Robert J. Linhardt

Professor

Contact Info

Office: (518) 276-3404
Fax: (518) 276-3405
E-mail: linhar@rpi.edu

Campus Address:
4005C BioTechnology Bldg.
110 8th Street
Troy NY 12180

Biography

After 21 years on the faculty of the University of Iowa, Linhardt joined Rensselaer in 2003 as a senior constellation professor. Since 2008 Dr. Linhardt's group has been working on a collaboration to bioengineer Heparin from E. coli. During his career in Iowa, he spent eight years as the university’s F. Wendell Miller Distinguished Professor of Chemistry and ten years as a member of the Executive Committee of the Center for Biocatalysis and Bioprocessing. Linhardt began his professional career with a three-year postdoctorate in chemical engineering at Massachusetts Institute of Technology.

Curriculum Vitae


Education

1979-82 Post Doc in Biochemical Engineering and Bioorganic Chemistry in the Langer Lab, MIT, Cambridge, MA
1979 Organic Chemistry Ph.D. from The Johns Hopkins University, Baltimore. MD
1977 Organic Chemistry M.A. from The Johns Hopkins University, Baltimore. MD
1975 Chemistry B.S. from Marquett University, Milwaukee, WI

Research



Professional Experience

9/03- present Ann and John H. Broadbent Senior Constellation Chair in Biocatalysis and Metabolic Engineering, Professor of Chemistry, Biology and Chemical and Biological Engineering, Rensselaer Polytechnic Institute (RPI)
7/06-8/08 Acting Director, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute
1/15- Adjunct Professor, Orthopaedics, Mount Sinai School of Medicine, NY, NY
7/05- present Adjunct Professor of Pharmaceutical Sciences, Albany College of Pharmacy, Albany, NY
7/99-8/03 F. Wendell Miller Distinguished Professor of Chemistry
5/96-8/03 F. Wendell Miller Distinguished Professor of Medicinal and Natural Products Chemistry and Professor of Chemical and Biochemical Engineering
5/90-8/03 Professor of Medicinal and Natural Products Chemistry
1/92-9/92 Visiting Professor, University of California, San Diego, Cancer Center and the La Jolla Cancer Research Foundation
7/86-4/90 Associate Professor of Medicinal and Natural Products Chemistry
7/82-6/86 Assistant Professor of Medicinal and Natural Products Chemistry, College of Pharmacy, University of Iowa (UI)
1/81-present Industrial Consultant in the area of biocatalysis, biopolymers, carbohydrate chemistry and drug delivery
6/79-6/82 Research Associate, Biochemical Engineering, Department of Applied Biological Sciences and Harvard-MIT Joint Program in Biomedical Research at the Whitaker College of Health Sciences and Technology, Massachusetts Institute of Technology
9/75-5/79 Research/Teaching Assistant, Department of Chemistry, The Johns Hopkins University
Research in the Linhardt lab focuses on complex carbohydrates. Glycoprotein, proteoglycans, and other glycoconjugates are prepared by fermentation using recombinant technology, extraction from tissues, or by chemical and enzymatic synthesis. After determining the structure of these molecules, his group studies their biological activities. Research in the Linhardt group has many focuses, including the mapping of the glycome, embryonic stem cell proteoglycan glycomics, structural biology studies, GAG sequencing using mass spectrometry (MS), the specificity and kinetics of protein-carbohydrate interactions, the medical application of nanomaterials, and chemical and enzymatic synthesis of carbohydrates. For more information, refer to the Research section of the website.

Awards and Academic Honors

2019 Karl Meyer Award from the Society for Glycobiology
2015 Elected to National Academy of inventors (NAI) Fellow
2010 Melville L. Wolfrom Award Award from the American Chemical Society - For outstanding service to the Carbohydrate Division and to the field of carbohydrate chemistry
2010 Elected to the rank of American Association for the Advancement of Science (AAAS) Fellow
2009 Scientific American 10 - Recognized for contributions to American science and technology
2003 RPI Ann and John H. Broadbent Senior Constellation Chair in Biocatalysis and Metabolic Engineering awarded
2003 American Chemical Society Claude S. Hudson Award in Carbohydrate Chemistry
1999 Volwiler Research Achievement Award sponsored by Abbott, awarded by the AACP
1996 University of Iowa F. Wendell Miller Distinguished Professorship Awarded
1994 Horace S. Isbell Award from the American Chemical Society, Division of Carbohydrate Chemistry - Given for excellence of contributions to carbohydrate chemistry and continuing promise of quality contributions
1992 Iowa Regents Award for Faculty Excellence - Awarded for a sustained record of excellence across the spectrum of faculty endeavors
1989 University of Iowa Excellence in Teaching Award
1981 MIT Johnson & Johnson Postdoctoral Fellow - A competitive award given for exceptional biomedical research.
1979 The Johns Hopkins University Ernst M. Marks Award - Presented for excellence in teaching and research in organic chemistry

Professional Societies

Society for Glycobiology
American Society for Matrix Biology
American Society of Biochemistry and Molecular Biology
American Chemical Society, Divisions of Medicinal Chemistry, Biotechnology and Carbohydrate Chemistry
American Association of Pharmaceutical Scientists
American Association of Colleges of Pharmacy
American Association for the Advancement of Science – AAAS Fellow

National Appointments

Editorial Boards
The Journal of Biological Chemistry 1995-2000, 2005-2011
American Journal of Analytical Chemistry 2010-
Molecules 2009-
Polymers 2009-
Cell Health and Cytoskeleton 2008-
International Journal of Carbohydrate Chemistry 2008-
Organic Synthesis 2008-
Biochemistry Research International 2007-
Nanotechnology, Science and Applications 2007-
Open Glycoscience (Editor-in-Chief) 2007-
Glycobiology 2006-
Current Organic Synthesis (Regional Editor) 2002-
Mini Reviews in Organic Chemistry (Regional Editor) 2002-
Journal of Carbohydrate Chemistry 1995-
Analytical Biochemistry 1991-1997, 2001-
Carbohydrate Research 1990-2002
Applied Biochemistry and Biotechnology 1985-
Committees and Memberships:
2015 Fellow-National Academy of Inventors
2012 Chair–Proteoglycans Gordon Conference
2009 Synthetic and Biological Chemistry B, Biological Chemistry and (Macromolecular Biophysics ad hoc member
2008 FDA Adverse Reactions Working Group
2008-2009 USP Advisory Committee on Heparin
2006 Synthetic and Biological Chemistry A Study Section ad hoc member
2004 President's Council on Competitiveness (National Initiative on Innovation, Skills subcommittee member)
2004 Thrombosis and Hemostasis Study Section ad hoc member
2003 Bioorganic and Natural Products Study Section ad hoc member
1988 National Institutes of Health, Pharmacology Special Study Section
1987 National Academy of Sciences Interacademy Exchange Scientist to Russia and the Ukraine