Heparin Induced Thrombocytopenia," D. Mikhailov,H. C. Young, R.J. Linhardt, K. H. Mayo, Journal of Biological Chemistry274,25317-25329, 1999. LINK
218. "A New Sulfated b-Galactan From Clamwith Anti-HIV Activity," C. Amornrut, T. Toida, T. Imanari, E.R. Woo, H.Park, S.J. Wu, R.J. Linhardt, Y.S. Kim, Carbohydrate Research, 321,121-127, 1999. LINK
217. "Production and Chemical Processing of Low Molecular Weight Heparins,"N. S. Gunay, R.J. Linhardt, Seminars in Thrombosis and Hemostasis,25,5-16, 1999. LINK
216. "Preparation and Isolation of Neoglycoconjugates Using Biotin-StreptavidinComplexes," B. Kuberan, N.S. Gunay, J.S. Dordick, R.J. Linhardt, GlycoconjugateJournal, 16, 271-281, 1999. LINK
215. "Synthesis of a Versatile Neuraminic Acid C-Disaccharideas Precursor for the Synthesis of C-Glycoside Analogs of Gangliosides"H.G. Bazin, Y. Du, T. Polat, R.J. Linhardt, Journal of Organic Chemistry,64,7254-7259, 1999. LINK
214. "Preparation and Anticoagulant Activity of Fully O-SulfonatedGlycosaminoglycans," T. Toida, T. Maruyama, Y. Ogita, A. Suzuki, H. Toyoda,T. Imanari, R.J. Linhardt, International Journal of Biological Macromolecules,26,233-241, 1999. LINK
213. "Interaction of Soluble and Surface-Bound Heparin Binding Growth-AssociatedMolecule with Heparin" M. Fath, V. VanderNoot, I. Kilpeläinen, T.Kinnunen, H. Rauvala, R.J. Linhardt, FEBS Letters, 454, 105-108, 1999. LINK
212. "Interaction of Heparin with Annexin V," I. Capila, V. A. VanderNoot,T. R. Mealy, B. A. Seaton, RJ. Linhardt, FEBS Letters, 446,327-330, 1999. LINK
211. "Release and Preparation of Intact and Unreduced N-linkedOligosaccharides from Sf-9 Insect Cells," M. W. Wolff, D. W. Murhammer,R.J. Linhardt, Preparative Biochemistry and Biotechnology, 29,1-21, 1999. LINK
210. "Regiospecific Synthesis of New Methyl Sufoglucopyranoside-BasedSurfactants: Nucleophilic Displacement of a Cyclic Sulfate," H. G. Bazin,R.J. Linhardt, Synthesis, 4, 621-624, 1999. LINK
209. "Heparinoids: Structure, Biological Activities and TherapeuticApplications," N. S. Gunay, R.J. Linhardt, Planta Medica, 65,301-306, 1999. LINK
208. "A Novel Fabrication of Poly (e-caprolactone)Microspheres from Blends of Poly (e-caprolactone)and Poly (ethylene glycol) s," W.J. Lin, D.R. Flanagan, R.J. Linhardt,Polymer40,1731-1735, 1999. LINK
207. "Heparin Binding and Augmentation of C1 Inhibitor Activity," E.E.O.Caldwell, A.M. Andreason, M.A. Blietz, J. N. Serrahn, V. VanderNoot, R.J.Linhardt, J.M. Weiler, Archives in Biochemistry and Biophysics,361,215-222, 1999. LINK
206. "Regio- and Stereoselective Synthesis of b-D-Gluco-, a -L-Ido-and a -L-Altro pyranosiduronicAcids from D 4-Uronates," H. G. Bazin,M.W. Wolff, R.J. Linhardt, Journal of Organic Chemistry, 64,144-152, 1999. LINK
205. "A General Method for the Stereospecific Synthesis of C-glycosidesof Ulosonic Acids by Samarium-Mediated Reductive Dechlorination," T. Polat,Y. Du, R.J. Linhardt, Synlett, 11, 1195-1196, 1998. LINK
204. "Diversity Does Make a Difference: Fibroblast Growth Factor - HeparinInteractions," S. Faham, R.J. Linhardt, D.C. Rees, Current Opinionsin Structural Biology, 8, 578-586 1998. LINK
203. "Resolution of Structurally Similar Glycoproteins by Affinity-BasedReversed Micellar Extraction and Separation," J.-H. Choe, V.A. VanderNoot,R.J. Linhardt, J.S. Dordick, AIChE Journal, 44, 2542-2548, 1998. LINK
202. "Circular Dichroism and Absolute Conformation of D4-UronateDerivatives: a Semi-empirical Rule for Inherent Chirala-Alkoxy Acrylates," I.R. Vlahov, H. G. Bazin, R.J. Linhardt, ChemicalCommunication, 1819-1820, 1998. LINK
201. "Thermodynamic Analysis of Heparin Interaction with a Basic CyclicProtein Using Isothermal Titration Calorimetry," R.E. Hileman, R. N. Jennings,R.J. Linhardt, Biochemistry, 37, 15231-15237, 1998. LINK
200. "Chemical Oversulfation and Anticoagulant Activity of Acharan Sulfate,"S.J. Wu, M. W. Chun, K. H. Shin, T. Toida, Y. Park, R.J. Linhardt, Y.S.Kim, Thrombosis Research, 92, 273-281, 1998. LINK
199. "Capillary Affinity Chromatography and Affinity Capillary Electrophoresisof Heparin Binding Proteins," X. Wu, R.J. Linhardt, Electrophoresis,19,2650-2653, 1998. LINK
198. "Isolation and Characterization of b-Cyclodextrin Sulfates by Preparative Gradient Polyacrylamide Gel Electrophoresis,Capillary Electrophoresis and Electrospray Ionization Mass Spectrometry,"R. E. Hileman, M. M. Siegel, K. Tabei, K. Balagurunathan, R.J. Linhardt,Electrophoresis,19,2677-2681, 1998. LINK
197. "The Stereospecific Synthesis of KDN a-C-glycosides by Samarium-Mediated Reductive Desulfonylation ofGlycosyl Phenylsulfone," Y. Du, T. Polat, R.J. Linhardt, TetrahedronLetters, 39, 5007-5010, 1998. LINK
196. "Tetrahedron Report Number 462 - Recent Advances in StereoselectiveC-Glycoside Synthesis," Y. Du, R.J. Linhardt, I.R. Vlahov, Tetrahedron,54,9913-9961, 1998. LINK
195. "Conformational Study of D 4-UronateMonosaccharide and Glycosaminoglycan-derived Disaccharide," H.G. Bazin,I. Capila, R.J. Linhardt, Carbohydrate Research, 309,135-144, 1998. LINK
194. "Synthesis of Sucrose-Based Surfactants Through RegioselectiveSulfonation of Acylsucrose and the Nucleophilic Opening of a Sucrose CyclicSulfate," H.G. Bazin, T. Polat, R.J. Linhardt, Carbohydrate Research,309,189-205, 1998. LINK
193. "Determination of the Structure of Oligosaccharides Prepared fromAcharan Sulfate," Y.S. Kim, M.Y. Ahn, S.J. Wu, D.-H. Kim, T. Toida, L.M.Teesch, Y. Park, G. Yu, J. Lin, R.J. Linhardt, Glycobiology, 8,869-877, 1998. LINK
192. "Stereospecific Synthesis of a -C-Glycosylderivatives ("a-C-Glycosides") of N-AcetylneuraminicAcid by Samarium-Mediated Reductive Desulfonylation of Glycosyl Phenylsulfone,"Y. Du, R.J. Linhardt, Carbohydrate Research, 308, 161-164, 1998. LINK
191. "Characterization of Bacteroides Species from Human Intestinethat Degrades Glycosaminoglycans, " M.Y. Ahn, K.H. Shin, D.-H. Kim, E.-A.Jung, T. Toida, R.J. Linhardt, Y.S. Kim, Canadian Journal of Microbiology,44,423-429, 1998. LINK
190. "Conformational Changes and Anticoagulant Activity of ChondroitinSulfate Following its O-Sulfonation," T. Maruyama, T. Toida, T.Imanari, G. Yu, R.J. Linhardt, Carbohydrate Research, 306,35-43, 1998. LINK
189. "Highly Swelling Hydrogels from Ordered Galactose-Based Poly (Acrylate)s,"B.D. Martin, R.J. Linhardt, J.S. Dordick, Biomaterials, 19,69-76, 1998. LINK
188. "A Sensitive Method for the Quantification of b-Glucuronidase Activity in Urine Using Capillary Electrophoresis with FluorescenceDetection," X. Wu, D. Loganathan, R.J. Linhardt, Journal of Chromatography,708,61-66, 1998. LINK
187. "Interaction of Secretory Leukocyte Protease Inhibitor with HeparinInhibits Proteases Involved in Asthma," M.A. Fath, X. Wu, R.E. Hileman,R.J. Linhardt, W.M. Abraham, M.A. Kashem, R.M. Nelson, and C.Wright, Journal of Biological Chemistry, 273, 13563-13569, 1998. LINK
186. "Differential Interactions of Heparin and Heparan Sulfate Glycosaminoglycanswith the Selectins. Implications for the Use of Unfractionated and LowMolecular Weight Heparins as Therapeutic Agents," A. Koenig, K. Norgard-Sumnicht,R.J. Linhardt, A. Varki, Journal of Clinical Investigation, 101,877-889, 1998. LINK
185. "Affinity Capillary Electrophoresis Employing Immobilized Glycosaminoglycanto Resolve Heparin-Binding Peptides," V.A. VanderNoot, R.E. Hileman, J.S.Dordick, R.J. Linhardt, Electrophoresis, 19, 437-441, 1998. LINK
184. "Glycosaminoglycan-Protein Interaction: Definition of ConsensusSites in Glycosaminoglycan Binding Proteins," R.E. Hileman, J.R. Fromm,J.M. Weiler, R.J. Linhardt, BioEssays, 20, 156-167, 1998. LINK
183. "Structural Analysis of Heparan Sulfate and Heparan Sulfate Oligosaccharides"T. Toida, R.J. Linhardt, Trends in Glycobiology and Glycotechnology,10,125-136, 1998. LINK
182. "New Strategy for the Synthesis of Differentially Protected D-GlucopyranuronicAcid Glycosyl Donors Containing a Latent C-4 Acceptor," Y. Du, I.R. Vlahov,R.J. Linhardt, Carbohydrate Letters, 3, 53-58, 1998. LINK
181. "NMR Solution Conformation of Heparin-Derived Hexasaccharide,"D. Mikhailov, R.J. Linhardt, K.H. Mayo, Biochemical Journal, 328, 51-61, 1997. LINK
180. "Detection of Glycosaminoglycans as a Copper (II) Complex in HPLC,"T. Toida, M. Shima, S. Azumaya, T. Maruyama, H. Toyoda, T. Imanari, R.J.Linhardt, Journal of Chromatography, 787, 266-270, 1997. LINK
179. "Regioselective Synthesis of L-Idopyranuronic Acid Derivatives:Intermolecular Aglycone Transfer Under Standard Glycosylation Conditions,"Y. Du, R.J. Linhardt, Journal of Carbohydrate Chemistry, 16,1327-1344, 1997. LINK
178. "Identification of a Heparin Binding Peptide on the ExtracellularDomain of the KDR VEGF Receptor," M. Dougher, L. Torley, H. Wasserstrom,L. Shridaran, P. Westdock, R.E. Hileman, J.R. Fromm, S. Lyman, R.J. Linhardt,J. Kaplan, B.I. Terman Growth Factors, 14, 257-268, 1997. LINK
177. "Enzyme Catalyzed Regioselective Synthesis of Sucrose Fatty AcidSurfactants," T. Polat, H. Bazin, R.J. Linhardt, Journal of CarbohydrateChemistry, 16, 1319-1325, 1997. LINK
176. "Interaction of Fibroblast Growth Factor-1 and Related Peptideswith Heparan Sulfate and Its Oligosaccharides," J. R. Fromm, R. E. Hileman,J. M. Weiler, R.J. Linhardt, Archives in Biochemistry and Biophysics,346,252-262, 1997. LINK
175. "Heparin-Dependent Fibroblast Growth Factor Activities: Effectsof Defined Heparin Oligosaccharides ," F.-Y. Zhou, M. Kan, R.T. Owens,W.L. McKeehan, J.A. Thompson, R.J. Linhardt, M. Höök , EuropeanJournal of Cell Biology, 73, 71-80, 1997. LINK
174. "Chemical Microdetermination of Heparin in Plasma " T. Toida, Y.Huang, T. Maruyama, H. Toyoda, T. Imanari, R.J. Linhardt, AnalyticalBiochemistry, 251, 219-226, 1997. LINK
173. "Glycosaminoglycans Can Influence Fibroblast Growth Factor-2 MitogenicityWithout Significant Growth Factor Binding, " H.M. Wang, T. Toida, Y.S.Kim, I Capila, R.E. Hileman, M. Bernfield, R.J. Linhardt, BiochemicalBiophysical Research Communications, 235, 369-373, 1997. Erratum242, 248, 1997. LINK
172. "Polysulfated Carbohydrates Analyzed as Ion-Paired Complexes withBasic Peptides and Proteins Using Electrospray Negative Ionization MassSpectrometry," Marshall M. Siegel, Kieko Tabei, M. Z. Kagan, I. R. Vlahov,R. E. Hileman, R.J. Linhardt, Journal of Mass Spectrometry, 32,760-772, 1997. LINK
171. "Parameters Affecting the Efficiency of Affinity-Based ReversedMicellar Extraction and Separation ," J.-H. Choe, V. A. VanderNoot R.J.Linhardt, J. S. Dordick, Biotechnology Progress, 13, 440-445, 1997. LINK
170. "Directional Immobilization of Heparin onto the Non-Porous Surfaceof Microtiter Plates," V. D. Nadkarni, R.J. Linhardt, BioTechniques,23,382-385, 1997. LINK
169. "Dengue Virus Infectivity Depends on Envelope Protein Binding toTarget Cell Heparan Sulfate," Y. Chen, T. Maguire, R. E. Hileman, J. R.Fromm, J. D. Esko, R.J. Linhardt, R. M. Marks, Nature Medicine,3,866-871, 1997. LINK
168. "Pattern and Spacing of Basic Amino Acids in Heparin Binding Sites,"J. R. Fromm, R. E. Hileman, E. E. O. Caldwell, J. M. Weiler, R.J. Linhardt,Archivesof Biochemistry and Biophysics, 343, 92-100, 1997. LINK
167. "Heparin Analogs-Development and Applications, " R.J. Linhardt,T. Toida, in Carbohydrates as Drugs, Z.B. Witczak, K.A. Nieforth,eds., Marcel Dekker, NY, Chapter 7, pp. 277-341, 1997. (Fulltext in PDF format Part A) (PartB) LINK
166. "Regioselective Synthesis of Sucrose Monoesters as Surfactants,"I. R. Vlahov, P. I. Vlahova, R.J. Linhardt, Journal of CarbohydrateChemistry, 16, 1-10, 1997. LINK
165. "Exploration of the Action Pattern of Streptomyces HyaluronateLyase Using High Resolution Capillary Electrophoresis," Y. Park, S. Cho,R.J. Linhardt, Biochimica et Biophysica Acta, 1337, 217-226,1997. LINK
164. "Regio and Stereoselective Synthesis of Derivatives of L-IdopyranuronicAcid and D-Glucopyranuronic Acid from D4-Uronates," H. G. Bazin, R.J. Kerns,R.J. Linhardt, Tetrahedron Letters, 38, 923-926, 1997. LINK
163. "Structural Differences and the Presence of Unsubstituted AminoGroups in Heparan Sulphates from Different Tissues and Species," T. Toida,H. Yoshida, H. Toyoda, I. Koshiishi, T. Imanari, R. E. Hileman, J. R. Fromm,R.J. Linhardt, Biochemical Journal, 322, 499-506, 1997. LINK
162. "Diastereocontrolled Synthesis of Carbon Glycosides of N-AcetylneuraminicAcid via Glycosyl Samarium(III) Intermediates," I. R. Vlahov, P. I. Vlahov,R.J. Linhardt, Journal of the American Chemical Society, 119,1480-1481, 1997. LINK
161. "Preparation and Structure of Heparin Lyase-Derived Heparan SulphateOligosaccharides," R. E. Hileman, T. Toida, A. E. Smith, R.J. Linhardt,Glycobiology,7,231-239, 1997. LINK
160. "Analysis of the Structure of Heparin and Heparan Sulfate by HighResolution Separation of Oligosaccharides, " R.J. Linhardt, T. Toida, A.E. Smith, R. E. Hileman, in A Laboratory Guide to Glycoconjugate Analysis,J. T. Gallagher, P. Jackson, eds., Birkhauser Verlag AG, Basel, 1997, Chapter10,pp 183-197. LINK
159. "An Unusual Ring Contraction of Silyl Glucopyranosides to Silyl Glucofuranosides," Y. G. Du, I. R. Vlahov, R.J. Linhardt, Carbohydrate Letters, 2,165-168, 1996. LINK
158. "Structure-Function Relationships in the Heparin Binding C-terminal Region of Insulin-Like Growth Factor Binding Protein-3," B.A. Booth, M. Boes, B.L. Dake, R.J. Linhardt, E. Caldwell, J. Weiler, R. S. Bar, Growth Regulation, 6, 206-213, 1996. LINK
157. "Enzymatic Preparation of Heparin Oligosaccharides Containing Antithrombin III Binding Sites," T. E. Toida, R. E. Hileman, A. E. Smith, P. I. Vlahova, R.J. Linhardt, Journal of Biological Chemistry, 271, 32040-32047, 1996. LINK
156. "Preparation and Biological Activity of N-Sulfated Chondroitin and Dermatan Sulfate Derivatives," V. D. Nadkarni, T. Toida, C.L. VanGorp, R.L. Schubert, J.M. Weiler, K.P. Hansen, E. E. O. Caldwell, R.J. Linhardt, Carbohydrate Research, 290, 87-96, 1996. LINK
155. "Heparin and Heparin Oligosaccharides: Preparation, Analysis, Applications and Biological Activities," R.J. Linhardt, R.J. Kerns, I. R. Vlahov, Biochemical Functions and Biotechnology of Natural and Artificial Polymers, M. Yalpani, ed., ATL Press, Science Publishers, Mt. Prospect, IL, 1996, pp 46-62. LINK
154. "NMR Solution Conformation of Heparin-Derived Tetrasaccharide," D. Mikhailov, K. Mayo, I. R. Vlahov, T.T. Toida, R.J. Linhardt, Biochemical Journal, 318, 93-102, 1996. LINK
153. "A New Glycosaminoglycan from the Giant African Snail Achatina fulica," Y.S. Kim, Y.T. Jo, I.M. Chang, T. E. Toida, Y. Park, R.J. Linhardt, Journal of Biological Chemistry, 271, 11750-11755, 1996. LINK
152. "Synthesis of the Bis-Tetrahydropyrano[2,3-b:2’,3’-e] Piperazine Ring System: A New Tricyclic Heterocycle from D-Glucosamine," R.J. Kerns, T. E. Toida, R.J. Linhardt, Journal of Carbohydrate Chemistry, 15, 581-590, 1996. LINK
151. "Selective N-Sulfation of Glucosamine Derivatives Using Phenyl Chlorosulfate in Non-Aqueous Solvent," R.J. Kerns, R.J. Linhardt, Synthetic Communications, 26, 2671-2680, 1996. LINK
150. "C-2 Epimerization of N-Acetylglucosamine in an Oligosaccharides Derived from Heparan Sulfate," T. E. Toida, I. R. Vlahov, A. E. Smith, R. E. Hileman, R.J. Linhardt, Journal of Carbohydrate Chemistry, 15, 351-360, 1996. LINK
149. "Crystallographic Analyses of Heparin Oligosaccharides Binding to Basic Fibroblast Growth Factor," S. Faham, R. E. Hileman, J. R. Fromm, R.J. Linhardt, D. C. Rees, Science, 271, 1116-1120, 1996. LINK
148. "Detection of Glycosaminoglycans as a Copper (II) Complex in Capillary Electrophoresis," T. E. Toida, R.J. Linhardt, Electrophoresis, 17, 341-346, 1996. LINK
147. "13C-NMR Relaxation Study of Heparin Disaccharide with Tripeptides GRG and GKG," D. Mikhailov, K. Mayo, R.J. Linhardt, A. Pervin Biochemical Journal, 315, 447-454, 1996. LINK
146. "Accelerated Heparin Stability Studies," K. Jandik, D. Kruep, M. Cartier, R.J. Linhardt, Journal of Pharmaceutical Science, 85, 45-51, 1996. LINK
145. "Importance of Basic Amino Acids in Heparin and Heparan Sulfate Protein Binding Sites," E. E. O. Caldwell, V. D. Nadkarni, J. R. Fromm, R.J. Linhardt, J. M. Weiler International Journal of Biochemistry and Cell Biology, 28, 203-216, 1996. LINK
144. "Separation of Acidic Carbohydrates by Capillary Electrophoresis," R.J. Linhardt, A. Pervin, Journal of Chromatography A, 720, 323-335, 1996. LINK
143. "Enzymatic and Chemoenzymatic Approaches to Synthesis of Sugar-Based Polymer and Hydrogels ," X. Chen, B. D. Martin, T. K. Neubauer, R. J. Linhardt, J. S. Dordick, D. G. Rethwisch, Carbohydrate Polymers, 28, 15-21, 1995. LINK
142. "Regioselective Synthesis of Derivatives of L-Idopyranuronic Acid: A Key Constituent of Glycosaminoglycans," I. R. Vlahov, R. J. Linhardt, Tetrahedron Letters, 36, 8379-8382, 1995. LINK
141. "Differences in the Interaction of Heparin with Arginine and Lysine and the Importance of Basic Amino Acids in the Binding of Heparin to aFGF," J. R. Fromm, R. E. Hileman, E. E. O. Caldwell, J. M. Weiler, R.J. Linhardt, Archives of Biochemistry and Biophysics, 323, 279-287, 1995. LINK
140. "Strategy for the Sequence Analysis of Heparin" J. Liu, U.R. Desai, X. Han, T. Toida, R.J. Linhardt, Glycobiology, 5, 765-774, 1995. LINK
139. "Isolation and Characterization of Heparan Sulfate from Crude Porcine Intestinal Mucosa Peptidoglycan Heparin," C. C. Griffin, R.J. Linhardt, C.L. VanGorp, T. Toida, R.E. Hileman, R.L. Schubert, S.E. Brown, Carbohydrate Research, 276, 183- 197, 1995. LINK
138. "Conformational Analysis of Sucrose Octasulfate by High Resolution Nuclear Magnetic Resonance Spectroscopy," U.R. Desai, I. R. Vlahov, A. Pervin, R. J. Linhardt, Carbohydrate Research, 275, 391-401, 1995. LINK
137. "Separation of Acidic Carbohydrates by Capillary Electrophoresis," R. J. Linhardt, A. Pervin, Journal of Chromatography A, 720, 323-335, 1995. LINK
136. "Purification, Characterization and Specificity of Chondroitin Lyases and Glucuronidase from Flavobacterium heparinum" K. Gu, R.J. Linhardt, M. Laliberte, K. Gu, J. Zimmerman, Biochemical Journal, 311, 569-577, 1995. LINK
135. "Carbohydrate-Protein Interactions in Vascular Biology," , R.M. Nelson, A. Venot, M.P. Bevilacqua, R.J. Linhardt, I. Stamenkovic, Annual Reviews in Cell and Developmental Biology, 11, 601-631, 1995. LINK
134. "Separation of Hydroxyl-Protected Heparin Derived Disaccharides using Reversed-Phase High Performance Liquid Chromatography," R. J. Kerns, R. J. Linhardt, Journal of Chromatography A, 705, 369-373, 1995. LINK
133. "Modified Assay for the Measurement of Biotin in the Presence of Heparin," V. D. Nadkarni, R. J. Linhardt, Analytical Biochemistry, 227, 402-404, 1995. LINK
132. "Two-Dimension Affinity Resolution Electrophoresis Demonstrates that Three Distinct Heparin Populations Interact with Antithrombin III" R. E. Edens, J. R. Fromm, S. J. Fromm, R.J. Linhardt, J. M. Weiler, Biochemistry, 34, 2400-2407, 1995. LINK
131. "Molecular Weight of Heparin Using 13C Nuclear Magnetic Resonance Spectroscopy," U.R. Desai, R.J. Linhardt, Journal of Pharmaceutical Science, 84, 212-215, 1995. LINK
130. "Measurement of the Antithrombin III Binding Site in Low Molecular Weight Heparins Using 13C NMR and Capillary Electrophoresis," U.R. Desai, D. Hoppensteadt, J. Fareed, R.J. Linhardt, Pharmaceutical Science, 1, 349-353, 1995. LINK
129. "Dermatan Sulfate as a Potential Therapeutic Agent," R. J. Linhardt, R. E. Hileman, General Pharmacology, 26, 443-451, 1995. LINK
128. "Lectin Affinity Electrophoresis," R. J. Linhardt, X.J. Han, J. R. Fromm, Molecular Biotechnology, 3, 191-197, 1995. LINK
127. "Capillary Electrophoresis for Monitoring Chemical Reactions: Sulfation and Synthetic Manipulation of Sulfated Carbohydrates," R. J. Kerns, I. R. Vlahov, R. J. Linhardt, Carbohydrate Research, 267, 143-152, 1995. LINK
126. "Analysis of Fluorescently Labeled Sugars by Reversed-Phase Ion-Pairing High Performance Liquid Chromatography," Y. S. Kim, J. Liu, X.J. Han, A. Pervin, R. J. Linhardt, Journal of Chromatographic Science, 33, 162-167 1995. LINK
125. "Preparation and Structural Characterization of Large Heparin-Derived Oligosaccharides," A. Pervin, C. Gallo, K. Jandik, X.-J. Han, R. J. Linhardt, Glycobiology, 5, 83-95, 1995. LINK
124. "IGFBP-3 and IGFBP-5 Association with Endothelial Cells: Role of C-terminal Heparin Binding Domain," B.A. Booth, M. Boes, D.L. Andress, B.L. Dake, M.C. Kiefer, C. Maack, R.J. Linhardt, K. Bar, E.E.O. Caldwell, J. Weiler, R.S. Bar, Growth Regulations, 5, 1-17, 1995. LINK
123. "Human Milk Glycosaminoglycans Inhibit HIV Glycoprotein GP120 Binding to Its Host Cell CD4 Receptor " D.S. Newburg, R.J. Linhardt, S.A. Ampofo, R.H. Yolken, Journal of Nutrition, 125, 419-424, 1995. LINK
122. "Directional Immobilization of Heparin to Beaded Supports," V. D. Nadkarni, A. Pervin , R. J. Linhardt, Analytical Biochemistry, 222, 59-67, 1994. LINK
121. "Separation of Glycosaminoglycan Derived Oligosaccharides by Capillary Electrophoresis Using Reverse Polarity," A. Pervin, A. Al-Hakim, R. J. Linhardt, Analytical Biochemistry, 221, 182-188, 1994. LINK
120. "Chemical and biochemical catalysis to make swellable polymers. " J. S. Dordick, R.J. Linhardt, D.G. Rethwisch, Chemtech, 24, 33-39, 1994. LINK
119. "New Approaches for the Preparation of Hydrophobic Heparin Derivatives," J. Liu, A. Pervin, C. M. Gallo, U.R. Desai, C.L. VanGorp, R.J. Linhardt, Journal of Pharmaceutical Science , 83, 1034-1039, 1994. LINK
118. "Accelerated Degradation of Poly(e-caprolactone) by Organic Amines," W.-J. Lin, D.R. Flanagan, R.J. Linhardt, Pharmaceutical Research, 11, 1030-1034, 1994. LINK
117. "Action Pattern of Polysaccharide Lyases on Glycosaminoglycans" K.A. Jandik, K. Gu, R.J. Linhardt, Glycobiology, 4, 289-296, 1994. LINK
116. "Importance of Distinct Water Environments in the Hydrolysis of Poly(D,L-lactide-co-glycolide)," E.A. Schmitt, D.R. Flanagan, R.J. Linhardt, Macromolecules, 27, 743-748, 1994. LINK
115. "Capillary Electrophoresis of Oligosaccharides" R.J. Linhardt, in Methods in Enzymology, Guide to Techniques in Glycobiology, W.J. Lennarz, G.W. Hart (eds.), Volume 230, Chapter 16, pp 265-280, Academic Press, San Diego, 1994. LINK
114. "Interaction of Heparin with Synthetic Antithrombin III Peptide Analogues," J. Bae, U.R. Desai, A. Pervin, E.O. Caldwell, J.M. Weiler, R. J. Linhardt, Biochemical Journal, 301, 121-129, 1994. LINK
113. "Low Molecular Weight Dermatan Sulfate as an Antithrombotic Agent: Structure Activity Relationship Studies" R.J. Linhardt, U.R. Desai, J. Liu, A. Pervin, D. Hoppensteadt, J. Fareed, Biochemical Pharmacology, 47, 1241-1252 (1994). LINK
112. "Molecular Weight of Low Molecular Heparins by 13C NMR Spectroscopy," U.R. Desai, R.J. Linhardt, Carbohydrate Research, 255, 193-212 (1994). LINK
111. "Analysis of Glycosaminoglycans with Polysaccharide Lyases" R. J. Linhardt, in Current Protocols in Molecular Biology, Analysis of Glycoconjugates, A. Varki (ed.), V 2, 17.13.17-17.13.32, Wiley Interscience, 1994. LINK
110. "Biodegradable Polymers for the Controlled Delivery of Vaccines," E. Schmitt, D.R. Flanagan, R.J. Linhardt, in Biotechnology and Bioactive Polymers, Plenum Publishing Company, New York, C.G. Gebelein (Ed.), pp 249-259, 1994. LINK
109. "Heparin and Derivatized Heparin Inhibit Cobra Venom Factor Activation of Complement in Serum," R.E. Edens, R.J. Linhardt, J.M. Weiler, Immunopharmacology, 27, 145-153, 1994. LINK
108. "Capillary Electrophoresis to Measure Sulfoesterase Activity on Chondroitin Sulfate and Heparin Derived Disaccharides," A. Pervin, K. Gu, R. J. Linhardt, Applied and Theoretical Electrophoresis, 3, 297-303 (1993). LINK
107. "Substrate Specificity of the Heparin Lyases from Flavobacterium heparinum," U.R. Desai, H.M. Wang, R.J. Linhardt, Archives of Biochemistry and Biophysics, 306, 461-468 (1993). LINK
106. "Specificity Studies on the Heparin Lyases from Flavobacterium heparinum," U.R. Desai, H.M. Wang, R.J. Linhardt, Biochemistry, 32, 8140-8145 (1993). LINK
105. "Oligosaccharide Compositional Analysis of Heparin and Low Molecular Weight Heparins by Capillary Electrophoresis," U.R. Desai, H.M. Wang, S.A. Ampofo, R.J. Linhardt, Analytical Biochemistry, 213, 120-127 (1993). LINK
104. "Heparin Oligosaccharides Bind P- and L-Selectin and Inhibit Acute Inflammation," R.M. Nelson, O. Cecconi, W.G. Roberts, A. Aruffo, R.J. Linhardt, M.P. Bevilacqua, Blood, 82, 3253-3258 (1993). LINK
103. "Mapping and Sequencing of Oligosaccharides by Electrophoresis" R.J. Linhardt, J. Liu, X. -J. Han, Trends in Glycoscience and Glycotechnology, 5, 181-192 (1993). LINK
102. "Comparison of the Activity of Two Chondroitin AC Lyases on Dermatan Sulfate," K. Gu, J. Liu, A. Pervin, R.J. Linhardt, Carbohydrate Research, 244, 369-377 (1993). LINK
101. "Monoclonal Antibodies Prepared Against Heparin Lyase I and their Reactivity Towards Heparin Lyases I, II and III," K. Gu., R.E. Edens, K.A. Jandik, R.J. Linhardt, International Journal of Biochemistry, 25, 331-336 (1993). LINK
100. "Heparin, Not Just an Anticoagulant Anymore: Six and One Half Decades of Studies on the Ability of Heparin to Regulate Complement Activation," R.E. Edens, J.M. Weiler, R.J. Linhardt, Complement Profiles, 1, 96-120 (1993). LINK
99. "Structure Elucidation of a Novel Acidic Tetrasaccharide and Hexasaccharide Derived From a Chemically Modified Heparin," U.R. Desai, H.M. Wang, T.R. Kelly, R.J. Linhardt, Carbohydrate Research, 241, 249-259 (1993). LINK
98. "Nature of the Interaction of Heparin with Acidic Fibroblast Growth Factor," H. Mach, D.B. Volkin, C.J. Burke, C.R. Middaugh, R.J. Linhardt, J. Fromm, D. Loganathan, L. Mattsson, Biochemistry, 32, 5480-5489 (1993). LINK
97. "Degradation and Release Properties of Poly (D,L-Lactide-co-Glycolide, 50:50) Pellets Fabricated From Three Commercial Polymers," E.A. Schmitt, D.R. Flanagan, R.J. Linhardt, Journal of Pharmaceutical Sciences, 82, 326-329 (1993). LINK
96. "Physical Stabilization of Acidic Fibroblast Growth Factor by Polyanions," D.B. Volkin, P.K. Tsai, J.M. Dabora, J.O. Gress, C.J. Burke, R.J. Linhardt, C.R. Middaugh, Archives in Biochemistry and Biophysics, 300, 30-41, (1993). LINK
95. "Biocatalytic Synthesis of Sugar-Containing Polyacrylates," B.D. Martin, S.A. Ampofo, R.J. Linhardt, J.S. Dordick, Macromolecules, 25, 7081-7085 (1992). LINK
94. "Purification and Characterization of Heparin Lyases from Flavobacterium heparinum," D.L. Lohse, R.J. Linhardt, Journal of Biological Chemistry, 267, 24347-24355, (1992). LINK
93. "Negative-Ion Fast Atom Bombardment Tandem Mass Spectrometry to Determine Sulfate and Linkage Position in Glycosaminoglycan-Derived Disaccharides," D.J. Lamb, H.M. Wang, L.M. Mallis, R.J. Linhardt, Journal of the American Society for Mass Spectrometry, 3, 797-803 (1992). LINK
92. "Heparin and Modified Heparin Inhibit C Activation In Vivo," J.M. Weiler, R.E. Edens, R.J. Linhardt, D.P. Kapelanski, Journal of Immunology, 148, 3210-3215 (1992). LINK
91. "Fundamental Studies on the Hydration, Erosion and Release Properties of Biodegradable Poly(esters)," E. Schmitt, D.R. Flanagan, R.J. Linhardt, Proceedings of the ACS Division of Polymeric Materials: Science and Engineering, 66, 95-96 (1992). LINK
90. "Biodegradable Polymers for the Controlled Delivery of Vaccines," E. Schmitt, D.R. Flanagan, R.J. Linhardt, Proceedings of the ACS Division of Polymeric Materials: Science and Engineering, 66, 493-494 (1992). LINK
89. "Lectin Affinity Electrophoresis for the Separation of Fluorescently Labeled Sugar Derivatives," K.B. Lee, Y.S. Kim, R.J. Linhardt, Analytical Biochemistry, 203, 206-210 (1992). LINK
88. "An Electrophoresis-Based Assay For Glycosyltransferase Activity," K.B. Lee, U.R. Desai, M.M. Palcic, O. Hindsgaul, R.J. Linhardt, Analytical Biochemistry, 205, 108-114 (1992). LINK
87. "New Methodologies in Heparin Structure Analysis and the Generation of Low Molecular Weight Heparins," R.J. Linhardt, H.M. Wang, S.A. Ampofo, in Heparin and Related Polysaccharides, Plenum Press, New York, D. Lane and U. Lindahl (Eds.), pp. 37-47, 1992. LINK
86. "Search for the Heparin Antithrombin III Binding Site Precursor," R.J. Linhardt, H.M. Wang, D. Loganathan, J.H. Bae, The Journal of Biological Chemistry, 267, 2380-2387 (1992). LINK
85. "Isolation and Characterization of a Human Heparin," R.J. Linhardt, S.A. Ampofo, J. Fareed, D. Hoppensteadt, J. B. Mulliken, J. Folkman, Biochemistry, 31, 12441-12445 (1992). LINK
84. "Gradient Polyacrylamide Gel Electrophoresis for Determination of the Molecular Weight of Heparin and Low Molecular Weight Heparin Derivatives," R.E. Edens, A. Al-Hakim, J.M. Weiler, D.G. Rethwisch, J. Fareed, R.J. Linhardt, Journal of Pharmaceutical Sciences, 81, 823-827 (1992). LINK
83. "Analysis of Glycosaminoglycan-Derived Oligosaccharides Using Fast Atom Bombardment Mass Spectrometry," R.J. Linhardt, H.M. Wang, D. Loganathan, D. Lamb, L.M. Mallis, Carbohydrate Research, 225, 137-145 (1992). LINK
82. "Chemical and Enzymatic Methods for the Depolymerization and Modification of Heparin," R.J. Linhardt, in Carbohydrates-Synthetic Methods and Applications in Medicinal Chemistry, Kodansha/VCH Publishers, Tokyo/Weinheim, H. Ogura, A. Hasegawa, T. Suami (Eds.), Chap. 20, pp 385-401, 1992. LINK
81. "Controlled Release of Protein and Vaccines from Poly(Ester) Microspheres In Vitro," H.T. Wang, H. Palmer, R.J. Linhardt, D.R. Flanagan, E. Schmitt, Proceedings of the ACS Symposium on Polymers Cosmetics and Pharmaceutical Applications, 239-253 (1991). LINK
80. "Controlled Release of Protein and Vaccines from Poly(Ester) Microspheres In Vitro," H.T. Wang, H. Palmer, R.J. Linhardt, D.R. Flanagan, E. Schmitt, in Cosmetic and Pharmaceutical Applications of Polymers, Plenum Publishing Company, New York, C.G. Gebelein, T.C. Cheng, V.C. Yang (Eds.), pp 239-253, 1991. LINK
79. "Detection of Chitinase Activity Using a Fluorescently Labelled Substrate on Polyacrylamide Gel," Y.S. Kim, K.B. Lee, R.J. Linhardt, Korean Biochemical Journal, 24, 466-471 (1991). LINK
78. "Disaccharide Compositional Analysis of Heparin and Heparan Sulfate Using Capillary Zone Electrophoresis," S.A. Ampofo, H.M. Wang, R.J. Linhardt, Analytical Biochemistry, 199, 249-255, (1991). LINK
77. "Capillary Zone Electrophoresis for the Quantitation of Oligosaccharides Formed Through the Action of Chitinase", K.B. Lee, Y.S. Kim, R.J. Linhardt, Electrophoresis, 12, 636-640 (1991). LINK
76. "Capillary Electrophoresis for the Analysis of Chondroitin Sulfate and Dermatan Sulfate-Derived Disaccharides," A. Al-Hakim, R.J. Linhardt, Analytical Biochemistry, 195, 68-73 (1991). LINK
75. "Structural Features of Dermatan Sulfates and their Relationship to Anticoagulant and Antithrombotic Activities," R.J. Linhardt, A. Al-Hakim, J. Liu, D. Hoppensteadt, J. Fareed, G. Mascellani, P. Bianchini, Biochemical Pharmacology, 42, 1609-1619 (1991). LINK
74. "Determination of the pKa of Glucuronic Acid and Heparin's Carboxyl Groups by 13C NMR," H.M. Wang, D. Loganathan, R.J. Linhardt, Biochemical Journal, 278, 689-695 (1991). LINK
73. "Antithrombin III Regulates Complement Activity," J.M. Weiler, R.J. Linhardt, Journal of Immunology, 146, 3889-3894 (1991). LINK
72. "Heparin: An Important Drug Enters its Seventh Decade," R.J. Linhardt, Chemistry & Industry, 2, 45-50 (1991). LINK
71. "Rhamnose from the Products of Microbial Fermentation," R.J. Linhardt,SIM Industrial Microbiology News, 41, 113-118 (1991). LINK
70. "Influence of Formulation Methods on the In Vitro Controlled Release of Protein from Poly(Ester) Microspheres," H.T. Wang, E. Schmitt, D.R. Flanagan, R.J. Linhardt, Journal of Controlled Release, 17, 23-32 (1991). LINK
69. "Acidic Polysaccharides, Their Modification and Uses," R.J. Linhardt, A. Al-Hakim, J. Liu, in Polymers from Biotechnology, Plenum Publishing Company, New York, C.G. Gebelein (Ed.) 1991, pp. 115-165. LINK
68. "A New Method for Sequencing Linear Oligosaccharides on Gels Using Charged, Fluorescent Conjugates," K.B. Lee, A. Al-Hakim, D. Loganathan, R.J. Linhardt, Carbohydrate Research, 214, 155-168 (1991). LINK
67. "Molecular Profile of Dermatan Sulfates from Different Origins," R.J. Linhardt, A. Al-Hakim, S.Y. Liu, Y.S. Kim, J. Fareed, Seminars in Thrombosis and Hemostasis, 17, 15-22 (1991). LINK
66. "Biocatalysts for the Synthesis and Modification of Biopolymers," R.J. Linhardt and A. Al-Hakim in Biocatalysts for Industry, Topics in Applied Chemistry, Plenum Publishing Company, New York, J.S. Dordick (Ed.), Chapter 5, pp. 83-112, 1991. LINK
65. "Electrophoresis and Detection of Nanogram Quantities of Exogenous and Endogenous Glycosaminoglycans in Biological Fluids," A. Al-Hakim, R.J. Linhardt, Applied and Theoretical Electrophoresis, 1, 305-312 (1991). LINK
64. "Immobilization of C3b with Retention of Functional Activity," R.E. Edens, R.J. Linhardt, J.M. Weiler, Journal of Immunological Methods, 133, 67-70 (1990). LINK
63. "Biodegradable Poly(Esters) for the Controlled Delivery of Vaccines," R.J. Linhardt, H.T. Wang, D.R. Flanagan, E. Schmitt, H. Palmer, Proceedings of the ACS Division of Polymeric Materials: Science and Engineering, 63, 39-42 (1990). LINK
62. "Structure and Metabolism of Glycosaminoglycans," R.J. Linhardt, A. Al-Hakim, S. Ampofo, D. Loganathan, in New Trends in Haemostasis: Coagulation Proteins, Endothelium, and Tissue Factors, Springer Verlag Publishers, Heidelberg, G. Schettler, L. Heene, J. Harenberg (Eds.), pp. 12-26, 1990. LINK
61. "Low Molecular Weight Heparin and Heparinoids in Cerebrovascular Disease," D.L. Gordon, R. Linhardt, H.P. Adams, Clinical Neuropharmacology, 13, 522-543 (1990). LINK
60. "Degradation of Poly(Ester) Microspheres," H.T. Wang, H. Palmer, R.J. Linhardt, D.R. Flanagan, E. Schmitt, Biomaterials, 11, 679-685 (1990). LINK
59. "Randomness in the Heparin Polymer: Computer Simulations of Alternative Action Patterns of Heparin Lyase," D.M. Cohen, R.J. Linhardt, Biopolymers, 30, 733-741 (1990). LINK
58. "Oligosaccharide Mapping of Low Molecular Weight Heparins: Structural Differences and their Relationship to Activity," R.J. Linhardt, D. Loganathan, A. Al-Hakim, H.M. Wang, J.M. Walenga, D. Hoppensteadt, J. Fareed, Journal of Medicinal Chemistry, 33, 1639-1645 (1990). LINK
57. "Biodegradable Poly(Esters) for the Delivery of Bioactive Agents," R.J. Linhardt, D.R. Flanagan, H.T. Wang, E. Schmitt, Polymer Preprints, 31, 249-250 (1990). LINK
56. "Modification and Potential Uses of Heparin and Other Acidic Polysaccharides," R.J. Linhardt, Proceedings of the ACS Division of Polymeric Materials: Science and Engineering, 62, 488-491 (1990). LINK
55. "Examination of the Substrate Specificity of Heparin and Heparan Sulfate Lyases," R.J. Linhardt, J.E. Turnbull, H.M. Wang, D. Loganathan, J.T. Gallagher, Biochemistry, 29, 2611-2617 (1990). LINK
54. "Structural Variation of the Antithrombin III Binding Site and its Occurrence in Heparin from Different Sources," D. Loganathan, H.M. Wang, L.M. Mallis, R.J. Linhardt, Biochemistry, 29, 4362-4368 (1990). LINK
53. "Isolation and Recovery of Acidic Oligosaccharides from Polyacrylamide Gels by Semi-Dry Electrotransfer," A. Al-Hakim, R.J. Linhardt, Electrophoresis, 11, 23-28 (1990). LINK
52. "Carbohydrate Analysis of Glycoproteins," K.B. Lee, D. Loganathan, Z.M. Merchant, R.J. Linhardt, Applied Biochemistry and Biotechnology, 23, 53-80 (1990). LINK
51. "Heparin, Heparinoids and Heparin Oligosaccharides: Structure and Biological Activities," R.J. Linhardt and D. Loganathan, in Biomimetic Polymers, G. Gebelein (ed.), Plenum Press, New York, pp. 135-175, (1990). LINK
50. "Structure of Therafectin, A Novel Anti-Inflammatory Agent," R.J. Linhardt, N.C. Baenziger, B. Ronsen, Journal of Pharmaceutical Science, 79, 158-162 (1990). LINK
49. "Analysis of Glycosaminoglycan-Derived Oligosaccharides Using Reversed Phase Ion-Pairing HPLC and Ion Exchange Chromatography With Suppressed Conductivity Detection," R.J. Linhardt, K.N. Gu, D. Loganathan, S.R. Carter, Analytical Biochemistry, 181, 288-296 (1989). LINK
48. "Sequence Analysis of Highly Sulfated Heparin-Derived Oligosaccharides Using Fast Atom Bombardment Mass Spectrometry," L.M. Mallis, H.M. Wang, D. Loganathan, R.J. Linhardt, Analytical Chemistry, 61, 1453-1458 (1989). LINK
47. "Comparison of the Activity of Polyanions and Polycations on the Classical and Alternative-Amplification Pathways of Complement," J.M. Weiler, R.J. Linhardt, Immunopharmacology, 17, 65-72 (1989). LINK
46. "Quantitative Analysis of the Monomer Products Formed on the Hydrolysis of Poly(Esters) and Poly(Anhydrides)," R.J. Linhardt, D.R. Flanagan, E. Schmitt, H.T. Wang, Polymer Preprints, 30, 464-465 (1989). LINK
45. "Structural Features of Heparin and Their Effect on Heparin Cofactor II Mediated Inhibition of Thrombin," Y.S. Kim and R.J. Linhardt, Thrombosis Research, 53, 55-71 (1989). LINK
44. "Non-Random Structural Features in the Heparin Polymer," R.J. Linhardt, D.M. Cohen, K.G. Rice, Biochemistry, 28, 2888-2894 (1989). LINK
43. "Biodegradable Polymers For Controlled Release of Drugs," R.J. Linhardt, in Controlled Release of Drugs: Polymers and Aggregate Systems, Verlag Chemie Critical Review Series, M. Rosoff (Ed.), Chapter 2, pp 53-95, 1989. LINK
42. "Resistance of Heparinase-Derived Heparin Fragments to Biotransformation," A.K. Larsen, R.J. Linhardt, K.G. Rice, G. Wogan, R. Langer, The Journal of Biological Chemistry, 264, 1570-1577. (1989). LINK
41. "A Dose Escalation Study or Org 10172 (Low Molecular Weight Heparinoid) in Stroke," J. Biller, E.W. Massey, J.R. Marler, H.P. Adams, J.N. Davis, A. Bruno, R.A. Henriksen, R.J. Linhardt, L.B. Goldstein, M. Alberts, C.T. Kisker, G.J. Toffol, C.S. Greenberg, K.J. Banwart, C. Bertels, D.W. Beck, M. Walker, H.N. Maganani, Neurology, 39, 262-265 (1989). LINK
40. "Study of Defined Oligosaccharide Substrates of Heparin and Heparan Monosulfate Lyases," K.G. Rice and R.J. Linhardt, Carbohydrate Research, 190, 219-233 (1989). LINK
39. "Microbially Produced Rhamnolipid as a Source of Rhamnose," R.J. Linhardt, R. Bakhit, L. Daniels, F. Mayerl, and W. Pickenhagen, Biotechnology and Bioengineering, 33, 365-368 (1989). LINK
38. "Mapping and Quantification of the Major Oligosaccharide Components of Heparin," R.J. Linhardt, K.G. Rice, Y.S. Kim, D.L. Lohse, H.M. Wang, D. Loganathan," Biochemical Journal, 254, 781-787 (1988). LINK
37. "Microheterogeneity of Plasma Glycoproteins Antithrombin III and Heparin Cofactor II and Their Carbohydrate Analysis," Y.S. Kim, K.B. Lee and R.J. Linhardt, Thrombosis Research, 51, 97-104 (1988). LINK
36. "Homogeneous, Structurally Defined Heparin-Oligosaccharides With Low Anticoagulant Activity Inhibit the Generation of the Amplification Pathway C3 Convertase In Vitro," R.J. Linhardt, K.G. Rice, Y.S. Kim, J. Engelken, J. Weiler, The Journal of Biological Chemistry, 263, 13090-13096 (1988). LINK
35. "Use of Computer Simulation on the Massively Parallel Processor to Study the Structural Features of Heparin," D.M. Cohen, R.J. Linhardt, Proceedings of the Third International Conference on Super-computing: Supercomputing Projects, Applications and Artificial Intelligence, Volume 1, pp 210-213, L.P. Kartashev and S.I. Kartashev (Eds.), International Supercomputing Institute, St. Petersburg, FL, 1988. LINK
34. "Fractionation of Heparin-Derived Oligosaccharides by Gradient Polyacrylamide-Gel Electrophoresis," K.G. Rice, M.K. Rottink, R.J. Linhardt, Biochemical Journal, 244, 515-522 (1987). LINK
33. "New Approaches for Anticoagulation in Extracorporeal Therapy," R.J. Linhardt, R. Langer, Journal of Biomaterials, Artificial Cells and Artificial Organs, 15, 91-100 (1987). LINK
32. "Structure and Activity of a Unique Heparin-Derived Hexasaccharide," R.J. Linhardt, K.G. Rice, Z.M. Merchant, Y.S. Kim, D.L. Lohse, The Journal of Biological Chemistry, 261, 14448-14454 (1986). LINK
31. "Effect of Very Low Molecular Weight Heparin-Derived Oligosaccharides on Lipoprotein Lipase Release in Rabbits," Z.M. Merchant, E.E. Erbe, W.P. Eddy, D. Patel, R.J. Linhardt, Atherosclerosis, 62, 151-158 (1986). LINK
30. "Variation in Composition and Yield of Exopolysaccharides Produced by Klebsiella Serotype K32 and Acinetobacter calcoaceticus BD4," B.A. Bryan, R.J. Linhardt, L. Daniels, Applied and Environmental Microbiology, 51, 1304-1308 (1986). LINK
29. "Effect of Heparin, Heparin Fragments, and Cortisone on Cerebral Endothelial Cell Growth In Vitro and In Vivo," D.W. Beck, J.J. Olson, R.J. Linhardt, Journal of Neuropathology and Experimental Neurology, 45, 503-512 (1986). LINK
28. "Polysaccharide Lyases," R.J. Linhardt, P.M. Galliher, C.L. Cooney, Applied Biochemistry and Biotechnology, 12, 135-177 (1986). LINK
27. "Evidence of Random Structural Features in the Heparin Polymer," R.J. Linhardt, Z.M. Merchant, K.G. Rice, Y.S. Kim, G.L. Fitzgerald, A.C. Grant, R. Langer, Biochemistry, 24, 7805-7810 (1985). LINK
26. "High-Performance Liquid Chromatographic Separation of Heparin Derived Oligosaccharides," K.G. Rice, Y.S. Kim, A.C. Grant, Z.M. Merchant, R.J. Linhardt, Analytical Biochemistry, 150, 325-331 (1985). LINK
25. "Immuno-Affinity Purification of Heparinase," R.J. Linhardt, Z.M. Merchant, D.W. Persinger, The International Journal of Biochemistry, 17, 1179-1183 (1985). LINK
24. "Structure of Heparin Derived Tetrasaccharides," Z.M. Merchant, Y.S. Kim, K.G. Rice, R.J. Linhardt, Biochemical Journal, 229, 369-377 (1985). LINK
23. "Small Heparin Fragments Regulate the Amplification Pathway of Complement," M.D. Sharath, J.M. Weiler, Z.M. Merchant, Y.S. Kim, K.G. Rice, R.J. Linhardt, Immunopharmacology, 9, 73-80 (1985). LINK
22. "Purification and Characterization of Heparinase from Flavobacterium heparinum," V.C. Yang, R.J. Linhardt, H. Bernstein, C.L. Cooney, R. Langer, The Journal of Biological Chemistry, 260, 1849-1857 (1985). LINK
21. "Polymer Based Drug Delivery: Magnetic Modulation and Bioerodible Systems," E. Edelmen, R.J. Linhardt, H. Bobeck, J. Kost, H.B. Rosen, R. Langer, Polymers as Biomaterials, pp. 279-292, S.W. Shalaby, A.S. Hoffman, B.D. Ratner and T.A. Horbett (Eds.) Plenum Press, 1984. LINK
20. "The Effect of Extracorporeal Enzymatic Deheparinization on the Formed Blood Components," A. Larsen, R.J. Linhardt, M. Klein, D. Tapper, R. Langer, Artificial Organs, 8, 198-203 (1984). LINK
19. "Metachromatic Activity of Heparin and Heparin Fragments," A.C. Grant, R.J. Linhardt, G.. Fitzgerald, J.J. Park, R. Langer, Analytical Biochemistry, 137, 25-32 (1984). LINK
18. "An Immobilized Microbial Heparinase for Blood Deheparinization," R.J. Linhardt, C.L. Cooney, A. Larsen, C.A. Zannetos, D. Tapper, R. Langer, Applied Biochemistry and Biotechnology, 9, 41-55 (1984). LINK
17. "Bioerodable Polyanhydrides for Controlled Drug Delivery," R.J. Linhardt, H.B. Rosen, R. Langer, Polymer Preprints, 24, 47-48 (1983). LINK
16. "Angiogenesis Inhibition and Tumor Regression Caused by Heparin or a Heparin Fragment in the Presence of Cortisone," J. Folkman, R. Langer, R.J. Linhardt, C. Haudenschild, S. Taylor, Science, 221, 719-725 (1983). LINK
15. "Heparinase: In Vivo Activity and Immunogenicity in Rabbits," M.D. Klein, R.A. Drongowski, R.J. Linhardt, C.L. Cooney, R.S. Langer, Journal of Clinical and Laboratory Medicine, 102, 828-837 (1983). LINK
14. "Bioerodible Polyanhydrides For Controlled Drug Delivery," H. Rosen, J. Chang, G. Wenik, R.J. Linhardt, R. Langer, Biomaterials, 4, 131-133 (1983). LINK
13. "In Vivo Activity of Microbial Heparinase," R. Langer, R.J. Linhardt, A.K. Larsen, C.L. Cooney, D. Tapper, M. Klein, Transactions of the American Society for Artificial Internal Organs, 28, 387-390 (1982). LINK
12. "A Colorimetric Assay for Chemical Heparin in Plasma," M. Klein, R.A. Drongowski, R.J. Linhardt, R. Langer, Analytical Biochemistry, 124, 59-64 (1982). LINK
11. "Differential Anticoagulant Activity of Heparin Fragments Prepared Using Microbial Heparinase," R.J. Linhardt, A. Grant, C.L. Cooney, R. Langer, The Journal of Biological Chemistry, 257, 7310-7313 (1982). LINK
10. "The Regulation of Heparinase Production in Flavobacterium heparinum," P.M. Galliher, R.J. Linhardt, L.J. Conway, R. Langer, C.L. Cooney, European Journal of Applied Microbiology and Biotechnology, 15, 252-257 (1982). LINK
9. "An Enzymatic System for Removing Heparin in Extracorporeal Therapy," R. Langer, R.J. Linhardt, C.L. Cooney, M. Klein, D. Tapper, S.M. Hoffberg, A. Larsen, Science, 217, 261-263 (1982). LINK
8. "Mode of Action of Heparin Lyase On Heparin," R.J. Linhardt, G.L. Fitzgerald, C.L. Cooney, R. Langer, Biochimica et Biophysica Acta, 702, 197-203 (1982). LINK
7. "Immobilized Heparinase: Productions, Purification, and Application In Extracorporeal Therapy," R. Langer, R.J. Linhardt, C.L. Cooney, D. Tapper, M.D. Klein, Enzyme Engineering Vol. 6, pp. 433-441, I. Chibata, S. Fukui and L. Wingard (Eds.), Plenum Press, New York, 1982. LINK
6. "A System for Heparin Removal," R. Langer, R.J. Linhardt, M. Klein, P.M. Galliher, C.L. Cooney and M.M. Flanagan, Biomaterials: Inter-facial Phenomenon and Applications, Advances in Chemistry Symposium Series, Chapter 31, pp. 493-509, S. Cooper, A. Hoffman, N. Pepas and B. Ratner (Eds.), Washington, D.C. 1982. LINK
5. "Mechanism of Diacyl Peroxide Decomposition," R.J. Linhardt, B.L. Murr, E. Montgomery, J. Osby and J. Sherbine, The Journal of Organic Chemistry, 47, 2242-2251 (1982). LINK
4. "Blood Deheparinization Using Immobilized Microbial Heparinase," R.J. Linhardt, R. Langer, C.L. Cooney, P.M. Galliher, M.M. Flanagan, S.M. Hoffberg, Proceedings of the Second World Congress of Chemical Engineering, Montreal, Canada, Vol. I, pp. 183-185, 1981. LINK
3. "Heparinase Production by Flavobacterium heparinum," P.M. Galliher, C.L. Cooney, R. Langer and R.J. Linhardt, Applied and Environmental Microbiology, 41, 360-365 (1981). LINK
2. "The Mechanism of Diacyl Peroxide Decomposition," R.J. Linhardt, Ph.D. Dissertation, The Johns Hopkins University, 1979. (Abstract in PDF format) LINK
1. "Mechanism of Decomposition for Diacyl Peroxides and Related Carboxy Inversion Products in Aqueous Acetone," R.J. Linhardt and B.L. Murr, Tetrahedron Letters, 12, 1007-1010 (1979). LINK