46. "Heparan sulfate proteoglycan compositions and use thereof," A. de Agostini, R. J. Linhardt, U.S. PATENT PENDING.

45. "Blood Compatible Activated Carbon Beads for Extracorporeal Blood Detoxification," R. J. Linhardt, T. Park, S. Murugesan, J. Martin, U.S. PATENT PENDING.

44. "Energy Storage Devices and Composite Articles Associated with the Same," P. M. Ajayan, R. J. Linhardt, O. Nalamasu, A. Kumar, S. Murugesan, S. M. Manikoth, V. L. Pushparaj, U.S. PATENT PENDING

43. "Enzymatic Synthesis of Heparin and Heparan Sulfate," J. Liu, J. Chen, R. J. Linhardt, F. Y. Avci, E. M. Munoz, U.S. PATENT PENDING.

42."Fabrication of carbohydrate-Based Biomaterials Using Room Temperature Ionic Liquids," R. J. Linhardt, S. Murugesan, U.S. PATENT PENDING.

41. "Nano-Based Neoproteoglycans-Blood Compatible Nanomaterials," R. J. Linhardt, S. Murugesan, T. Park, U.S. PATENT PENDING.

40. "Composition and Method for Treating Occlusive Vascular Diseases, Nerve Regeneration and Wound Healing using Novel Sulfated Saccharides and Conjugated Polymeric Forms by Promoting Angiogenesis, Vasculargenesis and Neurogenesis," S. Mousa, R. J. Linhardt, U.S. PATENT PENDING.

39. "Treatment and Prevention of Abnormal Cellular Proliferation," C.A. Hales, H.G. Garg, R.J. Linhardt, L. Yu, U.S. PATENT # 7,538,096 (2009).

38. "O-Acetylated Low Molecular Weight Heparins as Antiproliferative Agents for Vascular Smooth Muscle Cells and Cancer," C.A. Hales, H.G. Garg, R.J. Linhardt, L. Yu, U.S. PATENT PENDING; EUROPEAN PATENT WO 2005/089365 A2.

37. "Sulfo-Protected Polysaccharides and Methods and Intermediates Useful in their Preparation Groups in Donors and Building Blocks Used in Glycosylation Reactions," R.J. Linhardt, Tasneem Islam, Nathalie Karst, EUROPEAN PATENT WO 2005/000907 A1, 2005, U.S. PATENT PENDING.

36. "Structure-Based Design and Synthesis of FGF Inhibitors and FGF Modulator Compounds," M. Mohammadi, D. Green, R.J. Linhardt, U.S. PATENT PENDING.

35. "C-Glycoside Analogs and Methods for their Preparation and Use," R.J. Linhardt, H.G. Bazin, Y. Du, T. Polat, U.S. PATENT #6,245,902 (2001).

34. "Method for Synthesizing the C-Glycosides of Ulosonic Acids," Y. Du, T. Polat, R.J. Linhardt, U.S. PATENT # 6,590,110, 2003; EUROPEAN PATENT WO 00/18777, April 6, 2000, JAPANESE PATENT # 2001-502356, February 20. 2001.

33. "Synthesis of Fully Sulfated Chondroitin Sulfates with Anticoagulant Activity," T. Maruyama, T. Toida, T. Imanari, G. Yu, R.J. Linhardt, Japanese PATENT PENDING.

32. "Method for Synthesizing the C-Glycosides of Ulosonic Acids," I.R. Vlahov, R.J. Linhardt, European Patent EP 0 901 498 B1 (2004),German Patent DE 698 26 394 T2 (2005).

31. "Diastereocontrolled Synthesis of Carbon Glycosides of N-Acetylneuraminic Acid via Glycosyl Samarium (III) Intermediates," I.R. Vlahov, R.J. Linhardt, U.S. PATENT #6,376,662 (2002).

30. "Dermatan Disulfate, An Inhibitor of Thrombin and Complement Activation," S.J. Brister, M.R. Buchanan, C.C. Griffin, C.L. Van Gorp, R.J. Linhardt, EUROPEAN PATENT PENDING 97936042.7-2115.

29. "Methods and Composition for Isolation, Diagnosis and Treatment of Polyanion-Binding Microorganisms," R.M. Marks, Y. Chen, T. Maguire, R.J. Linhardt, U.S. PATENT # 6,197,568 (2001).

28. "Sucrose Based Surfactants and Methods Therefor," R.J. Linhardt, H.G. Bazin, T. Polat, U.S. PATENT #6,184,196 (2001).

27. "Regioselective Synthesis of Glucose-Based Surfactants," H.G. Bazin, R.J. Linhardt, U.S. PATENT #6,121,430 (2000).

26. "Chondroitin Lyase Enzymes," C. Bennett, M. Laliberte, K. Gu, J. Zimmerman, L. Tkaleck, Lydia A., D. Fink, R.J. Linhardt, U.S. PATENT #6,093,563 (2000). European Patent Application #05075080.1 (2005).

25. "Angiogenesis Inhibitors and Use Thereof," M. Bernfield, R.J. Linhardt, Y. Kim, U.S. PATENT #6,028,061, (2000).

24. "Chondroitin Lyase Enzymes," C. Bennett, M. Laliberte, K. Gu, J. Zimmerman, L. Tkalec, D. Fink, R.J. Linhardt, U.S. PATENT #6,054,569 (2000).

23. "Dermatan Disulfate, An Inhibitor of Thrombin and Complement Activation," S.J. Brister, M.R. Buchanan, C.C. Griffin, C.L. Van Gorp, R.J. Linhardt, U.S. PATENT #5,922,690 (1999).

22. "Sugar-Based Polymers," J.S. Dordick, D.G. Rethwisch, D.R. Patel, B.D. Martin, R.J. Linhardt, U.S. PATENT #5,854,030 (1998), MEXICAN PATENT #192304 (1999).

21. "Purification of Heparin Lyase I, II and III from Flavobacterium Heparinum," R. Sasisekharan, D.L. Lohse, C. Cooney, R.J. Linhardt, R.S. Langer, CANADIAN PATENT #2,150,263 (1998).

20. "Snail Extract Including Acharan Sulfate," Y.S. Kim, Y. Park, R.J. Linhardt, KOREAN PATENT #170064, 1998.

19. "Process to Activate Sulfated Polysaccharides," M. Yafuso, R.J. Linhardt, U.S. PATENT #5,583,213 (1996).

18. "Purification, Composition and Specificity of Heparin Lyase I, II and III from Flavobacterium Heparinum," R. Sasisekharan, D.L. Lohse, C. Cooney, R.J. Linhardt, R.S. Langer, U.S. PATENT #5,569,600 (1996), Japanese Patent # 2004-135684 (2004);European Patent # EP 0 670 892 B1 (2005); German Patent #693 33 834.2 (2005); Danish Patent # 0 670 892 (2005); French, United Kingdom, Belgium, Swiss, Spanish, Swedish, The Netherlands, Italian Patent # 94 902 450.9 (2005)..

17. "Selectin Receptor Modulating Composition," M.P. Bevilacqua, R.M. Nelson, R.J. Linhardt, U.S. PATENT #5,527,785 (1996).

16. "Purification of Heparin Lyase I, II and III from Flavobacterium Heparinum," R. Sasisekharan, D.L. Lohse, C. Cooney, R.J. Linhardt, R.S. Langer, JAPANESE PATENT #8-505767 (1996).

15. "Purification of Heparin Lyase I, II and III from Flavobacterium Heparinum," R. Sasisekharan, D.L. Lohse, C. Cooney, R.J. Linhardt, R.S. Langer, U.S. Patent #5,389,539 (1995).

14. "Method of Making Poly (Sugar Acrylates) Using Hydrolytic Enzymes," J.S. Dordick, B.D. Martin, S. Ampofo, R.J. Linhardt, EUROPEAN PATENT WO 9414823 (1995).

13. "Method of Making Poly (Sugar Acrylates) Using Hydrolytic Enzymes," J.S. Dordick, B.D. Martin, S. Ampofo, R.J. Linhardt, U.S. PATENT #5,474,915 (1995).

12. "Purification of Heparin Lyase I, II and III from Flavobacterium Heparinum," R. Sasisekharan, D.L. Lohse, C. Cooney, R.J. Linhardt, R.S. Langer, European PATENT WO 9412618 (1994).

11. "Gel-Based Sequencing of Oligosaccharides and Polysaccharides," R.J. Linhardt, K.B. Lee, A. Al-Hakim, D. Loganathan, (1994), U.S. PATENT #5,284,558 (1994).

10. "Method for Producing Rhamnose," L. Daniels, B. Bryan, R.J. Linhardt, U.S. PATENT #4,933,281 (1990).

9. "Bioerodible Polyanhydrides for Controlled Drug Delivery," R.S. Langer, H. B. Rosen, R.J. Linhardt, K. Leong, U.S. PATENT #4,906,474 (1990).

8. "Bioerodible Polyanhydrides for Controlled Drug Delivery," R.S. Langer, H.B. Rosen, R.J. Linhardt and K.W. Leong, U.S. PATENT #4,891,225 (1990).

7. "Oligosaccharide Heparin Fragments as Inhibitors of Complement Cascade," R.J. Linhardt, J.M. Weiler, EUROPEAN PATENT WO 89909088.0 (1990).

6. "Oligosaccharide Heparin Fragments as Inhibitors of Complement Cascade," R.J. Linhardt, J.M. Weiler, U.S. PATENT #4,916,219 (1990).

5. "Low Molecular Weight Heparin Fragments as Inhibitors of Complement Activation," R.J. Linhardt, Z.M. Merchant, J.M. Weiler, M.D. Sharath. U.S. PATENT #4,847,338 (1989).

4. "Process for Producing Heparinase," R.S. Langer, R.J. Linhardt, C.L. Cooney, and P.M. Galliher. U.S. PATENT #4,443,545 (1984).

3. "Heparinase Derived Anticoagulants," R.S. Langer, R.J. Linhardt, C.L. Cooney, G. Fitzgerald, and A. Grant. U.S. PATENT #4,396,762 (1983).

2. "Process for Neutralizing Heparin," R.S. Langer, R. Linhardt, C.L. Cooney, P.M. Galliher, M.M. Flanagan and M. Klein. U.S. PATENT #4,373,023 (1983).

1. "Process for Producing Heparinase," R.S. Langer, R. Linhardt, C.L. Cooney, P.M. Galliher. U.S. PATENT #4,341,869 (1982).

Back to Home Page