Patents From the Linhardt Lab


59. "Reversible heparin molecules and methods of making and using the same. ," R. J. Linhardt, J Liu, Y. Xu, E. Harris, U.S. PATENT PENDING. (2014)


58. "Fiber composites for drug detoxification,," R. J. Linhardt, S. A. Mousa, U.S. PATENT # 8,607,989 (2013).


57. "Effect of a variety of carbon nanotubes on the iodine-iodine redox pair,," R.J. Linhardt, T. J. Simmons, J. Miao, J.S. Dordick, U.S. PATENT PENDING.


56. "Cellulose and hydroxyapatite composite membrane for protein purification,," R. J. Linhardt, J. S. Dordick, S. Cramer, J.Miao, K. Srinivasan, J.A. Woo, U.S. PATENT PENDING.


55. "Ultrasensitive carbohydrate detection by Glyco-qPCR amplification and applications in glycobiology," R. J. Linhardt, J. S. Dordick, S.- J. Kwon, K. Bok Lee, K. Solakyildirim, C. Cai, U.S. PATENT PENDING.


54. "High cell density cultivation of a key enzyme in bioengineered heparin production," R. J. Linhardt, J. S. Dordick, U. Bhaskar, Odile Francesca Restaino, P. Paul, L. Li, U.S. PATENT PENDING.


53. "Single step heparosan N-deacetylation and depolymerization for making bioengineered heparin," R.J. Linhardt, J. S. Dordick, Z. Wang, U.S. PATENT PENDING.


52. "Ozonolysis of the double bonds from unsaturated polysaccharides," R.J. Linhardt, T. Toida, S. Masuko, K. Higashi, J. Dordick, U.S. Patent Pending


51. "Controlled Photochemical Depolymerization of K5 Heparosan," T. Toida, R. J. Linhardt, J. S. Dordick, K.Higashi, Z. Wang, U. Bhaskar, M. Ly, F. Zhang, U.S. Patent Pending


50. "K5 heparosan fermentation and purification," R. J. Linhardt, Z. Wang J. S. Dordick, U.S. Patent# 8,883,452, Chinese Patent No. 201080038931.0 (2014)


49. "Chemoenzymatic Synthesis of Arixtra," R. J. Linhardt, J. Liu, M. Weïwer S. Masuka J. S. Dordick, U.S. Patent Pending


48. "Synthetic wood composite," J. S. Dordick, T. J. Simmons, M. Miyauchi, S.-H. Lee, U.S. Patent # 8,772,406 (2104)


47. "An artificial organelle on a digital microfluidic chip used to redesign the biological activities of heparan sulfate," , R. J. Linhardt, J. S. Dordick, J. G. Martin, U.S. Patent Pending


46. "Heparan sulfate proteoglycan compositions and use thereof," R. J. Linhardt, A. de Agostini, U.S. Patent Pending


45. "Blood Compatible Activated Carbon Beads for Extracorporeal Blood Detoxification," S. Murugesan, T. Park, R. J. Linhardt, J. Martin, U.S. Patent Pending


44. "Energy Storage Devices and Composite Articles Associated with the Same," R. J. Linhardt, S. Murugesan, P. M. Ajayan, O. Nalamasu, A. Kumar, S. M. Manikoth, V. L. Pushparaj, U.S. Patent Pending


43. "Enzymatic Synthesis of Sulfated Polysaccharides," R. J. Linhardt, J. Liu, J. Chen, F. Y. Avci, E. M. Munoz, U.S. Patent # 8,771,995 (2014)


42. "Fabrication of carbohydrate-Based Biomaterials Using Room Temperature Ionic Liquids," S. Murugesan, R. J. Linhardt, U.S. Patent Pending


41. "Blood Compatible Nanomaterials and Methods of Making and Using the Same," R. J. Linhardt, S. Murugesan, T. Park, PCT WO 2008/045021 A2, U.S. Patent Pending


40. "Composition and Method for Treating Occlusive Vascular Diseases, Nerve Regeneration and Wound Healing using Novel Sulfated Saccharides and Conjugated Polymeric Forms by Promoting Angiogenesis, Vasculargenesis and Neurogenesis," S. Mousa, R. J. Linhardt, U.S. Patent #7,741,311 (2010)


39. "Treatment and Prevention of Abnormal Cellular Proliferation," R.J. Linhardt, C.A. Hales, H.G. Garg, L. Yu, U.S. Patent # 7,538,096 (2009)


38. "O-Acetylated Low Molecular Weight Heparins as Antiproliferative Agents for Vascular Smooth Muscle Cells and Cancer," R.J. Linhardt, C.A. Hales, H.G. Garg, L. Yu, U.S. Patent Pending; European Patent WO 2005/089365 A2.


37. "Sulfo-Protected Polysaccharides and Methods and Intermediates Useful in their Preparation Groups in Donors and Building Blocks Used in Glycosylation Reactions," R.J. Linhardt, Tasneem Islam, Nathalie Karst, European Patent WO 2005/000907 A1, U.S. Patent Pending


36. "Structure-Based Design and Synthesis of FGF Inhibitors and FGF Modulator Compounds," R.J. Linhardt, M. Mohammadi, D. Green, U.S. Patent Pending


35. "C-Glycoside Analogs and Methods for their Preparation and Use," R.J. Linhardt, H.G. Bazin, T. Polat, Y. Du, U.S. Patent #6,245,902 (2001)


34. "Method for Synthesizing the C-Glycosides of Ulosonic Acids," R.J. Linhardt, T. Polat, Y. Du, U.S. Patent # 6,590,110, 2003; European Patent WO 00/18777, April 6, 2000, Japanese Patent # 2001-502356, February 20. (2001)


33. "Synthesis of Fully Sulfated Chondroitin Sulfates with Anticoagulant Activity," R.J. Linhardt, T. Maruyama, T. Toida, T. Imanari, G. Yu, Japanese Patent Pending


32. "Method for Synthesizing the C-Glycosides of Ulosonic Acids," R.J. Linhardt, I.R. Vlahov, European Patent EP 0 901 498 B1 (2004),German Patent DE 698 26 394 T2 (2005)


31. "Diastereocontrolled Synthesis of Carbon Glycosides of N-Acetylneuraminic Acid via Glycosyl Samarium (III) Intermediates," R.J. Linhardt, I.R. Vlahov, U.S. Patent #6,376,662 (2002)


30. "Dermatan Disulfate, An Inhibitor of Thrombin and Complement Activation," R.J. Linhardt, S.J. Brister, M.R. Buchanan, C.C. Griffin, C.L. Van Gorp, European Patent Pending 97936042.7-2115.


29. "Methods and Composition for Isolation, Diagnosis and Treatment of Polyanion-Binding Microorganisms," R.J. Linhardt, R.M. Marks, Y. Chen, T. Maguire, U.S. Patent # 6,197,568 (2001)


28. "Sucrose Based Surfactants and Methods Therefor," R.J. Linhardt, H.G. Bazin, T. Polat, U.S. Patent #6,184,196 (2001)


27. "Regioselective Synthesis of Glucose-Based Surfactants," R.J. Linhardt, H.G. Bazin, U.S. Patent #6,121,430 (2000)


26. "Chondroitin Lyase Enzymes," R.J. Linhardt, C. Bennett, M. Laliberte, K. Gu, J. Zimmerman, D. Fink, L. Tkaleck, Lydia A., U.S. Patent #6,093,563 (2000). European Patent Application #05075080.1 (2005)


25. "Angiogenesis Inhibitors and Use Thereof," R.J. Linhardt, M. Bernfield, Y. Kim, U.S. Patent #6,028,061, (2000)


24. "Chondroitin Lyase Enzymes," R.J. Linhardt, C. Bennett, M. Laliberte, K. Gu, J. Zimmerman, L. Tkalec, D. Fink, U.S. Patent #6,054,569 (2000)


23. "Dermatan Disulfate, An Inhibitor of Thrombin and Complement Activation," R.J. Linhardt, S.J. Brister, M.R. Buchanan, C.C. Griffin, C.L. Van Gorp, U.S. Patent #5,922,690 (1999)


22. "Sugar-Based Polymers," R.J. Linhardt, J.S. Dordick, B.D. Martin, D.G. Rethwisch, D.R. Patel, U.S. Patent #5,854,030 (1998), Mexican Patent #192304 (1999)


21. "Purification of Heparin Lyase I, II and III from Flavobacterium Heparinum," R.J. Linhardt, R. Sasisekharan, D.L. Lohse, C. Cooney, R.S. Langer, Canadian Patent #2,150,263 (1998)


20. "Snail Extract Including Acharan Sulfate," R.J. Linhardt, Y.S. Kim, Y. Park, Korean Patent #170064 (1998)


19. "Process to Activate Sulfated Polysaccharides," R.J. Linhardt, M. Yafuso, U.S. Patent #5,583,213 (1996)


18. "Purification, Composition and Specificity of Heparin Lyase I, II and III from Flavobacterium Heparinum," R.J. Linhardt, R. Sasisekharan, D.L. Lohse, C. Cooney, R.S. Langer, U.S. Patent #5,569,600 (1996), Japanese Patent # 2004-135684 (2004);European Patent # EP 0 670 892 B1 (2005); German Patent #693 33 834.2 (2005); Danish Patent # 0 670 892 (2005); French, United Kingdom, Belgium, Swiss, Spanish, Swedish, The Netherlands, Italian Patent # 94 902 450.9 (2005)


17. "Selectin Receptor Modulating Composition," R.J. Linhardt, M.P. Bevilacqua, R.M. Nelson, U.S. Patent #5,527,785 (1996)


16. "Purification of Heparin Lyase I, II and III from Flavobacterium Heparinum," R.J. Linhardt, R. Sasisekharan, D.L. Lohse, C. Cooney, R.S. Langer, Japanese Patent #8-505767 (1996)


15. "Purification of Heparin Lyase I, II and III from Flavobacterium Heparinum," R.J. Linhardt, R. Sasisekharan, D.L. Lohse, C. Cooney, R.S. Langer, U.S. Patent #5,389,539 (1995)


14. "Method of Making Poly (Sugar Acrylates) Using Hydrolytic Enzymes," R.J. Linhardt, J.S. Dordick, B.D. Martin, S. Ampofo, European Patent WO 9414823 (1995)


13. "Method of Making Poly (Sugar Acrylates) Using Hydrolytic Enzymes," R.J. Linhardt, J.S. Dordick, B.D. Martin, S. Ampofo, U.S. Patent #5,474,915 (1995)


12. "Purification of Heparin Lyase I, II and III from Flavobacterium Heparinum," R.J. Linhardt, R. Sasisekharan, D.L. Lohse, C. Cooney, R.S. Langer, European Patent WO 9412618 (1994)


11. "Gel-Based Sequencing of Oligosaccharides and Polysaccharides," R.J. Linhardt, K.B. Lee, A. Al-Hakim, D. Loganathan, U.S. Patent #5,284,558 (1994)


10. "Method for Producing Rhamnose," R.J. Linhardt, L. Daniels, B. Bryan, U.S. Patent #4,933,281 (1990)


9. "Bioerodible Polyanhydrides for Controlled Drug Delivery," R.S. Langer, R.J. Linhardt, H. B. Rosen, K. Leong, U.S. Patent #4,906,474 (1990)


8. "Bioerodible Polyanhydrides for Controlled Drug Delivery," R.S. Langer, R.J. Linhardt, H.B. Rosen, K.W. Leong, U.S. Patent #4,891,225 (1990)


7. "Oligosaccharide Heparin Fragments as Inhibitors of Complement Cascade," R.J. Linhardt, J.M. Weiler, European Patent WO 89909088.0 (1990)


6. "Oligosaccharide Heparin Fragments as Inhibitors of Complement Cascade," R.J. Linhardt, J.M. Weiler, U.S. Patent #4,916,219 (1990)


5. "Low Molecular Weight Heparin Fragments as Inhibitors of Complement Activation," R.J. Linhardt, Z.M. Merchant, J.M. Weiler, M.D. Sharath, U.S. Patent #4,847,338 (1989)


4. "Process for Producing Heparinase," R.S. Langer, R.J. Linhardt, C.L. Cooney, and P.M. Galliher, U.S. Patent #4,443,545 (1984)


3. "Heparinase Derived Anticoagulants," R.S. Langer, R. Linhardt, C. L. Cooney, G. Fitzgerald, A. Grant, U.S. Patent #4,396,762 (1983)


2. "Process for Neutralizing Heparin," R.S. Langer, R. Linhardt, C. L. Cooney, P.M. Galliher, M.M. Flanagan, M. Klein, U.S. Patent #4,373,023 (1983)


1. "Process for Producing Heparinase," R.S. Langer, R. Linhardt, C. L. Cooney, P.M. Galliher, U.S. Patent #4,341,869 (1982)